ANCA-associated vasculitis – Should we change the standard of care?
Publication date: Available online 1 October 2015 Source:Indian Journal of Rheumatology Author(s): Poonam Sharma, Max Yates, Chetan Mukhtyar Collaborative clinical trials over the last 25 years have revolutionised the care of patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis. This has led to production of management recommendations and standards of care. This paper reviews the existing standards and the recent evidence that has fed further evolution of standards of care. Pattern recognition remains vital to early diagnosis and therefore initiation treatment. While cyclophosphamide rem...
Source: Indian Journal of Rheumatology - October 1, 2015 Category: Rheumatology Source Type: research
Fracture odontoid process as the first presentation of calcium pyrophosphate deposition disease
Publication date: Available online 26 September 2015 Source:Indian Journal of Rheumatology Author(s): Pui-Shan Julia Chan, Moon-Ho Leung (Source: Indian Journal of Rheumatology)
Source: Indian Journal of Rheumatology - September 26, 2015 Category: Rheumatology Source Type: research
Assessment of disease activity in Takayasu's arteritis
Publication date: Available online 26 September 2015 Source:Indian Journal of Rheumatology Author(s): Durga Prasanna Misra, Ramnath Misra Takayasu's arteritis (TA) is a large vessel vasculitis of unknown etiology, more common among Asians. Since it is a smoldering, chronic disease, assessment of disease activity is a challenge. Acute phase reactants, erythrocyte sedimentation rate and CRP, imperfectly correlate with disease activity on histopathology. The earliest clinical criteria to assess disease activity were the NIH criteria, taking a composite of clinical features, inflammatory markers, and imaging to assess ...
Source: Indian Journal of Rheumatology - September 26, 2015 Category: Rheumatology Source Type: research
Perspective: ‘Which way is vasculitis research heading?’
Publication date: Available online 26 September 2015 Source:Indian Journal of Rheumatology Author(s): Paul Bacon Clinical research is driving the improved prognosis for patients with systemic vasculitis. The major progress has been in ANCA-related vasculitis, where the need now is to incorporate the lessons from limited term controlled trials into evidence-based treat-to-target regimes related to individual responses over a prolonged period. This perspective examines the research aimed to establish the biomarkers needed for such an approach to succeed. It also looks at the more basic research needed to establish the ...
Source: Indian Journal of Rheumatology - September 26, 2015 Category: Rheumatology Source Type: research
Polyarteritis nodosa and microscopic polyangiitis – The Indian experience
Publication date: Available online 16 September 2015 Source:Indian Journal of Rheumatology Author(s): Rohini Handa Polyarteritis nodosa (PAN) and microscopic polyangiitis (MPA) are systemic necrotising vasculitides, with a propensity to involve multiple organs. MPA is an ANCA (antineutrophil cytoplasmic antibody)-associated vasculitis while PAN is characterised by the absence of ANCA/other autoantibodies. The clinical profile in India is no different from that reported elsewhere. Lack of physician awareness contributes to diagnostic delays. In absence of disease registries, long-term outcome data from India are spars...
Source: Indian Journal of Rheumatology - September 16, 2015 Category: Rheumatology Source Type: research
Polyarteritis nodosa – Challenges and options in management
Publication date: Available online 24 August 2015 Source:Indian Journal of Rheumatology Author(s): Christian Pagnoux, Nader A. Khalidi Polyarteritis nodosa (PAN) was one of the first systemic necrotizing vasculitides to be described, in the late 19th century. Hepatitis B virus (HBV) was the major cause of the observed PAN cases between 1970 and the early 2000s. However, in the revised 2012 Chapel Hill Consensus Conference nomenclature, HBV-related PAN is now included with vasculitides associated with probable etiologies (and named HBV-associated vasculitis). PAN should thus now refer exclusively to primary cases, w...
Source: Indian Journal of Rheumatology - August 25, 2015 Category: Rheumatology Source Type: research
Granulomatosis with polyangiitis: Indian experience
Publication date: Available online 24 August 2015 Source:Indian Journal of Rheumatology Author(s): Ashok Kumar, Anil Abrol Granulomatosis with polyangiitis (GPA) is now a well-recognised clinical entity in India. The earliest description of GPA in India (then called Wegener's granulomatosis) appeared as a single case in a series of 108 cases of systemic vasculitis published in 1985. Later, several short case-series (mostly from northern India) and a number of case reports were published. The number of published cases of GPA from India till date is about 130 (actual burden of disease is certainly much larger as only...
Source: Indian Journal of Rheumatology - August 25, 2015 Category: Rheumatology Source Type: research
International publications of interest from India (March–May 2015)
Publication date: September 2015 Source:Indian Journal of Rheumatology, Volume 10, Issue 3 Author(s): Vivek Arya (Source: Indian Journal of Rheumatology)
Source: Indian Journal of Rheumatology - August 23, 2015 Category: Rheumatology Source Type: research
A comparison of clinical and laboratory profile of non-radiographic axial spondyloarthritis and ankylosing spondylitis
Conclusion Though the clinical features and HLA B27 frequency is similar in nr-axSpA and AS, Patients with AS were older and had longer disease duration. (Source: Indian Journal of Rheumatology)
Source: Indian Journal of Rheumatology - August 23, 2015 Category: Rheumatology Source Type: research
Non-radiographic spondyloarthritis
Publication date: September 2015 Source:Indian Journal of Rheumatology, Volume 10, Issue 3 Author(s): Vinod Ravindran, Amita Aggarwal (Source: Indian Journal of Rheumatology)
Source: Indian Journal of Rheumatology - August 23, 2015 Category: Rheumatology Source Type: research
Takayasu's arteritis: Review of epidemiology and etiopathogenesis
Publication date: Available online 19 August 2015 Source:Indian Journal of Rheumatology Author(s): Sanjay Jain, Sathish Kumar Pondaiah Takayasu's arteritis (TA) is a systemic large vessel chronic inflammatory disease affecting the aorta and its branches. Epidemiological data on the prevalence of TA are limited to the hospital-based studies. The prevalence, clinical features and outcomes of TA vary across the globe. Although TA is reported from all parts of the world, the prevalence of the disease appears to be high in oriental countries especially in Japan, India, Korea, and Thailand. The exact pathogenesis of the ...
Source: Indian Journal of Rheumatology - August 19, 2015 Category: Rheumatology Source Type: research
Antineutrophil cytoplasmic antibodies (ANCA): Role in disease pathogenesis, diagnosis, and monitoring ANCA associated vasculitis
Publication date: Available online 10 August 2015 Source:Indian Journal of Rheumatology Author(s): Ashish Aggarwal, Aman Sharma, Manish Rathi, Kusum Sharma, Ranjana Walker Minz Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a small-vessel vasculitis. The exact mechanism of ANCA involvement in the pathogenesis of AAV is not fully understood. It is an autoimmune disease with multifactorial pathophysiology. The most common ANCA target antigens are myeloperoxidase and proteinase 3. In addition to autoantibodies, dysregulated T and B cells have a pivotal pathophysiological role in this d...
Source: Indian Journal of Rheumatology - August 11, 2015 Category: Rheumatology Source Type: research
Kawasaki disease in the state of Jammu and Kashmir: A decade of experience
Conclusion KD is infrequently diagnosed in the state of Jammu and Kashmir. All clinicians, especially pediatricians need to update knowledge regarding KD, so that patients are diagnosed and treated early. (Source: Indian Journal of Rheumatology)
Source: Indian Journal of Rheumatology - August 8, 2015 Category: Rheumatology Source Type: research
Metabolic syndrome in patients with systemic lupus erythematosus from South India
Conclusion South Indian SLE patients have higher prevalence of NCEP ATP III and WHO defined metabolic syndrome compared to healthy controls. SLE patients have an altered lipid profile, but there was no IR and no association of metabolic syndrome with disease activity or damage. (Source: Indian Journal of Rheumatology)
Source: Indian Journal of Rheumatology - August 7, 2015 Category: Rheumatology Source Type: research
A survey of knowledge, attitudes, and practices relating to musculoskeletal examination among pediatricians in Maharashtra, India
Conclusions Many pediatricians are not confident in MSKe and are less confident compared to other bodily systems. There is need for greater training and awareness about the importance of MSKe at both undergraduate and postgraduate level. As a simple validated clinical skill, there is considerable potential to increase teaching of pGALS and thereby ultimately potentially improve MSKe performance in clinical practice. (Source: Indian Journal of Rheumatology)
Source: Indian Journal of Rheumatology - August 7, 2015 Category: Rheumatology Source Type: research
