O-089 A Genome Wide Association Study in men with unexplained infertility identifies nine SNPs at the FSHB locus to be associated with Follicle Stimulating Hormone level
This study shows that not one single SNP, but rather a genomic region has an impact on FSH serum level in men with unexplained male infertility. This effect is even more pronounced in the more severe phenotype of oligozoospermic men.Limitations, reasons for cautionThe study is restricted to men with unexplained infertility, which might cause a selection bias. Validation and functional evaluation of the eight newly identified SNPs in independent cohorts would emphasize the results more. The sample size of 742 limits detection of loci with smaller effect on FSH levels.Wider implications of the findingsThe determination of on...
Source: Human Reproduction - August 6, 2021 Category: Reproduction Medicine Source Type: research
O-082 The ratio AMH/antral follicle count varies according to the etiologies of diminished ovarian reserve suggesting differences in follicular health
AbstractStudy questionDoes diminished ovarian reserve (DOR) and its etiology impact the AMH/AFC ratio?Summary answerAMH/AFC ratio varies according to the etiology of DOR in young women, suggesting different impact on the follicular health, and further oocyte quality.What is known alreadyAnti-M üllerian hormone and antral follicle count currently represent the two most accurate markers of the follicular ovarian status. Even though they may diagnose a reduction in the follicular stockpile, low values remain inefficient for predicting poor oocyte quality, in particular in young women. Since AMH is produced by the granulosa c...
Source: Human Reproduction - August 6, 2021 Category: Reproduction Medicine Source Type: research
O-074 No methylome differences observed in IVF children born after embryo culture in different culture media
AbstractStudy questionDoes human embryo culture in different IVF culture media lead to DNA methylation alterations in IVF offspring?Summary answerGenome-wide analyses identified no significant DNA methylation differences between culture medium groups in IVF children (neonates or 9-year olds) from two culture media studies.What is known alreadyDuring in vitro fertilisation (IVF) treatments, embryos undergo preimplantation development in an artificial environment, while concurrently undergoing epigenetic reprogramming. Adversity during this period, such as peri-conception calorie restriction, has been linked to persistent DN...
Source: Human Reproduction - August 6, 2021 Category: Reproduction Medicine Source Type: research
P –789 Obstetric and perinatal outcomes in poor ovarian responders and normal responders flowing fresh embryo transfer: a prospective, monocentric, observational study
AbstractStudy questionWhether women pregnant after a poor response in IVF have obstetric and perinatal complications more frequently than women with pregnancies after a normal response in IVF?Summary answerThere were no statistically significant differences in obstetric and perinatal complications rate between poor responders and normal responders in Chinese women.What is known alreadyPoor ovarian response usually indicates a reduction in follicular response, resulting in a reduced number of retrieved oocytes. Patients are less likely to conceive and have a higher risk of cycle cancellation and low clinical pregnancy rate....
Source: Human Reproduction - August 6, 2021 Category: Reproduction Medicine Source Type: research
P –788 Health outcomes at birth, 12 and 24 months of 747 children conceived after Preimplantation Genetic Testing: a single centre experience
AbstractStudy questionDoes conception by Preimplantation Genetic Testing (PGT-M, PGT-SR) adversely affect health outcomes in children born through this assisted reproductive technique?Summary answerNo significant difference was noted in the rate of congenital malformations in children born after PGT-M and PGT-SR compared with IVF-ICSI children.What is known alreadyIt is already known that the risk of congenital anomalies in IVF-ICSI pregnancies is higher when compared with pregnancies conceived naturally.Study design, size, durationThis is a prospective study on 747 children born between December 1999 and July 2016 after a...
Source: Human Reproduction - August 6, 2021 Category: Reproduction Medicine Source Type: research
P –787 Impact of delaying ART to promote weight loss: a large multicentre study accounting for the combined effect of female/male age and body mass index (BMI)
AbstractStudy questionIs postponing the start of ART (to promote a reduction in female BMI) beneficial for cumulative live birth rates (CLBR) when accounting for the female/male ageing this delay will cause?Summary answerPostponing ART treatment in one year to promote female weight loss could be detrimental in women of advanced maternal age (AMA,>35 years-old).What is known alreadyOverweight/obese couples are frequently encouraged to lose weight prior to infertility treatment to enhance ART outcomes. However, a meaningful weight loss is often difficult to achieve for these couples, frequently taking at least one year to...
Source: Human Reproduction - August 6, 2021 Category: Reproduction Medicine Source Type: research
O-044 Chinese Society of Reproductive Medicine 2018 annual report on ART
ConclusionsThis study uses "CSRM data reporting system" data to describe and analyze the current status of ART, basically consistent with the comparison in 2016 and 2017 that most cycles with good outcomes. However, no clear conclusions have been drawn on the changes of PGD/PGS cycle, all-freeze cycle and comprehensive analysis should be conducted by combining with laboratory data.Trial registration number:Study funding:Funding source: (Source: Human Reproduction)
Source: Human Reproduction - August 6, 2021 Category: Reproduction Medicine Source Type: research
O-043 International committee for monitoring assisted reproductive technologies (ICMART) preliminary world report on ART, 2017
(Source: Human Reproduction)
Source: Human Reproduction - August 6, 2021 Category: Reproduction Medicine Source Type: research
O-029
(Source: Human Reproduction)
Source: Human Reproduction - August 6, 2021 Category: Reproduction Medicine Source Type: research
O-028 Uterine congenital anomalies
(Source: Human Reproduction)
Source: Human Reproduction - August 6, 2021 Category: Reproduction Medicine Source Type: research
P-525 Analysis of segregation patterns of trivalent structure and the effect on genome stability in Robertsonian translocation carriers
This study analyzed the influencing factors of the separation patterns of trivalent, and verified the existence of ICE. This suggest that PGT-SR can have a better outcome in patients with Robertsonian translocation, especially in male carriers. These results will provide carrier couple with more appropriate genetic counseling.Trial registration numberno (Source: Human Reproduction)
Source: Human Reproduction - August 6, 2021 Category: Reproduction Medicine Source Type: research
P-523 Whole-chromosome aneuploidies revealed by transcriptome of trophectoderm biopsied from human pre-implantation blastocyst
AbstractStudy questionWhether mRNA transcriptome of biopsied trophectoderm (TE) in human pre-implantation blastocyst can predict embryo karyotype?Summary answermRNA transcriptome of biopsied TE can precisely predict whole-chromosome aneuploidies but not mosaicism or segmental aneuploidies.What is known alreadyKaryotype of human pre-implantation blastocyst is well recognized by PGT-A. However, genome can ’t demonstrate gene expression level which might infer the development potential of euploidy. Transcriptome of blastocyst by singe-cell RNA-seq has revealed the lineage segregation of human pre-implantation blastocyst. It...
Source: Human Reproduction - August 6, 2021 Category: Reproduction Medicine Source Type: research
O-007 Do Mullerian anomalies need surgical correction
(Source: Human Reproduction)
Source: Human Reproduction - August 6, 2021 Category: Reproduction Medicine Source Type: research
O-006 Diagnosis debate – USG vs endoscopy
Abstract textMULLERIAN ANOMAIES – DEBATE USG OR ENDOSCOPYMullerian duct anomalies are a complex spectrum of congenital anomalies resulting from defective fusion or canalization leading to different uterine anomalies. Early detection and proper diagnosis of uterine anomalies are paramount for proper management. Outflow obstructio n defects like transvers septal defects or non canalised functional horn present early with complaint of pain while rest of patients present with amenorrhoea , infertility, repeated first-trimester abortion, fetal intrauterine growth restriction, and obstetric complications.The prevalence of uter...
Source: Human Reproduction - August 6, 2021 Category: Reproduction Medicine Source Type: research
O-091 Semen microbiota in patients with astenozoospermia and healthy controls: cluster analysis of real-time PCR data
AbstractStudy questionWhat are the differences in the semen microbiota composition of patients with asthenozoospermia and normospermia according to cluster analysis of PCR data?Summary answerThe detection rate of 4 stable semen microbiota clusters and the dominant bacteria groups varied in patients with asthenozoospermia and normospermia.What is known alreadyMost of the research dedicated to analyzing normal and pathological semen microbiota is based on 16S rRNA gene specific Next generation sequencing (NGS). It has shown that microbiota is represented by polymicrobial communities (clusters) that consist of microorganisms ...
Source: Human Reproduction - August 6, 2021 Category: Reproduction Medicine Source Type: research
