O-026 Advanced Glycation Endproducts: A new player in obesity related infertility
Abstract textGlobally, 39% of the adult population is overweight or obese, with the prevalence of obesity following an upward trajectory over the recent decades (WHO). Up to 30% of women of reproductive age in Western countries are obese before conception, and obese women experience higher rates of infertility and pregnancy complications than lean women; however, the mechanisms underpinning obesity-related infertility are poorly understood. Advanced Glycation Endproducts (AGEs) are a proinflammatory modification of proteins exposed to sugars, formed through the Maillard reaction. AGEs are elevated four-fold in the uterine ...
Source: Human Reproduction - August 6, 2021 Category: Reproduction Medicine Source Type: research
O-015 How do genes impact?
(Source: Human Reproduction)
Source: Human Reproduction - August 6, 2021 Category: Reproduction Medicine Source Type: research
O-014 How effective is oocyte cryopreservation?
Abstract textThe challenge of cryopreserve, store for prolonged period, and successfully implant the female gamete is nowadays feasible thanks to vitrification. The technology that was initially validated in oocyte recipients is currently applied to a vast population, including women at risk of losing their ovarian function due either to iatrogenic causes as occurs in cancer patients, or due to the natural depletion of the ovarian reserve as a result of age related fertility decline. That is the case of a growing population of women who wish to postpone childbearing and decide on oocyte vitrification as a means of fertilit...
Source: Human Reproduction - August 6, 2021 Category: Reproduction Medicine Source Type: research
P-622 Prothrombotic biomarkers during controlled ovarian stimulation for assisted reproductive techniques
AbstractStudy questionDoes the evolution of prothrombotic biomarkers over time differ between antagonist and long agonist stimulation protocols for assisted reproductive techniques (ART) ?Summary answerThe hypercoagulable state was higher and persistent in the agonist and antagonist with hCG triggering groups compared to the antagonist with GnRH agonist triggering group.What is known alreadyControlled ovarian stimulation (COS) for ART is associated with supra-physiological serum estradiol levels, a hypercoagulable state and an increased risk of venous thrombosis. Most thromboembolic events associated with COS occur in the ...
Source: Human Reproduction - August 6, 2021 Category: Reproduction Medicine Source Type: research
P-783 Clinical, obstetric and perinatal outcomes after vitrified-warmed euploid blastocyst transfer are independent of cryo-storage duration
AbstractStudy questionIs cryo-storage duration associated with the outcomes after vitrified-warmed euploid single blastocyst transfer?Summary answerLower live-birth-rates from blastocysts cryo-stored for periods longer than 3-months are mostly imputable to the worse quality of the embryos being warmed across sequential transfers.What is known alreadyBlastocyst vitrification is crucial in modern IVF. Given its widespread application, a constant comprehensive monitoring of its effect on reproductive outcomes is pivotal. For instance, the effect of cryo-storage duration on embryo implantation potential, gestational and perina...
Source: Human Reproduction - August 6, 2021 Category: Reproduction Medicine Source Type: research
O-095 Is the process to retract fabricated randomised clinical trials in reproductive medicine working sufficiently?
AbstractStudy questionHow do journal editors and publishers respond on randomised clinical trials in reproductive medicine that have been identified as fabricated?Summary answerDespite clear proof of fabrication, only a small minority of fabricated RCTs is retracted within 12 months.What is known alreadyRandomised controlled trials (RCTs) are recognised as scientific investigations that have the least potential for bias and are therefore widely used to direct clinical practice. The validity of data in RCTs matters to the accountability of medical practice and the wellbeing of patients. Detection of integrity problems and s...
Source: Human Reproduction - August 6, 2021 Category: Reproduction Medicine Source Type: research
O-008 Improving outcomes in women with Mullerian anomalies
Abstract textMullerian Anomalies are present in approximately 5% to 7% of the general population and the incidence is a little more in infertile and recurrent miscarriage women. Most of the recent studies have reported that the obstetric outcome is compromised in this group with greater risk of infertility, recurrent pregnancy loss, intrauterine growth retardation, preterm birth and many other obstetric complications, which may be individually related to the different types of Mullerian Anomalies. In this presentation, We are going to discuss on how the outcomes are different in the various Mullerian Anomalies depending up...
Source: Human Reproduction - August 6, 2021 Category: Reproduction Medicine Source Type: research
O-090 Correcting a PLC ζ mutation in the human germ line to overcome hereditary infertility
AbstractStudy questionCan clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 gene editing result in the correction of a single base pair substitution that causes male infertility?Summary answerCRISPR/Cas9 administration during intracytoplasmic sperm injection (ICSI) leads to correction attempts of mutant phospholipase C zeta (PLC ζ), howeverc loss-of-heterozygosity (LOH).What is known alreadyFailed fertilization after ICSI can be caused by mutations in the sperm-related oocyte factor PLC ζ which can be overcome by assisted oocyte activation (AOA). In this way, children may inherit the infertility-cau...
Source: Human Reproduction - August 6, 2021 Category: Reproduction Medicine Source Type: research
O-081 High variability of molecular isoforms of AMH in follicular fluid and granulosa cells from human small antral follicles
AbstractStudy questionIs the composition of AMH isoforms different in follicular fluids (FF) and granulosa cells (GCs) from human small antral follicles?Summary answerThere is a high viability of AMH isoforms in FFs and GCs. Even between same size follicles from the same women, the isoform composition differs.What is known alreadyAnti M üllerian Hormone (AMH) is a member of the TGF-β superfamily produced by follicular granulosa cells (GCs) in women from late gestation to the end of reproductive live. AMH is suggested to inhibit aromatase (i.e. CYP19) expression and thereby decreasing the conversion of androgens to oestro...
Source: Human Reproduction - August 6, 2021 Category: Reproduction Medicine Source Type: research
O-078 Predictive factors of autologous Oocyte Post-warming Survival rate
AbstractStudy questionAre there any clinical or paraclinical predictive factors of Oocyte Post-warming Survival (OPS) rate?Summary answerWoman age, Body mass Index, estradiol level on triggering day and estradiol/oocyte ratio are critical predicting factors that should be considered before performing oocyte vitrification.What is known alreadySince the development and the validation of oocyte vitrification, we vitrify oocytes in different medical situations for patients who benefit ICSI. Although the OPS rate in our centre is satisfying, occasionally, it happens to be lower. OPS is dependent on quality of oocyte as demonstr...
Source: Human Reproduction - August 6, 2021 Category: Reproduction Medicine Source Type: research
O-018 Endometriosis is a Systemic disease
(Source: Human Reproduction)
Source: Human Reproduction - August 6, 2021 Category: Reproduction Medicine Source Type: research
P-681 Will the hCG trigger dose used for final oocyte maturation in IVF impact endogenous progesterone during the luteal phase? - A randomized controlled trial
AbstractStudy questionIs there an association between the hCG dose used for ovulation trigger and the endogenous progesterone production during the luteal phase?Summary answerIncreased hCG dosing significantly increased the endogenous progesterone level during the luteal phase.What is known alreadyDuring the luteal phase of an IVF treatment, the endogenous progesterone (P4) production is negatively impacted due to reduced circulating endogenous LH, caused by negative feed-back of elevated steroids; thus, luteal phase support (LPS) with exogenous P4 remains mandatory in IVF. Apart from inducing final oocyte maturation, the ...
Source: Human Reproduction - August 6, 2021 Category: Reproduction Medicine Source Type: research
P-646 Pregnancy outcomes in women with panhypopituitarism - A population-based study
AbstractStudy questionWhat are the consequences of panhypopituitarism on pregnancy outcomes?Summary answerAfter controlling for confounding effects, women with panhypopituitarism have a higher prevalence of adverse obstetrical (including post-partum hemorrhage, hysterectomy and maternal death) and neonatal outcomes.What is known alreadyPanhypopituitarism is a condition of inadequate or absent anterior pituitary hormone production. Pregnancy in women with panhypopituitarism is uncommon and there is only limited data (mainly case reports) regarding pregnancy outcomes in these women. Given the scarcity of data we sought to as...
Source: Human Reproduction - August 6, 2021 Category: Reproduction Medicine Source Type: research
O-005 Mullerian anomalies overview
Abstract textMullerian Duct Anomalies- An OverviewProf. Sudha PrasadPresident Indian Fertility Society, Director, Matritava Advanced IVF& Training Centre, New Delhi, IndiaCongenital anomalies of the mullerian duct system is one of the complex disorder encountered in gynecological practice. Mullerian ducts are paired embryological structures which undergo fusion and resorption in utero to form the uterus, fallopian tubes, cervix and upper two-thirds of the vagina. Disruption in the mullerian duct development throughout embryogenesis could result a large spectrum of inherent abnormalities identified as mullerian duct ano...
Source: Human Reproduction - August 6, 2021 Category: Reproduction Medicine Source Type: research
O-004 Self-correction in human preimplantation development: What do we know?
Abstract textRecent advances in preimplantation genetic testing for aneuploidy (PGT-A) and time-lapse imaging have improved our understanding of the early human embryo confirming the variable patterns of development and chromosomal status. Aneuploidy is common and increased sensitivity in PGT-A allows the non-binary reporting of euploid-aneuploid mosaicism. The PGT-A result is the inference of the biopsied embryo ’s ploidy status at a point in time, by assessment of a small percentage of cells, and, whilst concordance with the rest of the embryo is high; it is not absolute.Many reports have demonstrated that, with the tr...
Source: Human Reproduction - August 6, 2021 Category: Reproduction Medicine Source Type: research
