P –591 Mass spectrometry-based glycomic profiling of the follicular fluid total immunoglobulin G and proteome N-glycomes reveals deregulated inflammatory processes associated with specific controlled ovarian stimulation protocols
AbstractStudy questionIs there a significant inflammatory-related difference between analyzed follicular fluid (FF) glycome profiles regarding the ovarian stimulation protocol used in patients?Summary answerObserved differences between analyzed glycome profiles from patients that underwent different controlled ovarian stimulation (COS) protocols point to deregulated inflammatory processes associated with specific COS.What is known alreadySuccessful physiological folliculogenesis and ovulation require an adequate inflammatory response. On the other hand, COS application in ART relies on induced hormonal activation of system...
Source: Human Reproduction - August 6, 2021 Category: Reproduction Medicine Source Type: research
P –590 Women with hypothalamic hypogonadism have lower live birth rates following frozen embryo transfer
This study is limited by its retrospective nature and the small sample size of women with hypothalamic hypogonadism. Additionally, these data represent outcomes from a single academic center, so generalizability of our findings may be limited.Wider implications of the findings: Lower live birth rates for HH patients undergoing frozen embryo transfer cycles are not correlated with endometrial stripe thickness. This may be due to absent gonadotropin signaling on endometrial receptors. A prospective randomized trial of HH patients to modified natural versus programmed frozen embryo transfer would best support this hypothesis....
Source: Human Reproduction - August 6, 2021 Category: Reproduction Medicine Source Type: research
P –589 The effects of vanillic acid on production of testosterone and function of insulin in adipose and ovarian tissues in rat model of polycyctic ovary syndrome
In this study, the effects of vanillic acid (VA) on metabolic and endocrine abnormalities were evaluated in the adipose and ovarian tissues of a letrozole-induced rat model of PCOS.Study design, size, durationIn this study, a letrozole-induced rat model was established and then the experimental groups were treated by VA and MET through oral gavage for one month. Before and after the treatment with drugs, the vaginal smear was carried out . Ovarian and adipose tissues were collected and frozen at − 80 for further analysis following euthanasia of the rats.Participants/materials, setting, methodsThirty Six -week- old W...
Source: Human Reproduction - August 6, 2021 Category: Reproduction Medicine Source Type: research
P –588 Follicle-stimulating hormone receptor genotype and its influence on the results of double ovarian stimulation in IVF cycles
AbstractStudy questionDoes the follicle-stimulating hormone receptor (FSHR) genotype influence the results of the ovarian stimulation treatment in the luteal phase?Summary answerAll patients undergoing in-vitro fertilization benefit from luteal phase ovarian stimulation, regardless of their follicle-stimulating hormone receptor genotype.What is known alreadyPrevious studies suggest that FSH receptor polymorphism in position 680 influences the response to ovarian stimulation in the luteal phase. It was observed that patients with SS genotype seems to require a higher dose to obtain an optimal ovarian response. Later, it was...
Source: Human Reproduction - August 6, 2021 Category: Reproduction Medicine Source Type: research
P –587 Highly purified human menopausal gonadotrophin (HP-hMG, Menopur) as a ready-to-use solution for injection in pre-filled pen is bioequivalent to HP-hMG powder for reconstitution
AbstractStudy questionAre serum FSH levels after single subcutaneous dosing of HP-hMG in a liquid formulation and a powder formulation bioequivalent?Summary answerThe 90% CIs for the geometric mean ratios of serum FSH AUCt and Cmax were both within 0.8000 –1.2500, thus the two formulations are bioequivalent.What is known alreadyFor several decades, HP-hMG (Menopur) has been used for the treatment of infertility; its efficacy and safety compared to other gonadotropins have been consistently demonstrated in several prospective, randomised controlled trials and meta-analyses (Deeks et al 2018; Bordewijk et al 2019). Menopur...
Source: Human Reproduction - August 6, 2021 Category: Reproduction Medicine Source Type: research
