O-197 Maternal and neonatal characteristics and outcomes of COVID-19 from early pregnancy until labor: an overview of systematic reviews
In conclusion, a rapid increase of CS was observed, especially at the beginning of the pandemic, most likely due to lack of knowledge and robust recommendations. Preterm birth rates were elevated, with iatrogenic reasons potentially involved. Even though neonatal infections were rare, the probability of vertical transmission cannot be eliminated.Trial registration numbernot applicable ’ (Source: Human Reproduction)
Source: Human Reproduction - August 6, 2021 Category: Reproduction Medicine Source Type: research
O-196 The impact of providing couples with their IVF-prognosis on the expectations and anxiety of women and men
AbstractStudy questionWhat is the impact of providing couples with their IVF-prognosis on expectations and anxiety in women and men on the day of embryo transfer?Summary answerOnly couples with a less than average IVF-prognosis updated their high expectations and IVF-prognosis was negatively associated with anxiety, especially in women.What is known alreadyFemale IVF-patients are known to expect a pregnancy rate per IVF-cycle of no less than 49-55%. Qualitative interviews and a survey showed that well informed women expect unrealistically high pregnancy rates as they think that their (family ’s) fertility and their clini...
Source: Human Reproduction - August 6, 2021 Category: Reproduction Medicine Source Type: research
O-195 The impact of the COVID-19 outbreak on psychological distress due to the cancellation of ART. A systematic review and meta-analysis
AbstractStudy questionIs there evidence that infertile patients have been more likely to experience distress during the COVID-19 outbreak with the consequent interruption of treatment plans?Summary answerHigh levels of psychological distress among infertile patients have been found during the COVID-19 pandemic, greater than that reported in the general population.What is known alreadyPreliminary research on the negative consequences of the COVID-19 outbreak on mental health evidenced heightened levels of anxiety, depression and post-traumatic stress in some clinical populations as well as in community samples. However, lit...
Source: Human Reproduction - August 6, 2021 Category: Reproduction Medicine Source Type: research
O-194 Insights from smartphone app based emotional tracking data on the impact of the Covid-19 pandemic on IVF patients
AbstractStudy questionIs the emotional experience of patients during IVF different since the start of the global Covid-19 pandemic?Summary answerTracking data since re-opening demonstrated patients lower positive challenge emotions but no significant change in harm, threat, or stress.What is known alreadyCovid-19 caused widespread shutdown of fertility centres, including in the UK, when the HFEA mandated closure from March until May 2020. Research shows clinic closure and an uncertain future were a significant psychological burden for patients anticipating treatment. However, emotional experiences before, during and after ...
Source: Human Reproduction - August 6, 2021 Category: Reproduction Medicine Source Type: research
O-057 The impact of diagnosis endometriosis as part of the fertility workup
AbstractAbstract textThe impact of diagnosis endometriosis as part of the Fertility workupEndometriosis is a multifaceted disease that may go from completely asymptomatic to a debilitating condition with severe pelvic pain complicated infertility. In the last few years, how we approach fertility in women with endometriosis has clearly changed, postponing definitive/radical surgery till the patient has completed her family. As a clear association exists with endometriosis and infertility, during the fertility workup it is one of the diseases to investigate, as it may have been missed in previous annual gynecologic checkups....
Source: Human Reproduction - August 6, 2021 Category: Reproduction Medicine Source Type: research
O-168 Chronic pelvic pain is the most troublesome endometriosis pain symptom for women ’s quality of life
AbstractStudy questionWhich pre-operative endometriosis pain symptom is most troublesome for the quality-of-life of women assessed at different meta-levels?Summary answerOf five pain symptoms chronic pelvic pain is most troublesome or has the strongest correlation to women ’s overall quality-of-life and overall and endometriosis-specific health status.What is known alreadyEndometriosis affects women ’s quality of life negatively, and its impact seems to depend more on women’s symptoms than on their degree of endometriosis. Experts proposed to include ‘the most troublesome symptom’ and ‘overall pain’ as core o...
Source: Human Reproduction - August 6, 2021 Category: Reproduction Medicine Source Type: research
O-167 Sleep quality and affecting factors in women undergoing in vitro fertilization treatment
AbstractStudy questionDoes in vitro fertilization (IVF) treatment affects the sleep quality of women and which factors reduce the sleep quality in different stages of this treatment?Summary answerThe sleep quality decreased as the IVF treatment process progresses. Advanced age, prolonged treatment, economical concerns, stress ect. were factors that adversely affected women sleep.What is known alreadyAccording to worldwide research, women receiving IVF treatment may suffer from physiological and psychological symptoms and even experience sleep disturbance. Sleep disturbances are thought to be frequent in women undergoing IV...
Source: Human Reproduction - August 6, 2021 Category: Reproduction Medicine Source Type: research
O-166 A smartphone video clip on the patient journey to reduce patient ’s anxiety: a randomized controlled trial
AbstractStudy questionCan a smartphone video clip detailing the patient journey decrease the anxiety of women and men on the day of their first oocyte aspiration?Summary answerThe video clip does not affect the anxiety of women but does reduce the anxiety of men on the day of couples ’ first oocyte aspiration.What is known alreadyInfertility and in vitro fertilisation (IVF) decrease the personal wellbeing of women and men. Couples shared that this contributed to their IVF discontinuation despite a good prognosis and reimbursement of IVF. Previous longitudinal studies confirmed that pre-IVF anxiety is associated with IVF ...
Source: Human Reproduction - August 6, 2021 Category: Reproduction Medicine Source Type: research
O-136 Once-daily relugolix combination therapy results in sustained reduction in symptoms and improved quality of life in women with uterine fibroids treated over 52 weeks
AbstractStudy questionWhat is the effect of relugolix combination therapy (Relugolix-CT) on symptom burden and health-related quality-of-life (HR-QoL) in patients with uterine fibroids (UF) over 52 weeks?Summary answerRelugolix-CT demonstrated sustained, clinically meaningful improvement in patient-reported symptom severity and HR-QoL over 52 weeks in women with UF.What is known alreadyIn LIBERTY 1 and 2 randomized clinical trials, once-daily Relugolix-CT (40  mg relugolix, an oral gonadotropin-releasing hormone receptor antagonist, estradiol 1 mg, norethindrone acetate 0.5 mg) significantly reduced menstrual blood l...
Source: Human Reproduction - August 6, 2021 Category: Reproduction Medicine Source Type: research
O-135 Long term secondary efficacy of linzagolix for heavy menstrual bleeding (HMB) due to uterine fibroids (UF): 52-week results from two placebo-controlled, randomized, phase 3 trials
AbstractStudy questionAre symptomatic improvements in women with UF observed after 24 weeks of linzagolix treatment with or without add-back therapy (ABT) maintained over 52 weeks?Summary answerImprovements in anemia, pain and quality of life previously reported at 24 weeks were maintained at 52 weeks.What is known alreadyWe previously reported that partial or full suppression of estradiol (E2) with once daily doses of either 100 or 200  mg linzagolix for 24 weeks, with or without ABT, were effective in reducing heavy menstrual bleeding associated with uterine fibroids, improving other symptoms such as pain and anemia an...
Source: Human Reproduction - August 6, 2021 Category: Reproduction Medicine Source Type: research
O-134 Cochrane review on the effect of pentoxifylline for endometriosis
AbstractStudy questionTo assess the effect of pentoxifylline, a methyl-xanthine with anti-inflammatory effects, for the management of premenopausal women with endometriosis.Summary answerThere is not enough evidence to support the use of pentoxifylline in the management of premenopausal women with endometriosis to improve fertility and pain outcomes.What is known alreadyEndometriosis is a chronic, inflammatory condition that occurs mainly during the reproductive years. It is characterized by endometrium-like tissue developing outside the uterine cavity. This endometriotic tissue development is dependent on estrogen produce...
Source: Human Reproduction - August 6, 2021 Category: Reproduction Medicine Source Type: research
O-133 Effect of non-surgical treatments on the size of endometrioma: A systematic review and Meta-Analysis
ConclusionsMedical treatment from different groups significantly reduces the endometrioma size, and relives painful symptoms.Limitations, reasons for cautionDespite the nature of the randomized includedstudies, the results of this study are still subjected to confounders relating to clinical and statistical heterogeneity. the studies reported the outcomes differentlyWider implications of the findingsmedical treatment can be given the surgery can be avoided, therefore preserve the ovarian tissue. There is limited controlled study to examine the effectiveness of the treatment for endometrioma.Trial registration number––â...
Source: Human Reproduction - August 6, 2021 Category: Reproduction Medicine Source Type: research
O-040 The evolution of WHO Manual. Where are we now?
Abstract textMale factor infertility is associated with impaired overall health, decreased life expectancy, lower quality of life and may affect reproductive outcomes even under assisted reproductive technology (ART) settings. Male factors, alone or combined with female factors, contribute to at least 50% of reported infertility cases. Despite this, the male partner is often overlooked in the evaluation and treatment of infertility. A routine semen analysis is frequently the only test carried out to assess a man ’s fertility potential.The state-of-art on how the human semen should be assessed is provided by the World Hea...
Source: Human Reproduction - August 6, 2021 Category: Reproduction Medicine Source Type: research
O-039 Mitochondrial ATP generation in mammalian eggs and Ca2+ signaling
Abstract textIn metaphase II arrested mammalian oocytes (eggs) and cleavage stage embryos the mitochondria are responsible for nearly all ATP production because glycolysis is inactivated. Luciferase assays show that ATP levels in eggs are strictly dependent upon pyruvate and fatty acid oxidation. The level of ATP in eggs appears to be maximal in conventional medium because the addition of extra mitochondrial substrates to eggs does not increase cytosolic ATP. The only clear elevation of ATP is seen at fertilization and is associated with sperm induced Ca2+ oscillations. Our recent findings suggest that the level of ATP mod...
Source: Human Reproduction - August 6, 2021 Category: Reproduction Medicine Source Type: research
O-023 Con - FET: An individualised approach is required
(Source: Human Reproduction)
Source: Human Reproduction - August 6, 2021 Category: Reproduction Medicine Source Type: research
