O-114 Improved safety and efficiency of individualised versus conventional gonadotropin dosing for ovarian stimulation in IVF/ICSI: an individual patient meta-analysis (IPD-MA)
This study addresses the performance of a new human recombinant FSH (follitropin delta) with individualised dosing based on AMH and body weight.Study design, size, durationThis is an individual participant data meta-analysis (IPD-MA) of three follitropin delta phase 3 trials, executed in Europe and North- and South America, South-East Asia, and Japan. All trials were randomized, controlled, assessor-blinded, multicenter studies in which individualised follitropin delta vs. conventional follitropin alpha or beta were compared. Women were followed from inclusion, at start of their first fresh IVF/ICSI cycle, until 4 weeks af...
Source: Human Reproduction - August 6, 2021 Category: Reproduction Medicine Source Type: research
O-113 Effectiveness and treatment cost of assisted reproduction technology for women stimulated by gonadotropin in France: A cohort study using the National Health Database
AbstractStudy questionHow effective is Assisted Reproduction Technology (ART) in terms of cumulative live birth rate (CLBR) in France, depending on the gonadotropin used?Summary answerAmong 214,539 stimulations, originator follitropin-alfa was associated with significantly higher CLBR when compared to Highly Purified-Human Menopausal Gonadotropin (HP-HMG) and biosimilars.What is known alreadyDeciding which type of gonadotropin to prescribe for a woman undergoing controlled ovarian stimulation (COS) remains difficult. The effectiveness of different gonadotropins is one factor to consider. However, studies comparing r-hFSH-a...
Source: Human Reproduction - August 6, 2021 Category: Reproduction Medicine Source Type: research
O-112 Outcomes of random-start ovarian stimulation protocols as a possible evidence of the theory of antral follicles continuous recruitment
AbstractStudy questionWe tried to validate the possibility and efficiency of ovarian stimulation (OS) started on any day of the menstrual cycle, based on a theory of continuous recruitment of antral follicles.Summary answerFormation of a pool of follicles with higher sensitivity to gonadotropic stimulation occurs several times during the menstrual cycle (MC).What is known alreadyAccording to classical concepts and fundamental positions formulated in the middle of the last century, follicular recruitment occurs only once during the menstrual cycle - in the early follicular phase. Nowadays there is increasing evidence to sug...
Source: Human Reproduction - August 6, 2021 Category: Reproduction Medicine Source Type: research
O-111 The DuoStim strategy shortens the time to obtain an euploid embryo in poor prognosis patients: a non-inferiority, randomized controlled trial
This study clearly showed that the DuoStim protocol is not inferior to the conventional stimulation in terms of ovarian response and laboratory outcomes. Moreover, the DuoStim reduces the time to obtain an euploid embryo in poor prognosis patients, which is of great clinical utility.Trial registration numberNCT03291821 (Source: Human Reproduction)
Source: Human Reproduction - August 6, 2021 Category: Reproduction Medicine Source Type: research
O-102 Polymeric scaffold loaded with CD133+ BMDSCs for endometrial regeneration in Asherman ’s syndrome
AbstractStudy questionCan CD133+ bone marrow-derived stem cells (BMDSCs) loaded in polyethylene glycol diacrylate (PEGda) and gelatin divide and decidualize?Summary answerBiocompatible porous PEGda and gelatin scaffold provides a three-dimensional environment for CD133+ cells to attach, divide, and decidualizein vitro.What is known alreadyIntrauterine adhesions (IUA) develop due to acquired damages in the endometrium resulting in partial to complete endometrial dysfunction in the Asherman syndrome. Previous works from our group have demonstrated the engraftment of CD133+ BMDSCs and its paracrine effect on endometrial proli...
Source: Human Reproduction - August 6, 2021 Category: Reproduction Medicine Source Type: research
O-101 Neospermatogenesis benefits from a three-dimensional culture system
AbstractStudy questionDoes a three-dimensional (3D) culture system increase the efficiency of male germline differentiation of mouse embryonic stem cells (mESC) over a bidimensional method?Summary answerOur 3D culture system based on direct spherification proves superior to the standard bidimensional plating in promoting neogametogenesis of mESC into post-meiotic male germ cells.What is known alreadyTwo-dimensional monolayer cell cultures are common in stem cell research. However, this method does not replicate a physiological 3D spatial relationship and may provide an inaccurate replication ofin vivo environments. A 3D sp...
Source: Human Reproduction - August 6, 2021 Category: Reproduction Medicine Source Type: research
P-503 Focus groups with health care professionals, patient advocates and patients to explore how the potential need for multiple cycles is managed during fertility treatment consultations
AbstractStudy questionHow is possibility of failure and potential need for multiple cycles discussed with patients during the first or repeat IVF/ICSI treatment consultation?Summary answerHealth Care Professionals plan treatment on a cycle-by-cycle basis because it is the normative way to plan treatment, but patients see advantages in multi-cycle planningWhat is known alreadyMany patients need more than one round of IVF/ICSI stimulation to achieve their parenthood goals. A recent study has found around 60% of patients to be willing to plan for multiple cycles of treatment. However, it is not clear how patients are informed...
Source: Human Reproduction - August 6, 2021 Category: Reproduction Medicine Source Type: research
P-490 Recurrent pregnancy loss acts as a posttraumatic stress event in both women and men
AbstractStudy questionWhat are the psychological impacts of recurrent pregnancy loss (RPL) on men and women and their interdependencies?Summary answerWomen show higher psychological risks than men, except for lack of social support. Avoidance behaviour of men correlates with higher posttraumatic stress of their partner.What is known alreadyAbout 1-3% of all couples trying to conceive are affected by RPL. The loss of the unborn child can be the most traumatic experience in a woman ’s life and is associated with significant psychological distress besides the instant grief. RPL can also be stressful for the partner, even th...
Source: Human Reproduction - August 6, 2021 Category: Reproduction Medicine Source Type: research
P-719 Self-declared infertility and child desire among women of reproductive age in the National Survey of Demography and Health, Brazil
This article aims to characterize from a socio-demographic point of view, women of reproductive age who wish to have children, declared themselves infertile, and their search for treatments and outcomes.Summary answerIt is essential to develop specific population surveys on infertility in Brazil to identify its magnitude and main economic and social components.What is known alreadyCommonly neglected in developing countries where public policy is incipient, infertility brings social, economic and psychological consequences to couples. It is considered as a serious public health problem whose impact varies among different po...
Source: Human Reproduction - August 6, 2021 Category: Reproduction Medicine Source Type: research
P-718 Paternal smoking in the preconception period is associated with an increased risk of spontaneous miscarriage in a dose-dependent manner: a systematic review and meta-analysis
AbstractStudy questionWhat is the association between paternal lifestyle factors in the preconception period and the risk of spontaneous miscarriage?Summary answerPreconception paternal cigarette smoking is associated with an increased risk of spontaneous miscarriage, while no associations were found with paternal alcohol consumption and obesity.What is known alreadyAlthough maternal lifestyle risk factors for miscarriage are well-established, studies on potentially contributing paternal factors remain sparse. Recently, a significant association was found between advanced paternal age and spontaneous miscarriage. Biologi...
Source: Human Reproduction - August 6, 2021 Category: Reproduction Medicine Source Type: research
O-003 The puzzling unknowns of abnormal fertilization and first cleavage
Abstract textFertilization is a critical event in development in that it provides the connection between the gametes and the earliest stages of embryogenesis. Yet, despite the central importance of this process in contributing to embryo developmental fate, clinical embryologists have historically assessed fertilization merely by the number of pronuclei and, if two are present, perhaps, by the presence of two polar bodies. Even though over 20 years ago, time lapse imaging was applied for defining early events of fertilization (Payne et al., 1997), it is only with contemporary time-lapse imaging systems in the last few years...
Source: Human Reproduction - August 6, 2021 Category: Reproduction Medicine Source Type: research
O-085 In-depth analysis of embryo development: Differences among monosomic, trisomic and chromosomally chaotic embryos compared to euploid embryos
AbstractStudy questionIs there any visible variation in the development of aneuploid embryos depending on the type of chromosome abnormality?Summary answerThere were significant visible differences in the development of euploid, monosomic, trisomic and, especially, chaotic embryos.What is known alreadyAneuploidy rates are remarkably high in in vitro fertilized human embryos, with up to 50% of embryos diagnosed as aneuploid based on preimplantation genetic testing for aneuploidies (PGT-A). However, very little is known about the impact of specific aneuploidies during the early human embryo development. A recent publication ...
Source: Human Reproduction - August 6, 2021 Category: Reproduction Medicine Source Type: research
O-077 Cancer risk in a nationwide cohort of children and young adults conceived by assisted reproductive technology in 1983-2012
AbstractStudy questionAre children conceived by assisted reproductive technology (ART) at increased cancer risk, compared with the general population and with non-ART conceived offspring from subfertile women?Summary answerOverall cancer risk was not increased in ART-conceived offspring compared with non-ART conceived offspring from subfertile women (median follow-up, 17 years).What is known alreadyThere is growing evidence that ART procedures could perturb epigenetic processes during the pre-implantation period. Although the results of most studies are reassuring for children born after in vitro fertilization (IVF), recen...
Source: Human Reproduction - August 6, 2021 Category: Reproduction Medicine Source Type: research
O-053 Early life factors that may influence adult male reproductive
Abstract textThis presentation will provide a brief overview of testicular development and will describe a critical period of development at approximately 8-14 weeks of gestation, when the testicle may be vulnerable to external influences, potentially having a negative effect on subsequent development. The talk with then describe the testicular dysgenesis syndrome hypothesis, proposed by Niels Skakkebæk, and using the presenters work within the Western Australian (Raine) Cohort will go onto demonstrate how early life exposures may influence mature testicular function. Worryingly, the presentation will describe how adole...
Source: Human Reproduction - August 6, 2021 Category: Reproduction Medicine Source Type: research
O-020 Aneuploidy and mosaicism in human embryos: How correct detection may improve IVF clinical outcomes
Abstract textStudy questionCan new next-generation sequencing (NGS) based strategies for preimplantation genetic testing of aneuploidy (PGT-A) improve clinical outcomes after assisted reproductive technology (ART)?Summary answerRecent randomised controlled trials (RCTs) suggest that NGS-based PGT-A strategies can improve clinical outcomes for older women. The clinical management of mosaic embryos remains controversial.What is known alreadyThere are two types of chromosome abnormalities present in embryos, meiotic arising mostly during oogenesis, and mitotic arising after fertilisation. Meiotic aneuploidies are present in a...
Source: Human Reproduction - August 6, 2021 Category: Reproduction Medicine Source Type: research
