The impact of general anesthesia on the outcomes of preterm infants with gestational age less than 32 weeks delivered via cesarean section
Conclusion:This study revealed the significant impact of GA on adverse outcomes among VPIs. In cases when GA is required, proactive measures should be instituted for the care of VPIs such as expediting the interval from skin incision to fetal delivery. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - March 20, 2024 Category: Drugs & Pharmacology Source Type: research
Evaluating cardiac disorders associated with triazole antifungal agents based on the US Food and Drug Administration Adverse Event reporting system database
Conclusion:Isavuconazole might be the safest of the five TAAs for cardiac AEs. TAA-associated cardiac disorders may result in serious adverse outcomes. Therefore, in addition to AEs on the drug label, we should pay attention to new AEs unrecorded on the drug label during the clinical use of TAAs. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - March 20, 2024 Category: Drugs & Pharmacology Source Type: research
Effective dose of intranasal remimazolam for preoperative sedation in preschool children: a dose-finding study using Dixon ’s up-and-down method
Conclusion:Intranasal remimazolam is feasible for preschool children with a short onset time. For successful pre-induction sedation, the ED50 and ED95 of intranasal remimazolam were 0.65 and 0.78 mg/kg, respectively. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - March 20, 2024 Category: Drugs & Pharmacology Source Type: research
Trichostatin A relieves anxiety-and depression-like symptoms in APP/PS1 mice
Conclusion:Overall, these findings support the idea that TSA might be beneficial for reducing neurobehavioral disorders in AD and this could be due to suppression of CST7-related microglial inflammation. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - March 20, 2024 Category: Drugs & Pharmacology Source Type: research
A review of chemotherapeutic drugs-induced arrhythmia and potential intervention with traditional Chinese medicines
Significant advances in chemotherapy drugs have reduced mortality in patients with malignant tumors. However, chemotherapy-related cardiotoxicity increases the morbidity and mortality of patients, and has become the second leading cause of death after tumor recurrence, which has received more and more attention in recent years. Arrhythmia is one of the common types of chemotherapy-induced cardiotoxicity, and has become a new risk related to chemotherapy treatment, which seriously affects the therapeutic outcome in patients. Traditional Chinese medicine has experienced thousands of years of clinical practice in China, and h...
Source: Frontiers in Pharmacology - March 20, 2024 Category: Drugs & Pharmacology Source Type: research
Astragaloside IV attenuates renal tubule injury in DKD rats via suppression of CD36-mediated NLRP3 inflammasome activation
Conclusion:AS-IV alleviated renal tubule interstitial inflammation and tubule epithelial cell apoptosis in DKD rats by inhibiting CD36-mediated lipid accumulation and NLRP3 inflammasome activation. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - March 20, 2024 Category: Drugs & Pharmacology Source Type: research
Mitochondrial energy metabolism-related gene signature as a prognostic indicator for pancreatic adenocarcinoma
Conclusion: Our study provides a novel two-prognostic gene signature—based on MMRGs—that accurately predicted the survival of patients with PAAD and could be used for mitochondrial energy metabolism–related therapies in the future. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - March 20, 2024 Category: Drugs & Pharmacology Source Type: research
The effect of scutellaria baicalensis and its active ingredients on major depressive disorder: a systematic review and meta-analysis of literature in pre-clinical research
Conclusion: These results preliminarily suggest that scutellaria baicalensis can alleviate depressive behaviors and modulate underlying mechanisms, which is expected to be a promising antidepressant. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - March 20, 2024 Category: Drugs & Pharmacology Source Type: research
Antibody-drug conjugates targeting HER2 for the treatment of urothelial carcinoma: potential therapies for HER2-positive urothelial carcinoma
Urothelial carcinoma (UC) is a common cancer characterized by high morbidity and mortality rates. Despite advancements in treatment, challenges such as recurrence and low response rates persist. Antibody-drug conjugates (ADCs) have emerged as a promising therapeutic approach for various cancers, although their application in UC is currently limited. This review focuses on recent research regarding ADCs designed to treat UC by targeting human epidermal growth factor receptor 2 (HER2), a surface antigen expressed on tumor cells. ADCs comprise three main components: an antibody, a linker, and a cytotoxic payload. The antibody...
Source: Frontiers in Pharmacology - March 20, 2024 Category: Drugs & Pharmacology Source Type: research
Sex-specific differenceschanges in protein expression of membrane transporters in the brain cortex of 5xFAD mouse model of Alzheimer's disease
Membrane transporters playing an important role in the passage of drugs, metabolites and nutrients across the membranes of the brain cells have been shown to be involved in pathogenesis of Alzheimer’s disease (AD). However, little is known about sex-specific changes in transporter protein expression at the brain in AD. Here, we investigated sex-specific alterations in protein expression of three ATP-binding cassette (ABC) and five solute carriers (SLC) transporters in the prefrontal cortex of a commonly used model of familial AD (FAD), 5xFAD mice. Sensitive liquid chromatography tandem mass spectrometry-based quantitativ...
Source: Frontiers in Pharmacology - March 20, 2024 Category: Drugs & Pharmacology Source Type: research
Identification of TBK1 inhibitors against breast cancer using a computational approach supported by machine learning
Discussion: All these four molecules displayed solvent based free energy values of −48.78, −47.56, −46.78 and −45.47 Kcal/mol and glide docking score of −10.4, −9.84, −10.03, −10.06 Kcal/mol respectively. The molecules displayed highly stable RMSD plots, hydrogen bond patterns and MMPBSA score close to or higher than BX795 molecule. In future, all these compounds can be further refined or validated by in vitro as well as in vivo activity. Also, we have found two novel groups that have the potential to be utilized in a fragment-based design strategy for the discovery and development of novel inhibitors tar...
Source: Frontiers in Pharmacology - March 19, 2024 Category: Drugs & Pharmacology Source Type: research
Antidepressant and anxiolytic potential of Citrus reticulata Blanco essential oil: a network pharmacology and animal model study
Conclusion:Linalool, p-cymene, α-terpinene, terpinen-4-ol, and α-terpineol cymene might be mainly contributing to CBEO’s antidepressant effect by regulating neuroactive ligand-receptor interaction, neuron projection, and receptor signaling pathway. A mixture of these compounds showed rapid antidepressant potential via intranasal administration, which was comparable to that of CBEO. The mixture also exhibited an anxiolytic effect while not seen in CBEO. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - March 19, 2024 Category: Drugs & Pharmacology Source Type: research
Unraveling DDIT4 in the VDR-mTOR pathway: a novel target for drug discovery in diabetic kidney disease
Conclusion:Unraveling DDIT4’s involvement in the VDR-mTOR pathway provides insights for innovative DKD drug discovery, emphasizing its potential as a therapeutic target for future interventions. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - March 19, 2024 Category: Drugs & Pharmacology Source Type: research
Safety assessment of Acori Tatarinowii Rhizoma: acute and subacute oral toxicity
Discussion: The study highlights the function of ATR in reducing blood lipids and provides a new idea for its widespread clinical use in the future. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - March 19, 2024 Category: Drugs & Pharmacology Source Type: research
Design, synthesis, and evaluation of the novel ozagrel –paeonol codrug with antiplatelet aggregation activities as a potent anti-stroke therapeutic agent
Conclusion: The codrugs synthesized in this study display promising pharmacological activities and have the potential for development as an oral formulation. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - March 19, 2024 Category: Drugs & Pharmacology Source Type: research
