Ultrasound combined with microbubble mediated immunotherapy for tumor microenvironment
This article reviews the research progress of ultrasound combined with microbubbles in the treatment of tumors and their application in the tumor microenvironment. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - February 29, 2024 Category: Drugs & Pharmacology Source Type: research
The potential anti-tumor effect of anesthetics on cancer by regulating autophagy
Autophagy is a conserved, cellular self-degradation system that is essential for maintaining intracellular homeostasis. Increasing evidence suggests that autophagy plays an important dual regulatory role in the development of many human diseases, such as cancer. Recent studies have shown that the autophagy process in tumor cells can be regulated by various stimuli from both intracellular and extracellular environments, including the effects of anesthesia. Anesthetics have been shown to not only have clinical anesthetic and sedative effects but also play important roles in the progression of tumors. The effects of different...
Source: Frontiers in Pharmacology - February 28, 2024 Category: Drugs & Pharmacology Source Type: research
Prenatal maternal inactivated COVID-19 vaccination: the maternal and neonatal outcomes, a retrospective cohort study
Conclusion: Although we found a slightly lower gestational week of delivery and a possible increased rate of late preterm birth in the vaccination group, there was no difference in mean neonatal weight, incidence of low birth weight infants and other neonatal adverse complications. Meanwhile, there was no difference in pregnancy and maternal outcomes between the two groups. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - February 28, 2024 Category: Drugs & Pharmacology Source Type: research
Immunomodulatory effects of curcumin on macrophage polarization in rheumatoid arthritis
Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by synovial inflammation, cartilage destruction, pannus formation and bone erosion. Various immune cells, including macrophages, are involved in RA pathogenesis. The heterogeneity and plasticity of macrophages render them pivotal regulators of both the induction and resolution of the inflammatory response. Predominantly, two different phenotypes of macrophages have been identified: classically activated M1 macrophages exacerbate inflammation via the production of cytokines, chemokines and other inflammatory mediators, while alternatively activated M2 ...
Source: Frontiers in Pharmacology - February 28, 2024 Category: Drugs & Pharmacology Source Type: research
In vitro characterization of novel hyaluronan-antioxidant conjugates as potential topical therapeutics against hearing loss
This study focused on the development and characterization of a novel series of antioxidant compounds that would be suitable for non or minimally invasive topical inner ear delivery and could mitigate reactive oxygen species associated cellular damage. Specifically, a series of covalent conjugates were synthesized by using hyaluronan as a drug carrier, and methionine, cysteine or glutathione as antioxidant drugs. The conjugates were tested for their ability to readily permeate though in vitro round window membrane and tympanic membrane permeation models, as well as their in vitro internalization into cochlear cells. Our da...
Source: Frontiers in Pharmacology - February 28, 2024 Category: Drugs & Pharmacology Source Type: research
