Safety of midodrine in patients with heart failure with reduced ejection fraction: a retrospective cohort study
Conclusion: In this large-scale study, midodrine use was associated with reduced ER visits but increased risks of respiratory failure, prolonged ICU stays, higher hospitalizations, and elevated mortality in HFrEF patients. Further research is needed to clarify midodrine’s role in hemodynamic support and strengthen existing evidence. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - March 6, 2024 Category: Drugs & Pharmacology Source Type: research
Tumor integrin targeted theranostic iron oxide nanoparticles for delivery of caffeic acid phenethyl ester: preparation, characterization, and anti-myeloma activities
In conclusion, we demonstrate that water-insoluble CAPE can be loaded to RGD-IONP to greatly improve the biocompatibility and significantly inhibit the growth of MM cells in vitro through the induction of apoptosis. This study paves the way for investigating the MRI-trackable delivery of CAPE for MM treatment in animal models in the future. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - March 6, 2024 Category: Drugs & Pharmacology Source Type: research
A systematic review of flurbiprofen 8.75 mg dose and risk of adverse events (excluding haemorrhagic) resulting from drug-drug interactions
Conclusion: Results from this systematic review on the risk of non-haemorrhagic events did not provide evidence for these events occurring as a result of interaction with other medicinal products. Additional appropriately designed studies would be required to confirm whether these findings suggest a true absence of risk or limitations in reporting. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - March 6, 2024 Category: Drugs & Pharmacology Source Type: research
Mechanism of traditional Chinese medicine in elderly diabetes mellitus and a systematic review of its clinical application
Conclusion: TCM has the advantages of multi-target and synergistic treatment in the treatment of elderly diabetes. However, current clinical researches have shortcomings including the inclusion of age criteria and diagnosis of subjects are unclear, imprecise research design, non-standard intervention measures, and its safety needs further exploration. In the future, the diagnosis of elderly people with diabetes needs to be further clarified. Traditional Chinese patent medicines included in the pharmacopoeia can be used to conduct more rigorous RCTs, and then gradually standardize the traditional Chinese medicine prescripti...
Source: Frontiers in Pharmacology - March 6, 2024 Category: Drugs & Pharmacology Source Type: research
Chinese medicine Phragmites communis (Lu Gen) for acute respiratory tract infections: a systematic review and meta-analysis of randomized controlled trials
Conclusion: Low- or very low-certainty evidence suggests that P. communis preparations may improve the cure rate of ARTIs, shorten the fever clearance time in febrile patients, and improve the pulmonary function of patients with acute exacerbation of chronic obstructive pulmonary disease or chronic bronchitis. However, these findings are inconclusive and need to be confirmed in rigorously designed trials.Systematic review registration: PROSPERO, identifier CRD42021239936 (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - March 6, 2024 Category: Drugs & Pharmacology Source Type: research
Integrating network pharmacology with molecular docking to rationalize the ethnomedicinal use of Alchornea laxiflora (Benth.) Pax & K. Hoffm. for efficient treatment of depression
Conclusion: The present study elucidates the bioactive compounds, potential targets, and pertinent mechanism of action of A. laxiflora in treating depression. A. laxiflora might exert an antidepressant effect by regulating PI3K-Akt and MAPK signaling pathways. However, further investigations are required to validate. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - March 5, 2024 Category: Drugs & Pharmacology Source Type: research
Efficacy of Forsythia suspensa (Thunb.) Vahl on mouse and rat models of inflammation-related diseases: a meta-analysis
Conclusion: FS effectively reversed the change in acute or chronic inflammation indicators in animal models, and the regulation of multiple channel proteins in inflammatory signaling pathways suggests that FS is a good potential drug for inflammatory disease drug therapy. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - March 4, 2024 Category: Drugs & Pharmacology Source Type: research
Exploring inter-ethnic and inter-patient variability and optimal dosing of osimertinib: a physiologically based pharmacokinetic modeling approach
Conclusion: In conclusion, this study’s PBPK simulations highlighted potential ethnic and inter-patient variability in OSI PK and EGFRm+ inhibition between Caucasian, Japanese, and Chinese populations, while also providing insights into optimal dosing regimens of OSI. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - March 4, 2024 Category: Drugs & Pharmacology Source Type: research
Erratum: Surgical procedure of intratympanic injection and inner ear pharmacokinetics simulation in domestic pigs
(Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - March 4, 2024 Category: Drugs & Pharmacology Source Type: research
Corrigendum: In vitro and in vivo antitumor activity of cucurbitacin C, a novel natural product from cucumber
(Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - March 4, 2024 Category: Drugs & Pharmacology Source Type: research
Traditional Chinese medicine and its active substances reduce vascular injury in diabetes via regulating autophagic activity
Due to its high prevalence, poor prognosis, and heavy burden on healthcare costs, diabetic vascular complications have become a significant public health issue. Currently, the molecular and pathophysiological mechanisms underlying diabetes-induced vascular complications remain incompletely understood. Autophagy, a highly conserved process of lysosomal degradation, maintains intracellular homeostasis and energy balance via removing protein aggregates, damaged organelles, and exogenous pathogens. Increasing evidence suggests that dysregulated autophagy may contribute to vascular abnormalities in various types of blood vessel...
Source: Frontiers in Pharmacology - March 4, 2024 Category: Drugs & Pharmacology Source Type: research
Pathophysiological aspects of transferrin-A potential nano-based drug delivery signaling molecule in therapeutic target for varied diseases
Transferrin (Tf), widely known for its role as an iron-binding protein, exemplifies multitasking in biological processes. The role of Tf in iron metabolism involves both the uptake of iron from Tf by various cells, as well as the endocytosis mediated by the complex of Tf and the transferrin receptor (TfR). The direct conjugation of the therapeutic compound and immunotoxin studies using Tf peptide or anti-Tf receptor antibodies as targeting moieties aims to prolong drug circulation time and augment efficient cellular drug uptake, diminish systemic toxicity, traverse the blood-brain barrier, restrict systemic exposure, overc...
Source: Frontiers in Pharmacology - March 4, 2024 Category: Drugs & Pharmacology Source Type: research
Factors determining the sensitivity to proteasome inhibitors of multiple myeloma cells
Multiple myeloma is an incurable cancer that originates from antibody-producing plasma cells. It is characterized by an intrinsic ability to produce large amounts of immunoglobulin-like proteins. The high rate of synthesis makes myeloma cells dependent on protein processing mechanisms related to the proteasome. This dependence made proteasome inhibitors such as bortezomib and carfilzomib one of the most important classes of drugs used in multiple myeloma treatment. Inhibition of the proteasome is associated with alteration of a number of important biological processes leading, in consequence, to inhibition of angiogenesis....
Source: Frontiers in Pharmacology - March 4, 2024 Category: Drugs & Pharmacology Source Type: research
Synthesis, biological and computational evaluation of novel cyanomethyl vinyl ether derivatives
This work explores the biological evaluation of novel cyanomethyl vinyl ether derivatives as antiproliferative agents. Tubulin, crucial to microtubule structure and function, is a target for cancer therapies. In vitro cytotoxicity assessments revealed significant activity in SKOV3 ovarian carcinoma cells and A549 lung carcinoma cells. Structure-Activity Relationship (SAR) analysis indicated that the E isomer and specific substitutions influenced the biological activity. Computational assays predicted favorable ADME properties, highlighting potential as anticancerous agents. Molecular docking studies demonstrated that compo...
Source: Frontiers in Pharmacology - March 4, 2024 Category: Drugs & Pharmacology Source Type: research
Integrated virtual screening and in vitro studies for exploring the mechanism of triterpenoids in Chebulae Fructus alleviating mesaconitine-induced cardiotoxicity via TRPV1 channel
Conclusion: The triterpenoids in CF can reduce the cardiotoxicity caused by MA. The MSA and AR function as TRPV1 agonists with comparatively reduced activity but a greater capacity to bind to TRPV1 receptors, thus antagonizing the excessive activation of TRPV1 by MA. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - March 4, 2024 Category: Drugs & Pharmacology Source Type: research
