Effect of elexacaftor-tezacaftor-ivacaftor on nasal potential difference and lung function in Phe508del rats
Discussion: These findings validate the usefulness of this rat model for future investigations of modulator therapy in CF. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - March 13, 2024 Category: Drugs & Pharmacology Source Type: research
Development of a prognostic model based on different disulfidptosis related genes typing for kidney renal clear cell carcinoma
Conclusion: This study contributes to the understanding of KIRC and provides a potential prognostic model using disulfidptosis gene for personalized management in KIRC patients. The risk signature shows clinical applicability and sheds light on the biological mechanisms associated with disulfide-induced cell death. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - March 13, 2024 Category: Drugs & Pharmacology Source Type: research
Diuretic drug utilization in neonates: a French prescription database analysis
Conclusion: Diuretic prescription practices vary between centers. The administration of these drugs is often non-evidence based, doses and duration of treatment easily exceed toxic thresholds. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - March 13, 2024 Category: Drugs & Pharmacology Source Type: research
The protective effect of traditional Chinese medicine Jinteng Qingbi granules on rats with rheumatoid arthritis
Conclusion: Our findings demonstrated that JTQBG was effective against RA by alleviating synovial inflammation, synovial hyperplasia, and joint destruction. The anti-RA properties of JTQBG were likely attributed to the inhibition of the NF-κB pathway and the regulation of serum metabolite disorders. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - March 13, 2024 Category: Drugs & Pharmacology Source Type: research
Different biologics for biological-na ïve patients with psoriatic arthritis: a systematic review and network meta-analysis
Conclusion: In 2023, considering both efficacy and safety, IL-17Ai may be the better treatment option for biological-naïve patients with PsA requiring biological therapy. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - March 13, 2024 Category: Drugs & Pharmacology Source Type: research
Aiming the magic bullet: targeted delivery of imaging and therapeutic agents to solid tumors by pHLIP peptides
The family of pH (Low) Insertion Peptides (pHLIP) comprises a tumor-agnostic technology that uses the low pH (or high acidity) at the surfaces of cells within the tumor microenvironment (TME) as a targeted biomarker. pHLIPs can be used for extracellular and intracellular delivery of a variety of imaging and therapeutic payloads. Unlike therapeutic delivery targeted to specific receptors on the surfaces of particular cells, pHLIP targets cancer, stromal and some immune cells all at once. Since the TME exhibits complex cellular crosstalk interactions, simultaneous targeting and delivery to different cell types leads to a sig...
Source: Frontiers in Pharmacology - March 13, 2024 Category: Drugs & Pharmacology Source Type: research
A real-world disproportionality analysis of Everolimus: data mining of the public version of FDA adverse event reporting system
Conclusion: This study provided novel insights into the monitoring, surveillance, and management of adverse drug reaction associated with Everolimus. The outcome of serious adverse events and the corresponding detection signals, as well as the unexpected significant adverse events signals are worthy of attention in order to improving clinical medication safety during treatment of Everolimus. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - March 12, 2024 Category: Drugs & Pharmacology Source Type: research
Editorial: The evolution in pharmacology of infectious diseases: 2022
(Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - March 12, 2024 Category: Drugs & Pharmacology Source Type: research
Editorial: Treatment of tick-borne diseases: current status, challenges, and global perspectives
(Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - March 12, 2024 Category: Drugs & Pharmacology Source Type: research
New light on changes in the number and function of blood platelets stimulated by cocoa and its products
Hyperactivation of blood platelets, one of the causes of heart attack, and other cardiovascular diseases (CVDs), is influenced by various dietary components, including phenolic compounds from vegetables, fruits, teas, wines, cocoa and its products, including chocolate. The present paper sheds new light on the effect of cocoa and its products, especially dark chocolate, on the number and function of blood platelets, and the anti-platelet activity of their constituent phenolic compounds. A review was performed of papers identified in various electronic databases, including PubMed, Science Direct, Scopus, Web of Knowledge, an...
Source: Frontiers in Pharmacology - March 12, 2024 Category: Drugs & Pharmacology Source Type: research
Forcing a square into a circle: why South Africa ’s draft revised material transfer agreement is not fit for purpose
The South African National Health Research Ethics Council (NHREC) recently released a final draft revision of the standard material transfer agreement (MTA) that was promulgated into law in 2018. This new draft MTA raises pertinent questions about the NHREC’s mandate, the way in which the draft MTA deals with data and with human biological material, and its avoidance of the concept of ownership. After South Africa’s data protection legislation, the Protection of Personal Information Act (POPIA), became operational in mid 2021, the legal landscape changed and it is doubtful that the NHREC has a residual mandate to gover...
Source: Frontiers in Pharmacology - March 12, 2024 Category: Drugs & Pharmacology Source Type: research
The Prescription trends and dosing appropriateness analysis of novel oral anticoagulants in ischemic stroke patients: a retrospective study of 9 cities in China
Conclusion: The application of NOACs in the Chinese population is increasing. Our findings highlight the frequent deviation from labeled dosing of NOACs in clinical practice. Continued efforts are necessary to promote the appropriate use of NOACs according to the standard dosage in the drug insert. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - March 12, 2024 Category: Drugs & Pharmacology Source Type: research
Berberine-based self-assembly agents with enhanced synergistic antitumor efficacy
Tumors are still a major threat to people worldwide. Nanodrug delivery and targeting systems can significantly improve the therapeutic efficacy of chemotherapeutic drugs for antitumor purposes. However, many nanocarriers are likely to exhibit drawbacks such as a complex preparation process, limited drug-loading capacity, untargeted drug release, and toxicity associated with nanocarriers. Therefore, new therapeutic alternatives are urgently needed to develop antitumor drugs. Natural products with abundant scaffold diversity and structural complexity, which are derived from medicinal plants, are important sources of new anti...
Source: Frontiers in Pharmacology - March 12, 2024 Category: Drugs & Pharmacology Source Type: research
Redirecting pantoprazole as a metallo-beta-lactamase inhibitor in carbapenem-resistant Klebsiella pneumoniae
In conclusion, pantoprazole can be used in combination with meropenem as a new strategy for treating serious infections caused by metallo-β-lactamases producing K. pneumoniae. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - March 12, 2024 Category: Drugs & Pharmacology Source Type: research
Antiretroviral drugs from multiple classes induce loss of excitatory synapses between hippocampal neurons in culture
Discussion: At a concentration of 10 μM the protease inhibitors nelfinavir and saquinavir, the non-nucleoside reverse transcriptase inhibitors etravirine and the 8-OH metabolite of efavirenz, the integrase inhibitor bictegravir, and the capsid inhibitor lenacapavir produced synaptic toxicity. Only lenacapavir produced synapse loss at the nanomolar concentrations estimated free in the plasma, although all 4 ARV drugs induced synapse loss at Cmax. Evaluation of combination therapies did not reveal synergistic synaptic toxicity. Synapse loss developed fully by 24 h and persisted for at least 3 days. Bictegravir-induced sy...
Source: Frontiers in Pharmacology - March 12, 2024 Category: Drugs & Pharmacology Source Type: research
