CHF6297: a novel potent and selective p38 MAPK inhibitor with robust anti-inflammatory activity and suitable for inhaled pulmonary administration as dry powder
Inhibition of p38 mitogen-activated protein kinase (MAPKs) is a potential therapeutic approach for the treatment of acute and chronic pulmonary inflammatory conditions. Here, we report the in vitro and in vivo characterization of the anti-inflammatory effects of CHF6297, a novel potent and selective p38α inhibitor designed for inhalation delivery as a dry powder formulation. CHF6297 has been proven to inhibit p38α enzymatic activity with sub-nanomolar potency (IC50 = 0.14 ± 0.06 nM), with >1,000-fold selectivity against p38γ and p38δ. In human peripheral blood mononuclear cells (PBMCs) stimulated with lipopolysacc...
Source: Frontiers in Pharmacology - March 14, 2024 Category: Drugs & Pharmacology Source Type: research
Post-marketing safety evaluation of lurbinectedin: a pharmacovigilance analysis based on the FAERS database
Conclusion: Our study provided a comprehensive evaluation of lurbinectedin’s safety profile in the post-marketing setting. In addition to the adverse events consistent with the existing clinical trials and labeling information, we have also identified an unreported signal related to tumor lysis syndrome. This finding will better guide the clinical practice of lurbinectedin and provide valuable evidence for future research. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - March 14, 2024 Category: Drugs & Pharmacology Source Type: research
Prevalence of use of on-label and off-label psychotropics in the Greek pediatric population
With a global increased use of psychotropics in pediatrics, their off-label use is a concern due to uncertainty and risk. Data on psychotropics use in the Greek pediatric population do not exist to date. We analyzed retrospective data from the nationwide pharmacy claim database, to estimate the prevalence of psychotropics in pediatrics focusing on off-label use (March 2016-October 2019). In total 63,782 pediatric subjects had at least one identified psychotropic prescription. The prevalence of psychotropics use was 5.1–14.6/1,000 pediatric inhabitants. When excluding 42,508 subjects who received only short-time hydroxyzi...
Source: Frontiers in Pharmacology - March 14, 2024 Category: Drugs & Pharmacology Source Type: research
Corrigendum: Phytotherapy for attention deficit hyperactivity disorder (ADHD): a systematic review and meta-analysis
(Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - March 14, 2024 Category: Drugs & Pharmacology Source Type: research
Sedum aizoon L.: a review of its history, traditional uses, nutritional value, botany, phytochemistry, pharmacology, toxicology, and quality control
In China, Russia, Mongolia, Japan, North Korea, and Mexico, Sedum aizoon L. (S. aizoon) is used as an edible plant. Up to now, over 234 metabolites, including phenolic acids, flavonoids, triterpenes, phytosterols, and alkaloids, among others, have been identified. In addition to its antioxidant, anti-inflammatory, anti-fatigue, antimicrobial, anti-cancer, and hemostatic activities, S. aizoon is used for the treatment of cardiovascular disease. This paper provides an overview of the history, botany, nutritional value, traditional use, phytochemistry, pharmacology, toxicology, and quality control of S. aizoon. (Source: Front...
Source: Frontiers in Pharmacology - March 14, 2024 Category: Drugs & Pharmacology Source Type: research
Methanol extract of Ligusticum chuanxiong Hort. Rhizome ameliorates bilateral common carotid artery stenosis-induced cognitive deficit in mice by altering microglia and astrocyte activation
In traditional Asian medicine, Ligusticum chuanxiong Hort also known as Conioselinum anthriscoides “Chuanxiong”, is mainly used for improving blood circulation or for analgesic and anti-inflammatory purposes, but they also have a long history of use for pain disorders in the head and face, such as headache. Despite the possibility that the plant is effective for diseases such as cerebral infarction and vascular dementia (VaD), the mechanism of action is not well understood. To determine if the dried rhizomes of L. chuanxiong (Chuanxiong Rhizoma, CR) methanol extract (CRex) has activity in a VaD mice model. Through netw...
Source: Frontiers in Pharmacology - March 14, 2024 Category: Drugs & Pharmacology Source Type: research
Efficacy of botanical lozenges in the treatment of chronic pharyngitis: a randomized controlled trial
Conclusion: Botanical lozenges not only aided patients in recovering from chronic pharyngitis but also improved their positive perceptions of the disease, which helped them adhere to their treatment regimen.Clinical Trial Registration: [https://www.chictr.org.cn/], identifier [ChiCTR2200062139]. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - March 14, 2024 Category: Drugs & Pharmacology Source Type: research
Corrigendum: Liability for harm caused by AI in healthcare: an overview of the core legal concepts
(Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - March 14, 2024 Category: Drugs & Pharmacology Source Type: research
Impact of treatment adherence and inhalation technique on asthma outcomes of pediatric patients: a longitudinal study
Conclusion: Our results confirm longitudinal associations at the within-person level of the two indicators of quality use of inhalers: for adherence to maintenance treatment with symptom control and HRQoL, and for the inhalation technique with HRQoL. Although treatment adherence was shown to be excellent, a third of the participants reported a suboptimal inhalation technique, highlighting the need for actions for improving asthma management of the pediatric population. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - March 13, 2024 Category: Drugs & Pharmacology Source Type: research
Corrigendum: Unveiling the therapeutic potential of exogenous β-hydroxybutyrate for chronic colitis in rats: novel insights on autophagy, apoptosis, and pyroptosis
(Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - March 13, 2024 Category: Drugs & Pharmacology Source Type: research
Effectiveness and safety of Danshen injections in treatment of cardiac failure: a network meta-analysis
Conclusion: Current evidence shows that all seven Danshen injections are effective for heart failure. Due to the limited quantity and quality of the included studies, our findings need to be verified by more high-quality studies. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - March 13, 2024 Category: Drugs & Pharmacology Source Type: research
Extracellular vesicles in chronic kidney disease: diagnostic and therapeutic roles
Chronic kidney disease (CKD) is a progressive disorder characterized by structural and functional changes in the kidneys, providing a global health challenge with significant impacts on mortality rates. Extracellular vesicles (EVs), are vital in the physiological and pathological processes associated with CKD. They have been shown to modulate key pathways involved in renal injury, including inflammation, fibrosis, apoptosis, and oxidative stress. Currently, the application research of EVs in the diagnosis and treatment of CKD is highly prevalent. However, there is currently a lack of standardized guidelines for their appli...
Source: Frontiers in Pharmacology - March 13, 2024 Category: Drugs & Pharmacology Source Type: research
The protective effects of ligustrazine on ischemic stroke: a systematic review and meta-analysis of preclinical evidence and possible mechanisms
Conclusion: Ligustrazine has been shown to have a protective effect in animal models of cerebral ischemic injury. Its mechanism of action is believed to be associated with the reduction of inflammation and oxidative stress, the inhibition of apoptosis, and the repair of BBB permeability. However, further high-quality animal experiments are required to validate these findings. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - March 13, 2024 Category: Drugs & Pharmacology Source Type: research
Emerging therapeutic drug monitoring technologies: considerations and opportunities in precision medicine
In recent years, the development of sensor and wearable technologies have led to their increased adoption in clinical and health monitoring settings. One area that is in early, but promising, stages of development is the use of biosensors for therapeutic drug monitoring (TDM). Traditionally, TDM could only be performed in certified laboratories and was used in specific scenarios to optimize drug dosage based on measurement of plasma/blood drug concentrations. Although TDM has been typically pursued in settings involving medications that are challenging to manage, the basic approach is useful for characterizing drug activit...
Source: Frontiers in Pharmacology - March 13, 2024 Category: Drugs & Pharmacology Source Type: research
Landscape of m6A RNA methylation regulators in liver cancer and its therapeutic implications
Liver cancer remains as the third leading cause of cancer-related death globally as of 2020. Despite the significant progress made in the field of liver cancer treatment, there is still a lack of effective therapies in patients with advanced cancer and the molecular mechanisms underlying liver cancer progression remain largely elusive. N6-methyladenosine (m6A) modification, as the most prevalent and abundant internal RNA modification in eukaryotic RNAs, plays an essential role in regulating RNA metabolism including RNA splicing, stability, translation, degradation. To date, there is mounting evidence showing that m6A dysre...
Source: Frontiers in Pharmacology - March 13, 2024 Category: Drugs & Pharmacology Source Type: research
