Age and duration of hypertension are associated with carotid artery tortuosity
ConclusionCarotid artery tortuosity is a relatively common carotid artery disease. The incidence of carotid artery tortuosity may increase with age and the duration of hypertension. The consumption of antihypertensive drugs may reduce the incidence of carotid artery tortuosity. (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - March 11, 2024 Category: Neurology Source Type: research
Therapeutic potential to target sialylation and SIGLECs in neurodegenerative and psychiatric diseases
Sialic acids, commonly found as the terminal carbohydrate on the glycocalyx of mammalian cells, are pivotal checkpoint inhibitors of the innate immune system, particularly within the central nervous system (CNS). Sialic acid-binding immunoglobulin-like lectins (SIGLECs) expressed on microglia are key players in maintaining microglial homeostasis by recognizing intact sialylation. The finely balanced sialic acid-SIGLEC system ensures the prevention of excessive and detrimental immune responses in the CNS. However, loss of sialylation and SIGLEC receptor dysfunctions contribute to several chronic CNS diseases. Genetic varian...
Source: Frontiers in Neurology - March 11, 2024 Category: Neurology Source Type: research
Editorial: Hybrid (combined endovascular and microsurgical) treatments for cerebrovascular diseases
(Source: Frontiers in Neurology)
Source: Frontiers in Neurology - March 11, 2024 Category: Neurology Source Type: research
Epilepsy-related functional brain network alterations are already present at an early age in the GAERS rat model of genetic absence epilepsy
Discussionrs-fMRI, MEMRI, and volumetric data collectively suggest the significance of cortical networks in GAERS, which correlates with an increased fronto-central connectivity in childhood absence epilepsy (CAE). Our findings also verify involvement of basal ganglia and limbic regions. Epilepsy-related network alterations are already present in juvenile animals. Consequently, this early condition seems to play a greater role in dynamic brain function than chronic absence seizures. (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - March 11, 2024 Category: Neurology Source Type: research
Advancements in autologous peripheral nerve transplantation care: a review of strategies and practices to facilitate recovery
Autologous peripheral nerve transplantation, a pioneering technique in nerve injury treatment, has demonstrated remarkable progress. We examine recent nursing strategies and methodologies tailored to various anatomical sites, highlighting their role in postoperative recovery enhancement. Encompassing brachial plexus, upper limb, and lower limb nerve transplantation care, this discussion underscores the importance of personalized rehabilitation plans, interdisciplinary collaboration, and innovative approaches like nerve electrical stimulation and nerve growth factor therapy. Moreover, the exploration extends to effective co...
Source: Frontiers in Neurology - March 8, 2024 Category: Neurology Source Type: research
Eptinezumab for the preventive treatment of episodic and chronic migraine: a narrative review
Eptinezumab, a monoclonal antibody that targets calcitonin gene-related peptide (CGRP), was recently approved in Europe for the prophylactic treatment of migraine in adults who have at least four migraine days a month. Eptinezumab is administered by intravenous infusion every 12 weeks. During recent months, a considerable amount of evidence from eptinezumab trials has been published. The aim of this review is to describe the existing evidence on the tolerability, safety and efficacy of eptinezumab in patients with migraine. Data from randomized (PROMISE-1, PROMISE-2, RELIEF and DELIVER) and open-label (PREVAIL) phase 3 c...
Source: Frontiers in Neurology - March 8, 2024 Category: Neurology Source Type: research
Editorial: Improving clinical practice for the diagnosis and management of patients with leptomeningeal metastasis
(Source: Frontiers in Neurology)
Source: Frontiers in Neurology - March 8, 2024 Category: Neurology Source Type: research
Using the gross motor function measure evolution ratio to compare different dosage of hyperbaric treatment with conventional therapies in children with cerebral palsy – could it end the controversy?
ConclusionThe analysis of the included studies with the GMFMER showed that hyperbaric treatment can result in progress of gross motor function more than other recognized treatments in children with cerebral palsy. (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - March 8, 2024 Category: Neurology Source Type: research
Mapping knowledge of the stem cell in traumatic brain injury: a bibliometric and visualized analysis
ConclusionResearch on TBI and stem cells has shown a rapid growth trend in recent years. Existing studies mainly focus on the activation mechanism of endogenous neural stem cells and how to make exogenous stem cell therapy more effective. The combination with bioengineering technology is the trend in this field. Topics related to exosomes and immune regulation may be the future focus of TBI and stem cell research. (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - March 8, 2024 Category: Neurology Source Type: research
The effect of argatroban on early neurological deterioration and outcomes in minor ischemic stroke: preliminary findings
ConclusionIn patients with MIS, argatroban administration and reaching the target APTT can reduce the incidence of END and improve short-term functional prognosis. (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - March 8, 2024 Category: Neurology Source Type: research
Sensorineural correlates of failed functional recovery after natural regeneration of vestibular hair cells in adult mice
Vestibular hair cells (HCs) are mechanoreceptors that sense head motions by modulating the firing rate of vestibular ganglion neurons (VGNs), whose central processes project to vestibular nucleus neurons (VNNs) and cerebellar neurons. We explored vestibular function after HC destruction in adult Pou4f3+/DTR (DTR) mice, in which injections of high-dose (50 ng/g) diphtheria toxin (DT) destroyed most vestibular HCs within 2 weeks. At that time, DTR mice had lost the horizontal vestibulo-ocular reflex (aVORH), and their VNNs failed to upregulate nuclear cFos expression in response to a vestibular stimulus (centrifugation)....
Source: Frontiers in Neurology - March 8, 2024 Category: Neurology Source Type: research
Analyzing the causal relationship between lipid-lowering drug target genes and epilepsy: a Mendelian randomization study
ConclusionThe drug target MR investigation suggests a possible link between reduced epilepsy vulnerability and HMGCR and PCSK9 inhibition. (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - March 8, 2024 Category: Neurology Source Type: research
The effects of Tai Chi exercise on sleep quality among the elderly: a study based on polysomnographic monitoring
ConclusionThe findings indicate that Tai Chi exercise may improve subjective reported sleep quality. In addition, Tai Chi exercise may alleviate general drowsiness, extend sleep duration, and optimize the sleep process and structure. Consequently, Tai Chi exercise may be a suitable exercise to improve sleep quality in older individuals. (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - March 8, 2024 Category: Neurology Source Type: research
Erratum: Delimiting MOGAD as a disease entity using translational imaging
(Source: Frontiers in Neurology)
Source: Frontiers in Neurology - March 7, 2024 Category: Neurology Source Type: research
Nomogram prediction model for the risk of intracranial hemorrhagic transformation after intravenous thrombolysis in patients with acute ischemic stroke
ConclusionNomogram consisting of NIHSS, NT-pro BNP, NLR, SBP scores predict the risk of HT in AIS patients treated with IVT. (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - March 7, 2024 Category: Neurology Source Type: research
