Differential impact of unilateral stroke on the bihemispheric motor cortex representation of the jaw and tongue muscles in young and aged rats
ConclusionOur findings suggest the role of the intact and infarcted hemispheres in the recovery of oral motor function may differ between the tongue and jaw muscles, which may have important implications for rehabilitation, especially hemisphere-specific neuromodulatory approaches. This study addressed the natural course of recovery after stroke; future work should expand to focus on rehabilitation. (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - March 20, 2024 Category: Neurology Source Type: research

Gait instability, ophthalmoplegia, and chorea with orofacial dyskinesia in a man with anti-Ri antibodies: a case report
We report the rare manifestation of anti-Ri antibody-associated paraneoplastic neurological syndrome (PNS), and this case can alert us to the importance of respiratory management in this diverse neurologic disease. Furthermore, PNSs positive for anti-Ri antibodies should be added to the list of differential diagnoses of chorea with orofacial dyskinesia. (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - March 20, 2024 Category: Neurology Source Type: research

Construction and application of a time-saving mode in China for the treatment of acute ischemic stroke
ConclusionNo. 971 Hospital model can effectively shorten DAT, DCT, INT, and DNT, and improve the effectiveness of thrombolysis and prognoses of AIS patients. (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - March 19, 2024 Category: Neurology Source Type: research

Prediction of tissue outcome in acute ischemic stroke based on single-phase CT angiography at admission
Conclusion24 h follow-up infarct prediction using acute CTA imaging exclusively is feasible with DSC measures comparable to results of CTP-based algorithms reported in other studies. The proposed method might pave the way to a wider acceptance, feasibility, and applicability of follow-up infarct prediction based on artificial intelligence. (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - March 19, 2024 Category: Neurology Source Type: research

Recent insights from non-mammalian models of brain injuries: an emerging literature
Traumatic brain injury (TBI) is a major global health concern and is increasingly recognized as a risk factor for neurodegenerative diseases including Alzheimer’s disease (AD) and chronic traumatic encephalopathy (CTE). Repetitive TBIs (rTBIs), commonly observed in contact sports, military service, and intimate partner violence (IPV), pose a significant risk for long-term sequelae. To study the long-term consequences of TBI and rTBI, researchers have typically used mammalian models to recapitulate brain injury and neurodegenerative phenotypes. However, there are several limitations to these models, including: (1) lengthy...
Source: Frontiers in Neurology - March 19, 2024 Category: Neurology Source Type: research

Serum NFL and tau, but not serum UCHL-1 and GFAP or CSF SNAP-25, NPTX2, or sTREM2, correlate with delirium in a 3-year retrospective analysis
Delirium represents a common terminal pathway of heterogeneous neurological conditions characterized by disturbances in consciousness and attention. Contemporary theories highlight the acute impairment of synaptic function and network connectivity, driven by neuroinflammation, oxidative stress, and neurotransmitter imbalances. However, established biomarkers are still missing. Innovative diagnostic techniques, such as single-molecule array analysis, enable the detection of biomarkers in blood at picomolar concentrations. This approach paves the way for deeper insights into delirium and potentially therapeutic targets for t...
Source: Frontiers in Neurology - March 19, 2024 Category: Neurology Source Type: research

Guideline for standardized approach in the treatment of the Mal de Debarquement syndrome
ConclusionSymptoms improved subjectively and objectively in patients’ post-treatment. The overall success rate was 64.1%, with no significant difference between MT (64.2%) and SO (63.3%). This study supports the conclusion that VOR readaptation treatment provides relief for two-thirds of MdDS patients, irrespective of the onset type. Based on consistency in the findings, we propose a standardized method for treatment of MdDS based on the OKS with head roll paradigm. (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - March 19, 2024 Category: Neurology Source Type: research

Case Report: Taxifolin for neurosurgery-associated early-onset cerebral amyloid angiopathy
We describe a young 42-year-old man with a history of childhood traumatic brain injury that required a craniotomy for hematoma evacuation. He later presented with recurrent lobar intracerebral hemorrhage (ICH) decades later, which was histologically confirmed to be CAA. Serial 11C-Pittsburgh compound B positron emission tomography (11C-PiB-PET) imaging showed a 24% decrease in global standardized uptake value ratio (SUVR) at 10 months after taxifolin use. During this period, the patient experienced clinical improvement with improved consciousness and reduced recurrent ICH frequency, which may be partly attributable to th...
Source: Frontiers in Neurology - March 19, 2024 Category: Neurology Source Type: research

Exploring the role of in-patient magnetic resonance imaging use among admitted ischemic stroke patients in improving patient outcomes and reducing healthcare resource utilization
ConclusionA substantial proportion of admitted IS patients underwent MRI, and MRI use was associated with improved patient outcomes and reduced healthcare resource utilization. Considering the multifactorial nature of IS patient outcomes, further randomized controlled trials are suggested to investigate the role of increased MRI utilization in optimizing in-patient IS management. (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - March 18, 2024 Category: Neurology Source Type: research

Effectiveness of biomedical interventions on the chronic stage of traumatic brain injury: a systematic review of randomized controlled trials
Traumatic brain injury (TBI), in any form and severity, can pose risks for developing chronic symptoms that can profoundly hinder patients’ work/academic, social, and personal lives. In the past 3 decades, a multitude of pharmacological, stimulation, and exercise-based interventions have been proposed to ameliorate symptoms, memory impairment, mental fatigue, and/or sleep disturbances. However, most research is preliminary, thus limited influence on clinical practice. This review aims to systematically appraise the evidence derived from randomized controlled trials (RCT) regarding the effectiveness of pharmacological, st...
Source: Frontiers in Neurology - March 18, 2024 Category: Neurology Source Type: research

Combining various acupuncture therapies with multimodal analgesia to enhance postoperative pain management following total knee arthroplasty: a network meta-analysis of randomized controlled trials
ConclusionFor the clinical treatment of post-TKA pain, acupuncture-related therapies can be selected as a complementary and alternative therapy. EA + MA and TEAS+MA demonstrate superior efficacy in alleviating postoperative pain among TKA patients. ACU + MA is the optimal choice for promoting postoperative knee joint function recovery in TKA patients. AAT + MA is recommended for preventing postoperative adverse reactions.Systematic review registrationhttps://www.crd.york.ac.uk/, identifier (CRD42023492859). (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - March 18, 2024 Category: Neurology Source Type: research

Short-term reduction of ankle spasticity after surgical lengthening of the triceps surae in chronic post-stroke patients: a retrospective cohort study
DiscussionTS lengthening led to a short-term reduction of spasticity in 41% and 63% of chronic post-stroke patients in the gastro-soleus complex and soleus, respectively, with complete relief observed in 21% and 30% of the sample. Surgical lengthening can be considered an effective treatment that not only restores joint range of motion but also may reduce spasticity, even in chronic patients. (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - March 18, 2024 Category: Neurology Source Type: research

Relationship between sodium level and in-hospital mortality in traumatic brain injury patients of MIMIC IV database
ConclusionThe study reveals an L-shaped relationship between sodium levels and in-hospital deaths, with a pivotal point at 144.1 mmol/L. TBI patients displaying hypernatremia were independently linked to higher in-hospital mortality, underlining the need for further studies into targeted management of sodium levels in these patients. (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - March 18, 2024 Category: Neurology Source Type: research

Hemimasticatory spasm: a series of 17 cases and a comprehensive review of the literature
In conclusion, highly effective modalities are currently available, and it is necessary to raise awareness of HMS to ensure that it can be diagnosed and treated accurately by both medical and dental professionals. (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - March 18, 2024 Category: Neurology Source Type: research

Editorial: Personalized precision medicine in autism spectrum related disorders, volume II
(Source: Frontiers in Neurology)
Source: Frontiers in Neurology - March 18, 2024 Category: Neurology Source Type: research