Effect of tuina on sleep quality, psychological state and neurotransmitter level in patients with insomnia: a systematic review and meta-analysis
ConclusionTuina for insomnia has certain therapeutic advantages and can significantly improve sleep quality, relieve anxiety-depressive states, and increase 5-HT levels with high safety. Due to the limitations of the quality of the included studies, additional high-quality clinical trials are required for further verification.Systematic review registrationhttps://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=447839, identifier CRD42023447839. (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - February 21, 2024 Category: Neurology Source Type: research
Case report: Mirror paraclinoid aneurysm associated with mirror clinoidal meningioma
ConclusionThis case represents a unique occurrence of mirror ophthalmic segment internal carotid artery aneurysms associated with mirror clinoidal meningiomas, a combination not previously reported. Despite the limitations of MRA in detecting small meningiomas, it remains a valuable non-invasive screening tool for neurovascular diseases. The case underscores the need for further research to elucidate the association between cerebral aneurysms and meningiomas. (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - February 21, 2024 Category: Neurology Source Type: research
Optimizing adjuvant treatment options for patients with glioblastoma
ConclusionOur study suggests that BITES can effectively identify GBM patients likely to benefit from CRT. These ML models show promise in transforming the complex heterogeneity of real-world clinical practice into precise, personalized treatment recommendations. (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - February 21, 2024 Category: Neurology Source Type: research
Case report and literature review: Acute rhabdomyolysis caused by overheating of electric blanket complicated with Guillain-Barr é syndrome
This report presents the case of a 22-year-old man who developed RM subsequent to the use of an electric blanket. Despite undergoing plasma exchange and renal replacement therapy, the patient continued to exhibit poor muscle strength in both lower limbs. Subsequent comprehensive evaluation revealed the presence of concurrent GBS. Following a 5-day course of intravenous gamma globulin treatment, the patient experienced rapid recovery of muscle strength and was discharged. Additionally, we reviewed seven cases from the literature of coexistent RM and GBS. This indicated that investigation of the timing of onset of muscle str...
Source: Frontiers in Neurology - February 21, 2024 Category: Neurology Source Type: research
Neuroinflammation and acquired traumatic CNS injury: a mini review
Acquired traumatic central nervous system (CNS) injuries, including traumatic brain injury (TBI) and spinal cord injury (SCI), are devastating conditions with limited treatment options. Neuroinflammation plays a pivotal role in secondary damage, making it a prime target for therapeutic intervention. Emerging therapeutic strategies are designed to modulate the inflammatory response, ultimately promoting neuroprotection and neuroregeneration. The use of anti-inflammatory agents has yielded limited support in improving outcomes in patients, creating a critical need to re-envision novel approaches to both quell deleterious inf...
Source: Frontiers in Neurology - February 21, 2024 Category: Neurology Source Type: research
Association of CLDN molecules with sleep apnea hypopnea syndrome: new biomarker candidates
ConclusionCLDN molecules are promising as useful biomarkers for OSA, which may be related to the impaired barrier function related to OSA. (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - February 21, 2024 Category: Neurology Source Type: research
Postural impairments in unilateral and bilateral vestibulopathy
Chronic imbalance is a major complaint of patients suffering from bilateral vestibulopathy (BV) and is often reported by patients with chronic unilateral vestibulopathy (UV), leading to increased risk of falling. We used the Central SensoriMotor Integration (CSMI) test, which evaluates sensory integration, time delay, and motor activation contributions to standing balance control, to determine whether CSMI measures could distinguish between healthy control (HC), UV, and BV subjects and to characterize vestibular, proprioceptive, and visual contributions expressed as sensory weights. We also hypothesized that sensory weight...
Source: Frontiers in Neurology - February 21, 2024 Category: Neurology Source Type: research
Therapeutic inertia in the management of neuromyelitis optica spectrum disorder
ConclusionTI is a common phenomenon among neurologists managing NMOSD AQP4+. Identifying TI and implementing specific intervention strategies may be critical to improving therapeutic decisions and patient care. (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - February 21, 2024 Category: Neurology Source Type: research
The effects of combined transcranial brain stimulation and a 4-week visuomotor stepping training on voluntary step initiation in persons with chronic stroke —a pilot study
PurposeEvidence suggests that transcranial direct current stimulation (tDCS) can enhance motor performance and learning of hand tasks in persons with chronic stroke (PCS). However, the effects of tDCS on the locomotor tasks in PCS are unclear. This pilot study aimed to: (1) determine aggregate effects of anodal tDCS combined with step training on improvements of the neural and biomechanical attributes of stepping initiation in a small cohort of persons with chronic stroke (PCS) over a 4-week training program; and (2) assess the feasibility and efficacy of this novel approach for improving voluntary stepping initiation in P...
Source: Frontiers in Neurology - February 21, 2024 Category: Neurology Source Type: research
Peripheral nerve blocks of wrist and finger flexors can increase hand opening in chronic hemiparetic stroke
ConclusionOur results suggest that many individuals with stroke would see improved hand-opening with wrist and finger flexor activity curtailed by nerve block, especially when FES is used to drive the typically paretic finger and wrist extensor muscles. Such a nerve block (potentially produced by aforementioned emerging electrical nerve block technologies) could thus significantly address prior observed shortcomings of FES interventions for individuals with stroke. (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - February 21, 2024 Category: Neurology Source Type: research
Multi-frequency VEMPs improve detection of present otolith responses in bilateral vestibulopathy
ConclusionMulti-frequency VEMP testing improves the detection rate of present otolith responses in BV patients. Therefore, multi-frequency VEMPs should be considered when evaluation of (residual) otolith function is indicated. (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - February 21, 2024 Category: Neurology Source Type: research
Motor and neurocognitive profiles of children with symptomatic spinal muscular atrophy type 1 with two copies of SMN2 before and after treatment: a longitudinal observational study
IntroductionSpinal muscular atrophy (SMA) is a neurodegenerative disease caused by mutations in the survival motor neuron 1 (SMN1) gene. In clinical studies, gene replacement therapy with onasemnogene abeparvovec (formerly AVXS-101, Zolgensma®, Novartis) was efficacious in improving motor functioning in children with SMA. However, its effects on cognitive and language skills are largely unknown.MethodsThis longitudinal observational study evaluated changes in motor and neurocognitive functioning over a 1-year period after administration of onasemnogene abeparvovec in 12 symptomatic SMA type 1 patients with two copies of S...
Source: Frontiers in Neurology - February 21, 2024 Category: Neurology Source Type: research
Feasibility of video-based real-time nystagmus tracking: a lightweight deep learning model approach using ocular object segmentation
ConclusionThe potential of our model, which can automatically segment ocular regions and track nystagmus in real time from eye movement videos, holds significant promise for emergency settings or remote intervention within the field of neurotology. (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - February 21, 2024 Category: Neurology Source Type: research
The efficacy of contralaterally controlled functional electrical stimulation compared to conventional neuromuscular electrical stimulation for recovery of limb function following a stroke: a systematic review and meta-analysis
ConclusionThe results of this study provide strong evidence that shows CCFES being a better electrical stimulation modality compared to conventional NMES. This could be explained by the fact that CCFES is bilateral in nature which offers a platform for better neuroplasticity following a stroke. There is still a need for high-quality studies with a standardized approach comparing CCFES to other treatment modalities.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?RecordID=342670, identifier CRD42022342670. (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - February 21, 2024 Category: Neurology Source Type: research
Sex-driven variability in TSPO-expressing microglia in MS patients and healthy individuals
ConclusionWe observed higher TSPO-binding in males compared to females among people with MS and in healthy individuals. This sex-driven inherent variability in TSPO-expressing microglia may predispose male MS patients to greater likelihood of disease progression. (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - February 20, 2024 Category: Neurology Source Type: research
