MicroRNA as a potential diagnostic and prognostic biomarker in brain gliomas: a systematic review and meta-analysis
IntroductionBrain neoplasms and central nervous system (CNS) disorders, particularly gliomas, have shown a notable increase in incidence over the last three decades, posing significant diagnostic and therapeutic challenges. MicroRNAs (miRNAs) have emerged as promising biomarkers due to their regulatory role in gene expression, offering potential enhancements in glioma diagnosis and prognosis.MethodsThis systematic review and meta-analysis, adhering to PRISMA guidelines, included 25 studies for diagnostic accuracy and 99 for prognostic analysis, published until August 27th, 2023. Studies were identified through comprehensiv...
Source: Frontiers in Neurology - February 29, 2024 Category: Neurology Source Type: research
Case report: Acute HHV6B encephalitis/myelitis post CAR-T cell therapy in patients with relapsed/refractory aggressive B-cell lymphoma
ConclusionConsidering its fatal potential, HHV6B encephalitis/myelitis should be urgently diagnosed post CAR-T cell-based therapy. Furthermore, hematologists should differentially diagnose these conditions from CRS or other immunotherapy-related neurotoxicities as early as possible. The results of this study demonstrate the potential of mNGS in the early diagnosis of HHV6B infection, particularly when the organism is difficult to culture. (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - February 29, 2024 Category: Neurology Source Type: research
Successful switch to ofatumumab after liver injury associated with ocrelizumab treatment in multiple sclerosis: a case report
Drug-induced liver injury (DILI) is a potential adverse event of disease-modifying therapies (DMTs) for the treatment of multiple sclerosis (MS), as well as of methylprednisolone pulsed therapy used in case of MS relapse. DILI may be induced by different mechanisms, including idiosyncratic reaction, autoimmune hepatitis or viral reactivation. In patients receiving the humanized anti-CD20 monoclonal antibody (mAb) ocrelizumab, DILI has been rarely reported and was mostly associated with hepatitis B virus (HBV) reactivation. Here we present the case of a woman with highly active relapsing–remitting MS who had experienced t...
Source: Frontiers in Neurology - February 29, 2024 Category: Neurology Source Type: research
Clinical and imaging markers for the prognosis of acute ischemic stroke
ConclusionPerfusion and diffusion metrics could reflect the microstructure and blood flow characteristics of the lesion, which were the key factors for the salvage ability and prognosis of the infarction tissue. The characteristics of the infarction core and peripheral regions have different effects on the outcomes. Diffusion of infarction core has strong relations with the prognosis, whereas the time metrics (MTT, TTP) were more important for peripheral regions. MK had a more significant association with prognosis than MD. These factors were the primary markers influencing the prognosis of cerebral infarction patients. (S...
Source: Frontiers in Neurology - February 29, 2024 Category: Neurology Source Type: research
Prevalence and factors associated with depressive symptoms among patients with epilepsy in Ethiopia: a national-based systematic review and meta-analysis
ConclusionWe found that depressive symptoms affects at least four out of ten patients with epilepsy, indicating an immense burden. Depressive symptoms were extremely prevalent in those who had high levels of stigma, a monthly seizure frequency of once or more, and perceived stress. Therefore, physicians should take extra precautions when treating patients with epilepsy who have certain conditions.Systematic review registrationThis study was registered according to The International Prospective Register of Systemic Review (PROSPERO) with the registration ID (CRD42023484308). (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - February 28, 2024 Category: Neurology Source Type: research
Case report: A novel variant (H49N) in Myelin Protein Zero gene is responsible for a patient with Charcot –Marie–Tooth disease
This report presents a case of Charcot–Marie–Tooth dominant intermediate D (CMTDID), a rare subtype of Charcot–Marie–Tooth disease, in a 52 years-old male patient. The patient exhibited mobility impairment, foot abnormalities (pes cavus), and calf muscle atrophy. Whole exome sequencing and Sanger sequencing suggested that a novel variant (NM_000530.8, c.145C>A/p.His49Asn) of MPZ may be the genetic lesion in the patient. The bioinformatic program predicted that the new variant (p.His49Asn), located at an evolutionarily conserved site of MPZ, was neutral. Our study expands the variant spectrum of MPZ and the num...
Source: Frontiers in Neurology - February 28, 2024 Category: Neurology Source Type: research
Effect of high-frequency (5Hz) rTMS stimulating left DLPFC combined with galantamine on cognitive impairment after ischemic stroke and serum homocysteine and neuron-specific enolase
ConclusionCognitive rehabilitation combined with HF-rTMS and galantamine could improve the cognitive function of patients to the greatest extent, promote the recovery of physical activity, improve the self-care ability of daily life, and effectively reduce the serum HCY and NSE levels in patients with cognitive impairment after stroke. No randomized controlled trials of similar combination treatments have been reported. The better therapeutic effect may be related to the fact that galantamine combined with repetitive transcranial magnetism can activate the brain cholinergic system more extensively, promote brain neural rem...
Source: Frontiers in Neurology - February 28, 2024 Category: Neurology Source Type: research
Prediction of pulmonary infection in patients with severe myelitis by NPAR combined with spinal cord lesion segments
ConclusionThe nomogram model constructed based on NPAR combined with high cervical cord lesion at admission has good clinical application value in predicting pulmonary infection in patients with severe myelitis, which is conducive to clinicians’ evaluation of patients. (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - February 28, 2024 Category: Neurology Source Type: research
The dose-effect relationship of acupuncture on limb dysfunction after acute stroke: a systematic review and meta-analysis
ConclusionOur study demonstrated the effectiveness of different acupuncture dose in improving limb dysfunction. The pooled data suggested that the optimal intervention dose for acupuncture interval time was low (every other day) and moderate frequency (once a day), the optimal intervention dose for needle course time was short course treatment (less than 2 weeks). But we did not find the optimal intervention dose for needle retention time. Future studies of higher quality are needed to confirm this.Systematic Review Registration:https://www.crd.york.ac.uk/PROSPERO/, CRD42023447202. (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - February 28, 2024 Category: Neurology Source Type: research
Adult supratentorial extraventricular anaplastic ependymoma with cerebrospinal fluid dissemination metastases: a case report
ConclusionAdult SEAE is a rare tumor with high malignancy and have a tendency to disseminate into the CSF, resulting in drop metastases. Immunohistochemistry is very important for the diagnosis of SEAE. It is recommended to administer adjuvant chemotherapy or radiation therapy appropriately after surgery, based on the tumor being completely resected as much as possible. (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - February 28, 2024 Category: Neurology Source Type: research
Factors affecting driving performance in patients with Multiple Sclerosis – still an open question
ConclusionDriving performance in a simulator seems to be reduced in PwMS at an early stage of disease compared to controls, as a result of increased erroneous driving, reduced reaction time and higher accident rate. MS-related impairment in mobility, vision, cognition, and in psychological and demographic aspects showed no or only minimal association to driving ability, but impairment in different areas of cognition such as spatial short-term memory, working memory and selective attention correlated with the number of accidents, and might indicate a higher risk for driving errors and worse performance. These results show t...
Source: Frontiers in Neurology - February 28, 2024 Category: Neurology Source Type: research
Is Alzheimer's disease an individual-centered disease? Hypotheses from the atomic levels up to mathematical models for biological systems
(Source: Frontiers in Neurology)
Source: Frontiers in Neurology - February 28, 2024 Category: Neurology Source Type: research
Assessment of focused ultrasound stimulation to induce peripheral nerve activity and potential damage in vivo
DiscussionPast reports on the ability of ultrasound to stimulate the peripheral nerve are controversial. After testing a wide range of FUS conditions, we conclude that it is not a reliable and safe method for stimulating the peripheral nerve. Special consideration should be taken, especially when low-frequency FUS is applied, as it may lead to nerve damage. (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - February 28, 2024 Category: Neurology Source Type: research
Stroke-associated pneumonia according to mCDC criteria: impact on prognosis and antibiotic therapy
The objective was to investigate the impact of SAP on stroke outcome depending on whether or not it conforms to mCDC criteria. Our secondary objective was to identify the responsible factors for antibiotic initiation in stroke patients.MethodsWe conducted a prospective, multicenter, observational study of ischemic stroke patients with moderate to severe stroke (NIHSS≥4) admitted within 24 h. For 7 days, mCDC criteria were assessed daily, and infections and antibiotics were recorded. Pneumonias were divided into those fulfilling mCDC criteria (mCDC-SAP) or not (other pneumonias, OPn). The effect of each type of pneumoni...
Source: Frontiers in Neurology - February 28, 2024 Category: Neurology Source Type: research
Evaluating circulating tumour cell enrichment techniques to establish an appropriate method for clinical application in glioblastomas
Brain tumours reduce life expectancy for an average of 20 years per patient, the highest of any cancer. A third of brain tumour patients visit their GP at least five times before diagnosis and many of those are diagnosed late through emergency departments. A possible solution to this challenge is to utilise a “liquid biopsy” blood test designed for circulating tumour cells (CTCs). Such a test could be applied at a primary healthcare centre, contributing to informed decision making for diagnostic imaging referrals. Furthermore, it could also be applied at secondary health care centres for the ongoing monitoring of dis...
Source: Frontiers in Neurology - February 28, 2024 Category: Neurology Source Type: research
