Stress-associated neurobiological activity associates with the risk for and timing of subsequent Takotsubo syndrome
ConclusionHigher AmygA associates with an increased risk for TTS among a retrospective population with a high rate of malignancy. This heightened neurobiological activity is present years before the onset of TTS and may impact the timing of the syndrome. Accordingly, heightened stress-associated neural activity may represent a therapeutic target to reduce stress-related diseases, including TTS. (Source: European Heart Journal)
Source: European Heart Journal - March 26, 2021 Category: Cardiology Source Type: research
What do we learn by repeating the ABC?
(Source: European Heart Journal)
Source: European Heart Journal - March 26, 2021 Category: Cardiology Source Type: research
Validation of risk scores for ischaemic stroke in atrial fibrillation across the spectrum of kidney function
Conclusion In the most clinically relevant stages of CKD, predictive performance of the majority of risk scores was poor, increasing the risk of misclassification and thus of over- or undertreatment. The Modified CHADS2 score performed good and consistently across all kidney function strata, and should therefore be preferred for risk estimation in AF patients. (Source: European Heart Journal)
Source: European Heart Journal - March 26, 2021 Category: Cardiology Source Type: research
Jiri Widimsky MD
(Source: European Heart Journal)
Source: European Heart Journal - March 25, 2021 Category: Cardiology Source Type: research
Serial assessment of biomarkers and the risk of stroke or systemic embolism and bleeding in patients with atrial fibrillation in the ENGAGE AF-TIMI 48 trial
ConclusionSerial assessment of hsTnT, NT-proBNP, and GDF-15 revealed that a substantial proportion of patients with AF had dynamic values. Greater increases in these biomarkers measured over 1 year are associated with important clinical outcomes in anticoagulated patients with AF. (Source: European Heart Journal)
Source: European Heart Journal - March 24, 2021 Category: Cardiology Source Type: research
Cryoblation as first-line treatment of new-onset atrial fibrillation?
Key PointsThe simultaneously published Early Aggressive Invasive Intervention for Atrial Fibrillation (EARLY-AF)1 and Cryoballon Catheter Ablation in Antiarrhythmic Drug Na ïve Paroxysmal Atrial Fibrillation (STOP AF First)2 are multicentre, open-label, randomized trials aimed at investigating the safety and efficacy of cryoablation as first-line therapy in naive atrial fibrillation (AF).Patients (n = 303 in EARLY-AF1 andn = 203 in STOP AF First2) with untreated symptomatic paroxysmal atrial fibrillation were randomized to receive Class I or III antiarrhythmic drugs or pulmonary vein isolation with cryoballoon.The primary...
Source: European Heart Journal - March 24, 2021 Category: Cardiology Source Type: research
Handling time elements for in-hospital cardiac arrest
(Source: European Heart Journal)
Source: European Heart Journal - March 23, 2021 Category: Cardiology Source Type: research
In-hospital resuscitation of Covid-19 patients is impeded by serious delays, but the problem is obscured by poor time data
This commentary refers to ‘Cardiac arrest in COVID-19: characteristics and outcomes of in- and out-of-hospital cardiac arrest. A report from the Swedish Registry for Cardiopulmonary Resuscitation’, by P. Sultanianet al., doi:10.1093/eurheartj/ehaa1067 and the discussion piece ‘Handling time elements for in-hospital cardiac arrest’, by P. Sultanianet al., doi:10.1093/eurheartj/ehaa163. (Source: European Heart Journal)
Source: European Heart Journal - March 23, 2021 Category: Cardiology Source Type: research
Association between prophylactic angiotensin-converting enzyme inhibitors and overall survival in Duchenne muscular dystrophy —analysis of registry data
ConclusionProphylactic ACEi treatment in DMD was associated with a significantly higher overall survival and lower rates of hospitalization for HF. (Source: European Heart Journal)
Source: European Heart Journal - March 22, 2021 Category: Cardiology Source Type: research
Influenza vaccination: a ‘shot’ at INVESTing in cardiovascular health
AbstractThe link between viral respiratory infection and non-pulmonary organ-specific injury, including cardiac injury, has become increasingly appreciated during the current coronavirus disease 2019 (COVID-19) pandemic. Even prior to the pandemic, however, the association between acute infection with influenza and elevated cardiovascular risk was evident. The recently published results of the NHLBI-funded INfluenza Vaccine to Effectively Stop CardioThoracic Events and Decompensated (INVESTED) trial, a 5200 patient comparative effectiveness study of high-dose vs. standard-dose influenza vaccine to reduce cardiopulmonary ev...
Source: European Heart Journal - March 22, 2021 Category: Cardiology Source Type: research
Cardioprotection in Duchenne muscular dystrophy
(Source: European Heart Journal)
Source: European Heart Journal - March 22, 2021 Category: Cardiology Source Type: research
Genetically determined NLRP3 inflammasome activation associates with systemic inflammation and cardiovascular mortality
ConclusionTheNLRP3 intronic variant rs10754555 is associated with increased systemic inflammation, inflammasome activation, prevalent coronary artery disease, and mortality. This study provides evidence for a substantial role of genetically driven systemic inflammation in CVD and highlights the NLRP3 inflammasome as a therapeutic target. (Source: European Heart Journal)
Source: European Heart Journal - March 22, 2021 Category: Cardiology Source Type: research
Joint editors unveiled for CardioPulse
Mark Nicholls speaks to joint editors Professor Francesco Paneni and Dr Luca Liberale about their plans and aspirations for CardioPulse as they take up the helm (Source: European Heart Journal)
Source: European Heart Journal - March 22, 2021 Category: Cardiology Source Type: research
New therapeutic targets in lipid lowering: high-sugar feeding in infants, lipoprotein(a), and lipoprotein lipase
(Source: European Heart Journal)
Source: European Heart Journal - March 21, 2021 Category: Cardiology Source Type: research
Effectiveness of Closed Loop Stimulation pacing in patients with cardio-inhibitory vasovagal reflex syncope is questionable
This commentary refers to ‘Cardiac pacing in severe recurrent reflex syncope and tilt induced asystole’, by M. Brignoleet al., doi:10.1093/eurheartj/ehaa936 and the discussion piece ‘Are convictions more dangerous enemies of truth than lies?’ by M. Brignoleet al., doi:10.1093/eurheartj/ehab164. (Source: European Heart Journal)
Source: European Heart Journal - March 18, 2021 Category: Cardiology Source Type: research
