Impact of cholesterol on proinflammatory monocyte production by the bone marrow
ConclusionsCollectively, these data highlight that LDL-C impacts haematopoiesis, promoting both the number and the proinflammatory activation of circulating monocytes. Furthermore, this study reveals a potential contributory role of HSPC transcriptomic reprogramming to residual inflammatory risk in FH patients despite cholesterol-lowering therapy. (Source: European Heart Journal)
Source: European Heart Journal - August 3, 2021 Category: Cardiology Source Type: research
Remnant cholesterol predicts cardiovascular disease beyond LDL and ApoB: a primary prevention study
ConclusionsIn ASCVD-free individuals, elevated RC levels were associated with ASCVD independent of traditional risk factors, LDL-C, and apoB levels. The mechanisms of RC association with ASCVD, surprisingly beyond apoB, and the potential value of targeted RC-lowering in primary prevention need to be further investigated. (Source: European Heart Journal)
Source: European Heart Journal - July 19, 2021 Category: Cardiology Source Type: research
Endocardial/endothelial angiocrines regulate cardiomyocyte development and maturation and induce features of ventricular non-compaction
ConclusionsThese findings support a model where coronary endothelial cells normally promote myocardial compaction through secreted factors, but that endocardial and endothelial cells can secrete factors that contribute to non-compaction under pathological conditions. (Source: European Heart Journal)
Source: European Heart Journal - July 19, 2021 Category: Cardiology Source Type: research
Lack of specialist care is associated with increased morbidity and mortality in adult congenital heart disease: a population-based study
ConclusionCardiology care compared with primary care is associated with superior survival and lower rates of major complications in ACHD. It is alarming that even in a high resource setting with well-established specialist ACHD care approximately 50% of contemporary ACHD patients are still not linked to regular cardiac care. Almost all patients had at least one contact with a PCP during the study period, suggesting that opportunities to refer patients to cardiac specialists were missed at PCP level. More efforts are required to alert PCPs and patients to appropriate ACHD care. (Source: European Heart Journal)
Source: European Heart Journal - July 16, 2021 Category: Cardiology Source Type: research
STING, a cytosolic DNA sensor, plays a critical role in atherogenesis: a link between innate immunity and chronic inflammation caused by lifestyle-related diseases
ConclusionStimulator of interferon genes stimulates pro-inflammatory activation of macrophages, leading to the development of atherosclerosis. Stimulator of interferon genes signalling may serve as a potential therapeutic target for atherosclerosis. (Source: European Heart Journal)
Source: European Heart Journal - July 6, 2021 Category: Cardiology Source Type: research
DNA damage and extranuclear DNA sensors: a dangerous duo in atherosclerosis
(Source: European Heart Journal)
Source: European Heart Journal - July 6, 2021 Category: Cardiology Source Type: research
Transition to adulthood and transfer to adult care of adolescents with congenital heart disease: a global consensus statement of the ESC Association of Cardiovascular Nursing and Allied Professions (ACNAP), the ESC Working Group on Adult Congenital Heart Disease (WG ACHD), the Association for European Paediatric and Congenital Cardiology (AEPC), the Pan-African Society of Cardiology (PASCAR), the Asia-Pacific Pediatric Cardiac Society (APPCS), the Inter-American Society of Cardiology (IASC), the Cardiac Society of Australia and New Zealand (CSANZ), the International Society for Adult Congenital Heart Disease (ISACHD), the World Heart Federation (WHF), the European Congenital Heart Disease Organisation (ECHDO), and the Global Alliance for Rheumatic and Congenital Hearts (Global ARCH)
AbstractThe vast majority of children with congenital heart disease (CHD) in high-income countries survive into adulthood. Further, paediatric cardiac services have expanded in middle-income countries. Both evolutions have resulted in an increasing number of CHD survivors. Expert care across the life span is necessitated. In adolescence, patients transition from being a dependent child to an independent adult. They are also advised to transfer from paediatrics to adult care. There is no universal consensus regarding how transitional care should be provided and how the transfer should be organized. This is even more challen...
Source: European Heart Journal - July 1, 2021 Category: Cardiology Source Type: research
Retractions in medicine: the tip of the iceberg
In 1983, in the aftermath of what was then considered one of the most significant cases of scientific fraud ever,The New York Times reported that 82 papers by John Darsee, formerly of Harvard and Emory, had been retracted (available athttps://www.nytimes.com/1983/06/14/science/notorious-darsee-case-shakes-assumptions-about-science.html). That idea persisted: ∼30 years later,Nature said that>80 of Darsee ’s papers had been withdrawn.1 (Source: European Heart Journal)
Source: European Heart Journal - June 28, 2021 Category: Cardiology Source Type: research
Maintaining high standards of clinical research during the Covid-19 pandemic: insights from an excellence clinical research centre
Science Foundation Ireland InfrastructureRSF 1413 (Source: European Heart Journal)
Source: European Heart Journal - June 28, 2021 Category: Cardiology Source Type: research
Selecting the right cohorts and endpoints for the validation of pre-test probability models for obstructive coronary artery disease
This commentary refers to ‘Validation of the European Society of Cardiology pre-test probability model for obstructive coronary artery disease’, by S. Wintheret al.,https://doi.org/10.1093/eurheartj/ehaa755. and the discussion piece ‘Coronary artery stenosis prediction does not mean coronary artery stenosis obstruction’, by F. Derimayet al.,https://doi.org/10.1093/eurheartj/ehab332. (Source: European Heart Journal)
Source: European Heart Journal - June 20, 2021 Category: Cardiology Source Type: research
Coronary artery stenosis prediction does not mean coronary artery stenosis obstruction
This commentary refers to ‘Validation of the European Society of Cardiology pre-test probability model for obstructive coronary artery disease’, by S. Wintheret al.,https://doi.org/10.1093/eurheartj/ehaa755 and the discussion piece ‘Selecting the right cohorts and endpoints for the validation of pre-test probability models for obstructive coronary artery disease’, by S. Wintheret al.,https://doi.org/10.1093/eurheartj/ehab336. (Source: European Heart Journal)
Source: European Heart Journal - June 20, 2021 Category: Cardiology Source Type: research
Spontaneous true lumen expansion in chronic type B aortic dissection
A 32-year-old man presented to a hospital with severe back pain and contrast-enhanced computed tomography (CT) revealed acute type B aortic dissection (Panel A, Supplementary material online, Video S1Supplementary material online,Video S1). The patient was transferred to our hospital for further management. Physical examination did not indicate any evidence of connective tissue disorders. CT revealed that the aortic dissection extended from the left subclavian artery to both external iliac arteries without any organ malperfusion. His blood pressure was well controlled with multiple oral antihypertensive drugs includin...
Source: European Heart Journal - June 20, 2021 Category: Cardiology Source Type: research
Don ’t be alarmed: the need for enhanced partnerships between medical communities to improve outcomes for adults living with congenital heart disease
(Source: European Heart Journal)
Source: European Heart Journal - June 3, 2021 Category: Cardiology Source Type: research
Backup natural pacemaker found in the heart
A UK-based team has discovered a backup natural pacemaker in the heart, which they believe will change understanding of the anatomy of the cardiac pacemaker tissues. The findings by researchers from the University of Manchester and Manchester University NHS Foundation Trust show the ‘subsidiary atrial pacemaker’, which is able to generate a pulse and, in time, control the heart rate, has implications on the work of cardiologists and for heart surgery and may advance the testing of treatments for sinus node disease that could reduce the dependence on pacemakers. (Source: European Heart Journal)
Source: European Heart Journal - May 29, 2021 Category: Cardiology Source Type: research
Cardiovascular Genetics in the European Heart Journal
The team of Deputy and Associate Editors Heribert Schunkert, Sharlene Day and Peter Schwartz (Source: European Heart Journal)
Source: European Heart Journal - May 22, 2021 Category: Cardiology Source Type: research
