Takayasu arteritis-associated pulmonary hypertension
(Source: European Heart Journal)
Source: European Heart Journal - September 20, 2021 Category: Cardiology Source Type: research
Long-term outcomes of new-generation coronary stents in China
Yaling Han, Editor-in-Chief, reviews two highly interesting papers published inThe Chinese Journal of Cardiology. (Source: European Heart Journal)
Source: European Heart Journal - September 18, 2021 Category: Cardiology Source Type: research
Untargeted metabolomics identifies succinate as a biomarker and therapeutic target in aortic aneurysm and dissection
ConclusionPlasma succinate concentrations allow to distinguish patients with AAD from both healthy controls and patients with AMI or PE. Succinate concentrations are regulated by the p38 α–CREB–OGDH axis in macrophages. (Source: European Heart Journal)
Source: European Heart Journal - September 17, 2021 Category: Cardiology Source Type: research
The “ten commandments” for the 2021 ESC/EACTS Guidelines on valvular heart disease
Since the previous version of the guidelines on the management of patients with valvular heart disease (VHD), new data and experience have accumulated, making a revision of the document necessary. The 10 main messages of the new guidelines are: (Source: European Heart Journal)
Source: European Heart Journal - September 16, 2021 Category: Cardiology Source Type: research
Is tirzepatide in the surpass lane over GLP-1 receptor agonists for the treatment of diabetes?
The results of ‘Efficacy and Safety of a Novel Dual GIP and GLP-1 Receptor Agonist Tirzepatide in Patients with type 2 Diabetes (SURPASS-1): A Double-Blind, Randomised, Phase 3 Trial’ have been published inLancet. doi:10.1016/S0140-6736(21)01324-6. (Source: European Heart Journal)
Source: European Heart Journal - September 13, 2021 Category: Cardiology Source Type: research
LDL-cholesterol drives reversible myelomonocytic skewing in human bone marrow
(Source: European Heart Journal)
Source: European Heart Journal - September 11, 2021 Category: Cardiology Source Type: research
An inflammatory ageing clock to detect cardiovascular and other age-related diseases: a new approach to preventive medicine
Key PointsThe Stanford 1000 Immunomes Project consists of 1001 individuals aged 8 –96 (66% females) recruited between 2007 and 2016 for studies of ageing, vaccination, and chronic fatigue syndrome.1 Peripheral blood samples were analysed for gene expression; serum cytokines, chemokines, and growth factors; cell subset composition; cellular responses to multiple stimuli; and seropositivity to cytomegalovirus infection. A comprehensive health assessment using a 53-feature clinical questionnaire was performed in 902 individuals. Cardiovascular screening was conducted in 97 extremely healthy adults.A deep-learning method tha...
Source: European Heart Journal - September 11, 2021 Category: Cardiology Source Type: research
Clinical features and survival in Takayasu ’s arteritis-associated pulmonary hypertension: a nationwide study
ConclusionPatients with TA-PH were predominantly female and had severely compromised haemodynamics. More than 80% of patients in our cohort survived for at least 3 years. Medical treatment was based on investigators’ personal opinions, and no clear risk-to-benefit ratio can be derived from the presented data. (Source: European Heart Journal)
Source: European Heart Journal - September 10, 2021 Category: Cardiology Source Type: research
Big cohort studies offer insights into preventable risk factors
Alzheimer ’s Society10.13039/501100017506450-AS-PG-18-018Wellcome Trust Clinical Research Career Development Fellowship206589/Z/17/Z (Source: European Heart Journal)
Source: European Heart Journal - September 4, 2021 Category: Cardiology Source Type: research
Cerebrotoxicity of antihypertensive therapy in the UK Biobank Cohort Study
This commentary refers to ‘On cerebrotoxicity of antihypertensive therapy and risk factor cosmetics’, by F.H. Messerliet al.,https://doi.org/10.1093/eurheartj/ehaa971; ‘Midlife blood pressure is associated with the severity of white matter hyperintensities: analysis of the UK Biobank Cohort Study’, by K.A. Wartolowska and A.J.S. Webb,https://doi.org/10.1093/eurheartj/ehaa756; and the discussion piece ‘Big cohort studies offer insights into preventable risk factors’, by K.A. Wartolowska and A.J.S. Webb,https://doi.org/10.1093/eurheartj/ehab566. (Source: European Heart Journal)
Source: European Heart Journal - September 4, 2021 Category: Cardiology Source Type: research
Management of acute cardiovascular complications in pregnancy
This article covers the diagnosis, risk stratification, and therapy and is organized according to the clinical presentation and the type of complication, providing a reference for the practicing cardiologist, obstetrician, and acute medicine specialist, while highlighting areas of need and potential future research. (Source: European Heart Journal)
Source: European Heart Journal - August 18, 2021 Category: Cardiology Source Type: research
The endothelial niche in heart failure: from development to regeneration
(Source: European Heart Journal)
Source: European Heart Journal - August 15, 2021 Category: Cardiology Source Type: research
Telomerase therapy reverses vascular senescence and extends lifespan in progeria mice
ConclusionVascular rejuvenation using telomerase mRNA is a promising approach for progeria and other age-related diseases. (Source: European Heart Journal)
Source: European Heart Journal - August 14, 2021 Category: Cardiology Source Type: research
Keeping remnants in perspective
(Source: European Heart Journal)
Source: European Heart Journal - August 5, 2021 Category: Cardiology Source Type: research
The JAK –STAT pathway: an emerging target for cardiovascular disease in rheumatoid arthritis and myeloproliferative neoplasms
AbstractInflammation contributes centrally to cardiovascular diseases, and anti-inflammatory treatments can reduce cardiovascular events. The JAK –STAT pathway is an emerging target in inflammation, mainly in rheumatoid arthritis (RA) and chronic myeloproliferative neoplasms (MPNs), disorders that heighten cardiovascular risk. The aim of this study was to review the international literature on the relationship between dysregulation of the J AK–STAT pathway in RA/MPNs and cardiovascular risk and on the potential cardiovascular effects of JAK–STAT inhibitors. The JAK–STAT pathway sustains inflammatory and thrombotic ...
Source: European Heart Journal - August 3, 2021 Category: Cardiology Source Type: research
