Empagliflozin and health-related quality of life outcomes in patients with heart failure with reduced ejection fraction: the EMPEROR-Reduced trial
ConclusionEmpagliflozin improved cardiovascular death or heart failure hospitalization risk across the range of baseline health status. Empagliflozin improved health status across various domains, and this benefit was sustained during long-term follow-up.Clinical trial registrationURL:https://www.clinicaltrials.gov. Unique identifier: NCT03057977. (Source: European Heart Journal)
Source: European Heart Journal - January 9, 2021 Category: Cardiology Source Type: research
Brugada syndrome and reduced right ventricular outflow tract conduction reserve: a final common pathway?
AbstractBrugada syndrome (BrS) was first described as a primary electrical disorder predisposing to the risk of sudden cardiac death and characterized by right precordial lead ST elevation. Early description of right ventricular structural abnormalities and of right ventricular outflow tract (RVOT) conduction delay in BrS patients set the stage for the current controversy over the pathophysiology underlying the syndrome: channelopathy or cardiomyopathy; repolarization or depolarization. This review examines the current understanding of the BrS substrate, its genetic and non-genetic basis, theories of pathophysiology, and t...
Source: European Heart Journal - January 9, 2021 Category: Cardiology Source Type: research
Immune cell-based cardiovascular risk assessment: spotlight on the neutrophil –lymphocyte ratio
This editorial refers to ‘The neutrophil–lymphocyte ratio and incident atherosclerotic events: analyses from five contemporary randomized trials’††, by N.H. Adamsteinet al., on page896. (Source: European Heart Journal)
Source: European Heart Journal - January 9, 2021 Category: Cardiology Source Type: research
Predicted benefit of an implantable cardioverter-defibrillator: the MADIT-ICD benefit score
ConclusionsWe propose the novel MADIT-ICD benefit score that predicts the likelihood of prophylactic ICD benefit through personalized assessment of the risk of VT/VF weighed against the risk of non-arrhythmic mortality. (Source: European Heart Journal)
Source: European Heart Journal - January 8, 2021 Category: Cardiology Source Type: research
Professor Anthony H. Gershlick
Interventional cardiology has lost one of its most prominent leaders, trainers, and researchers in Professor Tony Gershlick who died from COVID-19 on 20th November 2020 at the hospital he had worked in for over 30 years (Source: European Heart Journal)
Source: European Heart Journal - January 8, 2021 Category: Cardiology Source Type: research
The neutrophil –lymphocyte ratio and incident atherosclerotic events: analyses from five contemporary randomized trials
ConclusionThe NLR, an easily obtained inflammatory biomarker, independently predicts CV risk and all-cause mortality, and is reduced by interleukin-1 β blockade with canakinumab. (Source: European Heart Journal)
Source: European Heart Journal - January 8, 2021 Category: Cardiology Source Type: research
The new European Heart Journal Digital Health and Innovations Team
TheEHJ announces a new team of Deputy Editor Panos Vardas and Associate Editors, Folkert W. Asselbergs& Maarten van Smeden. (Source: European Heart Journal)
Source: European Heart Journal - January 7, 2021 Category: Cardiology Source Type: research
Prognostication after out-of-hospital cardiac arrest: biases and caveats
This commentary refers to ‘A practical risk score for early prediction of neurological outcome after out-of-hospital cardiac arrest: MIRACLE2’ by N. Pareeket al., doi:10.1093/eurheartj/ehaa570 and the discussion piece ‘Early prediction of out of hospital cardiac arrest: challenging the status quo’, by N. Pareeket al., doi:10.1093/eurheartj/ehaa1053. (Source: European Heart Journal)
Source: European Heart Journal - January 7, 2021 Category: Cardiology Source Type: research
Early prediction of out of hospital cardiac arrest: challenging the status quo
This commentary refers to ‘A practical risk score for early prediction of neurological outcome after out-of-hospital cardiac arrest: MIRACLE2’ by N. Pareeket al., doi:10.1093/eurheartj/ehaa570 and the discussion piece ‘Prognostication after out-of-hospital cardiac arrest: biases and caveats’, by A. Williamset al., doi:10.1093/eurheartj/ehaa1052. (Source: European Heart Journal)
Source: European Heart Journal - January 7, 2021 Category: Cardiology Source Type: research
Cardiac troponin elevation after elective PCI: adding infarct to major injury
This editorial refers to ‘Cardiac procedural myocardial injury, infarction, and mortality in patients undergoing elective percutaneous coronary intervention: a pooled analysis of patient-level data’††, by J. Silvainet al., on page323. (Source: European Heart Journal)
Source: European Heart Journal - January 7, 2021 Category: Cardiology Source Type: research
Significant pinching of dominant left circumflex artery during provisional left main bifurcation angioplasty: what next?
A 51-year-old male, a case of ST elevation anterior wall myocardial infarction, thrombolysed with tenecteplase 10 days ago, presented with complaints of rest angina. At presentation, ECG showed poor R wave progression and ST elevation in anterior chest leads. 2D echocardiography showed severe left anterior descending (LAD) territory hypokinesia with preserved thickness and ejection fraction of 30%. Coronary angiography revealed left dominant circulation, left main (LM) bifurcation lesion (Medina class 1,1,0) with 90% distal LM stenosis (Panel A). The patient was planned for provisional LM bifurcation angioplasty. Intra-...
Source: European Heart Journal - January 6, 2021 Category: Cardiology Source Type: research
Preventing a diabetes pandemic through lifestyle intervention
Comment on the Norfolk Diabetes Prevention Study (NDPS) published inthe JAMA Internal Medicine (https://doi : 10.1001/jamainternmed.2020.5938I)Key PointsThis parallel, three-arm, group-based, randomized clinical trial, involving 135 primary care practices and eight intervention sites in the East of England, recruited 1028 participants who had either impaired fasting glucose (IFG) with elevated fasting plasma glucose (FPG) level alone ( ≥110 and<126 mg/dL) or an elevated glycated haemoglobin (HbA1c) level [ ≥6.0% to<6.5%; non-diabetic hyperglycaemia (NDH)] with an elevated FPG level ( ≥100 to<110 mg/dL). They...
Source: European Heart Journal - January 5, 2021 Category: Cardiology Source Type: research
Differences in the 2020 ESC versus 2019 ACC/AHA/HRS guidelines on atrial fibrillation
The recent publication of the 2020 European Society of Cardiology (ESC) and the 2019 American College of Cardiology (ACC) guidelines have updated the knowledge about multiple aspects of atrial fibrillation (AF) management.1,2 However, some discrepancies exist between the two guidelines regarding management approaches and classes of recommendations. (Source: European Heart Journal)
Source: European Heart Journal - January 4, 2021 Category: Cardiology Source Type: research
Should we all go pesco-vegetarian?
(Source: European Heart Journal)
Source: European Heart Journal - January 4, 2021 Category: Cardiology Source Type: research
Does a myocardial infarction boost your (B cell) memory?
AbstractGraphical abstractEstablishment of an autoreactive B cell memory after myocardial infarction: a working hypothesis. The demise of cardiac cells leads to the release of cryptoantigens that induce a humoral immune response that leads to accumulation of immunoglobulins in plaques and eventually amplifies atherogenesis at remote sites. (Source: European Heart Journal)
Source: European Heart Journal - January 4, 2021 Category: Cardiology Source Type: research
