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Real-world evidence of Pressure-Enabled Drug Delivery for trans-arterial chemoembolization and radioembolization among patients with hepatocellular carcinoma and liver metastases
Conclusion: Despite higher baseline disease burden and complexity, post-procedure HRU and clinical complications for PEDD patients were similar to non-PEDD patients. The complex baseline clinical profile may reflect selection of challenging cases for PEDD use. Future studies should validate the benefits observed with PEDD embolization in larger samples with greater statistical power.PMID:38414420 | DOI:10.1080/03007995.2024.2322057 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - February 28, 2024 Category: Research Authors: Keziah Cook Deepshekhar Gupta Yunjuan Liu Chris Miller-Rosales Fangzhou Wei Edward Tuttle Steven C Katz Richard Marshak Alexander Y Kim Source Type: research

Prevalence of comorbidities with the potential to increase the risk of nonadherence to topical ocular hypotensive medication in patients with open-angle glaucoma
CONCLUSIONS: The presence of comorbidities should be considered when determining whether eye drops are suitable treatment for glaucoma. Neurodegenerative disease affecting cognition and memory, motor disease, and low vision are common comorbidities that may impact adherence to eye drops, and affected patients may benefit from non-drop treatment modalities.PMID:38410906 | DOI:10.1080/03007995.2024.2322048 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - February 27, 2024 Category: Research Authors: M Francesca Cordeiro Philippe Denis Carlo Astarita Jonathan Belsey Marcos Rivas Juli án García-Feijoo Source Type: research

Personality dimensions and treatment adherence among glaucoma patients: the role of self-transcendence
CONCLUSIONS: The results suggest that POAG patients with higher scores on the Self-Transcendent personality dimension are more likely to experience difficulties adhering to medication regimen. The study highlights the importance of a holistic approach to glaucoma treatment, which takes into account not only the biological aspects of disease but also the psychosocial factors that influence patient behavior. Healthcare providers may need to consider glaucoma patients' personality dimensions, beliefs and values when developing treatment plans and strategies to improve medication adherence.PMID:38404158 | DOI:10.1080/03007995....
Source: Current Medical Research and Opinion - February 26, 2024 Category: Research Authors: Dina Le šin Gaćina Darko Mar činko Tomislav Kuzman Ivan Škegro Sania Vidas Pauk Bernarda Škegro Martina Tomi ć Tomislav Bulum Sonja Jandrokovi ć Source Type: research

Patient characteristics, treatment patterns, healthcare resource utilization, and costs among patients diagnosed with neurofibromatosis type 1 with and without plexiform neurofibromas in Japan
CONCLUSIONS: NF1 is treated primarily with supportive care with analgesics/non-steroidal anti-inflammatory drugs being the most frequently prescribed NF1 medications in Japan. Findings underscored the unmet need and substantial economic burden among patients with NF1 and highlighted the need for new treatment options for patients with this disease.PMID:38404173 | DOI:10.1080/03007995.2024.2322698 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - February 26, 2024 Category: Research Authors: Yuichi Yoshida Keiichi Tozawa Ryo Koto Chikako Iwao Yong-Jin Kim Lu Ban Volkan Barut Source Type: research

Antidepressant medications have evolved in terms of speed of onset of efficacy: how can we best measure antidepressant treatment response?
Curr Med Res Opin. 2024 Feb 25:1-8. doi: 10.1080/03007995.2024.2323638. Online ahead of print.NO ABSTRACTPMID:38404189 | DOI:10.1080/03007995.2024.2323638 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - February 26, 2024 Category: Research Authors: Jan A Sedway Mark G A Opler Leslie Citrome Source Type: research

Model-based simulation of glycaemic effect and body weight loss when switching from semaglutide or dulaglutide to once weekly tirzepatide
CONCLUSION: In this model-based simulation, switching from approved maintenance doses of semaglutide or dulaglutide to tirzepatide, even at the lowest approved maintenance dose of 5 mg, showed the potential to further improve HbA1c and body weight reductions.PMID:38407177 | DOI:10.1080/03007995.2024.2322072 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - February 26, 2024 Category: Research Authors: Shweta Urva Joshua A Levine Karen Schneck Cheng Cai Tang Source Type: research