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Diabetes: a review of its pathophysiology, and advanced methods of mitigation
Curr Med Res Opin. 2024 Mar 21:1-24. doi: 10.1080/03007995.2024.2333440. Online ahead of print.ABSTRACTDiabetes mellitus (DM) is a long-lasting metabolic non-communicable disease often characterized by an increase in the level of glucose in the blood or hyperglycemia. Approximately, 415 million people between the ages of 20 and 79 years had DM in 2015 and this figure will rise by 200 million by 2040. In a study conducted by CARRS, it's been found that in Delhi the prevalence of diabetes is around 27% and for prediabetic cases, it is more than 46%. The disease DM can be both short-term and long-term and is often associated ...
Source: Current Medical Research and Opinion - March 21, 2024 Category: Research Authors: Sarika Gupta Nitin Sharma Sandeep Arora Saurabh Verma Source Type: research

Methamphetamine intoxication and suicidal ideation/behavior in the Emergency Department
CONCLUSION: These results underscore the urgent need for targeted interventions to address the complex interplay between MA use and suicidal risks in the emergency department setting, as well as broader public health strategies to combat the increasing prevalence of MA use.PMID:38511972 | DOI:10.1080/03007995.2024.2333429 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 21, 2024 Category: Research Authors: Huseyin Bayazit Regina Baronia Sarah M Wakefield Source Type: research

The use of routinely collected healthcare records for outcome assessment in clinical trials: a UK perspective
This article discusses the key considerations that trialists should take into account when incorporating EHR into their trials. These include considerations of the clinical relevance of the outcome, data timeliness and quality, ethical and regulatory issues, and some practical considerations for clinical trials units.In addition, this article describes the benefits of using EHR which include cost, reduced trial burden for participants and staff, follow up efficiencies, and improved health economic evaluation procedures. We also describe the major regulatory and start up costs of using EHR in clinical trials.This article fo...
Source: Current Medical Research and Opinion - March 21, 2024 Category: Research Authors: Abilash Sathyanarayana Source Type: research

Clinical validation of a fast-acting acetaminophen: a randomized, active and placebo controlled dental pain study
Conclusions: This study supports previous studies, demonstrating faster onset of analgesia with FA-acetaminophen 1000 mg compared to OTC ES-acetaminophen 1000 mg and OTC LG-ibuprofen 400 mg.ClinicalTrials.gov Identifier: NCT03224403 https://clinicaltrials.gov/ct2/show/NCT03224403.PMID:38505928 | DOI:10.1080/03007995.2024.2331159 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 20, 2024 Category: Research Authors: Andrew Myers Todd Bertoch Paul Zhang Stephen A Cooper Source Type: research

Sex differences in clinical features, utilization of oral anticoagulant agents, and one-year outcome in Middle Eastern patients with atrial fibrillation
CONCLUSION: Females with AF are more symptomatic, yet they are treated less with rhythm control. Despite higher risk, females have similar risk-adjusted all-cause cardiovascular death and stroke rates compared to males. Future studies should explore how treatments and interventions can influence quality of life and cardiovascular outcomes in females with AF.PMID:38507072 | DOI:10.1080/03007995.2024.2332440 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 20, 2024 Category: Research Authors: Nasr Alrabadi Mohammed Al-Nusair Razan Haddad Basheer S Alghizzawi Nashmi Al-Nusair Saleh Alhaj Mohammad Saif M Shteiwi Maryam K El-Zubi Zaid Marie Ayham Alnsour Mohamad Jarrah Karem H Alzoubi Ayman Hammoudeh Source Type: research

Preferences of healthcare providers in Switzerland for attributes of pediatric hexavalent vaccines: a discrete-choice experiment
CONCLUSION: Hib seroprotection at 11-12 months was the most important hexavalent vaccine attribute to HCPs in this study.PMID:38501272 | DOI:10.1080/03007995.2024.2325550 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 19, 2024 Category: Research Authors: Salome Samant Susanne Oberle Tomas Marcek Christine Poulos Phani Chintakayala Edith Langevin Tanaz Petigara Marco Boeri Source Type: research

Addressing hepatitis delta in primary care practices in the US: a narrative review
CONCLUSIONS: PCPs can be a valuable point of care for patients to access HDV/HBV screening, HBV immunization, and education, and can comanage patients with HBV and/or HDV infection.PMID:38487951 | DOI:10.1080/03007995.2024.2318004 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 15, 2024 Category: Research Authors: Tatyana Kushner Richard R Andrews Source Type: research