Ivy leaf dry extract EA 575 for the treatment of acute and chronic cough in pediatric patients: review and expert survey
CONCLUSIONS: EA 575 has minimal side effects in pediatric patients with cough, as demonstrated by large, real-world studies. EA 575 may provide clinical benefits in pediatric patients; however, more robust clinical trials are needed to confirm its efficacy.PMID:37731370 | DOI:10.1080/03007995.2023.2258777 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - September 21, 2023 Category: Research Authors: Georg Seifert Laura Upstone Christopher P Watling Christian Vogelberg Source Type: research

Correction
Curr Med Res Opin. 2023 Sep 20:1. doi: 10.1080/03007995.2023.2257985. Online ahead of print.NO ABSTRACTPMID:37729081 | DOI:10.1080/03007995.2023.2257985 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - September 20, 2023 Category: Research Source Type: research

Neutrophil/high-density lipoprotein cholesterol (HDL), monocyte/HDL and platelet/HDL ratios are increased in acute mania as markers of inflammation, even after controlling for confounding factors
Conclusions: These results provide information about the role of inflammation in the pathophysiology of BD-M. Even after controlling for confounding factors, MHR, NHR, PHR and AIP are potential biomarkers for BD-M. Moreover, the increase in AIP may explain the co-morbidity between BD and cardiovascular diseases. However, the severity of the illness or the psychotic feature of the manic episode did not significantly affect the levels of inflammation ratios used in our study. Due to the low cost and widespread use of lipid metabolism and related inflammation rates, it may be beneficial to know the MHR, NHR, PHR and AIP level...
Source: Current Medical Research and Opinion - September 19, 2023 Category: Research Authors: Şükrü Alperen Korkmaz Sadice K ızgın Source Type: research

If deprivation worsens dementia outcomes, stimulation should improve them
Curr Med Res Opin. 2023 Sep 19:1-9. doi: 10.1080/03007995.2023.2260741. Online ahead of print.ABSTRACTIt is still not known what causes Alzheimer's Disease (AD). In this period of uncertainty, an emerging literature on risk factors suggests that the concept of "stimulation" is a useful pragmatic tool both before and after diagnosis to improve cognitive health. Before diagnosis of AD, stimulation of the brain through education, exercise, and social stimulation provides fortification against later cognitive decline. After diagnosis, specific electrical stimulation of brain circuits may protect cognitive function, and non-spe...
Source: Current Medical Research and Opinion - September 19, 2023 Category: Research Authors: Timothy Daly Source Type: research

Does biological agent treatment have an impact on serum uric acid levels in patients with psoriasis?
CONCLUSIONS: Since high serum uric acid levels have been associated with increased risk for cardiovascular diseases and metabolic syndrome, treatment of psoriasis with adalimumab, infliximab, ixekizumab, secukinumab and ustekinumab may have a positive impact on cardiometabolic comorbidities.PMID:37725100 | DOI:10.1080/03007995.2023.2260304 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - September 19, 2023 Category: Research Authors: Funda Tamer Yusuf Can Edek Ahmet Burhan Aksakal Source Type: research

Neutrophil/high-density lipoprotein cholesterol (HDL), monocyte/HDL and platelet/HDL ratios are increased in acute mania as markers of inflammation, even after controlling for confounding factors
Conclusions: These results provide information about the role of inflammation in the pathophysiology of BD-M. Even after controlling for confounding factors, MHR, NHR, PHR and AIP are potential biomarkers for BD-M. Moreover, the increase in AIP may explain the co-morbidity between BD and cardiovascular diseases. However, the severity of the illness or the psychotic feature of the manic episode did not significantly affect the levels of inflammation ratios used in our study. Due to the low cost and widespread use of lipid metabolism and related inflammation rates, it may be beneficial to know the MHR, NHR, PHR and AIP level...
Source: Current Medical Research and Opinion - September 19, 2023 Category: Research Authors: Şükrü Alperen Korkmaz Sadice K ızgın Source Type: research

If deprivation worsens dementia outcomes, stimulation should improve them
Curr Med Res Opin. 2023 Sep 19:1-9. doi: 10.1080/03007995.2023.2260741. Online ahead of print.ABSTRACTIt is still not known what causes Alzheimer's Disease (AD). In this period of uncertainty, an emerging literature on risk factors suggests that the concept of "stimulation" is a useful pragmatic tool both before and after diagnosis to improve cognitive health. Before diagnosis of AD, stimulation of the brain through education, exercise, and social stimulation provides fortification against later cognitive decline. After diagnosis, specific electrical stimulation of brain circuits may protect cognitive function, and non-spe...
Source: Current Medical Research and Opinion - September 19, 2023 Category: Research Authors: Timothy Daly Source Type: research

Does biological agent treatment have an impact on serum uric acid levels in patients with psoriasis?
CONCLUSIONS: Since high serum uric acid levels have been associated with increased risk for cardiovascular diseases and metabolic syndrome, treatment of psoriasis with adalimumab, infliximab, ixekizumab, secukinumab and ustekinumab may have a positive impact on cardiometabolic comorbidities.PMID:37725100 | DOI:10.1080/03007995.2023.2260304 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - September 19, 2023 Category: Research Authors: Funda Tamer Yusuf Can Edek Ahmet Burhan Aksakal Source Type: research

NASP 2023 Annual Meeting & amp; Expo: Research Presentation Abstracts
Curr Med Res Opin. 2023;39(sup2):1. doi: 10.1080/03007995.2023.2236891.NO ABSTRACTPMID:37715621 | DOI:10.1080/03007995.2023.2236891 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - September 16, 2023 Category: Research Authors: Rebekah H Anguiano Sheila M Arquette Source Type: research

Psychometric evaluation of the Worst Pruritus Numerical Rating Scale (NRS), Atopic Dermatitis Symptom Scale (ADerm-SS), and Atopic Dermatitis Impact Scale (ADerm-IS)
CONCLUSIONS: These results provide evidence that the scores produced by the Worst Pruritus NRS, ADerm-SS, and ADerm-IS are reliable and construct-valid when completed by adults and adolescents with moderate to severe AD in a clinical trial setting. The results presented here expand upon the previous qualitative evidence of these tools and provide further support for their use in future clinical studies. While results are specific to clinical trials, next steps would be to evaluate the use of these questionnaires in clinical practice. This can provide clinicians and dermatologists a window into the patient's disease experie...
Source: Current Medical Research and Opinion - September 11, 2023 Category: Research Authors: Jonathan I Silverberg Yael A Leshem Brian M Calimlim Jeffrey McDonald Leighann Litcher-Kelly Source Type: research

Systemic immune-inflammation index as a potential biomarker to monitor ulcerative colitis
CONCLUSION: SII is a potential biomarker for diagnosing UC and monitoring UC disease severity, especially in evaluating mucosal and histological healing during the long-term management in treat-to-target strategy. However, further research is needed to confirm its usefulness and optimize its clinical application.PMID:37691449 | DOI:10.1080/03007995.2023.2257599 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - September 11, 2023 Category: Research Authors: Jin Yan Feihong Deng Yuyong Tan Bingyi Zhou Deliang Liu Source Type: research

Role of β-blockers in the cardiovascular disease continuum: a collaborative Delphi survey-based consensus from Asia-Pacific
CONCLUSION: Attainment of consensus for almost all statements reconfirms the clinical benefits of β-blockers, particularly β1-selective blockers for the entire spectrum of cardiovascular diseases.PMID:37694536 | DOI:10.1080/03007995.2023.2256218 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - September 11, 2023 Category: Research Authors: Saumitra Ray Tiny Nair J P S Sawhney None Erwinanto Azhari Rosman Eugene Reyes Loewe Go Apichard Sukonthasarn Aekarach Ariyachaipanich Ph ạm Manh Hung Harshal Chaudhari Harshveer Singh Malhi Source Type: research