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Real-world evidence generation from patients, their caregivers and physicians supporting clinical, regulatory and guideline decisions: an update on Disease Specific Programmes
Conclusions: DSPs provide a wealth of RWD in addition to evidence generated by registries, clinical trials and observational research, with wide use for the pharmaceutical industry, government, funding/regulatory bodies, clinical practice guideline insights and, most importantly, informing improvements in people's lives. The depth, breadth and heritage of information collected via DSPs since 1995 is unparalleled, extending understanding of how diseases are managed by physicians in routine clinical practice and why treatment choices are made, patients' perceptions of their disease management and caregiver burden.PMID:379332...
Source: Current Medical Research and Opinion - November 7, 2023 Category: Research Authors: Peter Anderson Victoria Higgins Jonathan de Courcy Katerina Doslikova Victoria A Davis Maria Karavali James Piercy Source Type: research

Clinical profiles and outcomes in patients with inflammatory bowel disease receiving standard and escalated doses of targeted therapies: findings from a global real-world study
Conclusion: Dose escalation is not always an effective approach to resolve inadequate or loss of response in UC and CD, highlighting a need for more therapeutic options or alternative treatment strategies in patients unresponsive to TT.PMID:37927078 | DOI:10.1080/03007995.2023.2278695 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - November 6, 2023 Category: Research Authors: Axel Dignass Isabel Redondo Petra Streit Susanne Hartz Gamze Gurses Hannah Knight Sophie Barlow Niamh Harvey Theresa Hunter Source Type: research

International Society for Medical Publication Professionals (ISMPP) position statement and call to action on artificial intelligence
Curr Med Res Opin. 2023 Nov 1:1-2. doi: 10.1080/03007995.2023.2273139. Online ahead of print.NO ABSTRACTPMID:37909878 | DOI:10.1080/03007995.2023.2273139 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - November 1, 2023 Category: Research Source Type: research

Optimising levothyroxine treatment for subclinical hypothyroidism during pregnancy
Curr Med Res Opin. 2023 Oct 28:1-12. doi: 10.1080/03007995.2023.2276120. Online ahead of print.ABSTRACTThe onset of pregnancy places additional stress of the thyroid gland, which must produce additional thyroid hormones to support the developing foetus. Hypothyroidism, including subclinical hypothyroidism (SCH) may appear de novo at this time, or existing thyroid disease may become more severe. Accordingly, SCH is a relatively common complication of up to about 3% of pregnancies, with higher rates in some areas. There is strong evidence from systematic reviews and meta-analyses that uncontrolled SCH is associated with an i...
Source: Current Medical Research and Opinion - October 28, 2023 Category: Research Authors: Ulrike Gottwald-Hostalek George J Kahaly Source Type: research

Assessing the prevalence and predictors of anemia among pregnant women in India: findings from the India National Family Health Survey 2019-2021
CONCLUSION: Anemia affected half of all pregnant women in India. Anemia prevalence was higher among adolescents, illiterate, poor, and tribal communities. Social norm-based interventions and strengthening the community health facilitators should be implemented to reduce the high burden of anemia in India.PMID:37888841 | DOI:10.1080/03007995.2023.2276851 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - October 27, 2023 Category: Research Authors: Periyasamy Kuppusamy Ranjan K Prusty Shagufta A Khan Source Type: research

A real-world, retrospective, observational study examining treatment patterns and clinical outcomes in patients with FLT3m  + AML in Japan
CONCLUSIONS: The study found specific treatment patterns, trends and features in patients with FLT3m + AML. FLT3i was the most prescribed treatment across the study period and the overall median OS after initiating FLT3i treatment was over 1 year. The findings of this study could be helpful for clinicians to optimize treatment strategies for FLT3m + AML in Japan.PMID:37881860 | DOI:10.1080/03007995.2023.2271390 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - October 26, 2023 Category: Research Authors: Toru Kiguchi Masaya Sakurai Takeshi Mitomi Yusuke Tanaka Kazuyuki Kuramoto Yuki Kado Sono Sawada Source Type: research

Estimating the direct healthcare utilization and cost of musculoskeletal pain among people with comorbidity: a retrospective electronic health record study
CONCLUSION: This study highlights that individuals with painful musculoskeletal conditions have higher healthcare utiliszation and costs than those without painful musculoskeletal conditions. Given the high occurrence of musculoskeletal pain in patients with other conditions, effective management strategies are needed to reduce the burden on healthcare resources.PMID:37853741 | DOI:10.1080/03007995.2023.2271862 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - October 19, 2023 Category: Research Authors: May Ee Png Kayleigh J Mason Michelle Marshall Kelvin P Jordan James Bailey Martin Frisher Neil Heron Alyson L Huntley Christian D Mallen Mamas A Mamas Stephen Tatton Simon White John J Edwards Felix Achana Source Type: research