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Efficacy of tyrosine-kinase-2 and phosphodiesterase-4 inhibitors for scalp psoriasis: a systematic review and meta-analysis
CONCLUSIONS: Apremilast and deucravacitinib are effective for scalp psoriasis. Deucravacitinib may be more efficient in clearing the scalp.PMID:37997745 | DOI:10.1080/03007995.2023.2288280 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - November 24, 2023 Category: Research Authors: Sotirios G Tsiogkas Eleni K Karamitrou Maria G Grammatikopoulou Efterpi Zafiriou Dimitrios P Bogdanos Source Type: research

Aripiprazole 2-month ready-to-use 960  mg (Ari 2MRTU): review of its possible role in schizophrenia therapy
Curr Med Res Opin. 2023 Nov 24:1-23. doi: 10.1080/03007995.2023.2287612. Online ahead of print.ABSTRACTMost patients with schizophrenia need life-long treatment. There is therefore a continued need for effective and tolerable treatment options. A 2-monthly LAI formulation of aripiprazole, Aripiprazole 2-Month Ready-to-Use 960 mg (Ari 2MRTU 960) has recently been approved in the U.S. Here, the possible role in therapy for this new treatment option is discussed in a narrative review. PubMed was searched for literature on long-acting injectables with a focus on patient-reported outcomes and real-world evidence on extended inj...
Source: Current Medical Research and Opinion - November 24, 2023 Category: Research Authors: Bernhard T Baune Source Type: research

A real world study of cough burden and quality of life of UK patients who have undergone evaluation for chronic cough
CONCLUSION: Real-world data from a nationally representative UK population show significant unmet needs associated with CC, including multiple healthcare visits and limited treatment effectiveness, resulting in inadequate cough control and impaired health status.PMID:37994434 | DOI:10.1080/03007995.2023.2284371 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - November 23, 2023 Category: Research Authors: Lorcan P McGarvey Gavin Harper Mark Silvey Haya Langerman Source Type: research

Intravenous Ringer's lactate versus usual care during labor in nulliparous women: a systematic review and meta-analysis of randomized controlled trials
CONCLUSION: IV Ringer's lactate reduced the duration of active labor, the need for oxytocin augmentation and the prolonged labor incidence. However, it did not differ in effect on immediate neonatal health but was found to have more potential for reducing maternal vomiting as compared to usual care with unrestricted oral intake. Further research is needed to explore its effects in the larger and more diverse populations and with different IV fluids for evidence-based guidelines.PMID:37994865 | DOI:10.1080/03007995.2023.2287608 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - November 23, 2023 Category: Research Authors: Muhammad Imran Ateeba Kamran Nada Mostafa Al-Dardery Dawood Azam Farooq Mohamed El-Samahy Mohamad Ali Farho Source Type: research

ADA_ETA_BIO2021: real-world evaluation of adherence, persistence, and cost-effectiveness of originator and biosimilar biologic drugs in the treatment of rheumatoid arthritis: a multicenter study in Italy
CONCLUSIONS: This multicentre retrospective observational study of bDMARDs used in the treatment of RA showed that, for all the drugs studied, there was no problem with adherence to treatment but rather a difficulty in maintaining treatment with the same drug over time.PMID:37994874 | DOI:10.1080/03007995.2023.2287600 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - November 23, 2023 Category: Research Authors: Fiorenzo Santoleri Ruggero Lasala Paolo Abrate Laura Pestrin Enrico Pasut Germana Modesti Felice Musicco Chiara Fulgenzio Eva Zuzolo Gabriella Pieri Martina Roperti Pietro Gazzola Marco Gambera Isabella Martignoni Valentina Montresor Francesco De Vita Fra Source Type: research

Safety profile of methotrexate used off-label in ectopic pregnancy: an active monitoring study based on a Chinese hospital pharmacovigilance system
CONCLUSIONS: MTX is quite safe in ectopic pregnancy, despite its mild to moderate hematotoxicity, hepatotoxicity and nephrotoxicity. Taking CHPS can present the accurate denominator of the incidence of adverse drug reactions into account, our study advocates that it may have great potential to be used as an active monitoring tool for off-label drug use risk management.PMID:37975718 | DOI:10.1080/03007995.2023.2285375 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - November 17, 2023 Category: Research Authors: Lingsong Wang Can Cai Lurong Huang Danni Shi Quanyao Chen Yao Chen Weiwei Yu Source Type: research

Long-term economic outcomes of ureteral injury in the United States
CONCLUSIONS: UIs add substantial cost for payers and result in more healthcare visits for patients. These findings highlight the importance of including inpatient and outpatient settings for UI prevention. Although UIs are rare, the associated patient and payer burdens are high; thus, protocols or techniques are needed to recognize and avert UIs, as current guideline recommendations are lacking.PMID:37961772 | DOI:10.1080/03007995.2023.2283204 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - November 14, 2023 Category: Research Authors: Steven D McCarus Emily F Shortridge Tomomi Kimura Qi Feng Wei Han Baoguo Jiang Source Type: research

Features and prognosis of patients with lupus nephritis receiving glucocorticoid treatment: a descriptive study using a Japanese claims database
Conclusions: We found that the rate of treatment intensification was higher in the high-dose glucocorticoid groups than in the low-dose glucocorticoid groups. Further studies are needed to clarify the relationship between the initial dose of glucocorticoids and the prognosis of lupus nephritis patients.PMID:37962010 | DOI:10.1080/03007995.2023.2281498 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - November 14, 2023 Category: Research Authors: Kenichi Hiraga Izumi Sato Koji Kawakami Source Type: research

Long-term economic outcomes of ureteral injury in the United States
CONCLUSIONS: UIs add substantial cost for payers and result in more healthcare visits for patients. These findings highlight the importance of including inpatient and outpatient settings for UI prevention. Although UIs are rare, the associated patient and payer burdens are high; thus, protocols or techniques are needed to recognize and avert UIs, as current guideline recommendations are lacking.PMID:37961772 | DOI:10.1080/03007995.2023.2283204 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - November 14, 2023 Category: Research Authors: Steven D McCarus Emily F Shortridge Tomomi Kimura Qi Feng Wei Han Baoguo Jiang Source Type: research

Features and prognosis of patients with lupus nephritis receiving glucocorticoid treatment: a descriptive study using a Japanese claims database
Conclusions: We found that the rate of treatment intensification was higher in the high-dose glucocorticoid groups than in the low-dose glucocorticoid groups. Further studies are needed to clarify the relationship between the initial dose of glucocorticoids and the prognosis of lupus nephritis patients.PMID:37962010 | DOI:10.1080/03007995.2023.2281498 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - November 14, 2023 Category: Research Authors: Kenichi Hiraga Izumi Sato Koji Kawakami Source Type: research

Long-term economic outcomes of ureteral injury in the United States
CONCLUSIONS: UIs add substantial cost for payers and result in more healthcare visits for patients. These findings highlight the importance of including inpatient and outpatient settings for UI prevention. Although UIs are rare, the associated patient and payer burdens are high; thus, protocols or techniques are needed to recognize and avert UIs, as current guideline recommendations are lacking.PMID:37961772 | DOI:10.1080/03007995.2023.2283204 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - November 14, 2023 Category: Research Authors: Steven D McCarus Emily F Shortridge Tomomi Kimura Qi Feng Wei Han Baoguo Jiang Source Type: research