Cancers, Vol. 16, Pages 1524: Automatic Brain Tissue and Lesion Segmentation and Multi-Parametric Mapping of Contrast-Enhancing Gliomas without the Injection of Contrast Agents: A Preliminary Study
This study aimed to develop a rapid, 1 mm3 isotropic resolution, whole-brain MRI technique for automatic lesion segmentation and multi-parametric mapping without using contrast by continuously applying balanced steady-state free precession with inversion pulses throughout incomplete inversion recovery in a single 6 min scan. Modified k-means clustering was performed for automatic brain tissue and lesion segmentation using distinct signal evolutions that contained mixed T1/T2/magnetization transfer properties. Multi-compartment modeling was used to derive quantitative multi-parametric maps for tissue characterization. Fourt...
Source: Cancers - April 17, 2024 Category: Cancer & Oncology Authors: Jing Liu Angela Jakary Javier E. Villanueva-Meyer Nicholas A. Butowski David Saloner Jennifer L. Clarke Jennie W. Taylor Nancy Ann Oberheim Bush Susan M. Chang Duan Xu Janine M. Lupo Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1525: Dichloroacetate and Quercetin Prevent Cell Proliferation, Induce Cell Death and Slow Tumor Growth in a Mouse Model of HPV-Positive Head and Neck Cancer
h Miskimins
Elevated glucose uptake and production of lactate are common features of cancer cells. Among many tumor-promoting effects, lactate inhibits immune responses and is positively correlated with radioresistance. Dichloroacetate (DCA) is an inhibitor of pyruvate dehydrogenase kinase that decreases lactate production. Quercetin is a flavonoid compound found in fruits and vegetables that inhibits glucose uptake and lactate export. We investigated the potential role and mechanisms of DCA, quercetin, and their combination, in the treatment of HPV-positive head and neck squamous cell carcinoma, an antigenic cancer su...
Source: Cancers - April 17, 2024 Category: Cancer & Oncology Authors: Yongxian Zhuang Joseph D. Coppock Allison B. Haugrud John H. Lee Shanta M. Messerli W. Keith Miskimins Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1526: A Novel ceRNET Relying on the lncRNA JPX, miR-378a-3p, and Its mRNA Targets in Lung Cancer
letta Potenza
Lung cancer is the leading cause of cancer-related death worldwide. Non-coding RNAs are emerging as critical players for the onset and progression of cancer. Analyses of three different datasets revealed that the lncRNA JPX was overexpressed in adenocarcinoma tissues in comparison to normal lungs, as expected for an oncogene. Intriguingly, the predicted binding miR-378a-3p showed a significant inverse correlation with JPX expression. The lncRNA/miRNA physical interaction was validated by reporter vectors. Then, the oncogenic activity of JPX, the tumor-suppressive role of miR-378a-3p, and the contribution ...
Source: Cancers - April 17, 2024 Category: Cancer & Oncology Authors: Nicola Mosca Mariaceleste Pezzullo Ilenia De Leo Anna Truda Giovanna Marchese Aniello Russo Nicoletta Potenza Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1527: Perioperative Evaluation of the Physical Quality of Life of Patients with Non-Small Cell Lung Cancer: A Prospective Study
Saito
Yukinori Sakao
Surgery is the most effective treatment for early-stage lung cancer; however, it poses a higher physical burden than other treatment options. Therefore, understanding the perioperative course of patients is important. Using the Short Form Health Survey 36, we prospectively measured the physical quality of life of patients who underwent anatomical pulmonary resection for non-small cell lung cancer at Shonan Kamakura General Hospital, Kanagawa, Japan (n = 87). In the preoperative setting, patients who had lower performance status and lived alone had significantly worse physical quality of life sco...
Source: Cancers - April 17, 2024 Category: Cancer & Oncology Authors: Ryuta Fukai Tomoki Nishida Hideyasu Sugimoto Makoto Hibino Shigeto Horiuchi Tetsuri Kondo Shinichi Teshima Masahiro Hirata Keiko Asou Etsuko Shimizu Yuichi Saito Yukinori Sakao Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1529: Drug Cost Avoidance Resulting from Participation in Clinical Trials: A 10-Year Retrospective Analysis of Cancer Patients with Solid Tumors
The objective of this single-center retrospective study was to describe the clinical characteristics of adult patients with solid tumors enrolled in cancer clinical trials over a 10-year period (2010–2019) and to assess drug cost avoidance (DCA) associated with sponsors’ contributions. The sponsors’ contribution to pharmaceutical expenditure was calculated according to the actual price (for each year) of pharmaceutical specialties that the Vall d’Hebron University Hospital (HUVH) would have had to bear in the absence of sponsorship. A total of 2930 clinical trials wer...
Source: Cancers - April 17, 2024 Category: Cancer & Oncology Authors: Maria-Josep Carreras Berta Renedo-Mir ó Carolina Valdivia Elena Tom ás-Guillén Anna Farriols Laura Ma ñós Jana Vidal Mar ía Alcalde Isabel De la Paz In és Jiménez-Lozano Maria-Eugenia Palacio-Lacambra Nuria Sabat é Enriqueta Felip Elena Garralda Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1528: Perioperative and Oncological Outcomes of Percutaneous Radiofrequency Ablation versus Partial Nephrectomy for cT1a Renal Cancers: A Retrospective Study on Groups with Similar Clinical Characteristics
In this study, we investigated the results of US-guided percutaneous radiofrequency ablation (RFA) and partial nephrectomy (PN) in the treatment of cT1a renal cancers. Between August 2016 and February 2022, 271 patients with renal tumours underwent percutaneous RFA as initial treatment in our institution. In the same period, 396 patients with renal tumours underwent surgical tumour excision. For the purpose of this study, only patients with confirmed renal cancer with matched age and tumour characteristics (size, location) were selected for both groups. Thus, a group of 44 PN patients and 41 RFA patients were formed with t...
Source: Cancers - April 17, 2024 Category: Cancer & Oncology Authors: Milosz Jasinski Przemyslaw Wisniewski Marta Bielinska Jerzy Siekiera Krzysztof Kamecki Maciej Salagierski Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1530: Colorectal Cancer: Epidemiology, Risk Factors, and Prevention
zadeh
Colorectal cancer (CRC) is the third most common cancer and the second most common cause of cancer mortality worldwide. There are disparities in the epidemiology of CRC across different populations, most probably due to differences in exposure to lifestyle and environmental factors related to CRC. Prevention is the most effective method for controlling CRC. Primary prevention includes determining and avoiding modifiable risk factors (e.g., alcohol consumption, smoking, and dietary factors) as well as increasing protective factors (e.g., physical activity, aspirin). Further studies, especially randomized, controll...
Source: Cancers - April 17, 2024 Category: Cancer & Oncology Authors: Gholamreza Roshandel Fatemeh Ghasemi-Kebria Reza Malekzadeh Tags: Review Source Type: research
Cancers, Vol. 16, Pages 1531: The Role of Ion Channels and Chemokines in Cancer Growth and Metastasis: A Proposed Mode of Action using Peptides in Cancer Therapy
i
Metastasis (Met) largely contributes to the major cause of cancer deaths throughout the world, rather than the growth of the tumor mass itself. The present report brings together several of the pertinent contributors to cancer growth and metastatic processes from an activity standpoint. Such biological activities include the following: (1) cell adherence and detachment; (2) cell-to-cell contact; (3) contact inhibition; (4) the cell interfacing with the extracellular matrix (ECM); (5) tumor cell-to-stroma communication networks; (6) chemotaxis; and (7) cell membrane potential. Moreover, additional biochemical factors ...
Source: Cancers - April 17, 2024 Category: Cancer & Oncology Authors: Gerald J. Mizejewski Tags: Review Source Type: research
Cancers, Vol. 16, Pages 1532: Lysine Methyltransferase 9 (KMT9) Is an Actionable Target in Muscle-Invasive Bladder Cancer
In this study, we show that KMT9 regulates proliferation, migration, and invasion of various MIBC cell lines with different genetic mutations. KMT9α depletion results in the differential expression of genes regulating the cell cycle, cell adhesion, and migration. Differentially expressed genes include oncogenes such as EGFR and AKT1 as well as mediators of cell adhesion or migration such as DAG1 and ITGA6. Reduced cell proliferation upon KMT9α depletion is also observed in Pten/Trp53 knockout bladder tumor organoids, which cannot be rescued with an enzymatically inactive KMT9α muta...
Source: Cancers - April 17, 2024 Category: Cancer & Oncology Authors: Sainab Totonji Anna Ramos-Triguero Dominica Willmann Manuela Sum Sylvia Urban Helena Bauer Astrid Rieder Sheng Wang Holger Greschik Eric Metzger Roland Sch üle Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1533: Understanding the Role of Connexins in Hepatocellular Carcinoma: Molecular and Prognostic Implications
Stamatios Theocharis
Connexins, a family of tetraspan membrane proteins forming intercellular channels localized in gap junctions, play a pivotal role at the different stages of tumor progression presenting both pro- and anti-tumorigenic effects. Considering the potential role of connexins as tumor suppressors through multiple channel-independent mechanisms, their loss of expression may be associated with tumorigenic activity, while it is hypothesized that connexins favor the clonal expansion of tumor cells and promote cell migration, invasion, and proliferation, affecting metastasis and chemoresistance in some cases....
Source: Cancers - April 17, 2024 Category: Cancer & Oncology Authors: Stavros P. Papadakos Elena Chatzikalil Konstantinos Arvanitakis Georgios Vakadaris Ioanna E. Stergiou Maria-Loukia Koutsompina Alexandra Argyrou Vasileios Lekakis Ippokratis Konstantinidis Georgios Germanidis Stamatios Theocharis Tags: Review Source Type: research
Cancers, Vol. 16, Pages 1534: A Prospective Study on Deep Inspiration Breath Hold Thoracic Radiation Therapy Guided by Bronchoscopically Implanted Electromagnetic Transponders
Conclusions: Bronchoscopically implanted electromagnetic transponder–guided DIBH lung RT is feasible and safe, allowing for precise tumor targeting and reduced normal tissue exposure. Transponder–antenna distance was the most common challenge due to a limited antenna range, which could sometimes be circumvented by prone positioning. (Source: Cancers)
Source: Cancers - April 17, 2024 Category: Cancer & Oncology Authors: Yuzhong Jeff Meng Nikhil P. Mankuzhy Mohit Chawla Robert P. Lee Ellen D. Yorke Zhigang Zhang Emily Gelb Seng Boh Lim John J. Cuaron Abraham J. Wu Charles B. Simone Simone II Daphna Y. Gelblum Dale Michael Lovelock Wendy Harris Andreas Rimner Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1516: Proteomic Analysis of Spatial Heterogeneity Identifies HMGB2 as Putative Biomarker of Tumor Progression in Adult-Type Diffuse Astrocytomas
gia Grosu
Arnab Chakravarti
Although grading is defined by the highest histological grade observed in a glioma, most high-grade gliomas retain areas with histology reminiscent of their low-grade counterparts. We sought to achieve the following: (i) identify proteins and molecular pathways involved in glioma evolution; and (ii) validate the high mobility group protein B2 (HMGB2) as a key player in tumor progression and as a prognostic/predictive biomarker for diffuse astrocytomas. We performed liquid chromatography tandem mass spectrometry (LC-MS/MS) in multiple areas of adult-type astrocytomas and validated our findi...
Source: Cancers - April 16, 2024 Category: Cancer & Oncology Authors: Aline P. Becker Valesio Becker Joseph McElroy Amy Webb Chunhua Han Yingshi Guo Erica H. Bell Jessica Fleming Ilinca Popp Ori Staszewski Marco Prinz Jose J. Otero Saikh Jaharul Haque Anca-Ligia Grosu Arnab Chakravarti Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1517: Long-Term Intake of Proton-Pump Inhibitors Could Be Associated with an Increased Incidence of Liver Cancer in Women
Conclusions: Our data suggest that long-term PPI intake in women as well as in patients < 60 years might be associated with an increased risk of liver cancer. These findings support current efforts to reduce the inappropriate use of PPIs in routine clinical practice and to link PPI prescribing to a clear medical indication. (Source: Cancers)
Source: Cancers - April 16, 2024 Category: Cancer & Oncology Authors: Sven H. Loosen Markus S. J ördens Catherine Leyh Tom Luedde Christoph Roderburg Karel Kostev Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1518: Ocular and Periocular Metastasis in Breast Cancer: Clinical Characteristics, Prognostic Factors and Treatment Outcome
Conclusions: Ocular metastasis in breast cancer is rare (0.5%) but signifies poor outcome. It is linked to ILC and concurrent brain metastasis. Primary treatment involves radiation therapy, with a favorable visual prognosis. (Source: Cancers)
Source: Cancers - April 16, 2024 Category: Cancer & Oncology Authors: Yacoub A. Yousef Mona Mohammad Hanan Khalil Tala Khouri Rand Alsweiti Jakub Khzouz Dima Abu Laban Imad Jaradat Ahmad Kh. Ibrahimi Akram Al-Ibraheem Mahmoud Al Masri Ibrahim AlNawiaseh Hikmat Abdel-Razeq Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1519: Contrast Agent Dynamics Determine Radiomics Profiles in Oncologic Imaging
Conclusions: CT and MRI radiomics features in both prostate and lung tumors are significantly affected by interindividual differences in contrast agent dynamics. (Source: Cancers)
Source: Cancers - April 16, 2024 Category: Cancer & Oncology Authors: Martin L. Watzenboeck Lucian Beer Daria Kifjak Sebastian R öhrich Benedikt H. Heidinger Florian Prayer Ruxandra-Iulia Milos Paul Apfaltrer Georg Langs Pascal A. T. Baltzer Helmut Prosch Tags: Article Source Type: research
