Cancers, Vol. 16, Pages 1565: Genetic Diagnosis of Retinoblastoma Using Aqueous Humour & mdash;Findings from an Extended Cohort
Cancers, Vol. 16, Pages 1565: Genetic Diagnosis of Retinoblastoma Using Aqueous Humour—Findings from an Extended Cohort
Cancers doi: 10.3390/cancers16081565
Authors:
Amy Gerrish
Chipo Mashayamombe-Wolfgarten
Edward Stone
Claudia Román-Montañana
Joseph Abbott
Helen Jenkinson
Gerard Millen
Sam Gurney
Maureen McCalla
Sarah-Jane Staveley
Anu Kainth
Maria Kirk
Claire Bowen
Susan Cavanagh
Sancha Bunstone
Megan Carney
Ajay Mohite
Samuel Clokie
M. Ashwin Reddy
Alison Foster
Stephanie Allen
Manoj Parulekar
Trevor Cole
The identification of somatic RB1 variation is cruc...
Source: Cancers - April 19, 2024 Category: Cancer & Oncology Authors: Amy Gerrish Chipo Mashayamombe-Wolfgarten Edward Stone Claudia Rom án-Montañana Joseph Abbott Helen Jenkinson Gerard Millen Sam Gurney Maureen McCalla Sarah-Jane Staveley Anu Kainth Maria Kirk Claire Bowen Susan Cavanagh Sancha Bunstone Megan Carney Aja Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1576: Focused Ultrasound-Enhanced Liquid Biopsy: A Promising Diagnostic Tool for Brain Tumor Patients
In conclusion, FUS-BBBO-enhanced liquid biopsy using stable cavitation shows diagnostic potential for primary brain tumors. Further research is imperative before integrating FUS-BBBO for liquid biopsy enhancement into clinical practice. (Source: Cancers)
Source: Cancers - April 19, 2024 Category: Cancer & Oncology Authors: Akke Bakker Anna E. Ixkes Hema Venugopal Mario G. Ries Nathalie S. M. Lak Filip Y. F. L. de Vos Dannis G. van Vuurden Tom J. Snijders Tags: Systematic Review Source Type: research
Cancers, Vol. 16, Pages 1555: CDK Inhibitors and FDA: Approved and Orphan
kus
The protein kinases are a large family of enzymes which catalyze protein phosphorylation at certain amino acids [...] (Source: Cancers)
Source: Cancers - April 19, 2024 Category: Cancer & Oncology Authors: Jonas Cicenas Jokubas Simkus Tags: Editorial Source Type: research
Cancers, Vol. 16, Pages 1557: Glioma Stem Cells & mdash;Features for New Therapy Design
Cancers, Vol. 16, Pages 1557: Glioma Stem Cells—Features for New Therapy Design
Cancers doi: 10.3390/cancers16081557
Authors:
Nives Pećina-Šlaus
Reno Hrašćan
On a molecular level, glioma is very diverse and presents a whole spectrum of specific genetic and epigenetic alterations. The tumors are unfortunately resistant to available therapies and the survival rate is low. The explanation of significant intra- and inter-tumor heterogeneity and the infiltrative capability of gliomas, as well as its resistance to therapy, recurrence and aggressive behavior, lies in a small subset of tumor-initiating cell...
Source: Cancers - April 19, 2024 Category: Cancer & Oncology Authors: Nives Pe ćina-Šlaus Reno Hra šćan Tags: Review Source Type: research
Cancers, Vol. 16, Pages 1556: Presence of CD44v9-Expressing Cancer Stem Cells in Circulating Tumor Cells and Effects of Carcinoembryonic Antigen Levels on the Prognosis of Colorectal Cancer
Koneri
Circulating tumor cells (CTCs) are cancer cells released from the primary tumor into the bloodstream, and contain cancer stem cells that influence tumor survival, recurrence, and metastasis. Here, we investigated CD44v9 expression in CTCs and impact of preoperative carcinoembryonic antigen (CEA) levels on colorectal cancer (CRC) prognosis. We analyzed the expression of CD44v9 mRNA in CTCs using reverse transcription-polymerase chain reaction and preoperative CEA levels in blood samples obtained from 300 patients with CRC. Subsequently, we evaluated the association of CD44v9 expression and CEA levels with clinic...
Source: Cancers - April 19, 2024 Category: Cancer & Oncology Authors: Katsuji Sawai Takanori Goi Youhei Kimura Kenji Koneri Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1558: Therapeutic Strategies for RB1-Deficient Cancers: Intersecting Gene Regulation and Targeted Therapy
ang Lee
The retinoblastoma (RB) transcriptional corepressor 1 (RB1) is a critical tumor suppressor gene, governing diverse cellular processes implicated in cancer biology. Dysregulation or deletion in RB1 contributes to the development and progression of various cancers, making it a prime target for therapeutic intervention. RB1′s canonical function in cell cycle control and DNA repair mechanisms underscores its significance in restraining aberrant cell growth and maintaining genomic stability. Understanding the complex interplay between RB1 and cellular pathways is beneficial to fully elucidate its tumor...
Source: Cancers - April 19, 2024 Category: Cancer & Oncology Authors: Mo-Fan Huang Yuan-Xin Wang Yu-Ting Chou Dung-Fang Lee Tags: Review Source Type: research
Cancers, Vol. 16, Pages 1559: Pressurised Intraperitoneal Aerosolised Chemotherapy & mdash;Results from the First Hundred Consecutive Procedures
Cancers, Vol. 16, Pages 1559: Pressurised Intraperitoneal Aerosolised Chemotherapy—Results from the First Hundred Consecutive Procedures
Cancers doi: 10.3390/cancers16081559
Authors:
David Hoskovec
Zdeněk Krška
Michal Vočka
Soňa Argalácsová
Petr Dytrych
PIPAC is a new and promising technique for the intraperitoneal administration of chemotherapy. It can be used in patients with various peritoneal cancer metastases. It is mainly a palliative treatment, but there is some neoadjuvant treatment potential. We have operated on 41 patients with various intra-abdominal cancers. PIPAC was performed e...
Source: Cancers - April 19, 2024 Category: Cancer & Oncology Authors: David Hoskovec Zden ěk Krška Michal Vo čka So ňa Argalácsová Petr Dytrych Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1560: A Perspective Review: Analyzing Collagen Alterations in Ovarian Cancer by High-Resolution Optical Microscopy
gnola
High-grade serous ovarian cancer (HGSOC) is the predominant subtype of ovarian cancer (OC), occurring in more than 80% of patients diagnosed with this malignancy. Histological and genetic analysis have confirmed the secretory epithelial of the fallopian tube (FT) as a major site of origin of HGSOC. Although there have been significant strides in our understanding of this disease, early stage detection and diagnosis are still rare. Current clinical imaging modalities lack the ability to detect early stage pathogenesis in the fallopian tubes and the ovaries. However, there are several microscopic imaging techniques...
Source: Cancers - April 19, 2024 Category: Cancer & Oncology Authors: Kristal L. Gant Manish S. Patankar Paul J. Campagnola Tags: Review Source Type: research
Cancers, Vol. 16, Pages 1561: NGS-Guided Precision Oncology in Breast Cancer and Gynecological Tumors & mdash;A Retrospective Molecular Tumor Board Analysis
Conclusions: NGS-guided precision oncology demonstrated improved clinical outcomes in a subgroup of patients with gynecological and breast cancers. (Source: Cancers)
Source: Cancers - April 19, 2024 Category: Cancer & Oncology Authors: Niklas Gremke Fiona R. Rodepeter Julia Teply-Szymanski Sebastian Griewing Jelena Boekhoff Alina Stroh Thomas S. Tarawneh Jorge Riera-Knorrenschild Christina Balser Akira Hattesohl Martin Middeke Petra Ross Anne-Sophie Litmeyer Marcel Romey Thorsten Stiewe Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1562: Safety and Outcomes of Inferior Vena Cava Filter Placement in Oncology Patients: A Single-Centre Experience
In this study, we address the outcomes of placing IVC filters in the oncology population. This single-centre, observational, retrospective study included 62 patients with active malignancy and acute VTE who underwent an IVC filter implantation due to contraindications to anticoagulation during the period 2012–2023. The control group consisted of 117 trauma patients. In both groups, an urgent surgical procedure requiring temporary cessation of anticoagulation was the most noted reason for IVC filter placement—76% in the oncology group vs. 100% in the non-oncology group (p < 0.001). No ...
Source: Cancers - April 19, 2024 Category: Cancer & Oncology Authors: Pawe ł Kurzyna Marta Banaszkiewicz Micha ł Florczyk Jaros ław Kępski Micha ł Piłka Piotr K ędzierski Rafa ł Mańczak Piotr Szwed Krzysztof Kasperowicz Katarzyna Wrona Grzegorz Doroszewski Adam Torbicki Marcin Kurzyna Sebastian Szmit Szymon Darocha Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1543: Predicting Isocitrate Dehydrogenase Status in Non-Contrast-Enhanced Adult-Type Astrocytic Tumors Using Diffusion Tensor Imaging and 11C-Methionine, 11C-Choline, and 18F-Fluorodeoxyglucose PET
da
Tsuyoshi Izumo
We aimed to differentiate the isocitrate dehydrogenase (IDH) status among non-enhanced astrocytic tumors using preoperative MRI and PET. We analyzed 82 patients with non-contrast-enhanced, diffuse, supratentorial astrocytic tumors (IDH mutant [IDH-mut], 55 patients; IDH-wildtype [IDH-wt], 27 patients) who underwent MRI and PET between May 2012 and December 2022. We calculated the fractional anisotropy (FA) and mean diffusivity (MD) values using diffusion tensor imaging. We evaluated the tumor/normal brain uptake (T/N) ratios using 11C-methionine, 11C-choline, and 18F-fluorodeoxyglucose PET; extracte...
Source: Cancers - April 18, 2024 Category: Cancer & Oncology Authors: Shoji Yasuda Hirohito Yano Yuka Ikegame Soko Ikuta Takashi Maruyama Morio Kumagai Yoshihiro Muragaki Toru Iwama Jun Shinoda Tsuyoshi Izumo Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1544: Lower Limb Lymphedema Awareness among Gynecological Cancer Patients: An International Survey Supported by the European Network of Gynecological Cancer Advocacy Groups (ENGAGe) Group
We report a large lack of awareness and a significant gap of knowledge about the risks and treatment options related to postoperative lymphedema among gynecological cancer survivors. Institutional practice routines and awareness among professionals need to be urgently recalled and adapted to adequately inform and support gynecological cancer patients. (Source: Cancers)
Source: Cancers - April 18, 2024 Category: Cancer & Oncology Authors: Dimitrios Haidopoulos Vasilios Pergialiotis Maria Papageorgiou Michael J. Halaska Katerina Maxova Elena Ulrich Ignacio Zapardiel Alexandros Rodolakis Murat Gultekin Christina Fotopoulou Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1545: Prices and Trends in FDA-Approved Medications for Sarcomas
hulte
Sarcomas represent a diverse set of both malignant and benign subtypes consisting of often rare and ultra-rare conditions. Over the course of the last decade, there have been numerous FDA approvals for agents treating various sarcoma subtypes. Given this burgeoning landscape of sarcoma treatments, we seek to review current FDA-approved agents with respect to their rates of incidence, approval rates, and financial costs. We gathered clinical trial data by searching FDA approval announcements from 2013 to 2023. We determined the 30 day and one year cost of therapy for patients of FDA-approved sarcoma treatments in ...
Source: Cancers - April 18, 2024 Category: Cancer & Oncology Authors: Caleb Hwang Mark Agulnik Brian Schulte Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1546: Comparison of Survival Outcomes between Radical Antegrade Modular Pancreatosplenectomy and Conventional Distal Pancreatosplenectomy for Pancreatic Body and Tail Cancer: Korean Multicenter Propensity Score Match Analysis
Conclusions: Although RAMPS resulted in a higher retrieved lymph node count, survival outcomes were not different between the two groups. RAMPS was a surgical option to achieve R0 resection rather than a standard procedure. (Source: Cancers)
Source: Cancers - April 18, 2024 Category: Cancer & Oncology Authors: Jaewoo Kwon Huisong Lee Hongbeom Kim Sung Hyun Kim Jae Do Yang Woohyung Lee Jun Suh Lee Sang Hyun Shin Hee Joon Kim Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1547: Peritoneal Flap Following Lymph Node Dissection in Robotic Radical Prostatectomy: A Novel & ldquo;Bunching & rdquo; Technique
Conclusion: We have demonstrated a modified technique for a peritoneal flap (PBFB) with the initial elimination of postoperative symptomatic lymphoceles and promising short-term outcomes. (Source: Cancers)
Source: Cancers - April 18, 2024 Category: Cancer & Oncology Authors: Ahmed Gamal Marcio Covas Moschovas Abdel Rahman Jaber Shady Saikali Marco Sandri Ela Patel Evan Patel Travis Rogers Vipul Patel Tags: Article Source Type: research
