Cancers, Vol. 16, Pages 1481: EMP2 Serves as a Functional Biomarker for Chemotherapy-Resistant Triple-Negative Breast Cancer
In this study, the expression of the tetraspan protein epithelial membrane protein 2 (EMP2) was explored as a predictor of TNBC response to standard chemotherapy. We demonstrate that EMP2 functions as a prognostic biomarker for patients treated with taxane-based chemotherapy, with high expression at both transcriptomic and protein levels following treatment correlating with poor overall survival. Moreover, we show that targeting EMP2 in combination with docetaxel reduces tumor load in syngeneic and xenograft models of TNBC. These results provide support for the prognostic and therapeutic potential of this tetraspan protein...
Source: Cancers - April 12, 2024 Category: Cancer & Oncology Authors: Ann M. Chan Brian Aguirre Lucia Liu Vei Mah Justin M. Balko Jessica Tsui Navin P. Wadehra Neda A. Moatamed Mahdi Khoshchehreh Christen M. Dillard Meagan Kiyohara Yahya Elshimali Helena R. Chang Diana Marquez-Garban Nalo Hamilton Richard J. Pietras Lynn K. Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1482: Patient-Derived Exosomes as siRNA Carriers in Ovarian Cancer Treatment
Tadashi Kimura
RNA interference is a powerful gene-silencing tool with potential clinical applications. However, its therapeutic use is challenging because suitable carriers are unavailable. Exosomes are stable small endogenous vesicles that can transport functional molecules to target cells, making them ideal small interfering RNA (siRNA) carriers. Herein, we elucidated the therapeutic potential of patient-derived exosomes as an siRNA carrier for ovarian cancer (OC) treatment. The exosomes were extracted from the culture medium of primary fibroblasts collected from the omentum of patients with OC during surgery. ME...
Source: Cancers - April 12, 2024 Category: Cancer & Oncology Authors: Aasa Shimizu Kenjiro Sawada Masaki Kobayashi Yukako Oi Tadashi Oride Yasuto Kinose Michiko Kodama Kae Hashimoto Tadashi Kimura Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1484: Plasma IL-1 and IL-6 Family Cytokines with Soluble Receptor Levels at Diagnosis in Head and Neck Squamous Cell Carcinoma: High Levels Predict Decreased Five-Year Disease-Specific and Overall Survival
In conclusion, high plasma levels of IL-6, IL-31, and IL-1RA, as well as the soluble receptors IL-6Rα, gp130, and IL33Rα, predicted clinical outcome. This shows their potential as candidates for both general therapy and immune therapy stratification, as well as being future platforms for the development of new immunotherapy. (Source: Cancers)
Source: Cancers - April 12, 2024 Category: Cancer & Oncology Authors: Helene Hersvik Aarstad Svein Erik Emblem Moe Stein Lybak Øystein Bruserud Tor Henrik Anderson Tvedt Hans J ørgen Aarstad Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1476: Helicobacter pylori cagA, vacA, iceA and babA Genotypes from Peruvian Patients with Gastric Intestinal Metaplasia
This study was cross-sectional and included 158 H. pylori clinical isolates; each isolate corresponded to a different Peruvian patient, genotyped by polymerase chain reaction to detect cagA gene and EPIYA motifs, the vacA gene (alleles s1, s2, i1, i2, d1, d2, m1, m2 and subtypes s1a, s1b and s1c), the iceA gene (alleles 1 and 2), and the babA gene (allele 2). We observed that 38.6% presented with IM and that all clinical isolates were CagA positive. The EPIYA-ABC motif was predominant (68.4%), and we observed a high frequency for the vacA gene alleles s1 (94.9%), m1 (81.7%), i1 (63.9%), and d1 (70.9%). Strains with both ic...
Source: Cancers - April 12, 2024 Category: Cancer & Oncology Authors: Jes ús Guzmán Denis Castillo Anabel D. Gonz ález-Siccha Alejandro Bussalleu Alba A. Trespalacios-Rangel Andres G. Lescano Michel Sauvain Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1468: Long-Term Impact of Severe Postoperative Complications after Esophagectomy for Cancer: Individual Patient Data Meta-Analysis
Conclusions. This study suggests a statistically significant detrimental effect of SPCs on OS in patients undergoing curative esophagectomy for cancer. Also, a clinical trend toward reduced CSS and DFS was perceived. (Source: Cancers)
Source: Cancers - April 11, 2024 Category: Cancer & Oncology Authors: Davide Bona Michele Manara Gianluca Bonitta Guglielmo Guerrazzi Juxhin Guraj Francesca Lombardo Antonio Biondi Marta Cavalli Piero Giovanni Bruni Giampiero Campanelli Luigi Bonavina Alberto Aiolfi Tags: Systematic Review Source Type: research
Cancers, Vol. 16, Pages 1469: Delay in Cutaneous Squamous Cell Carcinoma Diagnosis Due to Interrupted Services Is Associated with Worse Prognoses and Modified Surgical Approaches
Conclusions: Diagnostic delays of cutaneous SCCs associated with reduced patient access to clinical and diagnostic services are associated with a 4.7-times increased risk of more severe invasion, a three-times increased risk of positive surgical margins, and a significant impact on surgical management, compared to the pre-pandemic period. Comparable patient cohort characteristics and time to surgery remained unchanged. (Source: Cancers)
Source: Cancers - April 11, 2024 Category: Cancer & Oncology Authors: Filippo Taccioli Claudio Gio Francesco Blessent Alessia Paganelli Francesca Fagioli Johanna Mary Chester Shaniko Kaleci Matteo Costantini Barbara Ferrari Chiara Fiorentini Giorgio De Santis Cristina Magnoni Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1470: Targeted Therapy for Highly Desmoplastic and Immunosuppressive Tumor Microenvironment of Pancreatic Ductal Adenocarcinoma
Guangfu Li
Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignancy with a very poor prognosis. Despite advancements in treatment strategies, PDAC remains recalcitrant to therapies because patients are often diagnosed at an advanced stage. The advanced stage of PDAC is characterized by metastasis, which typically renders it unresectable by surgery or untreatable by chemotherapy. The tumor microenvironment (TME) of PDAC comprises highly proliferative myofibroblast-like cells and hosts the intense deposition of a extracellular matrix component that forms dense fibrous connective tissue, a process called t...
Source: Cancers - April 11, 2024 Category: Cancer & Oncology Authors: Olamide T. Olaoba Ming Yang Temitope I. Adelusi Tessa Maidens Eric T. Kimchi Kevin F. Staveley-OCarroll Guangfu Li Tags: Review Source Type: research
Cancers, Vol. 16, Pages 1472: In Curative Stereotactic Body Radiation Therapy for Prostate Cancer, There Is a High Possibility That 45 Gy in Five Fractions Will Not Be Tolerated without a Hydrogel Spacer
This study was a phase 1 dose escalation trial conducted in Japan. Patients with histologically proven prostate cancer without lymph nodes or distant metastases were enrolled. The prescribed doses were 42.5, 45, or 47.5 Gy in five fractions. Dose-limiting toxicity (DLT) was defined as grade (G) 3+ gastrointestinal or genitourinary toxicity within 180 days after SBRT completion, and a 6 plus 6 design was used as the method of dose escalation. A total of 16 patients were enrolled, with 6 in the 42.5 Gy group and 10 in the 45 Gy group. No DLT was observed in the 42.5 Gy group. In the 45 Gy group, one patient experienced G3 re...
Source: Cancers - April 11, 2024 Category: Cancer & Oncology Authors: Subaru Sawayanagi Hideomi Yamashita Mami Ogita Taketo Kawai Yusuke Sato Haruki Kume Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1471: Impact on the Transcriptome of Proton Beam Irradiation Targeted at Healthy Cardiac Tissue of Mice
astellani
Remondini
Zironi
Proton beam therapy is considered a step forward with respect to electromagnetic radiation, thanks to the reduction in the dose delivered. Among unwanted effects to healthy tissue, cardiovascular complications are a known long-term radiotherapy complication. The transcriptional response of cardiac tissue from xenografted BALB/c nude mice obtained at 3 and 10 days after proton irradiation covering both the tumor region and the underlying healthy tissue was analyzed as a function of dose and time. Three doses were used: 2 Gy, 6 Gy, and 9 Gy. The intermediate dose had caused the greatest i...
Source: Cancers - April 11, 2024 Category: Cancer & Oncology Authors: Sala Tarozzi Simonetti Pazzaglia Cammarata Russo Acquaviva Cirrone Petringa Catalano Elia Fede Manti Castellani Remondini Zironi Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1473: CD10 Expression Correlates with Earlier Tumour Stages and Left-Sided Tumour Location in Colorectal Cancer but Has No Prognostic Impact in a European Cohort
This study aims to analyse the relationship between CD10 expression and overall survival (OS) in a European cohort. To determine the association of CD10 expression with tumour phenotype, molecular features, and prognosis, a tissue microarray of 1469 colorectal carcinomas was analysed using immunohistochemistry and was compared with matched clinicopathologic data. CD10 expression correlated with earlier tumour stages (p = 0.017) and left-sided colon cancer (p < 0.001). However, no correlation was found between CD10 expression and lymph node involvement (p = 0.711), tumour grading (p = 0.397), or overall survival ...
Source: Cancers - April 11, 2024 Category: Cancer & Oncology Authors: Julia-Kristin Grass Katharina Grupp Martina Kluth Claudia Hube-Magg Ronald Simon Marius Kemper Jakob R. Izbicki Guido Sauter Nathaniel Melling Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1474: Human-Level Differentiation of Medulloblastoma from Pilocytic Astrocytoma: A Real-World Multicenter Pilot Study
Johann
Hau
Frühwald
Medulloblastoma and pilocytic astrocytoma are the two most common pediatric brain tumors with overlapping imaging features. In this proof-of-concept study, we investigated using a deep learning classifier trained on a multicenter data set to differentiate these tumor types. We developed a patch-based 3D-DenseNet classifier, utilizing automated tumor segmentation. Given the heterogeneity of imaging data (and available sequences), we used all individually available preoperative imaging sequences to make the model robust to varying input. We compared the classifier to diagnostic assessments by f...
Source: Cancers - April 11, 2024 Category: Cancer & Oncology Authors: Wiestler Bison Behrens T üchert Metz Griessmair Jakob Schlegel Binder von Luettichau Metzler Johann Hau Fr ühwald Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1475: Second Neoplasms in Italian Patients with Hairy Cell Leukemia after Treatment with Cladribine: A Multicenter Investigation and Literature Review
Volpetti
Ombretta Annibali
Sergio Storti
Caterina Stelitano
Francesco Marchesi
Sonia Morè
Luana Fianchi
Brunangelo Falini
Alessandro Pulsoni
Enrico Tiacci
Pier Luigi Zinzani
Livio Pagano
Concern has emerged about the prevalence of second cancers among patients with hairy cell leukemia (HCL) treated with purine analogs. We investigated 513 patients with HCL treated with cladribine over the last 30 years at 18 Italian centers and calculated their standardized incidence ratios (SIRs). We identified 24 patients with a second cancer diagnosed at a median time from treatment with cladribine of 59.9 mon...
Source: Cancers - April 11, 2024 Category: Cancer & Oncology Authors: Marianna Criscuolo Maria Elena Tosti Alessandro Broccoli Marzia Varettoni Alessio Maria Edoardo Maraglino Antonella Anastasia Maria Cantonetti Livio Trentin Sofia Kovalchuk Lorella Orsucci Marina Deodato Angelica Spolzino Stefano Volpetti Ombretta Annibal Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1460: The Real-Life Impact of Primary Tumor Resection of Synchronous Metastatic Colorectal Cancer & mdash;From a Clinical Oncologic Point of View
Conclusions: The role of PTR in smCRC is still not professionally justified. Our survey found that most patients had benefited from PTR. Nevertheless, further prospective trials are needed to clarify the optimal treatment sequence of smCRC patients and understand this cancer disease’s inherent biology. (Source: Cancers)
Source: Cancers - April 11, 2024 Category: Cancer & Oncology Authors: Bal ázs Pécsi L ászló Csaba Mangel Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1458: Predictors for Success and Failure in Transoral Robotic Surgery & mdash;A Retrospective Study in the North of the Netherlands
This study provides valuable insights into the outcomes and predictors of success and failure in TORS procedures across various conditions and may also help in patient selection and counseling. (Source: Cancers)
Source: Cancers - April 11, 2024 Category: Cancer & Oncology Authors: Alexandra G. L. Toppenberg Thomas S. Nijboer Wisse G. W. J. van der Laan Jan Wedman Leonora Q. Schwandt Robert E. Plaat Max J. H. Witjes Inge Wegner Gyorgy B. Halmos Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1459: Predictors of Survival, Treatment Modalities, and Clinical Outcomes of Diffuse Large B-Cell Lymphoma in Patients Older Than 70 Years Still an Unmet Medical Need in 2024 Based on Real-World Evidence
Conclusions: In this large and real-life Latin American cohort, we demonstrated that patients with DLBCL, NOS older than 70 years still do not have satisfactory clinical outcomes in 2024, with half of cases not reaching 5 years of life expectancy after diagnosis. Although the conventional R-CHOP offers response and survival advantages over attenuated regimens, its myelotoxicity is not negligible. Therefore, the outcomes reported and the prognostic factors here identified may assist clinicians in the appropriate selection of therapeutic strategies adapted to the risk for old and very old DLBCL patients. (Source: Cancers)
Source: Cancers - April 11, 2024 Category: Cancer & Oncology Authors: Lu ís Alberto de Pádua Covas Lage Rita Novello De Vita Lucas Bassolli de Oliveira Alves Mayara D ’Auria Jacomassi Hebert Fabr ício Culler Cadiele Oliana Reichert F ábio Alessandro de Freitas Vanderson Rocha Sheila Aparecida Coelho Siqueira Renata de Tags: Article Source Type: research
