Cancers, Vol. 16, Pages 1523: Head and Neck Paragangliomas: Overview of Institutional Experience
Brant
Yonghong Huan
Head and neck paragangliomas (HNPGLs) are rare and have high rates of genetic mutations. We conducted a retrospective review of 187 patients with 296 PGLs diagnosed between 1974 and 2023. The mean age of diagnosis was 48.8 years (range 10 to 82) with 69.0% female and 26.5% patients with multiple PGLs. Among 119 patients undergoing genetic testing, 70 (58.8%) patients had mutations, with SDHB (30) and SDHD (26) being the most common. The rates of metastasis and recurrence were higher among patients with SHDB mutations or SDHD mutations associated with multiple PGLs. Metabolic evaluation showed elev...
Source: Cancers - April 16, 2024 Category: Cancer & Oncology Authors: Swar N. Vimawala Alex Z. Graboyes Bonita Bennett Maria Bonanni Aleena Abbasi Tanaya Oliphant Michelle Alonso-Basanta Christopher Rassekh Debbie Cohen Jason A. Brant Yonghong Huan Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1511: CALR but Not JAK2 Mutations Are Associated with an Overexpression of Retinoid X Receptor Alpha in Essential Thrombocythemia
manos
Essential thrombocythemia (ET) is a blood cancer caused by mutations in JAK2 and CALR. It is widely recognized that both mutations lead to the constitutive activation of JAK2/STAT signaling, although other JAK/STAT-independent pathogenic mechanisms triggered by these alterations have also been described in ET. In an attempt to study JAK2/STAT-independent mechanisms derived from CALR mutations, our research group created a C. elegans model with patient-like mutations in calreticulin that lacks JAK counterparts. The introduction of patient-like mutations in the calreticulin of C. elegans leads to an increase in the...
Source: Cancers - April 16, 2024 Category: Cancer & Oncology Authors: Ana Guijarro-Hern ández Cristina Hurtado Mar Ãa José Larráyoz Mar Ãa José Calasanz Jos é Luis Vizmanos Tags: Communication Source Type: research
Cancers, Vol. 16, Pages 1512: Outcome of Tocilizumab Treatment in Febrile Neutropenic Children with Severe Sepsis/Septic Shock in a Single-Center Retrospective Case Series
Conclusions: Administration of tocilizumab reduced mortality of severe sepsis/septic shock in children with febrile neutropenia. However, it warrants confirmation with a larger number of patients and a longer follow-up. (Source: Cancers)
Source: Cancers - April 16, 2024 Category: Cancer & Oncology Authors: Shih-Hsiang Chen Tsung-Yen Chang Yi-Lun Wang En-Pei Lee Jainn-Jim Lin Yi-Wen Hsiao Tang-Her Jaing Chao-Ping Yang Iou-Jih Hung Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1513: Time-Restricted Feeding Attenuates Metabolic Dysfunction-Associated Steatohepatitis and Hepatocellular Carcinoma in Obese Male Mice
In this study, we tested a time-restricted feeding (TRF) nutritional intervention in mouse models of MASH and HCC. We show that TRF abrogated metabolic dysregulation induced by a Western diet without any calorie restriction or weight loss. TRF improved insulin sensitivity and reduced hyperinsulinemia, liver steatosis, inflammation, and fibrosis. Importantly, TRF inhibited liver tumors in two mouse models of obesity-driven HCC. Our data suggest that TRF is likely to be effective in abrogating MASH and HCC and warrant further studies of time-restricted eating in humans with MASH who are at higher risk of developing HCC. (Source: Cancers)
Source: Cancers - April 16, 2024 Category: Cancer & Oncology Authors: Manasi Das Deepak Kumar Consuelo Sauceda Alexis Oberg Lesley G. Ellies Liping Zeng Lily J. Jih Isabel G. Newton Nicholas J. G. Webster Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1514: Assessment of PSMA Expression of Healthy Organs in Different Stages of Prostate Cancer Using [68Ga]Ga-PSMA-11-PET Examinations
arcus Hacker
Sazan Rasul
The efficacy of radioligand therapy (RLT) targeting prostate-specific membrane antigen (PSMA) is currently being investigated for its application in patients with early-stage prostate cancer (PCa). However, little is known about PSMA expression in healthy organs in this cohort. Collectively, 202 [68Ga]Ga-PSMA-11 positron emission tomography (PET) scans from 152 patients were studied. Of these, 102 PET scans were from patients with primary PCa and hormone-sensitive biochemically recurrent PCa and 50 PET scans were from patients with metastatic castration-resistant PCa (mCRPC) before and after ...
Source: Cancers - April 16, 2024 Category: Cancer & Oncology Authors: Holger Einspieler Kilian Kluge David Haberl Katrin Schatz Lukas Nics Stefan Schmitl Barbara Katharina Geist Clemens P. Spielvogel Bernhard Grubm üller Pascal A. T. Baltzer Gero Kramer Shahrokh F. Shariat Marcus Hacker Sazan Rasul Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1515: First-Line LV5FU2 with or without Aflibercept in Patients with Non-Resectable Metastatic Colorectal Cancer: A Randomized Phase II Trial (PRODIGE 25-FFCD-FOLFA)
¯za Khemissa Akouz
Magali Terme
Côme Lepage
Valérie Boige
Fluropyrimidine monotherapy is an option for some patients with inoperable metastatic colorectal cancer. Unlike bevacizumab, the addition of aflibercept, an antibody acting as an anti-angiogenic agent, has never been evaluated in this context. The aim of the study was to determine whether aflibercept could increase the efficacy of fluoropyrimidine monotherapy without increasing toxicity. This multicenter phase II non-comparative trial evaluated the addition of aflibercept to infusional 5-fluorouracil/folinic acid (LV5FU2 regimen) as first-line treatment ...
Source: Cancers - April 16, 2024 Category: Cancer & Oncology Authors: Jean-Louis Legoux Roger Faroux Nicolas Barri ère Karine Le Malicot David Tougeron V éronique Lorgis V éronique Guerin-Meyer Vincent Bourgeois David Malka Thomas Aparicio Matthieu Baconnier Val érie Lebrun-Ly Jo ëlle Egreteau Fa ïza Khemissa Akouz Ma Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1507: Type I Diabetes Mellitus Suppresses Experimental Skin Carcinogenesis
This study explores the previously uncharted territory of the effects of ultraviolet (UV) radiation on diabetic skin, compared to its well-documented impact on normal skin, particularly focusing on carcinogenesis and aging. Employing hairless SKH-hr2, Type 1 and 2 diabetic, and nondiabetic male mice, the research subjected these to UV radiation thrice weekly for eight months. The investigation included comprehensive assessments of photoaging and photocarcinogenesis in diabetic versus normal skin, measuring factors such as hydration, trans-epidermal water loss, elasticity, skin thickness, melanin, sebum content, stratum cor...
Source: Cancers - April 15, 2024 Category: Cancer & Oncology Authors: Maria Giakoumaki George I. Lambrou Dimitrios Vlachodimitropoulos Anna Tagka Andreas Vitsos Maria Kyriazi Aggeliki Dimakopoulou Vasiliki Anagnostou Marina Karasmani Heleni Deli Andreas Grigoropoulos Evangelos Karalis Michail Christou Rallis Homer S. Black Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1508: Prognostic Biomarkers of Systemic Inflammation in Non-Small Cell Lung Cancer: A Narrative Review of Challenges and Opportunities
hillips
Non-small cell lung cancer (NSCLC) is a common malignancy and is associated with poor survival outcomes. Biomarkers of systemic inflammation derived from blood tests collected as part of routine clinical care offer prognostic information for patients with NSCLC that may assist clinical decision making. They are an attractive tool, as they are inexpensive, easily measured, and reproducible in a variety of healthcare settings. Despite the wealth of evidence available to support them, these inflammatory biomarkers are not yet routinely used in clinical practice. In this narrative review, the key inflammatory indic...
Source: Cancers - April 15, 2024 Category: Cancer & Oncology Authors: Mark Stares Leo R. Brown Dhruv Abhi Iain Phillips Tags: Review Source Type: research
Cancers, Vol. 16, Pages 1509: Early Stage Breast Cancer: Does Histologic Subtype (Ductal vs. Lobular) Impact 5 Year Overall Survival?
aise
Emmanuel Gabriel
Histology is an important predictor of the behavior of breast cancer. We aim to study the impact of histology on the overall survival (OS) of breast cancer patients. We studied 11,085 breast cancer patients diagnosed with T1–T2 tumors, clinically node-negative and non-metastatic, from 2004 to 2019 included in the National Cancer Database. Kaplan–Meier curves, log-rank tests and Cox regression models were used to study the impact of histology and other variables on OS. In our patient population, 8678 (78.28%) had ductal cancer (IDC), while 2407 (21.71%) had lobular can...
Source: Cancers - April 15, 2024 Category: Cancer & Oncology Authors: Fatima Mubarak Gabrielle Kowkabany Reed Popp Shivam Bansal Syeda Hoorulain Ahmed Seema Sharan Kulkaew B. Sukniam Swathi R. Raikot Paola Berrios Jimenez Kyle Popp Harsheen K. Manaise Emmanuel Gabriel Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1510: Synergistic Activity of DNA Damage Response Inhibitors in Combination with Radium-223 in Prostate Cancer
This study identified the ATR inhibitor as the most synergistic inhibitor for both radiation qualities, supporting further pre-clinical evaluation of DDR inhibitors in combination with 223Ra for the treatment of prostate cancer. (Source: Cancers)
Source: Cancers - April 15, 2024 Category: Cancer & Oncology Authors: Victoria L. Dunne Timothy C. Wright Francisco D. C. Guerra Liberal Joe M. O ’Sullivan Kevin M. Prise Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1502: The Performance of Different Parametric Ultrasounds in Prostate Cancer Diagnosis: Correlation with Radical Prostatectomy Specimens
Conclusions: The mpUS procedure provides high sensitivity and specificity in PCa detection, especially for clinically significant prostate cancer. (Source: Cancers)
Source: Cancers - April 15, 2024 Category: Cancer & Oncology Authors: Adel Jawli Ghulam Nabi Zhihong Huang Tags: Systematic Review Source Type: research
Cancers, Vol. 16, Pages 1503: Measurable (Minimal) Residual Disease in Myelodysplastic Neoplasms (MDS): Current State and Perspectives
adantonakis
Myelodysplastic Neoplasms (MDS) have been traditionally studied through the assessment of blood counts, cytogenetics, and morphology. In recent years, the introduction of molecular assays has improved our ability to diagnose MDS. The role of Measurable (minimal) Residual Disease (MRD) in MDS is evolving, and molecular and flow cytometry techniques have been used in several studies. In this review, we will highlight the evolving concept of MRD in MDS, outline the various techniques utilized, and provide an overview of the studies reporting MRD and the correlation with outcomes. (Source: Cancers)
Source: Cancers - April 15, 2024 Category: Cancer & Oncology Authors: Linsheng Zhang George Deeb Kristin K. Deeb Colin Vale Deniz Peker Barclift Nikolaos Papadantonakis Tags: Review Source Type: research
Cancers, Vol. 16, Pages 1504: Clinical and Diagnostic Utility of Genomic Profiling for Digestive Cancers: Real-World Evidence from Japan
Hajime Kuroda
Seigo Yukisawa
Takuya Aoki
Kei Takeshita
Shinichi Ueno
Junichi Nakazawa
Yu Sunakawa
Sachio Nohara
Chihiro Okada
Ko Nishimiya
Shigeki Tanishima
Hiroshi Nishihara
The usefulness of comprehensive genomic profiling (CGP) in the Japanese healthcare insurance system remains underexplored. Therefore, this large-scale study aimed to determine the usefulness of CGP in diagnosing digestive cancers. Patients with various cancer types recruited between March 2020 and October 2022 underwent the FoundationOne® CDx assay at the Keio PleSSision Group (19 hospitals in Japan). A scoring sy...
Source: Cancers - April 15, 2024 Category: Cancer & Oncology Authors: Marin Ishikawa Kohei Nakamura Ryutaro Kawano Hideyuki Hayashi Tatsuru Ikeda Makoto Saito Yo Niida Jiichiro Sasaki Hiroyuki Okuda Satoshi Ishihara Masatoshi Yamaguchi Hideaki Shimada Takeshi Isobe Yuki Yuza Akinobu Yoshimura Hajime Kuroda Seigo Yukisawa Ta Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1505: The Role of Hepatitis Viruses as Drivers of Hepatocancerogenesis
a Morisco
Recently, metabolic associated steatotic liver disease (MASLD) became the leading cause of chronic liver disease worldwide and one of the most frequent causes of hepatocellular carcinoma (HCC). Nonetheless, in this epidemiological trend, viral hepatitis remains the major driver in hepatic carcinogenesis. Globally, hepatitis B virus (HBV) is the leading cause of hepatocellular carcinoma, with an overall attributable risk of approximately 40%, followed by hepatitis C virus (HCV), which accounts for 28–30% of cases, with significant geographic variations between the Eastern and Western world. Consi...
Source: Cancers - April 15, 2024 Category: Cancer & Oncology Authors: Mario Capasso Valentina Cossiga Maria Guarino Luisa Ranieri Filomena Morisco Tags: Review Source Type: research
Cancers, Vol. 16, Pages 1506: Development and Validation of a Deep Learning Model for Histopathological Slide Analysis in Lung Cancer Diagnosis
This study presents a DL-based model for efficient lung cancer detection using whole-slide images. Our methodology combines convolutional neural networks (CNNs) and separable CNNs with residual blocks, thereby improving classification performance. Our model improves accuracy (96% to 98%) and robustness in distinguishing between cancerous and non-cancerous lung cell images in less than 10 s. Moreover, the model’s overall performance surpassed that of active pathologists, with an accuracy of 100% vs. 79%. There was a significant linear correlation between pathologists’ accuracy and years of experi...
Source: Cancers - April 15, 2024 Category: Cancer & Oncology Authors: Alhassan Ali Ahmed Muhammad Fawi Agnieszka Brychcy Mohamed Abouzid Martin Witt El żbieta Kaczmarek Tags: Article Source Type: research
