Cancers, Vol. 16, Pages 1281: Patient-Relevant Costs for Organ Preservation versus Radical Resection in Locally Advanced Rectal Cancer
ay Alexander Fabian Klaus Pietschmann Total neoadjuvant therapy (TNT) is an evolving treatment schedule for locally advanced rectal cancer (LARC), allowing for organ preservation in a relevant number of patients in the case of complete response. Patients who undergo this so-called “watch and wait” approach are likely to benefit regarding their quality of life (QoL), especially if definitive ostomy could be avoided. In this work, we performed the first cost-effectiveness analysis from the patient perspective to compare costs for TNT with radical resection after neoadjuvant chemoradiation ...
Source: Cancers - March 26, 2024 Category: Cancer & Oncology Authors: Georg W. Wurschi Alexander R ühle Justus Domschikowski Maike Trommer Simone Ferdinandus Jan-Niklas Becker Simon Boeke Mathias Sonnhoff Christoph A. Fink Lukas K äsmann Melanie Schneider Elodie Bockelmann David Krug Nils H. Nicolay Alexander Fabian Klaus Tags: Article Source Type: research

Cancers, Vol. 16, Pages 1280: Identification of Key Genes Associated with Tumor Microenvironment Infiltration and Survival in Gastric Adenocarcinoma via Bioinformatics Analysis
Conclusion: Our findings suggest that the identified hub genes, particularly BGN, FN1, COL1A2, THBS2, COL3A1, and COL5A1, play crucial roles in GC prognosis and TME cell infiltration. This comprehensive analysis enhances our understanding of the molecular mechanisms underlying GC development and may contribute to the identification of potential therapeutic targets and prognostic markers for GC patients. (Source: Cancers)
Source: Cancers - March 26, 2024 Category: Cancer & Oncology Authors: Georgios Konstantis Georgia Tsaousi Chryssa Pourzitaki Stefan Kasper-Virchow Gregor Zaun Elisavet Kitsikidou Moritz Passenberg Vasilis Spyridon Tseriotis Katharina Willuweit Hartmut H. Schmidt Jassin Rashidi-Alavijeh Tags: Article Source Type: research

Cancers, Vol. 16, Pages 1282: Temporal Trends in Treatment and Outcomes of Endometrial Carcinoma in the United States, 2005 & ndash;2020
Cancers, Vol. 16, Pages 1282: Temporal Trends in Treatment and Outcomes of Endometrial Carcinoma in the United States, 2005–2020 Cancers doi: 10.3390/cancers16071282 Authors: Victor Adekanmbi Fangjian Guo Christine D. Hsu Daoqi Gao Efstathia Polychronopoulou Itunu Sokale Yong-Fang Kuo Abbey B. Berenson Endometrial cancer has continued to see a rising incidence in the US over the years. The main aim of this study was to assess current trends in patients’ characteristics and outcomes of treatment for endometrial carcinoma over 16 years. A dataset from the National Cancer Database...
Source: Cancers - March 26, 2024 Category: Cancer & Oncology Authors: Victor Adekanmbi Fangjian Guo Christine D. Hsu Daoqi Gao Efstathia Polychronopoulou Itunu Sokale Yong-Fang Kuo Abbey B. Berenson Tags: Article Source Type: research

Cancers, Vol. 16, Pages 1283: Evaluation of a Population-Based Targeted Screening Approach for Skin Cancer with Long-Time Follow-Up in Austria including Potential Effects on Melanoma Mortality
Conclusions: given the uncertain effectiveness and high public expenditures of population-wide mass screening programs, primary prevention and targeted risk-based skin cancer screening might be promising alternatives. (Source: Cancers)
Source: Cancers - March 26, 2024 Category: Cancer & Oncology Authors: Wolfgang Brozek Patrick Clemens Hanno Ulmer Nina H äring Hans Concin Emanuel Zitt Gabriele Nagel Tags: Article Source Type: research

Cancers, Vol. 16, Pages 1284: Sacral-Nerve-Sparing Planning Strategy in Pelvic Sarcomas/Chordomas Treated with Carbon-Ion Radiotherapy
Piero Fossati To minimize radiation-induced lumbosacral neuropathy (RILSN), we employed sacral-nerve-sparing optimized carbon-ion therapy strategy (SNSo-CIRT) in treating 35 patients with pelvic sarcomas/chordomas. Plans were optimized using Local Effect Model-I (LEM-I), prescribed DRBE|LEM-I|D50% (median dose to HD-PTV) = 73.6 (70.4–76.8) Gy (RBE)/16 fractions. Sacral nerves were contoured between L5-S3 levels. DRBE|LEM-I to 5% of sacral nerves-to-spare (outside HD-CTV) (DRBE|LEM-I|D5%) were restricted to <69 Gy (RBE). The median follow-up was 25 months (range of 2–53). Three pa...
Source: Cancers - March 26, 2024 Category: Cancer & Oncology Authors: Ankita Nachankar Mansure Schafasand Eugen Hug Giovanna Martino Joanna G óra Antonio Carlino Markus Stock Piero Fossati Tags: Article Source Type: research

Cancers, Vol. 16, Pages 1285: Comparing R-Bendamustine vs. R-CHOP Plus Maintenance Therapy as First-Line Systemic Treatment in Follicular Lymphoma: A Multicenter Retrospective GELTAMO Study
In conclusion, R-B followed by rituximab maintenance therapy in patients with previously untreated FL resulted in significantly longer PFS than R-CHOP, with older patients also benefiting from this treatment without further toxicity. Adverse events during maintenance were more frequent with R-B without impacting mortality. (Source: Cancers)
Source: Cancers - March 26, 2024 Category: Cancer & Oncology Authors: Mariana Bastos-Oreiro Antonio Gutierrez Almudena Cabero Javier L ópez Paola Villafuerte Ana Jim énez-Ubieto Raquel de O ña Adolfo De la Fuente Bel én Navarro Javier Pe ñalver Pilar Mart ínez Carmen Alonso Mar ía Infante Ra úl Córdoba Blanca Perez Tags: Article Source Type: research

Cancers, Vol. 16, Pages 1273: RUVBL1 in Clear-Cell Renal Cell Carcinoma: Unraveling Prognostic Significance and Correlation with HIF1A
This study investigates the roles of RUVBL1 and HIF1A in ccRCC development and explores their clinical significance as prognostic biomarkers. mRNA and protein expressions were analyzed using TCGA data and an institutional tissue cohort, respectively. Correlations with clinicopathological parameters and patient outcomes were assessed. TCGA data revealed significantly elevated RUVBL1 mRNA expression in ccRCC tissues, associated with advanced histological grade, T stage, lymph node metastasis, and clinical stage. High RUVBL1 mRNA expression correlated with inferior overall survival and served as an adverse prognostic factor. ...
Source: Cancers - March 25, 2024 Category: Cancer & Oncology Authors: Justyna Dur ślewicz Aleksandra Maria Wybiera ła Sara Szczepanek Paulina Antosik Damian Jaworski Dariusz Grzanka Tags: Article Source Type: research

Cancers, Vol. 16, Pages 1274: Experimental and Computational Analysis of High-Intensity Focused Ultrasound Thermal Ablation in Breast Cancer Cells: Monolayers vs. Spheroids
This study contributes to a comprehensive understanding of acoustic energy conversion within the biological system during HIFU treatment for 2D versus 3D ablation targets, holding potential implications for refining and personalizing breast cancer therapeutic strategies. (Source: Cancers)
Source: Cancers - March 25, 2024 Category: Cancer & Oncology Authors: Heba M. Badawe Jean Paul Harouz Petra Raad Kareem Abu Anthony Freije Kamel Ghali Wassim Abou-Kheir Massoud L. Khraiche Tags: Article Source Type: research

Cancers, Vol. 16, Pages 1275: The Application of Long-Read Sequencing to Cancer
guez Cancer is a multifaceted disease arising from numerous genomic aberrations that have been identified as a result of advancements in sequencing technologies. While next-generation sequencing (NGS), which uses short reads, has transformed cancer research and diagnostics, it is limited by read length. Third-generation sequencing (TGS), led by the Pacific Biosciences and Oxford Nanopore Technologies platforms, employs long-read sequences, which have marked a paradigm shift in cancer research. Cancer genomes often harbour complex events, and TGS, with its ability to span large genomic regions, has facilitated their cha...
Source: Cancers - March 25, 2024 Category: Cancer & Oncology Authors: Ermini Driguez Tags: Review Source Type: research

Cancers, Vol. 16, Pages 1276: Immunotherapeutic Strategies for the Treatment of Glioblastoma: Current Challenges and Future Perspectives
ini Despite decades of research and the best up-to-date treatments, grade 4 Glioblastoma (GBM) remains uniformly fatal with a patient median overall survival of less than 2 years. Recent advances in immunotherapy have reignited interest in utilizing immunological approaches to fight cancer. However, current immunotherapies have so far not met the anticipated expectations, achieving modest results in their journey from bench to bedside for the treatment of GBM. Understanding the intrinsic features of GBM is of crucial importance for the development of effective antitumoral strategies to improve patient life expectancy a...
Source: Cancers - March 25, 2024 Category: Cancer & Oncology Authors: Ilaria Salvato Antonio Marchini Tags: Review Source Type: research

Cancers, Vol. 16, Pages 1270: Assessing Trifecta and Pentafecta Success Rates between Robot-Assisted vs. Open Radical Cystectomy: A Propensity Score-Matched Analysis
Conclusions: RARC offers distinct advantages over ORC in terms of reduced blood loss, while trifecta and pentafecta success rates do not differ significantly between the two surgical approaches. (Source: Cancers)
Source: Cancers - March 25, 2024 Category: Cancer & Oncology Authors: Filippo Gavi Nazario Foschi Daniele Fettucciari Pierluigi Russo Diana Giannarelli Mauro Ragonese Carlo Gandi Giovanni Balocchi Alessandra Francocci Francesco Pio Bizzarri Filippo Marino Giovanni Battista Filomena Giuseppe Palermo Angelo Totaro Marco Racio Tags: Article Source Type: research

Cancers, Vol. 16, Pages 1271: Locoregional Therapies for Hepatobiliary Tumors: Contemporary Strategies and Novel Applications
ary A large majority of primary hepatobiliary tumors are hepatocellular carcinomas (HCC), with the remainer being cholangiocarcinoma. While surgical resection remains the gold standard treatment for hepatobiliary tumors, relatively few patients are operative candidates, and systemic treatments have limited effectiveness. Locoregional therapies offer significant promise in the management of HCC. Ablation and radioembolization may offer similar outcomes to surgery for early-stage hepatocellular carcinoma while radioembolization and chemoembolization are valuable in the management of advanced disease. There is significant...
Source: Cancers - March 25, 2024 Category: Cancer & Oncology Authors: Andrei M. Jipa Mina S. Makary Tags: Review Source Type: research

Cancers, Vol. 16, Pages 1272: Modulation of sHLA-G, PD-1, and PD-L1 Expression in Cervical Lesions following Imiquimod Treatment and Its Association with Treatment Success
Conclusions: IMQ exhibits promise as a non-invasive treatment for CIN, emphasising its potential to modulate the immune microenvironment. Baseline sHLA-G levels emerge as potential predictors of treatment response. Understanding the nuanced dynamics of immune checkpoints sheds light on IMQ mechanism of action. Further exploration is warranted to decipher the intricate mechanisms underlying IMQ treatment in the context of cervical lesions. (Source: Cancers)
Source: Cancers - March 25, 2024 Category: Cancer & Oncology Authors: Andrej Cokan Neila Caroline Henrique da Silva Rajko Kavalar Igor But Maja Paki ž Sheilla Andrade de Oliveira Fabiana Oliveira dos Santos Gomes Rodrigo Soares da Silva Christina Alves Peixoto Norma Lucena-Silva Tags: Article Source Type: research

Cancers, Vol. 16, Pages 1266: The Use of CA-125 KELIM to Identify Which Patients Can Achieve Complete Cytoreduction after Neoadjuvant Chemotherapy in High-Grade Serous Advanced Ovarian Cancer
Conclusions: KELIM seems to safely triage patients after neoadjuvant chemotherapy and decide who will benefit from IDS. (Source: Cancers)
Source: Cancers - March 24, 2024 Category: Cancer & Oncology Authors: Dimitrios Zouzoulas Dimitrios Tsolakidis Panagiotis Tzitzis Iliana Sofianou Kimon Chatzistamatiou Vasilis Theodoulidis Maria Topalidou Eleni Timotheadou Grigoris Grimbizis Tags: Article Source Type: research

Cancers, Vol. 16, Pages 1265: A Biopsy-Controlled Prospective Study of Contrast-Enhancing Diffuse Glioma Infiltration Based on FET-PET and FLAIR
kowski Accurately defining glioma infiltration is crucial for optimizing radiotherapy and surgery, but glioma infiltration is heterogeneous and MRI imperfectly defines the tumor extent. Currently, it is impossible to determine the tumor infiltration gradient within a FLAIR signal. O-(2-[18F]fluoroethyl)-L-tyrosine (FET)-PET often reveals high-grade glioma infiltration beyond contrast-enhancing areas on MRI. Here, we studied FET uptake dynamics in tumor and normal brain structures by dual-timepoint (10 min and 40–60 min post-injection) acquisition to optimize analysis protocols for defining glioma infiltra...
Source: Cancers - March 24, 2024 Category: Cancer & Oncology Authors: Maciej Harat Izabela Miechowicz J ózefina Rakowska Izabela Zar ębska Bogdan Ma łkowski Tags: Article Source Type: research