Cancers, Vol. 16, Pages 1594: Endovascular Applications for the Management of High-Grade Gliomas in the Modern Era
Aziz-Sultan
Joshua D. Bernstock
High-grade gliomas (HGGs) have a poor prognosis and are difficult to treat. This review examines the evolving landscape of endovascular therapies for HGGs. Recent advances in endovascular catheter technology and delivery methods allow for super-selective intra-arterial cerebral infusion (SSIACI) with increasing precision. This treatment modality may offer the ability to deliver anti-tumoral therapies directly to tumor regions while minimizing systemic toxicity. However, challenges persist, including blood–brain barrier (BBB) penetration, hemodynamic complexities, and drug...
Source: Cancers - April 22, 2024 Category: Cancer & Oncology Authors: Ari D. Kappel Rohan Jha Saibaba Guggilapu William J. Smith Abdullah H. Feroze Adam A. Dmytriw Juan Vicenty-Padilla Rodolfo E. Alcedo Guardia Florian A. Gessler Nirav J. Patel Rose Du Alfred P. See Pier Paolo Peruzzi Mohammad A. Aziz-Sultan Joshua D. Berns Tags: Review Source Type: research
Cancers, Vol. 16, Pages 1595: Correlation of Molecular Status with Preoperative Olfactory Function in Olfactory Groove Meningioma
Conclusion: The study highlights PSH and perifocal oedema’s significant effect on olfactory function in OGM patients but finds no link between olfactory impairment and tumour mutations, possibly due to the small sample size. This suggests that age and gender affect olfactory impairment. Additional research with a larger group of participants is needed to explore the impact of OGM driver mutations on olfactory performance. (Source: Cancers)
Source: Cancers - April 22, 2024 Category: Cancer & Oncology Authors: Dino Podlesek Friederike Beyer Majd Alkhatib Dirk Daubner Mido Max Hijazi Jerry Hadi Juratli Susanne Weise Ilker Y. Ey üpoglu Gabriele Schackert Tareq A. Juratli Thomas Hummel Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1596: Robotic versus Laparoscopic Liver Resections for Colorectal Metastases: A Systematic Review and Meta-Analysis
urek
Lukasz Szarpak
Colorectal cancer is the third most common cancer worldwide, and the liver is the most common localization of metastatic disease. The incidence of minimally invasive liver surgery is increasing, and robotic surgery (RLR) is believed to overcome some limitations of a laparoscopic approach (LRL). We performed a systematic review and meta-analysis of operative and short-term oncologic outcomes of the laparoscopic versus robotic-assisted liver resection for colorectal liver metastases. An online search of PubMed, Embase, Scopus, and the Cochrane databases was performed. Eight studies involving 3210 pa...
Source: Cancers - April 22, 2024 Category: Cancer & Oncology Authors: Kamil Safiejko Michal Pedziwiatr Michal Pruc Radoslaw Tarkowski Marcin Juchimiuk Marian Domurat Jacek Smereka Khikmat Anvarov Przemyslaw Sielicki Krzysztof Kurek Lukasz Szarpak Tags: Systematic Review Source Type: research
Cancers, Vol. 16, Pages 1590: Unsaturated Fatty Acid Synthesis Is Associated with Worse Survival and Is Differentially Regulated by MYCN and Tumor Suppressor microRNAs in Neuroblastoma
John T. Powers
MYCN amplification (MNA) and disruption of tumor suppressor microRNA (TSmiR) function are key drivers of poor outcomes in neuroblastoma (NB). While MYCN and TSmiRs regulate glucose metabolism, their role in de novo fatty acid synthesis (FAS) and unsaturated FAS (UFAS) remains poorly understood. Here, we show that FAS and UFAS (U/FAS) genes FASN, ELOVL6, SCD, FADS2, and FADS1 are upregulated in high-risk (HR) NB and that their expression is associated with lower overall survival. RNA-Seq analysis of human NB cell lines revealed parallel U/FAS gene expression patterns. Consistent with this, we found tha...
Source: Cancers - April 21, 2024 Category: Cancer & Oncology Authors: Dennis A. Sheeter Secilia Garza Hui Gyu Park Lorraine-Rana E. Benhamou Niharika R. Badi Erika C. Espinosa Kumar S. D. Kothapalli J. Thomas Brenna John T. Powers Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1591: Effects of Tetrahydrolipstatin on Glioblastoma in Mice: MRI-Based Morphologic and Texture Analysis Correlated with Histopathology and Immunochemistry Findings & mdash;A Pilot Study
Conclusions: Orlistat showed effects on heterotopically implanted glioblastoma multiforme in MRI studies of mice based on morphologic and texture analysis. (Source: Cancers)
Source: Cancers - April 21, 2024 Category: Cancer & Oncology Authors: Sabine Wagner Christian Ewald Diana Freitag Karl-Heinz Herrmann Arend Koch Johannes Bauer Thomas J. Vogl Andr é Kemmling Hubert Gufler Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1592: Outcomes of Modified Mayo Stage IIIa and IIIb Cardiac Light-Chain Amyloidosis: Real-World Experience in Clinical Characteristics and Treatment & mdash;67 Patients Multicenter Analysis
Cancers, Vol. 16, Pages 1592: Outcomes of Modified Mayo Stage IIIa and IIIb Cardiac Light-Chain Amyloidosis: Real-World Experience in Clinical Characteristics and Treatment—67 Patients Multicenter Analysis
Cancers doi: 10.3390/cancers16081592
Authors:
Grzegorz Charliński
Maximilian Steinhardt
Leo Rasche
Veronica Gonzalez-Calle
Camila Peña
Harsh Parmar
Katarzyna Wiśniewska-Piąty
Julio Dávila Valls
Magdalena Olszewska-Szopa
Lidia Usnarska-Zubkiewicz
Alessandro Gozzetti
Sara Ciofini
Massimo Gentile
Elena Zamagni
Michał Kurlapski
Wojciech Legieć
David H. Vesole
Artur Jurcz...
Source: Cancers - April 21, 2024 Category: Cancer & Oncology Authors: Grzegorz Charli ński Maximilian Steinhardt Leo Rasche Veronica Gonzalez-Calle Camila Pe ña Harsh Parmar Katarzyna Wi śniewska-Piąty Julio D ávila Valls Magdalena Olszewska-Szopa Lidia Usnarska-Zubkiewicz Alessandro Gozzetti Sara Ciofini Massimo Genti Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1593: Upregulated Matrisomal Proteins and Extracellular Matrix Mechanosignaling Underlie Obesity-Associated Promotion of Pancreatic Ductal Adenocarcinoma
l
Stephen J. Pandol
Diet-induced obesity (DIO) promotes pancreatic ductal adenocarcinoma (PDAC) in mice expressing KRasG12D in the pancreas (KC mice), but the precise mechanisms remain unclear. Here, we performed multiplex quantitative proteomic and phosphoproteomic analysis by liquid chromatography–tandem mass spectrometry and further bioinformatic and spatial analysis of pancreas tissues from control-fed versus DIO KC mice after 3, 6, and 9 months. Normal pancreatic parenchyma and associated proteins were steadily eliminated and the novel proteins, phosphoproteins, and signaling pathways associated wi...
Source: Cancers - April 21, 2024 Category: Cancer & Oncology Authors: Richard T. Waldron Aurelia Lugea Hui-Hua Chang Hsin-Yuan Su Crystal Quiros Michael S. Lewis Mingtian Che V. Krishnan Ramanujan Enrique Rozengurt Guido Eibl Stephen J. Pandol Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1589: Targeted Nanoparticle-Based Diagnostic and Treatment Options for Pancreatic Cancer
nko
Pancreatic ductal adenocarcinoma (PDAC), one of the deadliest cancers, presents significant challenges in diagnosis and treatment due to its aggressive, metastatic nature and lack of early detection methods. A key obstacle in PDAC treatment is the highly complex tumor environment characterized by dense stroma surrounding the tumor, which hinders effective drug delivery. Nanotechnology can offer innovative solutions to these challenges, particularly in creating novel drug delivery systems for existing anticancer drugs for PDAC, such as gemcitabine and paclitaxel. By using customization methods such as incorporating ...
Source: Cancers - April 20, 2024 Category: Cancer & Oncology Authors: Xin Gu Tamara Minko Tags: Review Source Type: research
Cancers, Vol. 16, Pages 1577: National Experiences from 30 Years of Provider-Mediated Cascade Testing in Lynch Syndrome Families & mdash;The Danish Model
In conclusion, the Danish model combining family- and provider-mediated contact can increase the effect of cascade genetic testing. (Source: Cancers)
Source: Cancers - April 20, 2024 Category: Cancer & Oncology Authors: Lars Joachim Lindberg Karin A. W. Wadt Christina Therkildsen Helle Vendel Petersen Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1578: Breast Cancer Polygenic Risk Score Validation and Effects of Variable Imputation
. Ehli
Jouke-Jan Hottenga
Breast cancer (BC) is a complex disease affecting one in eight women in the USA. Advances in population genomics have led to the development of polygenic risk scores (PRSs) with the potential to augment current risk models, but replication is often limited. We evaluated 2 robust PRSs with 313 and 3820 SNPs and the effects of multiple genotype imputation replications in BC cases and control populations. Biological samples from BC cases and cancer-free controls were drawn from three European ancestry cohorts. Genotyping on the Illumina Global Screening Array was followed by stringent quality c...
Source: Cancers - April 20, 2024 Category: Cancer & Oncology Authors: Jeffrey J. Beck John L. Slunecka Brandon N. Johnson Austin J. Van Asselt Casey T. Finnicum Cheryl Ageton Amy Krie Heidi Nickles Kenneth Cowan Jessica Maxwell Dorret I. Boomsma Eco de Geus Erik A. Ehli Jouke-Jan Hottenga Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1579: High-Grade Glioma Recurrence Is Delayed in Hispanic Patients despite Severe Social Vulnerability: A Retrospective Cohort Study
Agarwal
High-grade gliomas (HGGs; WHO grade III or IV) are the most common and lethal brain malignancy. Patients of Hispanic ethnicity are diagnosed with HGGs earlier than non-Hispanic patients, but they exhibit improved HGG survival following diagnosis. Either environmental or biological factors could explain this survival benefit. We aimed to determine if post-diagnosis advantages would still be present in Hispanic patients with high social vulnerability, an environmental condition predisposing patients to poor oncologic outcomes. HGG outcomes were retrospectively assessed in a cohort of 22 Hispanic patients and 33 n...
Source: Cancers - April 20, 2024 Category: Cancer & Oncology Authors: Joshua A. Reynolds Isabella L. Pecorari Alexander Ledet Vijay Agarwal Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1580: T-Cell Engagers & mdash;The Structure and Functional Principle and Application in Hematological Malignancies
Cancers, Vol. 16, Pages 1580: T-Cell Engagers—The Structure and Functional Principle and Application in Hematological Malignancies
Cancers doi: 10.3390/cancers16081580
Authors:
Paweł Cech
Katarzyna Skórka
Laura Dziki
Krzysztof Giannopoulos
Recent advancements in cancer immunotherapy have made directing the cellular immune response onto cancer cells a promising strategy for the treatment of hematological malignancies. The introduction of monoclonal antibody-based (mAbs) targeted therapy has significantly improved the prognosis for hematological patients. Facing the issues of mAb-based therapies, a ...
Source: Cancers - April 20, 2024 Category: Cancer & Oncology Authors: Pawe ł Cech Katarzyna Sk órka Laura Dziki Krzysztof Giannopoulos Tags: Review Source Type: research
Cancers, Vol. 16, Pages 1581: Pain in Long-Term Cancer Survivors: Prevalence and Impact in a Cohort Composed Mostly of Breast Cancer Survivors
món Colomer
Cancer survival is becoming more common which means that there is now a growing population of cancer survivors, in whom pain may be common. However, its prevalence has hardly been addressed systematically. We aimed to assess the prevalence and explore the pathophysiology and impact of pain on health outcomes in cancer survivors. We conducted a retrospective–prospective cohort study in cancer-free patients diagnosed with cancer at least five years before the study start date. We used multivariable regression to establish the association of patients’ cancer characteristics with pa...
Source: Cancers - April 20, 2024 Category: Cancer & Oncology Authors: Concepci ón Pérez Dolores Ochoa Noelia S ánchez Ana Isabel Ballesteros Sheila Santidri án Isabel L ópez Rebeca Mond éjar Thiago Carnaval Jes ús Villoria Ram ón Colomer Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1582: Hepatocellular Carcinoma: Current Drug Therapeutic Status, Advances and Challenges
Wanjin Hong
Hepatocellular carcinoma (HCC) is the most common form of liver cancer, accounting for ~90% of liver neoplasms. It is the second leading cause of cancer-related deaths and the seventh most common cancer worldwide. Although there have been rapid developments in the treatment of HCC over the past decade, the incidence and mortality rates of HCC remain a challenge. With the widespread use of the hepatitis B vaccine and antiviral therapy, the etiology of HCC is shifting more toward metabolic-associated steatohepatitis (MASH). Early-stage HCC can be treated with potentially curative strategies such as surgical...
Source: Cancers - April 20, 2024 Category: Cancer & Oncology Authors: Shunzhen Zheng Siew Wee Chan Fei Liu Jun Liu Pierce Kah Hoe Chow Han Chong Toh Wanjin Hong Tags: Review Source Type: research
Cancers, Vol. 16, Pages 1583: Causes and Risk Factors of Breast Cancer, What Do We Know for Sure? An Evidence Synthesis of Systematic Reviews and Meta-Analyses
r Utne
Breast cancer affected more than 2.3 million women in 2022 and is the most diagnosed cancer among women worldwide. The incidence rates are greater in developed regions and are significantly higher among women with higher education and socioeconomic status. Therefore, it is reasonable to assume that the way women live their lives may impact their risk of being diagnosed with breast cancer. This systematic review aimed to identify what is known about the causes and risk factors of breast cancer, excluding genetic causes. A comprehensive systematic search identified 2387 systematic reviews, 122 were included and si...
Source: Cancers - April 20, 2024 Category: Cancer & Oncology Authors: Borghild L øyland Ida Hellum Sandbekken Ellen Karine Grov Inger Utne Tags: Systematic Review Source Type: research
