Cancers, Vol. 16, Pages 1266: The Use of CA-125 KELIM to Identify Which Patients Can Achieve Complete Cytoreduction after Neoadjuvant Chemotherapy in High-Grade Serous Advanced Ovarian Cancer
Conclusions: KELIM seems to safely triage patients after neoadjuvant chemotherapy and decide who will benefit from IDS. (Source: Cancers)
Source: Cancers - March 24, 2024 Category: Cancer & Oncology Authors: Dimitrios Zouzoulas Dimitrios Tsolakidis Panagiotis Tzitzis Iliana Sofianou Kimon Chatzistamatiou Vasilis Theodoulidis Maria Topalidou Eleni Timotheadou Grigoris Grimbizis Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1265: A Biopsy-Controlled Prospective Study of Contrast-Enhancing Diffuse Glioma Infiltration Based on FET-PET and FLAIR
kowski
Accurately defining glioma infiltration is crucial for optimizing radiotherapy and surgery, but glioma infiltration is heterogeneous and MRI imperfectly defines the tumor extent. Currently, it is impossible to determine the tumor infiltration gradient within a FLAIR signal. O-(2-[18F]fluoroethyl)-L-tyrosine (FET)-PET often reveals high-grade glioma infiltration beyond contrast-enhancing areas on MRI. Here, we studied FET uptake dynamics in tumor and normal brain structures by dual-timepoint (10 min and 40–60 min post-injection) acquisition to optimize analysis protocols for defining glioma infiltra...
Source: Cancers - March 24, 2024 Category: Cancer & Oncology Authors: Maciej Harat Izabela Miechowicz J ózefina Rakowska Izabela Zar ębska Bogdan Ma łkowski Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1267: Anti-Proliferative Effects of Lidocaine as an Autophagy Inducer in Bladder Cancer via Intravesical Instillation: In Vitro and Xenograft Mouse Model Experiments
young Hwa Kim
Lidocaine exerts potential anti-tumor effects on various cancer cell lines, and its intravesical instillation is considered safer than intravenous administration for bladder cancer. However, the mechanisms underlying its anti-tumor effects have not been fully elucidated. Here, we aimed to elucidate the anti-tumor molecular mechanisms of lidocaine in bladder cancer cells and a xenograft model to substantiate the efficacy of its intravesical administration. We investigated the anti-proliferative and autophagyinducing activities of lidocaine in Nara Bladder Tumor No. 2 (NBT-II) rat bladder carcinoma cells us...
Source: Cancers - March 24, 2024 Category: Cancer & Oncology Authors: Young Chul Yoo Na-Young Kim Seokyung Shin Yunil Yang Ji Hae Jun Ju Eun Oh Myoung Hwa Kim Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1268: Racial Differences in the Detection Rate of Bladder Cancer Using Blue Light Cystoscopy: Insights from a Multicenter Registry
rk D. Tyson
Yair Lotan
Siamak Daneshmand
the Blue Light Cystoscopy with Cysview Registry Group the Blue Light Cystoscopy with Cysview Registry Group
The use of blue light cystoscopy (BLC) has been shown to improve bladder tumor detection. However, data demonstrating the efficacy of BLC across different races are limited. Herein, we aim to evaluate heterogeneity in the characteristics of BLC for the detection of malignant lesions among various races. Clinicopathologic information was collected from patients enrolled in the multi-institutional Cysview® registry (2014–2021) who underwent tr...
Source: Cancers - March 24, 2024 Category: Cancer & Oncology Authors: Seyedeh-Sanam Ladi-Seyedian Alireza Ghoreifi Badrinath Konety Kamal Pohar Jeffrey M. Holzbeierlein John Taylor Max Kates Brian Willard Jennifer M. Taylor Joseph C. Liao Hristos Z. Kaimakliotis Sima P. Porten Gary D. Steinberg Mark D. Tyson Yair Lotan Siam Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1269: Sperm-Associated Antigen 5 Knockout Reduces Doxorubicin and Docetaxel Resistance in Triple-Negative Breast Cancer MDA-MB-231 and BT549 Cells
In conclusion, recombinant plasmid-based CRISPR-Cas9 technology can be used to delete the SPAG5 gene in the TNBC cell lines. SPAG5 has an important role in regulating cell proliferation and doxorubicin- and docetaxel-resistance in MDA-MB-231 and BT549 cells. (Source: Cancers)
Source: Cancers - March 24, 2024 Category: Cancer & Oncology Authors: Ji He Jiawei Li Yanbiao Liu Yan Li Tags: Article Source Type: research
