Cancers, Vol. 16, Pages 1309: Improving Quality of Life and Psychosocial Health for Penile Cancer Survivors: A Narrative Review
Chipollini Treatment of penile cancer (PC) focuses on organ preservation, employing various surgical and non-surgical approaches. These interventions may lead to disfigurement, impacting patients’ functional outcomes and psychosocial well-being. We reviewed studies related to penile health and PC up to February 2024, limited to studies published in English. Studies employing health-related quality of life (HRQoL) assessments have identified a detrimental association between aggressive treatment and overall health status, physical functioning, and relationships. In contrast, organ-sparing demonstrates impr...
Source: Cancers - March 28, 2024 Category: Cancer & Oncology Authors: Von Marie Torres Irizarry Irasema Concepcion Paster Vanessa Ogbuji D ’Andre Marquez Gomez Kyle Mccormick Juan Chipollini Tags: Review Source Type: research

Cancers, Vol. 16, Pages 1310: Autoimmune Atrophic Gastritis: A Clinical Review
In conclusion, atrophic autoimmune gastritis is an infrequent condition, often asymptomatic and misdiagnosed, that requires an early diagnosis for appropriate vitamin supplementation and endoscopic follow-up for the early diagnosis of NETs and gastric cancer. (Source: Cancers)
Source: Cancers - March 28, 2024 Category: Cancer & Oncology Authors: Chiara Castellana Leonardo Henry Eusebi Elton Dajti Veronica Iascone Amanda Vestito Pietro Fusaroli Lorenzo Fuccio Antonietta D ’Errico Rocco Maurizio Zagari Tags: Review Source Type: research

Cancers, Vol. 16, Pages 1311: Synergistic Effects of the RARalpha Agonist Tamibarotene and the Menin Inhibitor Revumenib in Acute Myeloid Leukemia Cells with KMT2A Rearrangement or NPM1 Mutation
In this study, the combination of revumenib and tamibarotene was investigated in various KMT2Ar or NPM1c AML cell lines and patient-derived blasts, focusing on the potential synergistic induction of differentiation or apoptosis. Both effects were analyzed by flow cytometry and validated by Western blot analysis. Synergy calculations were performed using viability assays. Regulation of the relevant key mediators for the MLL complex were quantified by RT-qPCR. In MV4:11 cells characterized by the highest relative mRNA levels of RARA, highly synergistic induction of apoptosis is demonstrated upon combination treatment. Induct...
Source: Cancers - March 28, 2024 Category: Cancer & Oncology Authors: Maximilian Fleischmann Julia Bechwar Diana Voigtl änder Mike Fischer Ulf Schnetzke Andreas Hochhaus Sebastian Scholl Tags: Article Source Type: research

Cancers, Vol. 16, Pages 1312: The Role of Natural Killer Cells in the Tumor Immune Microenvironment of EBV-Associated Nasopharyngeal Carcinoma
Lai-Wan Kwong Endemic nasopharyngeal carcinoma (NPC) is closely associated with the Epstein–Barr virus (EBV), which contributes to tumor development and influences the tumor immune microenvironment (TIME) in NPC. Natural killer (NK) cells, as part of the innate immune system, play a crucial role in responding to viral infections and malignant cell transformations. Notably, NK cells possess a unique ability to target tumor cells independent of major histocompatibility complex class I (MHC I) expression. This means that MHC I-deficient tumor cells, which can escape from effective T cell attack, are suscepti...
Source: Cancers - March 28, 2024 Category: Cancer & Oncology Authors: Shuzhan Li Wei Dai Ngar-Woon Kam Jiali Zhang Victor H. F. Lee Xiubao Ren Dora Lai-Wan Kwong Tags: Review Source Type: research

Cancers, Vol. 16, Pages 1304: Salvage Androgen Deprivation Therapy as Potential Treatment for Recurrence after Robot-Assisted Radical Prostatectomy
Conclusions: Salvage intermittent ADT may be an effective treatment option for BCR after RARP. In addition, it would be useful to confirm strong testosterone suppression as a criterion for transition to intermittent therapy. (Source: Cancers)
Source: Cancers - March 27, 2024 Category: Cancer & Oncology Authors: Hiroshi Kano Yoshifumi Kadono Renato Naito Tomoyuki Makino Hiroaki Iwamoto Hiroshi Yaegashi Shohei Kawaguchi Takahiro Nohara Kazuyoshi Shigehara Kouji Izumi Atsushi Mizokami Tags: Article Source Type: research

Cancers, Vol. 16, Pages 1305: Distinct Prostate Cancer Survival Outcomes in Firefighters: A Population-Based Study
Conclusion: Firefighters experience enhanced prostate cancer survival, primarily in cases diagnosed at localized stages, likely due to increased PSA testing. Nonetheless, for regional or distant stage, survival among older firefighters’ lags behind that of the general population. Further investigations are warranted to unravel factors influencing the development of aggressive disease beyond PSA and Gleason scores in this population, as well as to assess the impact of a higher rate of surgical treatment on firefighters’ quality of life. (Source: Cancers)
Source: Cancers - March 27, 2024 Category: Cancer & Oncology Authors: Paulo S. Pinheiro Tulay Koru-Sengul Wei Zhao Diana R. Hernandez Monique N. Hernandez Erin N. Kobetz Alberto J. Caban-Martinez David J. Lee Tags: Article Source Type: research

Cancers, Vol. 16, Pages 1306: Prognostic Importance of Axillary Lymph Node Response to Neoadjuvant Systemic Therapy on Axillary Surgery in Breast Cancer & mdash;A Single Center Experience
In conclusion, in node-positive patients with HER2+ and TN subtypes, who achieved breast-pCR after NST, de-escalation of axillary surgery could be considered in most cases. (Source: Cancers)
Source: Cancers - March 27, 2024 Category: Cancer & Oncology Authors: Cvetka Gra šič Kuhar James Geiger Fabienne Dominique Schwab Viola Heinzelmann-Schwartz Marcus Vetter Walter Paul Weber Christian Kurzeder Tags: Article Source Type: research

Cancers, Vol. 16, Pages 1307: Large Granular Lymphocytic Leukemia: Clinical Features, Molecular Pathogenesis, Diagnosis and Treatment
. Mustafa Ali Large granular lymphocytic (LGL) leukemia is a lymphoproliferative disorder characterized by persistent clonal expansion of mature T- or natural killer cells in the blood via chronic antigenic stimulation. LGL leukemia is associated with specific immunophenotypic and molecular features, particularly STAT3 and STAT5 mutations and activation of the JAK-STAT3, Fas/Fas-L and NF-κB signaling pathways. Disease-related deaths are mainly due to recurrent infections linked to severe neutropenia. The current treatment is based on immunosuppressive therapies, which frequently produce unsatisfactory lon...
Source: Cancers - March 27, 2024 Category: Cancer & Oncology Authors: Fauzia Ullah Mariam Markouli Mark Orland Olisaemeka Ogbue Danai Dima Najiullah Omar Moaath K. Mustafa Ali Tags: Review Source Type: research

Cancers, Vol. 16, Pages 1308: Sex-Based Differences in Melanoma Survival Improvement from 2004 to 2018
Conclusion: Overall, melanoma survival has improved in recent years, though some patient subgroups have experienced a lower improvement in survival from 2004 to 2018. (Source: Cancers)
Source: Cancers - March 27, 2024 Category: Cancer & Oncology Authors: Shaw Hudock Zhang Amos Cheng Tags: Article Source Type: research

Cancers, Vol. 16, Pages 1292: Non-Surgical Bladder-Sparing Multimodal Management in Organ-Confined Urothelial Carcinoma of the Urinary Bladder: A Population-Based Analysis
Conclusions: Strict trimodal therapy that includes both CT and RT after TURBT offers the best cancer control. When strict trimodal therapy cannot be delivered, cancer-specific survival outcomes appear to be superior with TURBT + chemotherapy compared to TURBT + RT. (Source: Cancers)
Source: Cancers - March 27, 2024 Category: Cancer & Oncology Authors: Mario de Angelis Andrea Baudo Carolin Siech Letizia Maria Ippolita Jannello Francesco Di Bello Jordan A. Goyal Zhe Tian Nicola Longo Ottavio de Cobelli Felix K. H. Chun Fred Saad Shahrokh F. Shariat Luca Carmignani Giorgio Gandaglia Marco Moschini Frances Tags: Article Source Type: research

Cancers, Vol. 16, Pages 1294: End-of-Life Symptom Burden among Patients with Cancer Who Were Provided Medical Assistance in Dying (MAID): A Longitudinal Propensity-Score-Matched Cohort Study
Bultz Fiona Schulte Cancer is the primary underlying condition for most Canadians who are provided Medical Assistance in Dying (MAID). However, it is unknown whether cancer patients who are provided MAID experience disproportionally higher symptom burden compared to those who are not provided MAID. Thus, we used a propensity-score-matched cohort design to evaluate longitudinal symptom trajectories over the last 12 months of patients’ lives, comparing cancer patients in Alberta who were and were not provided MAID. We utilized routinely collected retrospective Patient-Reported Outcomes (PROs) data from th...
Source: Cancers - March 27, 2024 Category: Cancer & Oncology Authors: K. Brooke Russell Caitlin Forbes Siwei Qi Claire Link Linda Watson Andrea Deiure Shuang Lu James Silvius Brian Kelly Barry D. Bultz Fiona Schulte Tags: Article Source Type: research

Cancers, Vol. 16, Pages 1295: Electrochemotherapy in Kaposi & rsquo;s Sarcoma Patients: From the Gold Standard Strategy to Locally Advanced Cutaneous and Subcutaneous Lesions
Cancers, Vol. 16, Pages 1295: Electrochemotherapy in Kaposi’s Sarcoma Patients: From the Gold Standard Strategy to Locally Advanced Cutaneous and Subcutaneous Lesions Cancers doi: 10.3390/cancers16071295 Authors: Vincenzo Rullo Francesco Castellaneta Santolo D’Antonio Anna De Rosa Michele Pio Grieco Tommaso Fabrizio Electrochemotherapy (ECT) is one of the newest therapeutic strategies employed as a medical procedure for skin neoplasms’ treatment, especially for classic Kaposi’s sarcoma (CKS). The aim of this study was to demonstrate ECT clinical response and the loc...
Source: Cancers - March 27, 2024 Category: Cancer & Oncology Authors: Vincenzo Rullo Francesco Castellaneta Santolo D ’Antonio Anna De Rosa Michele Pio Grieco Tommaso Fabrizio Tags: Article Source Type: research

Cancers, Vol. 16, Pages 1293: Impact of Thrombocytopenia on Survival in Patients with Hepatocellular Carcinoma: Updated Meta-Analysis and Systematic Review
Conclusion: Our meta-analysis confirmed that PLT count could act as a prognostic marker in HCC, especially with a PLT count cut off <100 × 103/mm3. Further prospective studies focusing on the role of PLT in clearly defined subgroups are necessary. (Source: Cancers)
Source: Cancers - March 27, 2024 Category: Cancer & Oncology Authors: Leszek Kraj Paulina Chmiel Maciej Gryziak Laretta Grabowska-Derlatka Łukasz Szymański Ewa Wysoki ńska Tags: Systematic Review Source Type: research

Cancers, Vol. 16, Pages 1296: Association of Insulin-like Growth Factor-1 with Bone Mineral Density in Survivors of Childhood Acute Leukemia
In this study, we investigated bone mineral deficits in children who survived childhood acute leukemia and explored the association between the insulin-like growth factor-1 (IGF-1) level and bone mineral density (BMD). This retrospective analysis enrolled 214 patients treated for acute leukemia, measuring various factors including height, weight, body mass index (BMI), and lumbar spine BMD after the end of treatment. The study found an overall prevalence of low BMD in 15% of participants. Notably, IGF-1 levels were significantly different between patients with low BMD and those with normal BMD, and correlation analyses rev...
Source: Cancers - March 27, 2024 Category: Cancer & Oncology Authors: Seulki Kim Jae Won Yoo Jae Wook Lee Min Ho Jung Bin Cho Byng-Kyu Suh Moon Bae Ahn Nack-Gyun Chung Tags: Article Source Type: research

Cancers, Vol. 16, Pages 1297: Causes of Childhood Cancer: A Review of the Recent Literature: Part I & mdash;Childhood Factors
Cancers, Vol. 16, Pages 1297: Causes of Childhood Cancer: A Review of the Recent Literature: Part I—Childhood Factors Cancers doi: 10.3390/cancers16071297 Authors: Angela M. Ricci Rebecca T. Emeny Pamela J. Bagley Heather B. Blunt Mary E. Butow Alexandra Morgan Jennifer A. Alford-Teaster Linda Titus Raymond R. Walston Judy R. Rees Purpose: To review the childhood risk factors for pediatric cancer (diagnosis before age 20). Methods: We conducted literature searches using Ovid Medline and Scopus to find primary research studies, review articles, and meta-analyses published from 2014 to 3 M...
Source: Cancers - March 27, 2024 Category: Cancer & Oncology Authors: Angela M. Ricci Rebecca T. Emeny Pamela J. Bagley Heather B. Blunt Mary E. Butow Alexandra Morgan Jennifer A. Alford-Teaster Linda Titus Raymond R. Walston Judy R. Rees Tags: Review Source Type: research