Cancers, Vol. 16, Pages 1342: NDRGs in Breast Cancer: A Review and In Silico Analysis
Debeb
The N-myc downstream regulated gene family (NDRGs) includes four members: NDRG1, NDRG2, NDRG3, and NDRG4. These members exhibit 53–65% amino acid identity. The role of NDRGs in tumor growth and metastasis appears to be tumor- and context-dependent. While many studies have reported that these family members have tumor suppressive roles, recent studies have demonstrated that NDRGs, particularly NDRG1 and NDRG2, function as oncogenes, promoting tumor growth and metastasis. Additionally, NDRGs are involved in regulating different signaling pathways and exhibit diverse cellular functions in breast cancer...
Source: Cancers - March 29, 2024 Category: Cancer & Oncology Authors: Emilly S. Villodre Anh P. N. Nguyen Bisrat G. Debeb Tags: Review Source Type: research
Cancers, Vol. 16, Pages 1343: Differential Competitive Growth of Transgenic Subclones of Neuroblastoma Cells Expressing Different Levels of Cathepsin D Co-Cultured in 2D and 3D in Response to EGF: Implications in Tumor Heterogeneity and Metastasis
si
Ciro Isidoro
Neuroblastoma (NB) is an embryonal tumor arising from the sympathetic central nervous system. The epidermal growth factor (EGF) plays a role in NB growth and metastatic behavior. Recently, we have demonstrated that cathepsin D (CD) contrasts EGF-induced NB cell growth in 2D by downregulating EGFR/MAPK signaling. Aggressive NB is highly metastatic to the bone and the brain. In the metastatic process, adherent cells detach to form clusters of suspended cells that adhere once they reach the metastatic site and form secondary colonies. Whether CD is involved in the survival of metastatic NB clones is not ...
Source: Cancers - March 29, 2024 Category: Cancer & Oncology Authors: Eleonora Secomandi Andrea Esposito Giulia Camurani Chiara Vidoni Amreen Salwa Chiara Lualdi Letizia Vallino Alessandra Ferraresi Ciro Isidoro Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1344: The Therapeutic Efficacy and Mechanism of Action of Gnetin C, a Natural Compound from the Melinjo Plant, in a Preclinical Mouse Model of Advanced Prostate Cancer
In this study, we employed a prostate-specific transgenic mouse model with MTA1 overexpression on the background of phosphatase and tensin homolog (Pten) null (R26MTA1; Ptenf/f) and PC3M prostate cancer cells which recapitulate altered molecular pathways in advanced prostate cancer. Mechanistically, the MTA1 knockdown or pharmacological inhibition of MTA1 by gnetin C (dimer resveratrol) in cultured PC3M cells resulted in the marked inactivation of mammalian target of rapamycin (mTOR) signaling. In vivo, mice tolerated a daily intraperitoneal treatment of gnetin C (7 mg/kg bw) for 12 weeks without any sign of toxicity. Trea...
Source: Cancers - March 29, 2024 Category: Cancer & Oncology Authors: Gisella Campanelli Ekniel Francois Prashanth Parupathi Lakshmi Sirisha Devarakonda Ching Yang Avinash Kumar Anait S. Levenson Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1345: Evaluating Radar Reflector Localisation in Targeted Axillary Dissection in Patients Undergoing Neoadjuvant Systemic Therapy for Node-Positive Early Breast Cancer: A Systematic Review and Pooled Analysis
Mokbel
SAVI SCOUT® or radar reflector localisation (RRL) has proven accurate in localising non-palpable breast and axillary lesions, with minimal interference with MRI. Targeted axillary dissection (TAD), combining marked lymph node biopsy (MLNB) and sentinel lymph node biopsy (SLNB), is becoming a standard post-neoadjuvant systemic therapy (NST) for node-positive early breast cancer. Compared to SLNB alone, TAD reduces the false negative rate (FNR) to below 6%, enabling safer axillary surgery de-escalation. This systematic review evaluates RRL’s performance during TAD, assessing localisation...
Source: Cancers - March 29, 2024 Category: Cancer & Oncology Authors: Umar Wazir Michael J. Michell Munaser Alamoodi Kefah Mokbel Tags: Systematic Review Source Type: research
Cancers, Vol. 16, Pages 1346: Risk-Tailoring Radiotherapy for Endometrial Cancer: A Narrative Review
In conclusion, this review summarizes ongoing research that aims to further individualize radiotherapy regimens for individuals in an attempt to improve patient outcomes. (Source: Cancers)
Source: Cancers - March 29, 2024 Category: Cancer & Oncology Authors: Kristin Hsieh Julie R. Bloom Daniel R. Dickstein Anuja Shah Catherine Yu Anthony D. Nehlsen Lucas Resende Salgado Vishal Gupta Manjeet Chadha Kunal K. Sindhu Tags: Review Source Type: research
Cancers, Vol. 16, Pages 1347: Targeted DNA Sequencing of Cutaneous Melanoma Identifies Prognostic and Predictive Alterations
Conclusions: NRAS mutation in CMs correlated with significantly worse overall survival. Elevated TMB was associated with increased progression-free survival for patients treated with a combination of dual ICI, supporting the potential utility of TMB as a predictive biomarker for ICI response in melanoma. (Source: Cancers)
Source: Cancers - March 29, 2024 Category: Cancer & Oncology Authors: Alexandra M. Haugh Robert C. Osorio Rony A. Francois Michael E. Tawil Katy K. Tsai Michael Tetzlaff Adil Daud Harish N. Vasudevan Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1348: Sunglasses for Sunlight: Considerations on New Treatment Opportunities for Refractory Colorectal Cancer
i
In 2023, two seminal studies were disseminated that significantly augmented the pharmacological armamentarium for the treatment of refractory metastatic colorectal carcinoma (MCRC) [...] (Source: Cancers)
Source: Cancers - March 29, 2024 Category: Cancer & Oncology Authors: Alberto Zaniboni Tags: Editorial Source Type: research
Cancers, Vol. 16, Pages 1349: Effects of Peptide Receptor Radiotherapy in Patients with Advanced Paraganglioma and Pheochromocytoma: A Nation-Wide Cohort Study
Conclusions: The median OS of around 6 years and median PFS of around 2.5 years found in this study are comparable to those reported in previous studies employing PRRT. Based on historical data, the efficacy of PRRT may be superior to 131I-MIBG therapy, and targeted therapy with sunitinib and PRRT might therefore be considered as first-line treatment in this patient group. (Source: Cancers)
Source: Cancers - March 29, 2024 Category: Cancer & Oncology Authors: Linda Skibsted Kornerup Mikkel Andreassen Ulrich Knigge Anne Kirstine Arveschoug Per L øgstup Poulsen Andreas Kj ær Peter Sandor Oturai Henning Gr ønbæk Gitte Dam Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1350: Identification of Interpretable Clusters and Associated Signatures in Breast Cancer Single-Cell Data: A Topic Modeling Approach
rtignetti
Topic modeling is a popular technique in machine learning and natural language processing, where a corpus of text documents is classified into themes or topics using word frequency analysis. This approach has proven successful in various biological data analysis applications, such as predicting cancer subtypes with high accuracy and identifying genes, enhancers, and stable cell types simultaneously from sparse single-cell epigenomics data. The advantage of using a topic model is that it not only serves as a clustering algorithm, but it can also explain clustering results by providing word probability distribu...
Source: Cancers - March 29, 2024 Category: Cancer & Oncology Authors: Gabriele Malagoli Filippo Valle Emmanuel Barillot Michele Caselle Loredana Martignetti Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1351: History of Developing Acute Promyelocytic Leukemia Treatment and Role of Promyelocytic Leukemia Bodies
é
The story of acute promyelocytic leukemia (APL) discovery, physiopathology, and treatment is a unique journey, transforming the most aggressive form of leukemia to the most curable. It followed an empirical route fueled by clinical breakthroughs driving major advances in biochemistry and cell biology, including the discovery of PML nuclear bodies (PML NBs) and their central role in APL physiopathology. Beyond APL, PML NBs have emerged as key players in a wide variety of biological functions, including tumor-suppression and SUMO-initiated protein degradation, underscoring their broad importance. The APL story is an e...
Source: Cancers - March 29, 2024 Category: Cancer & Oncology Authors: Pierre Bercier Hugues de Th é Tags: Review Source Type: research
Cancers, Vol. 16, Pages 1352: Association between Head and Neck Cancer and Increased Risk of Ischemic Heart Disease: A Retrospective Cohort Study Using National Population Data
u Kim
Although cancer and ischemic heart disease (IHD) frequently manifest in the same individual, the risk of IHD events in cancer, especially head and neck cancer (HNC), remains unclear. We aimed to examine the incidence and risk of IHD events in patients with HNC using a population-based cohort dataset in South Korea (2002–2013). Through rigorous propensity score matching, we compared data from 2816 individuals without HNC and 704 individuals with HNC. Key independent variables were matched between groups, and the Charlson Comorbidity Index was used to match comorbidities. The Kaplan–Meie...
Source: Cancers - March 29, 2024 Category: Cancer & Oncology Authors: Chulho Kim Hyunjae Yu Dong-Kyu Kim Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1353: The Use of Natural Language Processing Elements for Computer-Aided Diagnostics and Monitoring of Body Image Perception in Enterally Fed Patients with Head and Neck or Upper Gastrointestinal Tract Cancers
Conclusion: In conclusion, our study demonstrates the potential utility of integrating natural language processing (NLP) elements into psycho-oncological care for patients with head–neck or upper gastrointestinal tract cancers. The developed method offers a novel approach to comprehensively assessing patients’ emotional states and areas of difficulty, thereby facilitating tailored interventions and treatment planning. These findings underscore the importance of continued research and innovation in psycho-oncology to enhance patient care and outcomes. (Source: Cancers)
Source: Cancers - March 29, 2024 Category: Cancer & Oncology Authors: Agnieszka R óżańska Elwira Gliwska Klaudia Bara ńska Stella Ma ćkowska Adrianna Sobol Dominik Spinczyk Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1354: Transcription Factors and Markers Related to Epithelial & ndash;Mesenchymal Transition and Their Role in Resistance to Therapies in Head and Neck Cancers
Cancers, Vol. 16, Pages 1354: Transcription Factors and Markers Related to Epithelial–Mesenchymal Transition and Their Role in Resistance to Therapies in Head and Neck Cancers
Cancers doi: 10.3390/cancers16071354
Authors:
Marta Pawlicka
Ewelina Gumbarewicz
Ewa Błaszczak
Andrzej Stepulak
Head and neck cancers (HNCs) are heterogeneous and aggressive tumors of the upper aerodigestive tract. Although various histological types exist, the most common is squamous cell carcinoma (HNSCC). The incidence of HNSCC is increasing, making it an important public health concern. Tumor resistance to contemporary tr...
Source: Cancers - March 29, 2024 Category: Cancer & Oncology Authors: Marta Pawlicka Ewelina Gumbarewicz Ewa B łaszczak Andrzej Stepulak Tags: Review Source Type: research
Cancers, Vol. 16, Pages 1355: Functional Classification of Fusion Proteins in Sarcoma
äfer
Sarcomas comprise a heterogeneous group of malignant tumors of mesenchymal origin. More than 80 entities are associated with different mesenchymal lineages. Sarcomas with fibroblastic, muscle, bone, vascular, adipocytic, and other characteristics are distinguished. Nearly half of all entities contain specific chromosomal translocations that give rise to fusion proteins. These are mostly pathognomonic, and their detection by various molecular techniques supports histopathologic classification. Moreover, the fusion proteins act as oncogenic drivers, and their blockade represents a promising therapeutic approach. Th...
Source: Cancers - March 29, 2024 Category: Cancer & Oncology Authors: Marco Wachtel Didier Surdez Thomas G. P. Gr ünewald Beat W. Sch äfer Tags: Review Source Type: research
Cancers, Vol. 16, Pages 1356: PD-L1 Expression in High-Risk Non-Muscle-Invasive Bladder Cancer Is Influenced by Intravesical Bacillus Calmette & ndash;Gu & eacute;rin (BCG) Therapy
Cancers, Vol. 16, Pages 1356: PD-L1 Expression in High-Risk Non-Muscle-Invasive Bladder Cancer Is Influenced by Intravesical Bacillus Calmette–Guérin (BCG) Therapy
Cancers doi: 10.3390/cancers16071356
Authors:
Moritz Maas
Andreas Hilsendecker
Alexandra Pertoll
Viktoria Stühler
Simon Walz
Steffen Rausch
Arnulf Stenzl
Igor Tsaur
Jörg Hennenlotter
Stefan Aufderklamm
In the expanding landscape of immune checkpoint inhibitors (CPI) in high-risk (HR) non-muscle-invasive bladder cancer (NMIBC), the role of programmed death ligand 1 (PD-L1) as prognostic and predictive is increasing...
Source: Cancers - March 29, 2024 Category: Cancer & Oncology Authors: Moritz Maas Andreas Hilsendecker Alexandra Pertoll Viktoria St ühler Simon Walz Steffen Rausch Arnulf Stenzl Igor Tsaur J örg Hennenlotter Stefan Aufderklamm Tags: Article Source Type: research
