Cancers, Vol. 16, Pages 1414: Real-World Data and Evidence in Lung Cancer: A Review of Recent Developments
s Gkiozos
Conventional cancer clinical trials can be time-consuming and expensive, often yielding results with limited applicability to real-world scenarios and presenting challenges for patient participation. Real-world data (RWD) studies offer a promising solution to address evidence gaps and provide essential information about the effects of cancer treatments in real-world settings. The distinction between RWD and data derived from randomized clinical trials lies in the method of data collection, as RWD by definition are obtained at the point of care. Experimental designs resembling those used in traditional clinica...
Source: Cancers - April 4, 2024 Category: Cancer & Oncology Authors: Eleni Kokkotou Maximilian Anagnostakis Georgios Evangelou Nikolaos K. Syrigos Ioannis Gkiozos Tags: Review Source Type: research
Cancers, Vol. 16, Pages 1415: Extracellular Vesicle-Related Non-Coding RNAs in Hepatocellular Carcinoma: An Overview
Cusimano
Hepatocellular carcinoma (HCC) is the most common primary liver cancer. It is a major public health problem worldwide, and it is often diagnosed at advanced stages, when no effective treatment options are available. Extracellular vesicles (EVs) are nanosized double-layer lipid vesicles containing various biomolecule cargoes, such as lipids, proteins, and nucleic acids. EVs are released from nearly all types of cells and have been shown to play an important role in cell-to-cell communication. In recent years, many studies have investigated the role of EVs in cancer, including HCC. Emerging studies have shown th...
Source: Cancers - April 4, 2024 Category: Cancer & Oncology Authors: Augello Cusimano Cervello Cusimano Tags: Review Source Type: research
Cancers, Vol. 16, Pages 1411: Prognostic Value of PCSK9 Levels in Premenopausal Women at Risk of Breast Cancer & mdash;Evidence from a 17-Year Follow-Up Study
Conclusions: In premenopausal women at risk of early-stage breast cancer, PCSK9 did not appear to have a role as a prognostic biomarker of breast neoplastic events. Larger studies are warranted investigating patients in different settings. (Source: Cancers)
Source: Cancers - April 4, 2024 Category: Cancer & Oncology Authors: Massimiliano Ruscica Chiara Macchi Sara Gandini Debora Macis Aliana Guerrieri-Gonzaga Valentina Aristarco Davide Serrano Matteo Lazzeroni Alessandra Stefania Rizzuto Aurora Gaeta Alberto Corsini Marcella Gulisano Harriet Johansson Bernardo Bonanni Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1412: Review of the Use of Medicinal Cannabis Products in Palliative Care
nco
In this review, we discuss the potential role of cannabis and cannabinoids in the management of cancer-related symptoms. There is limited evidence demonstrating the effectiveness of cannabis-based products in treating cancer-related pain and gastrointestinal symptoms such as nausea, vomiting, and loss of appetite. Regarding the role of cannabis-based products in the treatment of insomnia and mood disorders, most studies looked at these symptoms as secondary outcomes with mixed results. Cannabis-based products have adverse effects, ranging from neuropsychiatric to systemic effects to potential drug interactions. (Source: Cancers)
Source: Cancers - April 4, 2024 Category: Cancer & Oncology Authors: James Troyer Kimberson Tanco Tags: Review Source Type: research
Cancers, Vol. 16, Pages 1406: Progress in Biological Research and Treatment of Pseudomyxoma Peritonei
ei Wu
Pseudomyxoma peritonei (PMP) is a rare disease characterized by extensive peritoneal implantation and mass secretion of mucus after primary mucinous tumors of the appendix or other organ ruptures. Cytoreductive surgery (CRS) combined with hyperthermic intraperitoneal chemotherapy (HIPEC) is currently the preferred treatment, with excellent efficacy and safety, and is associated with breakthrough progress in long-term disease control and prolonged survival. However, the high recurrence rate of PMP is the key challenge in its treatment, which limits the clinical application of multiple rounds of CRS-HIPEC and does ...
Source: Cancers - April 3, 2024 Category: Cancer & Oncology Authors: Xi Li Guodong Liu Wei Wu Tags: Review Source Type: research
Cancers, Vol. 16, Pages 1407: Further Clarification of Pain Management Complexity in Radiotherapy: Insights from Modern Statistical Approaches
Conclusions: The study underscores the dynamic nature of pain management during RT, suggesting improvements over the treatment course yet revealing specific challenges in non-cancer pain management, particularly among younger breast cancer patients. The use of advanced statistical techniques for analysis stresses the importance of a multifaceted approach to pain management, one that incorporates both cancer and non-cancer pain considerations to ensure a holistic and improved quality of oncological care. (Source: Cancers)
Source: Cancers - April 3, 2024 Category: Cancer & Oncology Authors: Costanza Maria Donati Erika Galietta Francesco Cellini Alessia Di Rito Maurizio Portaluri Cristina De Tommaso Anna Santacaterina Consuelo Tamburella Filippo Mammini Rossella Di Franco Salvatore Parisi Sabrina Cossa Antonella Bianculli Pierpaolo Ziccarelli Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1408: Colorectal Cancer Pulmonary Metastasectomy: When, Why and How
Tuoro
Diego Cortinovis
Colorectal cancer is the third-most-diagnosed cancer in males and in females, representing 8% of estimated new cases, and the third cause of cancer-related death in both sexes, accounting for 9% of cancer deaths in men and 8% in women. About 20% of patients diagnosed with CRC present metastatic disease. Although lung metachronous or synchronous metastatic spread without other involved sites has been reported in only a small proportion of patients, considering that this tumor is frequently diagnosed, the clinical approach to CRC pulmonary metastases represents a major issue for thoracic surgeon...
Source: Cancers - April 3, 2024 Category: Cancer & Oncology Authors: Francesco Petrella Federica Danuzzo Maria Chiara Sibilia Sara Vaquer Raffaella Longarini Alessandro Guidi Federico Raveglia Lidia Libretti Emanuele Pirondini Andrea Cara Enrico Mario Cassina Antonio Tuoro Diego Cortinovis Tags: Review Source Type: research
Cancers, Vol. 16, Pages 1409: Clinical Outcome of Nivolumab plus Ipilimumab in Patients with Locally Advanced Non-Small-Cell Lung Cancer with Relapse after Concurrent Chemoradiotherapy followed by Durvalumab
This study suggests that nivolumab plus ipilimumab is effective, especially in patients who have received durvalumab for 6 months or more, and tolerable for patients who relapsed after durvalumab following CCRT. (Source: Cancers)
Source: Cancers - April 3, 2024 Category: Cancer & Oncology Authors: Atsuto Mouri Satoshi Watanabe Takaaki Tokito Yoshiaki Nagai Yu Saida Hisao Imai Ou Yamaguchi Kunihiko Kobayashi Kyoichi Kaira Hiroshi Kagamu Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1410: Early-Stage Non-Small Cell Lung Cancer: Prevalence of Actionable Alterations in a Monocentric Consecutive Cohort
Andrea Sbrana
Greta Alì
Early-stage (ES) non-small cell lung cancer (NSCLC) is diagnosed in about 30% of cases. The preferred treatment is surgery, but a significant proportion of patients experience recurrence. Neoadjuvant and adjuvant chemotherapy has a limited clinical benefit. EGFR tyrosine kinase inhibitors and immunotherapy have recently opened new therapeutic scenarios. However, only a few data are available about the ES-NSCLC molecular landscape and the impact of oncogene addiction on therapy definition. Here, we determined the prevalence of the main lung cancer driver alterations in a monocentric consecutiv...
Source: Cancers - April 3, 2024 Category: Cancer & Oncology Authors: Rossella Bruno Anello Marcello Poma Martina Panozzi Alessandra Lenzini Gianmarco Elia Carmelina Cristina Zirafa Vittorio Aprile Marcello Carlo Ambrogi Editta Baldini Marco Lucchi Franca Melfi Antonio Chella Andrea Sbrana Greta Al ì Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1402: Unlocking Overexpressed Membrane Proteins to Guide Breast Cancer Precision Medicine
This study aims to address these challenges by proposing a strategy for identifying membrane proteins in tumors that can be targeted for specific BC therapy and diagnosis. The strategy involves the analyses of gene expressions in breast tumor and non-tumor tissues and other healthy tissues by using comprehensive bioinformatics analysis from The Cancer Genome Atlas (TCGA), UALCAN, TNM Plot, and LinkedOmics. By employing this strategy, we identified four transcripts (LRRC15, EFNA3, TSPAN13, and CA12) that encoded membrane proteins with an increased expression in BC tissue compared to healthy tissue. These four transcripts al...
Source: Cancers - April 3, 2024 Category: Cancer & Oncology Authors: J úlia Badaró Mendonça Priscila Valverde Fernandes Danielle C. Fernandes Fabiana Resende Rodrigues Mariana Caldas Waghabi Tatiana Martins Tilli Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1403: Obesity and Inflammatory Factors in the Progression of Early-Onset Colorectal Cancer
Galandiuk
Metabolic dysfunction associated with obesity leads to a chronic pro-inflammatory state with systemic effects, including the alteration of macrophage metabolism. Tumor-associated macrophages have been linked to the formation of cancer through the production of metabolites such as itaconate. Itaconate downregulates peroxisome proliferator-activated receptor gamma as a tumor-suppressing factor and upregulates anti-inflammatory cytokines in M2-like macrophages. Similarly, leptin and adiponectin also influence macrophage cytokine expression and contribute to the progression of colorectal cancer via changes in gen...
Source: Cancers - April 3, 2024 Category: Cancer & Oncology Authors: Alexandra N. Jones Katharina M. Scheurlen Anne Macleod Hillary L. Simon Susan Galandiuk Tags: Review Source Type: research
Cancers, Vol. 16, Pages 1404: Transperineal Laser Ablation (TPLA) Treatment of Focal Low & ndash;Intermediate Risk Prostate Cancer
Conclusions: FLA appears to be safe, feasible, and effective in the index lesion treatment of low–intermediate-risk prostate cancer, with a high rate of tumor eradication and preservation of quality of life. (Source: Cancers)
Source: Cancers - April 3, 2024 Category: Cancer & Oncology Authors: Gugliemo Manenti Tommaso Perretta Marco Nezzo Federico Romeo Fraioli Beatrice Carreri Paola Elda Gigliotti Andrea Micillo Andrea Malizia Daniele Di Giovanni Colleen Patricia Ryan Francesco Giuseppe Garaci Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1405: Clinical and Analytical Validation of Two Methods for Ki-67 Scoring in Formalin Fixed and Paraffin Embedded Tissue Sections of Early Breast Cancer
In this study, Ki-67 was retrospectively evaluated by three pathologists using two methods: a visual assessment of the entire slide and a quantitative assessment of the tumour margin in 411 early-stage breast cancer patients with a median follow-up of 26.8 years. We found excellent agreement between the three pathologists for both methods. The risk of recurrence for Ki-67 was time-dependent, as the high proliferation group (Ki-67 ≥ 30%) had a higher risk of recurrence initially, but after 4.5 years the risk was higher in the low proliferation group. In estrogen receptor (ER)-positive patients, the intermediate K...
Source: Cancers - April 3, 2024 Category: Cancer & Oncology Authors: Sne žana Đokić Barbara Gazi ć Biljana Gr čar Kuzmanov Jerca Blazina Simona Miceska Tanja Čugura Cvetka Gra šič Kuhar Jera Jeruc Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1399: Inhibition of Carbohydrate Metabolism Potentiated by the Therapeutic Effects of Oxidative Phosphorylation Inhibitors in Colon Cancer Cells
pielmann
Xifu Liu
Cancer cells undergo a significant level of “metabolic reprogramming” or “remodeling” to ensure an adequate supply of ATP and “building blocks” for cell survival and to facilitate accelerated proliferation. Cancer cells preferentially use glycolysis for ATP production (the Warburg effect); however, cancer cells, including colorectal cancer (CRC) cells, also depend on oxidative phosphorylation (OXPHOS) for ATP production, a finding that suggests that both glycolysis and OXPHOS play significant roles in facilitating ca...
Source: Cancers - April 2, 2024 Category: Cancer & Oncology Authors: Lichao Guo Baochen Zhang Wen Zhang Yanqi Xie Xi Chen Xueke Sun David S. Watt Chunming Liu H. Peter Spielmann Xifu Liu Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1398: Hyperthermic Intravesical Chemotherapy (HIVEC) Using Epirubicin in an Optimized Setting in Patients with NMIBC Recurrence after Failed BCG Therapy
Beat Roth
To evaluate hyperthermic intravesical chemotherapy (HIVEC) using conductive heating and epirubicin in an optimized setting as an alternative to radical cystectomy in patients with recurrent non-muscle invasive bladder cancer (NMIBC) who have failed bacillus Calmette-Guérin (BCG) therapy. We retrospectively analyzed our prospectively recorded database of patients who underwent HIVEC between 11/2017 and 11/2022 at two Swiss University Centers. Cox regression analysis was used for univariate/multivariate analysis, and the Kaplan–Meier method for survival analysis. Of the 39 patient...
Source: Cancers - April 2, 2024 Category: Cancer & Oncology Authors: Julien Blanc Jonathan Ruggiero Ilaria Lucca Nicolas Arnold Bernhard Kiss Beat Roth Tags: Article Source Type: research
