Cancers, Vol. 16, Pages 1399: Inhibition of Carbohydrate Metabolism Potentiated by the Therapeutic Effects of Oxidative Phosphorylation Inhibitors in Colon Cancer Cells
pielmann
Xifu Liu
Cancer cells undergo a significant level of “metabolic reprogramming” or “remodeling” to ensure an adequate supply of ATP and “building blocks” for cell survival and to facilitate accelerated proliferation. Cancer cells preferentially use glycolysis for ATP production (the Warburg effect); however, cancer cells, including colorectal cancer (CRC) cells, also depend on oxidative phosphorylation (OXPHOS) for ATP production, a finding that suggests that both glycolysis and OXPHOS play significant roles in facilitating ca...
Source: Cancers - April 2, 2024 Category: Cancer & Oncology Authors: Lichao Guo Baochen Zhang Wen Zhang Yanqi Xie Xi Chen Xueke Sun David S. Watt Chunming Liu H. Peter Spielmann Xifu Liu Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1398: Hyperthermic Intravesical Chemotherapy (HIVEC) Using Epirubicin in an Optimized Setting in Patients with NMIBC Recurrence after Failed BCG Therapy
Beat Roth
To evaluate hyperthermic intravesical chemotherapy (HIVEC) using conductive heating and epirubicin in an optimized setting as an alternative to radical cystectomy in patients with recurrent non-muscle invasive bladder cancer (NMIBC) who have failed bacillus Calmette-Guérin (BCG) therapy. We retrospectively analyzed our prospectively recorded database of patients who underwent HIVEC between 11/2017 and 11/2022 at two Swiss University Centers. Cox regression analysis was used for univariate/multivariate analysis, and the Kaplan–Meier method for survival analysis. Of the 39 patient...
Source: Cancers - April 2, 2024 Category: Cancer & Oncology Authors: Julien Blanc Jonathan Ruggiero Ilaria Lucca Nicolas Arnold Bernhard Kiss Beat Roth Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1400: Liquid Biopsy for Detection of Pancreaticobiliary Cancers by Functional Enrichment and Immunofluorescent Profiling of Circulating Tumor Cells and Their Clusters
Darshana Patil
Circulating tumor cells (CTCs) have historically been used for prognostication in oncology. We evaluate the performance of liquid biopsy CTC assay as a diagnostic tool in suspected pancreaticobiliary cancers (PBC). The assay utilizes functional enrichment of CTCs followed by immunofluorescent profiling of organ-specific markers. The performance of the assay was first evaluated in a multicentric case-control study of blood samples from 360 participants, including 188 PBC cases (pre-biopsy samples) and 172 healthy individuals. A subsequent prospective observational study included pre-biopsy blood sample...
Source: Cancers - April 2, 2024 Category: Cancer & Oncology Authors: Andrew Gaya Nitesh Rohatgi Sewanti Limaye Aditya Shreenivas Ramin Ajami Dadasaheb Akolkar Vineet Datta Ajay Srinivasan Darshana Patil Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1401: Advances in the Development of Positron Emission Tomography Tracers for Improved Detection of Differentiated Thyroid Cancer
rburg
Thyroid cancer poses a significant challenge in clinical management, necessitating precise diagnostic tools and treatment strategies for optimal patient outcomes. This review explores the evolving field of radiotracers in the diagnosis and management of thyroid cancer, focusing on prostate-specific membrane antigen (PSMA)-based radiotracers, fibroblast activation protein inhibitor (FAPI)-based radiotracers, Arg-Gly-Asp (RGD)-based radiotracers, and 18F-tetrafluoroborate (18F-TFB). PSMA-based radiotracers, initially developed for prostate cancer imaging, have shown promise in detecting thyroid cancer lesions; howe...
Source: Cancers - April 2, 2024 Category: Cancer & Oncology Authors: Hannelore Iris Coerts Bart de Keizer Frederik Anton Verburg Tags: Review Source Type: research
Cancers, Vol. 16, Pages 1396: Leveraging Programmatic Collaboration for a Radiopharmaceutical Clinic
n Chauhan
Radiation oncologists, radiopharmacists, nuclear medicine physicians, and medical oncologists have seen a renewed clinical interest in radiopharmaceuticals for the curative or the palliative treatment of cancer. To allow for the discovery and the clinical advancement of targeted radiopharmaceuticals, these stakeholders have reformed their trial efforts and remodeled their facilities to accommodate the obligations of a program centered upon radioactive investigational drug products. Now considered informally as drugs and not beam radiotherapy, radiopharmaceuticals can be more easily studied in the traditional ...
Source: Cancers - April 2, 2024 Category: Cancer & Oncology Authors: Charles A. Kunos Molly E. Martin Michalis F. Georgiou Russ A. Kuker Aman Chauhan Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1397: Long-Term Survival Rates and Treatment Trends of Burkitt Lymphoma in Patients with HIV & mdash;A National Cancer Database (NCDB) Study
Conclusions: There is an increased mortality rate from months 3 to 60 in BL patients with HIV compared to patients without HIV. Additionally, risk of death in the first 3 months is significantly decreased by 45% in patients with HIV treated with combination chemotherapy and immunotherapy compared to patients without HIV receiving combination chemotherapy and immunotherapy, providing valuable clinical insight into treatment decision making in the care of HIV-associated BL. (Source: Cancers)
Source: Cancers - April 2, 2024 Category: Cancer & Oncology Authors: Clare M. Wieland Ashley M. Tuin Elizabeth J. Dort Alexander G. Hall Mridula Krishnan Manasa Velagapudi Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1395: Clinical Relevance of Physical Function Outcomes in Cancer Cachexia
J. Anderson
Managing clinical manifestations of cancer/treatment burden on functional status and quality of life remains paramount across the cancer trajectory, particularly for patients with cachexia who display reduced functional capacity. However, clinically relevant criteria for classifying functional impairment at a single point in time or for classifying meaningful functional changes subsequent to disease and/or treatment progression are lacking. This unmet clinical need remains a major obstacle to the development of therapies for cancer cachexia. This review aims to describe current literature-based evidence for...
Source: Cancers - April 1, 2024 Category: Cancer & Oncology Authors: Lucas Caeiro Sofia Jaramillo Quiroz Jenna S. Hegarty Ellen Grewe Jose M. Garcia Lindsey J. Anderson Tags: Review Source Type: research
Cancers, Vol. 16, Pages 1393: Dexamethasone in Patients with Glioblastoma: A Systematic Review and Meta-Analysis
Conclusion: Despite the widespread use of dexamethasone in glioblastoma patients, its use is correlated with worse long-term outcomes. Consequently, Dexamethasone administration should be restricted to selected symptomatic patients. Future prospective studies are crucial to confirm these findings. (Source: Cancers)
Source: Cancers - April 1, 2024 Category: Cancer & Oncology Authors: Pierre Scheffler Christian Fung Shahan Momjian Dominik Koessinger Levin H äni Nicolas Neidert Jakob Straehle Florian Volz Oliver Schnell J ürgen Beck Amir El Rahal Tags: Systematic Review Source Type: research
Cancers, Vol. 16, Pages 1394: Dermoscopy as a Tool for Identifying Potentially Metastatic Thin Melanoma: A Clinical & ndash;Dermoscopic and Histopathological Case & ndash;Control Study
Cancers, Vol. 16, Pages 1394: Dermoscopy as a Tool for Identifying Potentially Metastatic Thin Melanoma: A Clinical–Dermoscopic and Histopathological Case–Control Study
Cancers doi: 10.3390/cancers16071394
Authors:
Vincenzo De Giorgi
Flavia Silvestri
Giovanni Cecchi
Federico Venturi
Biancamaria Zuccaro
Gabriella Perillo
Federica Cosso
Vincenza Maio
Sara Simi
Pietro Antonini
Serena Pillozzi
Lorenzo Antonuzzo
Daniela Massi
Laura Doni
Despite being early-stage tumors, thin cutaneous melanomas contribute significantly to mortality and have a rising incidence. A retrospectiv...
Source: Cancers - April 1, 2024 Category: Cancer & Oncology Authors: Vincenzo De Giorgi Flavia Silvestri Giovanni Cecchi Federico Venturi Biancamaria Zuccaro Gabriella Perillo Federica Cosso Vincenza Maio Sara Simi Pietro Antonini Serena Pillozzi Lorenzo Antonuzzo Daniela Massi Laura Doni Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1388: Management of Portal Hypertension in Patients with Hepatocellular Carcinoma on Systemic Treatment: Current Evidence and Future Perspectives
ni
Ponziani
The management of CSPH in patients undergoing systemic treatment for HCC has emerged as a critical concern due to the absence of reliable diagnostic criteria and uncertainties surrounding therapeutic approaches. This review aims to underscore the primary pathophysiological aspects linking HCC and PH, while also addressing the current and emerging clinical strategies for the management of portal hypertension. A review of studies from January 2003 to June 2023 was conducted using the PubMed database and employing MeSH terms, such as “hepatocellular carcinoma”, “imm...
Source: Cancers - March 31, 2024 Category: Cancer & Oncology Authors: De Gaetano Pallozzi Cerrito Santopaolo Stella Gasbarrini Ponziani Tags: Review Source Type: research
Cancers, Vol. 16, Pages 1389: Biphasic Regulation of Apoptosis following Gastric Irreversible Electroporation Using Tissue Immunohistochemistry of Activated Caspase-3 with TUNEL Method
This study aimed to investigate IRE-induced gastric tissue apoptosis in response to changes in the electric field intensity, followed by the repair process. Among the 52 rats used in this study, 24 were used to explore apoptosis, and 28 were used to study regeneration. The apoptosis-to-necrosis ratio of the electrical field strength was evaluated using terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick-end labeling and caspase-3 immunohistochemistry. The size of IRE-induced ulcers in the gastric tissue continuously increased with increasing electrical intensity (r2 = 0.830, p < 0.001)....
Source: Cancers - March 31, 2024 Category: Cancer & Oncology Authors: Han Jo Jeon Hoon Jai Chun Hyuk Soon Choi Bora Keum Hong Bae Kim Jong Hyuk Kim Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1390: Evaluation of the Implementation of the Dutch Breast Cancer Surveillance Decision Aid including Personalized Risk Estimates in the SHOUT-BC Study: A Mixed Methods Approach
Discussion: When the BCS-PtDA was used, patients were clearly given a choice regarding their post-treatment surveillance, but information provision and SDM application can be improved. (Source: Cancers)
Source: Cancers - March 31, 2024 Category: Cancer & Oncology Authors: Jet W. Ankersmid Ellen G. Engelhardt Fleur K. Lansink Rotgerink Regina The Luc J. A. Strobbe Constance H. C. Drossaert Sabine Siesling van Uden-Kraan Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1391: Endoscopic-Assisted Microsurgical Meningioma Resection in the Skull Base via Minicraniotomy: Is There a Difference in Radicality and Outcome between Anterior Skull Base and Posterior Fossa?
Conclusions: The results revealed that endoscopy was beneficial in both locations. The identification of remnant tumor tissue and the benefit of endoscopy were clearly higher in the posterior fossa. Endoscopic assistance is a very helpful tool for increasing radicality, providing a better anatomical overview during surgery, and better identifying remnant tumor tissue in skull base meningioma surgery. (Source: Cancers)
Source: Cancers - March 31, 2024 Category: Cancer & Oncology Authors: Thomas Kanczok Gerrit Fischer Sebastian Senger Stefan Linsler Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1392: Mixed Reality as a Digital Visualisation Solution for the Head and Neck Tumour Board: Application Creation and Implementation Study
Majeed Rana
The preparation and implementation of interdisciplinary oncological case reviews are time-consuming and complex. The variety of clinical and radiological information must be presented in a clear and comprehensible manner. Only if all relevant patient-specific information is demonstrated in a short time frame can well-founded treatment decisions be made on this basis. Mixed reality (MR) technology as a multimodal interactive user interface could enhance understanding in multidisciplinary collaboration by visualising radiological or clinical data. The aim of the work was to develop an MR-based software protot...
Source: Cancers - March 31, 2024 Category: Cancer & Oncology Authors: Nadia Karnatz Michael Schwerter Shufang Liu Aida Parviz Max Wilkat Majeed Rana Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1385: A Comprehensive Overview of Intraoperative Complications during Retzius-Sparing Robot-Assisted Radical Prostatectomy: Single Series from High-Volume Center
Conclusions: Intraoperative complications during RS-RARP are relatively infrequent, but should not be underestimated. Patients suffering from ICs are older, have a higher body mass index, a higher rate of intraoperative blood transfusion, and a longer length of stay. (Source: Cancers)
Source: Cancers - March 31, 2024 Category: Cancer & Oncology Authors: Alberto Olivero Stefano Tappero Francesco Chierigo Ofir Maltzman Silvia Secco Erika Palagonia Antonio Piccione Aldo Massimo Bocciardi Antonio Galfano Paolo Dell ’Oglio Tags: Article Source Type: research
