Cancers, Vol. 16, Pages 1508: Prognostic Biomarkers of Systemic Inflammation in Non-Small Cell Lung Cancer: A Narrative Review of Challenges and Opportunities
hillips
Non-small cell lung cancer (NSCLC) is a common malignancy and is associated with poor survival outcomes. Biomarkers of systemic inflammation derived from blood tests collected as part of routine clinical care offer prognostic information for patients with NSCLC that may assist clinical decision making. They are an attractive tool, as they are inexpensive, easily measured, and reproducible in a variety of healthcare settings. Despite the wealth of evidence available to support them, these inflammatory biomarkers are not yet routinely used in clinical practice. In this narrative review, the key inflammatory indic...
Source: Cancers - April 15, 2024 Category: Cancer & Oncology Authors: Mark Stares Leo R. Brown Dhruv Abhi Iain Phillips Tags: Review Source Type: research
Cancers, Vol. 16, Pages 1509: Early Stage Breast Cancer: Does Histologic Subtype (Ductal vs. Lobular) Impact 5 Year Overall Survival?
aise
Emmanuel Gabriel
Histology is an important predictor of the behavior of breast cancer. We aim to study the impact of histology on the overall survival (OS) of breast cancer patients. We studied 11,085 breast cancer patients diagnosed with T1–T2 tumors, clinically node-negative and non-metastatic, from 2004 to 2019 included in the National Cancer Database. Kaplan–Meier curves, log-rank tests and Cox regression models were used to study the impact of histology and other variables on OS. In our patient population, 8678 (78.28%) had ductal cancer (IDC), while 2407 (21.71%) had lobular can...
Source: Cancers - April 15, 2024 Category: Cancer & Oncology Authors: Fatima Mubarak Gabrielle Kowkabany Reed Popp Shivam Bansal Syeda Hoorulain Ahmed Seema Sharan Kulkaew B. Sukniam Swathi R. Raikot Paola Berrios Jimenez Kyle Popp Harsheen K. Manaise Emmanuel Gabriel Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1510: Synergistic Activity of DNA Damage Response Inhibitors in Combination with Radium-223 in Prostate Cancer
This study identified the ATR inhibitor as the most synergistic inhibitor for both radiation qualities, supporting further pre-clinical evaluation of DDR inhibitors in combination with 223Ra for the treatment of prostate cancer. (Source: Cancers)
Source: Cancers - April 15, 2024 Category: Cancer & Oncology Authors: Victoria L. Dunne Timothy C. Wright Francisco D. C. Guerra Liberal Joe M. O ’Sullivan Kevin M. Prise Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1502: The Performance of Different Parametric Ultrasounds in Prostate Cancer Diagnosis: Correlation with Radical Prostatectomy Specimens
Conclusions: The mpUS procedure provides high sensitivity and specificity in PCa detection, especially for clinically significant prostate cancer. (Source: Cancers)
Source: Cancers - April 15, 2024 Category: Cancer & Oncology Authors: Adel Jawli Ghulam Nabi Zhihong Huang Tags: Systematic Review Source Type: research
Cancers, Vol. 16, Pages 1503: Measurable (Minimal) Residual Disease in Myelodysplastic Neoplasms (MDS): Current State and Perspectives
adantonakis
Myelodysplastic Neoplasms (MDS) have been traditionally studied through the assessment of blood counts, cytogenetics, and morphology. In recent years, the introduction of molecular assays has improved our ability to diagnose MDS. The role of Measurable (minimal) Residual Disease (MRD) in MDS is evolving, and molecular and flow cytometry techniques have been used in several studies. In this review, we will highlight the evolving concept of MRD in MDS, outline the various techniques utilized, and provide an overview of the studies reporting MRD and the correlation with outcomes. (Source: Cancers)
Source: Cancers - April 15, 2024 Category: Cancer & Oncology Authors: Linsheng Zhang George Deeb Kristin K. Deeb Colin Vale Deniz Peker Barclift Nikolaos Papadantonakis Tags: Review Source Type: research
Cancers, Vol. 16, Pages 1504: Clinical and Diagnostic Utility of Genomic Profiling for Digestive Cancers: Real-World Evidence from Japan
Hajime Kuroda
Seigo Yukisawa
Takuya Aoki
Kei Takeshita
Shinichi Ueno
Junichi Nakazawa
Yu Sunakawa
Sachio Nohara
Chihiro Okada
Ko Nishimiya
Shigeki Tanishima
Hiroshi Nishihara
The usefulness of comprehensive genomic profiling (CGP) in the Japanese healthcare insurance system remains underexplored. Therefore, this large-scale study aimed to determine the usefulness of CGP in diagnosing digestive cancers. Patients with various cancer types recruited between March 2020 and October 2022 underwent the FoundationOne® CDx assay at the Keio PleSSision Group (19 hospitals in Japan). A scoring sy...
Source: Cancers - April 15, 2024 Category: Cancer & Oncology Authors: Marin Ishikawa Kohei Nakamura Ryutaro Kawano Hideyuki Hayashi Tatsuru Ikeda Makoto Saito Yo Niida Jiichiro Sasaki Hiroyuki Okuda Satoshi Ishihara Masatoshi Yamaguchi Hideaki Shimada Takeshi Isobe Yuki Yuza Akinobu Yoshimura Hajime Kuroda Seigo Yukisawa Ta Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1505: The Role of Hepatitis Viruses as Drivers of Hepatocancerogenesis
a Morisco
Recently, metabolic associated steatotic liver disease (MASLD) became the leading cause of chronic liver disease worldwide and one of the most frequent causes of hepatocellular carcinoma (HCC). Nonetheless, in this epidemiological trend, viral hepatitis remains the major driver in hepatic carcinogenesis. Globally, hepatitis B virus (HBV) is the leading cause of hepatocellular carcinoma, with an overall attributable risk of approximately 40%, followed by hepatitis C virus (HCV), which accounts for 28–30% of cases, with significant geographic variations between the Eastern and Western world. Consi...
Source: Cancers - April 15, 2024 Category: Cancer & Oncology Authors: Mario Capasso Valentina Cossiga Maria Guarino Luisa Ranieri Filomena Morisco Tags: Review Source Type: research
Cancers, Vol. 16, Pages 1506: Development and Validation of a Deep Learning Model for Histopathological Slide Analysis in Lung Cancer Diagnosis
This study presents a DL-based model for efficient lung cancer detection using whole-slide images. Our methodology combines convolutional neural networks (CNNs) and separable CNNs with residual blocks, thereby improving classification performance. Our model improves accuracy (96% to 98%) and robustness in distinguishing between cancerous and non-cancerous lung cell images in less than 10 s. Moreover, the model’s overall performance surpassed that of active pathologists, with an accuracy of 100% vs. 79%. There was a significant linear correlation between pathologists’ accuracy and years of experi...
Source: Cancers - April 15, 2024 Category: Cancer & Oncology Authors: Alhassan Ali Ahmed Muhammad Fawi Agnieszka Brychcy Mohamed Abouzid Martin Witt El żbieta Kaczmarek Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1501: Contemporary Approaches to the Surgical Management of Pancreatic Neuroendocrine Tumors
Ven Fong
The incidence of pancreatic neuroendocrine tumors (PNETs) is on the rise primarily due to the increasing use of cross-sectional imaging. Most of these incidentally detected lesions are non-functional PNETs with a small proportion of lesions being hormone-secreting, functional neoplasms. With recent advances in surgical approaches and systemic therapies, the management of PNETs have undergone a paradigm shift towards a more individualized approach. In this manuscript, we review the histologic classification and diagnostic approaches to both functional and non-functional PNETs. Additionally, we detail multidisc...
Source: Cancers - April 14, 2024 Category: Cancer & Oncology Authors: Akash Kartik Valerie L. Armstrong Chee-Chee Stucky Nabil Wasif Zhi Ven Fong Tags: Review Source Type: research
Cancers, Vol. 16, Pages 1500: Heat Shock Proteins, a Double-Edged Sword: Significance in Cancer Progression, Chemotherapy Resistance and Novel Therapeutic Perspectives
Kulbacka
Heat shock proteins (Hsps) are involved in one of the adaptive mechanisms protecting cells against environmental and metabolic stress. Moreover, the large role of these proteins in the carcinogenesis process, as well as in chemoresistance, was noticed. This review aims to draw attention to the possibilities of using Hsps in developing new cancer therapy methods, as well as to indicate directions for future research on this topic. In order to discuss this matter, a thorough review of the latest scientific literature was carried out, taking into account the importance of selected proteins from the Hsp family, i...
Source: Cancers - April 14, 2024 Category: Cancer & Oncology Authors: Dominika Kunachowicz Magdalena Kr ól-Kulikowska Wiktoria Raczycka Jakub Sleziak Marta B łażejewska Julita Kulbacka Tags: Review Source Type: research
Cancers, Vol. 16, Pages 1497: Evaluation of Helium Ion Radiotherapy in Combination with Gemcitabine in Pancreatic Cancer In Vitro
Conclusion: Our results demonstrate the cytotoxic efficacy of helium ion radiotherapy in pancreatic cancer in vitro as well as the capability of mMKM calculation and its value for biological plan optimization in helium ion therapy for pancreatic cancer. A combined treatment of helium irradiation and chemotherapy with gemcitabine leads to mainly additive cytotoxic effects in pancreatic cancer cell lines. The data generated in this study may serve as the radiobiological basis for future experimental and clinical works using helium ion radiotherapy in pancreatic cancer treatment. (Source: Cancers)
Source: Cancers - April 14, 2024 Category: Cancer & Oncology Authors: Bahar Cepni Thomas Tessonnier Ivana Dokic Stephan Brons Bouchra Tawk Andrea Mairani Amir Abdollahi J ürgen Debus Klaus Herfarth Jakob Liermann Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1498: Retrospective Long-Term Evaluation of Conventional Transarterial Chemoembolization for Hepatocellular Carcinoma over 20 Years
agy N. N. Naguib
The aim of this study was to retrospectively evaluate the effects of conventional transarterial chemoembolization (cTACE) for the treatment of hepatocellular carcinoma over 20 years regarding overall survival (OS) and prognostic factors for OS. During the period from 1996 to 2016, 836 patients with HCC were treated with cTACE. Data evaluation was performed on the basis of pre- and postinterventional MRI and CT scans. Survival analysis was performed by Kaplan–Meier estimator; prognostic factors were determined by the use of Cox regression analysis. Overall, 4084 (mean 4.89 TACE sessions/pa...
Source: Cancers - April 14, 2024 Category: Cancer & Oncology Authors: Thomas J. Vogl Hamzah Adwan Leonard Wolff Maximilian Lahrsow Tatjana Gruber-Rouh Nour-Eldin Abdelrehim Nour-Eldin J örg Trojan Wolf-Otto Bechstein Nagy N. N. Naguib Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1499: Reactivation of Varicella-Zoster Virus in Patients with Lung Cancer Receiving Immune Checkpoint Inhibitors: Retrospective Nationwide Population-Based Cohort Study from South Korea
Conclusions: In these real-world data from an Asian population with lung cancer, ICIs treatment might be associated with a reduced risk of HZ compared to that without ICIs treatment. (Source: Cancers)
Source: Cancers - April 14, 2024 Category: Cancer & Oncology Authors: Jiyun Jung Seong-Yeon Park Jae-Yoon Park Dalyong Kim Kyoungmin Lee Sungim Choi Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1490: Implementation and Evaluation of a Breast Cancer Disease Model Using Real-World Claims Data in Germany from 2010 to 2020
This study, the first to model breast cancer subtypes, stages, and outcomes using German claims data, provides valuable insights into real-world breast cancer epidemiology and demonstrates that this breast cancer disease model has the potential to be representative of treatment outcomes. (Source: Cancers)
Source: Cancers - April 13, 2024 Category: Cancer & Oncology Authors: Dominik Dannehl Alexandra von Au Tobias Engler L éa Louise Volmer Raphael Gutsfeld Johannes Felix Englisch Markus Hahn Sabine Hawighorst-Knapstein Ariane Chaudhuri Armin Bauer Markus Wallwiener Florin-Andrei Taran Diethelm Wallwiener Sara Yvonne Brucker Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1492: Possible Role of miR-375-3p in Cervical Lymph Node Metastasis of Oral Squamous Cell Carcinoma
In this study, we focused on the microRNAs (miRNAs) involved in the expression of numerous genes and explored those associated with latent cervical LNM in early OSCC (eOSCC). First, microarray and RT-PCR analyses revealed a significant downregulation of miR-375-3p expression in primary eOSCC tissues with latent cervical LNM. Next, we examined the effects of miR-375-3p mimics on the growth and migration of four human OSCC cell lines that do not express miR-375-3p. The overexpression of miR-375-3p significantly suppressed the cell proliferation and migration of human OSCC cells in vitro. Furthermore, miR-375-3p mimics marked...
Source: Cancers - April 13, 2024 Category: Cancer & Oncology Authors: Masato Saika Koh-ichi Nakashiro Norihiko Tokuzen Hiroyuki Shirai Daisuke Uchida Tags: Article Source Type: research
