Cancers, Vol. 16, Pages 1611: An Overview of the Spices Used for the Prevention and Potential Treatment of Gastric Cancer
We present the potential molecular mechanisms responsible for the effectivity of a given seasoning substance and their impact on GC cells. We discuss their potential effects on proliferation, apoptosis, and migration. For most of the spices discussed, we also outline the unavailability and side effects of their use. (Source: Cancers)
Source: Cancers - April 22, 2024 Category: Cancer & Oncology Authors: Katarzyna Kostelecka Łukasz Bryliński Olga Komar Justyna Michalczyk Agata Mi łosz Jan Bi łogras Filip Woli ński Alicja Forma Jacek Baj Tags: Review Source Type: research
Cancers, Vol. 16, Pages 1612: How Do Quality of Life (QoL) and Symptom Burden Evolve in Inpatient Palliative Care (PC) Patients Following One Week of Care in a Specialized Palliative Care Unit (PCU)? A Comparison of Two Groups, with One Receiving Specialized Outpatient Palliative Care Prior to Admission
Conclusion: The findings of our study demonstrate that QoL and several symptoms prevalent in cancer patients cared for in the PCU experienced significant enhancement over the span of just one week. Both groups, patients receiving specialized outpatient PC prior to admission and those without, equally benefited from inpatient PC. All mentioned changes from T0 to T1 are considered not only significant but clinically relevant. (Source: Cancers)
Source: Cancers - April 22, 2024 Category: Cancer & Oncology Authors: Hanna Salm Florian Dobersch ütz Franziska Hallmann Philipp Munzert Johannes Rahm Sarah Uhlig Daniel Pink Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1598: No Racial Disparities Observed Using Point-of-Care Genetic Counseling and Testing for Endometrial and Ovarian Cancer in a Diverse Patient Population: A Retrospective Cohort Study
gaux J. Kanis
We investigated genetic counseling and testing rates for patients with gynecologic malignancy at a tertiary care center with a large minority population. Our retrospective cohort included newly diagnosed epithelial ovarian, fallopian tube, peritoneal, or endometrial cancer patients between January 2014 and June 2022. For endometrial cancer, 373 patients were identified. A total of 207 (55%) patients were screened using mismatch repair immunohistochemistry (MMR IHC). A total of 82 (40%) had MMR deficiencies on IHC. Of these, 63 (77%) received genetic counseling. A total of 62 (98%) underwent genetic testin...
Source: Cancers - April 22, 2024 Category: Cancer & Oncology Authors: Michael Kim Judy Hayek Cheyenne Acker Anjile An Peilin Zhang Constantine Gorelick Margaux J. Kanis Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1599: Chimeric Antigen Receptor (CAR) T-Cell Therapy in Hematologic Malignancies: Clinical Implications and Limitations
er
Chimeric antigen receptor (CAR) T-cell therapy has become a powerful treatment option in B-cell and plasma cell malignancies, and many patients have benefited from its use. To date, six CAR T-cell products have been approved by the FDA and EMA, and many more are being developed and investigated in clinical trials. The whole field of adoptive cell transfer has experienced an unbelievable development process, and we are now at the edge of a new era of immune therapies that will have its impact beyond hematologic malignancies. Areas of interest are, e.g., solid oncology, autoimmune diseases, infectious diseases, and ot...
Source: Cancers - April 22, 2024 Category: Cancer & Oncology Authors: Philipp Bl üm Sabine Kayser Tags: Review Source Type: research
Cancers, Vol. 16, Pages 1600: Signaling by Type I Interferons in Immune Cells: Disease Consequences
anias
This review addresses interferon (IFN) signaling in immune cells and the tumor microenvironment (TME) and examines how this affects cancer progression. The data reveal that IFNs exert dual roles in cancers, dependent on the TME, exhibiting both anti-tumor activity and promoting cancer progression. We discuss the abnormal IFN signaling induced by cancerous cells that alters immune responses to permit their survival and proliferation. (Source: Cancers)
Source: Cancers - April 22, 2024 Category: Cancer & Oncology Authors: Markella Zannikou Eleanor N. Fish Leonidas C. Platanias Tags: Review Source Type: research
Cancers, Vol. 16, Pages 1601: Treatment of Gastric Cancer Means Surgery, but Not Surgery Alone
Rausei
Despite numerous studies, gastric cancer (GC) still presents a high mortality rate in Eastern and Western countries, increasing attention for new therapeutic strategies [...] (Source: Cancers)
Source: Cancers - April 22, 2024 Category: Cancer & Oncology Authors: Manrica Fabbi Christina D. Bali Georgios D. Lianos Stefano Rausei Tags: Editorial Source Type: research
Cancers, Vol. 16, Pages 1602: Robot-Assisted Radical Prostatectomy Performed with the Novel Surgical Robotic Platform Hugo & trade; RAS: Monocentric First Series of 132 Cases Reporting Surgical, and Early Functional and Oncological Outcomes at a Tertiary Referral Robotic Center
Conclusions: Our initial experience highlights the reliability of the HugoTM RAS system in performing RARP. Additionally, we also list problems and solutions found in our daily work. (Source: Cancers)
Source: Cancers - April 22, 2024 Category: Cancer & Oncology Authors: Angelo Totaro Eros Scarciglia Filippo Marino Marco Campetella Carlo Gandi Mauro Ragonese Riccardo Bientinesi Giuseppe Palermo Francesco Pio Bizzarri Antonio Cret ì Simona Presutti Andrea Russo Paola Aceto Pierfrancesco Bassi Francesco Pierconti Marco Rac Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1603: Advances in Molecular Mechanisms of Gastrointestinal Tumors
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Gastrointestinal cancer is one of the most common malignancies worldwide [...] (Source: Cancers)
Source: Cancers - April 22, 2024 Category: Cancer & Oncology Authors: Shihori Tanabe Tags: Editorial Source Type: research
Cancers, Vol. 16, Pages 1604: Treatment of Pelvic and Spinal Bone Metastases: Radiotherapy and Hyperthermia Alone vs. in Combination
The objective of our study was to present the results of RT combined with a special kind of HT (modulated electrohyperthermia, mEHT), in which some of the thermal effect is contributed by equivalent nonthermal components, drastically reducing the necessary power and energy. This retrospective study included 61 patients divided into three groups with pelvic and spinal bone metastases to compare the effects of RT and mEHT alone and in combination (RT + mEHT). A detailed evaluation of pain intensity, measured by the brief pain inventory score, MeM use, and breakthrough pain episodes, revealed no significant differences betwee...
Source: Cancers - April 22, 2024 Category: Cancer & Oncology Authors: Jong-Hun Kim Jin-Yong Shin Sun-Young Lee Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1605: Immune Therapies in AL Amyloidosis & mdash;A Glimpse to the Future
Cancers, Vol. 16, Pages 1605: Immune Therapies in AL Amyloidosis—A Glimpse to the Future
Cancers doi: 10.3390/cancers16081605
Authors:
Arnon Haran
Iuliana Vaxman
Moshe E. Gatt
Eyal Lebel
Light-chain (AL) amyloidosis is a rare plasma cell disorder characterized by the deposition of misfolded immunoglobulin light chains in target organs, leading to multi-organ dysfunction. Treatment approaches have historically mirrored but lagged behind those of multiple myeloma (MM). Recent advancements in MM immunotherapy are gradually being evaluated and adopted in AL amyloidosis. This review explores the current ...
Source: Cancers - April 22, 2024 Category: Cancer & Oncology Authors: Arnon Haran Iuliana Vaxman Moshe E. Gatt Eyal Lebel Tags: Review Source Type: research
Cancers, Vol. 16, Pages 1597: RETRACTED: Lai et al. MicroRNA-21 Plays Multiple Oncometabolic Roles in the Process of NAFLD-Related Hepatocellular Carcinoma via PI3K/AKT, TGF- & beta;, and STAT3 Signaling. Cancers 2021, 13, 940
Cancers, Vol. 16, Pages 1597: RETRACTED: Lai et al. MicroRNA-21 Plays Multiple Oncometabolic Roles in the Process of NAFLD-Related Hepatocellular Carcinoma via PI3K/AKT, TGF-β, and STAT3 Signaling. Cancers 2021, 13, 940
Cancers doi: 10.3390/cancers16081597
Authors:
Chi-Yu Lai
Kun-Yun Yeh
Chiu-Ya Lin
Yang-Wen Hsieh
Hsin-Hung Lai
Jim-Ray Chen
Chia-Chun Hsu
Guor Mour Her
The Cancers Editorial Office retracts the article, “MicroRNA-21 Plays Multiple Oncometabolic Roles in the Process of NAFLD-Related Hepatocellular Carcinoma via PI3K/AKT, TGF-β, and STAT3 Signaling&...
Source: Cancers - April 22, 2024 Category: Cancer & Oncology Authors: Chi-Yu Lai Kun-Yun Yeh Chiu-Ya Lin Yang-Wen Hsieh Hsin-Hung Lai Jim-Ray Chen Chia-Chun Hsu Guor Mour Her Tags: Retraction Source Type: research
Cancers, Vol. 16, Pages 1606: Seroprevalence of SARS-CoV-2 and Hepatitis B Virus Coinfections among Ethiopians with Acute Leukemia
new
Rawleigh Howe
SARS-CoV-2 and blood-borne viral coinfections are well reported. Nevertheless, little is known regarding the seroprevalence of SARS-CoV-2 and coinfection with blood-borne viruses in hematologic malignancy patients in Ethiopia. We aimed to assess the seroprevalence of SARS-CoV-2 and associated infections with hepatitis B and other viruses among adolescent and adult acute leukemia patients at Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia. A cross-sectional study was conducted from July 2020 to June 2021. Blood samples were tested for the presence of anti-SARS-CoV-2, HBV, HCV, and HIV with ...
Source: Cancers - April 22, 2024 Category: Cancer & Oncology Authors: Jemal Alemu Balako Gumi Aster Tsegaye Ziyada Rahimeto Dessalegn Fentahun Fozia Ibrahim Abdulaziz Abubeker Amha Gebremedhin Tesfaye Gelanew Rawleigh Howe Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1607: Deferral of Treatment for Small Choroidal Melanoma and the Risk of Metastasis: An Investigation Using the Liverpool Uveal Melanoma Prognosticator Online (LUMPO)
Conclusions: Deferring treatment of choroidal melanomas until documentation of growth may delay iatrogenic visual loss by months or years and is associated with minimal increase in metastatic mortality, at least with small tumors with usual growth rates of up to 40% per year. (Source: Cancers)
Source: Cancers - April 22, 2024 Category: Cancer & Oncology Authors: Bertil Damato Antonio Eleuteri Azzam Taktak Rumana Hussain Maria Fili Gustav St ålhammar Heinrich Heimann Sarah E. Coupland Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1608: Effects of Adjuvant Exercise and Nutrition Therapy on Muscle Fibre Biomechanics in Gastrointestinal Cancer Patients
Oliver Friedrich
Patients with aggressive cancer, e.g., gastrointestinal cancer, are prone (≥50% chance) to developing cancer cachexia (CC). Little is known about the effects of CC on the biomechanical function of muscle. A promising prevention strategy was found in the form of a multi-modal therapy combining mild resistance exercise (e.g., whole-body electro-myostimulation, WB-EMS) and a protein-rich diet. In a previous study of ours, this was effective in counteracting the loss of muscle mass, yet a systematic and comprehensive assessment of active and passive single muscle fibre functions was so far abs...
Source: Cancers - April 22, 2024 Category: Cancer & Oncology Authors: Michael Haug Raphaela Schwappacher Charlotte Pollmann Paul Ritter Mena Michael Hans Joachim Hermann Robert Gr ützmann Anke Mittelst ädt Markus Friedrich Neurath Yurdag ül Zopf Oliver Friedrich Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1609: Patients with Advanced or Metastasised Non-Small-Cell Lung Cancer with Viscum album L. Therapy in Addition to PD-1/PD-L1 Blockade: A Real-World Data Study
tian Grah
Immunotherapy with PD-1/PD-L1 inhibitors has significantly improved the survival rates of patients with metastatic non-small-cell lung cancer (NSCLC). Results of a real-world data study investigating add-on VA (Viscum album L.) to chemotherapy have shown an association with the improved overall survival of patients with NSCLC. We sought to investigate whether the addition of VA to PD-1/PD-L1 inhibitors in patients with advanced or metastasised NSCLC would have an additional survival benefit. In the present real-world data study, we enrolled patients from the accredited national registry, Network Oncology, wit...
Source: Cancers - April 22, 2024 Category: Cancer & Oncology Authors: Friedemann Schad Anja Thronicke Ralf-Dieter Hofheinz Harald Matthes Christian Grah Tags: Article Source Type: research
