Risk stratification of LA ‐NPC during chemoradiotherapy based on clinical classification and TVRR
ConclusionThe reliance on clinical types and TVRR facilitates risk stratification of NPC during chemoradiotherapy, providing a foundation for physicians to tailor therapeutic strategies. Moreover, the risk cluster delineated for NPC patients during the mid-term of chemoradiotherapy stands as an independent prognostic factor for progression-free survival (PFS), overall survival (OS), distantmetastasis-free survival (DMFS), and local recurrence-free (LRRFS) posttreatment. Additionally, individuals in the high-risk cluster are recommended to undergo adjuvant chemotherapy after CCRT. (Source: Cancer Medicine)
Source: Cancer Medicine - February 24, 2024 Category: Cancer & Oncology Authors: Qianlong Tang, Chaorong Mei, Bei Huang, Rui Huang, Le Kang, Ailin Chen, Na lei, Pengcheng Deng, Shouyan Ying, Peng Zhang, Yuan Qin Tags: RESEARCH ARTICLE Source Type: research

A meta ‐analysis comparing efficacy and safety between proton beam therapy versus carbon ion radiotherapy
ConclusionThis study highlighted the comparability of PBT and CIRT in terms of oncological outcomes and adverse events. (Source: Cancer Medicine)
Source: Cancer Medicine - February 24, 2024 Category: Cancer & Oncology Authors: Jeong Yun Jang, Kangpyo Kim, Miao ‐Fen Chen, Tetsuo Akimoto, Michael Lian Chek Wang, Min‐Ji Kim, Kyunga Kim, Tae Hoon Lee, Gyu Sang Yoo, Hee Chul Park Tags: RESEARCH ARTICLE Source Type: research

Guidelines for outpatient administration of naxitamab: Experience from Atrium Health Levine Children's Hospital
ConclusionsThis will provide a practical guide for institutions offering naxitamab to their patients, and ensure successful administration of this high acuity treatment in the outpatient setting. (Source: Cancer Medicine)
Source: Cancer Medicine - February 24, 2024 Category: Cancer & Oncology Authors: Erin Murphy Trovillion, Meghan Michael, Cathryn C. Jordan, Lauren Brown, Katlin Phillips, Javier Oesterheld, Giselle Saulnier ‐Sholler Tags: METHOD Source Type: research

The association of genomic alterations with PD ‐L1 expression in Chinese patients with EGFR/ALK wild‐type lung adenocarcinoma and potential predictive value of Hippo pathway mutations to immunotherapy
ConclusionsThis study offers insights into genomic features of Chinese EGFR/ALK wild-type lung adenocarcinoma patients based on PD-L1 expression. Notably, Hippo pathway alterations were linked to improved immunotherapy outcomes. These findings suggest connections between the Hippo pathway and PD-L1 expression, warranting further clinical and functional investigations. The research advances our understanding of PD-L1 expression's genomic context and immunotherapy response in EGFR/ALK wild-type lung adenocarcinoma. (Source: Cancer Medicine)
Source: Cancer Medicine - February 24, 2024 Category: Cancer & Oncology Authors: Fangfang Liu, Xuemei Zhang, Mengyao Lu, Chun Liu, Xiaodong Zhang, Qian Chu, Yuan Chen, Peng Zhang Tags: RESEARCH ARTICLE Source Type: research

Issue Information
(Source: Cancer Medicine)
Source: Cancer Medicine - February 23, 2024 Category: Cancer & Oncology Tags: ISSUE INFORMATION Source Type: research

Molecular complexity of intraductal carcinoma of the prostate
AbstractIntraductal carcinoma of the prostate (IDC-P) is an aggressive subtype of prostate cancer characterized by the growth of tumor cells within the prostate ducts. It is often found alongside invasive carcinoma and is associated with poor prognosis. Understanding the molecular mechanisms driving IDC-P is crucial for improved diagnosis, prognosis, and treatment strategies. This review summarizes the molecular characteristics of IDC-P and their prognostic indications, comparing them to conventional prostate acinar adenocarcinoma, to gain insights into its unique behavior and identify potential therapeutic targets. (Source: Cancer Medicine)
Source: Cancer Medicine - February 21, 2024 Category: Cancer & Oncology Authors: Sha Zhu, Nanwei Xu, Hao Zeng Tags: REVIEW Source Type: research

Schizandrin A induces non ‐small cell lung cancer apoptosis by suppressing the epidermal growth factor receptor activation
ConclusionsNetwork pharmacology analyses suggested that ERBB family members may be the targets of SchA. SchA can inhibit NSCLC at least in part by inhibiting EGFR phosphorylation, and activating the EGFR bypass can neutralize the cytotoxicity of SchA. (Source: Cancer Medicine)
Source: Cancer Medicine - February 20, 2024 Category: Cancer & Oncology Authors: Linhai Zhu, Yanye Wang, Xuhua Huang, Xide Liu, Bo Ye, Yi He, Haojie Yu, Wang Lv, Luming Wang, Jian Hu Tags: RESEARCH ARTICLE Source Type: research

Association of blood cell ‐based inflammatory markers with gut microbiota and cancer incidence in the Rotterdam study
To evaluate the association between gut microbiota and the immune response markers NLR, PLR, SII, and WBCs count with the subsequent risk of developing cancer in the Rotterdam study cohort (ERGO). The current study was performed on 8090 participants from the population-based Rotterdam study. A significant association was found between lymphocytes and three gut microbial taxa, namely the family Streptococcaceae, genus Streptococcus, and order Lactobacillales. By analyzing the cancer data, a significant association was observed between higher systemic immune-inflammation index (SII) levels at baseline and a higher count of l...
Source: Cancer Medicine - February 17, 2024 Category: Cancer & Oncology Authors: Shiva Najjary, Johan M. Kros, Bruno H. Stricker, Rikje Ruiter, Yu Shuai, Robert Kraaij, Kristel Van  Steen, Peter van der Spek, Casper H. J. Van Eijck, M. Arfan Ikram, Shahzad Ahmad Tags: RESEARCH ARTICLE Source Type: research

Diagnostic accuracy of serum protein induced by vitamin K absence (PIVKA ‐II), serum a‐fetoprotein and their combination for hepatocellular carcinoma among Caucasian cirrhotic patients with diagnostic or non‐diagnostic serum a‐fetoprotein levels
ConclusionsEach biomarker separately showed acceptable accuracy for detecting HCC in cirrhotic patients and excellent for those in BCLC-C stage. The combination of the biomarkers presented excellent results in BCLC-B/C patients. The diagnostic accuracy of PIVKA-II and the combination of the two biomarkers in patients expressing low/non-diagnostic AFP levels was good in BCLC-B and excellent in BCLC-C patients. (Source: Cancer Medicine)
Source: Cancer Medicine - February 16, 2024 Category: Cancer & Oncology Authors: Antonia Syriha, Spyridon Pantzios, Dionysia Mandilara, Petros Galanis, Ioanna Stathopoulou, Georgia Barla, Ioannis Elefsiniotis Tags: RESEARCH ARTICLE Source Type: research

Secondary bladder and colorectal cancer after treatments for prostate cancer: A population based study
ConclusionsCompared to PCa patients undergoing RP, the secondary bladder cancer was associated with EBRT, ADT, alone or in combination. The secondary colorectal cancer was also associated with receiving either EBRT, BT or ADT. (Source: Cancer Medicine)
Source: Cancer Medicine - February 14, 2024 Category: Cancer & Oncology Authors: Patricia Grisel Quintana B árcena, Armen Garo Aprikian, Alice Dragomir Tags: RESEARCH ARTICLE Source Type: research

Racial disparities in the relationship of regional socioeconomic status and colorectal cancer survival in the five regions of Georgia
ConclusionsBlack patients demonstrated lower CRC survival rates in Georgia compared to their White counterparts. White patients living in regions with persistent poverty, and Black patients living in regions with low education had an increased risk of CRC death. Our findings provide important evidence to all relevant stakeholders in allocating health resources aimed at CRC early detection and prevention and timely referral for CRC treatment by considering the patient's regional SES in Georgia. (Source: Cancer Medicine)
Source: Cancer Medicine - February 13, 2024 Category: Cancer & Oncology Authors: Meng ‐Han Tsai, Marlo Vernon, Shaoyong Su, Steven S. Coughlin, Yanbin Dong Tags: RESEARCH ARTICLE Source Type: research

The impact of body mass index on survival endpoints among patients with metastatic urothelial carcinoma undergoing treatment with immune checkpoint inhibitors: A real ‐world multicenter analysis
ConclusionBased on real-world data from the Asia-Pacific region, there appears to be a correlation between obesity and prolonged OS in patients receiving ICI treatment for mUC. (Source: Cancer Medicine)
Source: Cancer Medicine - February 10, 2024 Category: Cancer & Oncology Authors: Shih ‐Yu Huang, Po‐Jung Su, Chang‐Ting Lin, Ming‐Chun Kuo, Yi‐Hua Chen, Chia‐Che Wu, Hao‐Lun Luo, Chien‐Hsu Chen, Chih‐Chi Chou, Chun‐Chieh Huang, Chung‐Wen Kuo, Yu‐Li Su Tags: RESEARCH ARTICLE Source Type: research

Clinical and genetic characteristics predict outcomes of acute myeloid leukemia patients with FLT3 mutations receiving venetoclax ‐based therapy
ConclusionsFLT3 mutations may influence response to VEN-based therapy in R/R AML patients but not in ND AML patients. Furthermore, clinical and genetic characteristics could predict outcomes of FLT3mut patients receiving VEN-based therapy. (Source: Cancer Medicine)
Source: Cancer Medicine - February 9, 2024 Category: Cancer & Oncology Authors: Guangyang Weng, Jingya Huang, Na An, Yu Zhang, Guopan Yu, Zhiqiang Sun, Dongjun Lin, Lan Deng, Xinquan Liang, Jie Xiao, Hongyu Zhang, Ziwen Guo, Xin He, Hua Jin, Qifa Liu, Xin Du Tags: RESEARCH ARTICLE Source Type: research

PIEZO1 is essential for the survival and proliferation of acute myeloid leukemia cells
ConclusionsAltogether, our results reveal a new role for PIEZO1 mechanosensing in the survival and proliferation of leukemic blasts, which could pave the way for new therapeutic strategies to target AML cells. (Source: Cancer Medicine)
Source: Cancer Medicine - February 9, 2024 Category: Cancer & Oncology Authors: Delphine Lebon, Louison Collet, Stefan Djordjevic, Cathy Gomila, Hakim Ouled ‐Haddou, Jessica Platon, Yohann Demont, Jean‐Pierre Marolleau, Alexis Caulier, Loïc Garçon Tags: RESEARCH ARTICLE Source Type: research

Genetic variants in primary cilia ‐related genes associated with the prognosis of first‐line chemotherapy in colorectal cancer
ConclusionOur study indicates that rs4288573 inODF2L is a potential predictor of the chemotherapy prognosis of CRC. (Source: Cancer Medicine)
Source: Cancer Medicine - February 9, 2024 Category: Cancer & Oncology Authors: Lei Qiu, Silu Chen, Shuai Ben, Jinxin Cui, Shan Lu, Rong Qu, Jinghuan Lv, Wei Shao, Qiang Yu Tags: RESEARCH ARTICLE Source Type: research