Retrospective analysis of real ‐world prescribing data for managing cisplatin‐based chemotherapy‐induced nausea and vomiting in China
ConclusionsThe current study reveals suboptimal utilization of recommended antiemetic drugs for managing cisplatin-based HEC-induced nausea and vomiting in China. Improving the management of CINV is crucial, and these findings provide valuable insights into optimizing antiemetic drug practices. (Source: Cancer Medicine)
Source: Cancer Medicine - March 22, 2024 Category: Cancer & Oncology Authors: Xia Si,
Hongyan Zhang,
Qingming Ding,
Gang Liu,
Lin Huang,
Xin Sun Tags: RESEARCH ARTICLE Source Type: research
MAIT cells are associated with responsiveness to neoadjuvant immunotherapy in COPD ‐associated NSCLC
ConclusionsIn patients with NSCLC and COPD, response to immunotherapy is associated with accumulation of CD8+ MAIT cells showing immune exhaustion. These findings may contribute to innovative approaches for immunotherapy targeting CD8+ MAIT cells. (Source: Cancer Medicine)
Source: Cancer Medicine - March 21, 2024 Category: Cancer & Oncology Authors: Yanze Yin,
Ao Zeng,
Abudumijiti Abuduwayiti,
Zhilong Xu,
Keyi Chen,
Chao Wang,
Xinyun Fang,
Jiarui Wang,
Gening Jiang,
Jie Dai Tags: RESEARCH ARTICLE Source Type: research
Comparison of clinical outcomes of several risk stratification tools in newly diagnosed AML patients: A real ‐world evidence in our current therapeutic era
ConclusionsUsing Akaike ’s information criteria (AIC) to compare all five classifiers, ELN 2022 is the best classifier into younger and older patients and for prognosis. (Source: Cancer Medicine)
Source: Cancer Medicine - March 20, 2024 Category: Cancer & Oncology Authors: Alexandre Iat,
Michael Loschi,
Sami Benachour,
Anne Calleja,
Edmond Chiche,
Isabelle Sudaka,
Dani èle Aquaronne,
Corinne Ferrero,
Laurène Fenwarth,
Alice Marceau,
Elise Fournier,
Berengere Dadone‐Montaudie,
Thomas Cluzeau Tags: RESEARCH ARTICLE Source Type: research
Transcriptional profile and immune infiltration in colorectal cancer reveal the significance of inducible T ‐cell costimulator as a crucial immune checkpoint molecule
ConclusionICOS might serve as a robust immune checkpoint for prognosis with several genes being potential targets of ICOS-directed immunotherapy in CRC. (Source: Cancer Medicine)
Source: Cancer Medicine - March 20, 2024 Category: Cancer & Oncology Authors: Jian Chu,
Yinghang Wu,
Zhanbo Qu,
Jing Zhuang,
Jiang Liu,
Shugao Han,
Wei Wu,
Shuwen Han Tags: RESEARCH ARTICLE Source Type: research
“Better at home”: Mixed methods report of intricacies in pediatric febrile neutropenia management
ConclusionEarly discharge of LR FN episodes positively impacts QoL, yet risk-stratified management for FN is intricately complex. Optimal FN management should prioritize the patient's overall health; shared decision-making is recommended and can improve care delivery. These results should be confirmed in a larger, more heterogeneous population. (Source: Cancer Medicine)
Source: Cancer Medicine - March 20, 2024 Category: Cancer & Oncology Authors: Eleanor T. Smeallie,
Sung W. Choi,
Rajen Mody,
Timothy C. Guetterman,
Charles N. Nessle Tags: RESEARCH ARTICLE Source Type: research
Body composition change indices combined with Prognostic Nutritional Index predicts the clinical outcomes of patients with gastric cancer treated with immune checkpoint inhibitor
ConclusionThe comprehensive consideration of PNI-SFA and PNI-SMI proved to be a superior prognostic predictor for GC patients undergoing ICI treatment. (Source: Cancer Medicine)
Source: Cancer Medicine - March 20, 2024 Category: Cancer & Oncology Authors: Guiming Deng,
Dayong Zhu,
Zhongze Du,
Yingwei Xue,
Hongjiang Song,
Yuanzhou Li Tags: RESEARCH ARTICLE Source Type: research
A nomogram prediction model of pseudomyxoma peritonei established based on new prognostic factors of HE stained pathological images analysis
ConclusionsThe quantitative analysis of HE-stained PIs could extract the new prognostic information on PMP. A nomogram established by five independent prognosticators is the first model integrating digital pathological information with clinical data for improved clinical outcome prediction. (Source: Cancer Medicine)
Source: Cancer Medicine - March 20, 2024 Category: Cancer & Oncology Authors: Ru Ma,
Yan ‐Dong Su,
Feng‐Cai Yan,
Yu‐Lin Lin,
Ying Gao,
Yan Li Tags: RESEARCH ARTICLE Source Type: research
Clinicopathological features of adult T ‐cell leukemia/lymphoma with T‐follicular helper phenotype
ConclusionSome patients with ATLL may present a TFHP, which should not preclude the diagnosis of ATLL. Although presenting a TFHP does not affect prognosis, it is important to identify cases of ATLL with a TFHP since it may inform future treatment strategies. (Source: Cancer Medicine)
Source: Cancer Medicine - March 20, 2024 Category: Cancer & Oncology Authors: Reiji Muto,
Hiroaki Miyoshi,
Kazutaka Nakashima,
Mai Takeuchi,
Makoto Hamasaki,
Koichi Ohshima Tags: RESEARCH ARTICLE Source Type: research
Indicators describing the tumor lesion aggregation and dissemination and their impact on the prognosis of patients with diffuse large B cell lymphoma receiving chimeric antigen receptor T cell therapy
ConclusionsOverall, the relative positioning of tumor lesions significantly influences the prognosis of patients with DLBCL receiving CAR T cell therapy. The ideal scenario involves tumors with minimal dissemination and no aggregation. (Source: Cancer Medicine)
Source: Cancer Medicine - March 20, 2024 Category: Cancer & Oncology Authors: Xiuyong Dang,
Ping Li,
Aijun Shen,
Yan Lu,
Zeyv Zhu,
Min Zhang,
Wenbin Qian,
Aibin Liang,
Wenjun Zhang Tags: RESEARCH ARTICLE Source Type: research
Facilitators of and barriers to gastric cancer and precursor diagnosis among South Texas residents: Social determinants of health
ConclusionThese data indicate the importance of considering SDoH in diagnosis and treatment of GC and its precursors, and educating providers and patients on H. pylori risks for GC. (Source: Cancer Medicine)
Source: Cancer Medicine - March 20, 2024 Category: Cancer & Oncology Authors: Dorothy Long Parma,
Erin P. Finley,
Roman Fernandez,
Jonathan A. L. Gelfond,
Amelie G. Ramirez Tags: RESEARCH ARTICLE Source Type: research
Issue Information
(Source: Cancer Medicine)
Source: Cancer Medicine - March 20, 2024 Category: Cancer & Oncology Tags: ISSUE INFORMATION Source Type: research
A phase Ib study evaluating the recommended phase II dose, safety, tolerability, and efficacy of mivavotinib in combination with nivolumab in advanced solid tumors
AbstractMivavotinib (TAK-659/CB-659), a dual SYK/FLT3 inhibitor, reduced immunosuppressive immune cell populations and suppressed tumor growth in combination with anti-PD-1 therapy in cancer models. This dose-escalation/expansion study investigated the safety, pharmacokinetics, pharmacodynamics, and preliminary efficacy of mivavotinib plus nivolumab in patients with advanced solid tumors. Patients received oral mivavotinib 60 –100 mg once-daily plus intravenous nivolumab 3 mg/kg on days 1 and 15 in 28-day cycles until disease progression or unacceptable toxicity. The dose-escalation phase evaluated the recommended ...
Source: Cancer Medicine - March 20, 2024 Category: Cancer & Oncology Authors: Dejan Juric,
Minal Barve,
Ulka Vaishampayan,
Desamparados Roda,
Aitana Calvo,
Noelia Martinez Ja ñez,
Jose Trigo,
Alastair Greystoke,
R. Donald Harvey,
Anthony J. Olszanski,
Mateusz Opyrchal,
Alexander Spira,
Fiona Thistlethwaite,
Begoña Ji Tags: RESEARCH ARTICLE Source Type: research
Cancer patients with clonal hematopoiesis die from primary malignancy or comorbidities despite higher rates of transformation to myeloid neoplasms
ConclusionsIn a population including mostly cancer patients, CH was associated with comorbidities and myeloid transformation in patients with higher mutational burdens and anemia. Nevertheless, such patients were less likely to die of their myeloid neoplasm than of primary malignancy or comorbidities. (Source: Cancer Medicine)
Source: Cancer Medicine - March 19, 2024 Category: Cancer & Oncology Authors: Kelly S. Chien,
Faustine Ong,
Kunhwa Kim,
Ziyi Li,
Rashmi Kanagal ‐Shamanna,
Courtney D. DiNardo,
Koichi Takahashi,
Guillermo Montalban‐Bravo,
Danielle Hammond,
Koji Sasaki,
Sherry A. Pierce,
Hagop M. Kantarjian,
Guillermo Garcia‐Manero Tags: RESEARCH ARTICLE Source Type: research
The impact of multidisciplinary approaches on the outcomes of olfactory neuroblastoma treated with postoperative radiotherapy
ConclusionsThe local control rate of ONB treated with postoperative radiation therapy was 100%. This may be attributed to cross-departmental cooperation between head and neck surgeons, pathologists, and radiation oncologists, which resulted in accurate matching of CT images for treatment planning with the location of the tumor and positive margins. Longer follow-up periods are required to evaluate the effectiveness of our strategy. (Source: Cancer Medicine)
Source: Cancer Medicine - March 18, 2024 Category: Cancer & Oncology Authors: Yuki Tsutsumi,
Kazuhiro Omura,
Yoshikazu Kijima,
Masao Kobayashi,
Nei Fukasawa,
Teppei Takeda,
Teru Ebihara,
Satoshi Aoki,
Nobuyoshi Otori,
Hiromi Kojima,
Manabu Aoki Tags: RESEARCH ARTICLE Source Type: research
Decreased interleukin ‐17RA expression is associated with good prognosis in patients with colorectal cancer and inhibits tumor growth and vascularity in mice
ConclusionReduced IL-17RA expression also suppressed cellular proliferation, migration, and invasion, and the expression of EMT genes. Knockdown of IL-17RA inhibited tumor growth and vascularity and decreased the population of Tregs and MDSCs in mouse tumors. Overall, IL-17RA expression was identified to be independently associated with the prognosis of patients with CRC. (Source: Cancer Medicine)
Source: Cancer Medicine - March 17, 2024 Category: Cancer & Oncology Authors: Jeng ‐Kai Jiang,
Chi‐Hung Lin,
Ting‐An Chang,
Liang‐Chuan Lo,
Chien‐Ping Lin,
Ruey‐Hwa Lu,
Chih‐Yung Yang Tags: RESEARCH ARTICLE Source Type: research
