Household income and health ‐related quality of life in children receiving treatment for acute myeloid leukemia: Potential impact of selection bias in health equity research
ConclusionsWhile primary analyses suggested lower household income was associated with superior HRQOL, differential participation may have biased these results. Future studies should partner with patients/families to identify strategies for equitable participation in clinical research. (Source: Cancer Medicine)
Source: Cancer Medicine - April 5, 2024 Category: Cancer & Oncology Authors: Haley Newman,
Yimei Li,
Yuan ‐Shung V. Huang,
Caitlin W. Elgarten,
Regina M. Myers,
Jenny Ruiz,
Daniel J. Zheng,
Alison Barz Leahy,
Catherine Aftandilian,
Staci D. Arnold,
Kira Bona,
M. Monica Gramatges,
Mallorie B. Heneghan,
Kelly W. Malon Tags: RESEARCH ARTICLE Source Type: research
Real ‐world data of poly (ADP‐ribose) polymerase inhibitor response in Japanese patients with ovarian cancer
ConclusionsInflammation-related blood data, such as neutrophil count, obtained at the initial pre-treatment visit might serve as potential predictors for prolonged olaparib treatment. While this study offers valuable insights into potential indicators for prolonged olaparib treatment, it underscores the need for more expansive research to strengthen our understanding of PARP inhibitors and optimize treatment strategies in ovarian cancer. (Source: Cancer Medicine)
Source: Cancer Medicine - April 4, 2024 Category: Cancer & Oncology Authors: Ryosuke Uekusa,
Akira Yokoi,
Eri Watanabe,
Kosuke Yoshida,
Masato Yoshihara,
Satoshi Tamauchi,
Yusuke Shimizu,
Yoshiki Ikeda,
Nobuhisa Yoshikawa,
Kaoru Niimi,
Shiro Suzuki,
Hiroaki Kajiyama Tags: RESEARCH ARTICLE Source Type: research
Comparison between next ‐generation sequencing and multiplex polymerase chain reaction assays for nonsmall‐cell lung cancer molecular diagnosis
DiscussionThe AmoyDx PLC panel, a PCR-based multiplex diagnostic test, exhibits a high success rate. The frequency of the nine genes targeted for treatment detected by the AmoyDx PLC panel was comparable to the frequency of mutations detected by ODxTT-M. Clinicians should understand and use the AmoyDx PLC panel and ODxTT-M with respect to their respective performances and limitations. (Source: Cancer Medicine)
Source: Cancer Medicine - April 4, 2024 Category: Cancer & Oncology Authors: Shuji Murakami,
Kanako Shinada,
Yuka Otsutsumi,
Fumiko Komine,
Yuan Yuan,
Junko Nakamura,
Seigo Katakura,
Tetsuro Kondo,
Terufumi Kato,
Tomoyuki Yokose,
Haruhiro Saito Tags: RESEARCH ARTICLE Source Type: research
A population study comparing tracheal and lung adenoid cystic carcinoma
ConclusionsLACC is more aggressive and has a worse prognosis than TACC. TACC patients have more opportunities for local treatment, which is important for the prognosis of both TACC and LACC. Nomograms were created for TACC and LACC to aid in personalized survival predictions and clinical decisions. (Source: Cancer Medicine)
Source: Cancer Medicine - April 4, 2024 Category: Cancer & Oncology Authors: Yu Gu,
Songtao Lai,
Yang Wang,
Juan Yang,
Ping Zhou,
Tianxiang Chen Tags: RESEARCH ARTICLE Source Type: research
Changes in rural caregivers' health behaviors while supporting someone with cancer: A qualitative study
ConclusionsDesigning interventions to address rural caregivers' coping strategies, reduce carer burden and fatigue, improve access to cooking and exercise facilities and social support while away from home, reduce the need to travel for treatment, and increase the financial support available could yield widespread benefits for supporting the health and wellbeing of rural caregivers. (Source: Cancer Medicine)
Source: Cancer Medicine - April 4, 2024 Category: Cancer & Oncology Authors: Elizabeth A. Johnston,
Katelyn E. Collins,
Jazmin N. Vicario,
Chris Sibthorpe,
Michael J. Ireland,
Belinda C. Goodwin Tags: RESEARCH ARTICLE Source Type: research
The inverted U ‐shaped relationship between epinephrine and pancreatic ductal adenocarcinoma patients' survival with compensation of lymphocyte
ConclusionEpinephrine played an anti-tumor or pro-tumor effect depending on the specific concentration. Circulating lymphocyte count was elevated and might acted as a compensation pathway to reduce the pro-tumor effect of epinephrine to PDAC. (Source: Cancer Medicine)
Source: Cancer Medicine - April 4, 2024 Category: Cancer & Oncology Authors: Bing ‐Xue Li,
Xiao‐Cen Zhu,
Xia‐Xing Deng Tags: RESEARCH ARTICLE Source Type: research
Trends in breast, colon, pancreatic, and uterine cancers in women during the COVID ‐19 pandemic in North Carolina
Conclusion and RelevanceIn women, the COVID-19 pandemic resulted in a significant reduction in the incidence of breast and uterine cancers, but not colon or pancreatic cancers. A change in the proportion of poor prognosis breast and uterine cancers suggests that some cancers that otherwise would have been diagnosed at an earlier stage will be detected in later years. Continued analysis of long-term trends is needed to understand the full impact of the pandemic on cancer incidence and outcomes. (Source: Cancer Medicine)
Source: Cancer Medicine - April 4, 2024 Category: Cancer & Oncology Authors: Sarah J. Nyante,
Allison M. Deal,
Hillary M. Heiling,
Kyung Su Kim,
Cherie M. Kuzmiak,
Benjamin C. Calhoun,
Emily M. Ray Tags: RESEARCH ARTICLE Source Type: research
Treatment outcome and germline predictive factors of ropeginterferon alpha ‐2b in myeloproliferative neoplasm patients
ConclusionsOverall, this study provided valuable information on the ethnics- and genetics-based algorithm in the treatment of MPN. (Source: Cancer Medicine)
Source: Cancer Medicine - April 4, 2024 Category: Cancer & Oncology Authors: Chih ‐Cheng Chen,
Ming‐Chung Kuo,
Ying‐Hsuan Wang,
Sung‐Nan Pei,
Ming‐Lih Huang,
Chiu‐Chen Chen,
Cih‐En Huang,
Yi‐Yang Chen,
Lee‐Yung Shih Tags: RESEARCH ARTICLE Source Type: research
Identification of molecular characteristics of hepatocellular carcinoma with microvascular invasion based on deep targeted sequencing
ConclusionsTERTp+/TP53+ was significantly enriched in MVI-positive patients, leading to poor prognosis for HCC patients by promoting proliferation of HCC cell and inhibiting infiltration of immune cell surrounding HCC. TERTp+/TP53+ can be utilized as a potential indicator for predicting MVI-positive patients and poor prognosis, laying a preliminary foundation for further exploration of co-mutation in HCC with MVI and clinical treatment. (Source: Cancer Medicine)
Source: Cancer Medicine - April 4, 2024 Category: Cancer & Oncology Authors: Linlin Zheng,
Yaru Wang,
Zhenrong Liu,
Zhihao Wang,
Changcheng Tao,
Anke Wu,
Haiyang Li,
Ting Xiao,
Zhuo Li,
Weiqi Rong Tags: RESEARCH ARTICLE Source Type: research
Developing and validating a nomogram for penile cancer survival: A comprehensive study based on SEER and Chinese data
ConclusionPenile cancer, often overlooked in research, has lacked detailed investigative focus and guidelines. This study stands as the first to validate penile cancer prognosis using extensive data from the SEER database, supplemented by data from our own institution. Our findings equip surgeons with an essential tool to predict the prognosis of penile cancer better suited than TNM, thereby enhancing clinical decision-making processes. (Source: Cancer Medicine)
Source: Cancer Medicine - April 3, 2024 Category: Cancer & Oncology Authors: Jiawen Luo,
Jintao Hu,
Yelisudan Mulati,
Zhikai Wu,
Cong Lai,
Degeng Kong,
Cheng Liu,
Kewei Xu Tags: RESEARCH ARTICLE Source Type: research
Correction to “urban relatives ameliorate survival disparities for genitourinary cancer in rural patients”
(Source: Cancer Medicine)
Source: Cancer Medicine - April 2, 2024 Category: Cancer & Oncology Tags: CORRECTION Source Type: research
Correction to “Dose‐dependent effects of calorie restriction on gene expression, metabolism, and tumor progression are partially mediated by insulin‐like growth factor‐1”
(Source: Cancer Medicine)
Source: Cancer Medicine - April 2, 2024 Category: Cancer & Oncology Tags: CORRECTION Source Type: research
Analysis of related factors of CRA in lung cancer patients with different serum iron levels: A retrospective cohort study
ConclusionBoth models have good reliability and validity and have significant clinical value. They can help doctors better assess the risk of developing CRA in lung cancer patients. CRP is a risk factor for CRA in lung cancer patients with normal serum iron but not in patients with decreased serum iron. Therefore, whether CRP and the inflammatory state represented by CRP will further aggravate the decrease in serum iron levels, thus contributing to anemia, warrants further study. (Source: Cancer Medicine)
Source: Cancer Medicine - April 2, 2024 Category: Cancer & Oncology Authors: Quan ‐yao Li,
Wen‐xiao Yang,
Hui Liu,
Jia‐lin Yao,
Qin Wang,
Dan Lin,
Jun Shi Tags: RESEARCH ARTICLE Source Type: research
Association between novel genetic variants of Notch signaling pathway genes and survival of hepatitis B virus ‐related hepatocellular carcinoma
ConclusionsThree potentially functional SNPs ofNEURL1B,CNTN1 andFCER2 may serve as potential prognostic biomarkers for HBV-related HCC. (Source: Cancer Medicine)
Source: Cancer Medicine - April 2, 2024 Category: Cancer & Oncology Authors: Liming Qin,
Moqin Qiu,
Qiuling Lin,
Binbin Jiang,
Shicheng Zhan,
Xueyan Wei,
Junjie Wei,
Yingchun Liu,
Qiuping Wen,
Peiqin Chen,
Yanji Jiang,
Zihan Zhou,
Xiumei Liang,
Ji Cao,
Yizhen Gong,
Yuying Wei,
Xiaoxia Wei,
Hongping Yu Tags: RESEARCH ARTICLE Source Type: research
Metformin suppresses NFE2L1 pathway activation to inhibit gap junction beta protein expression in NSCLC
ConclusionThis emphasizes the potential of targeting GJBs as a viable treatment approach for NSCLC patients receiving metformin. (Source: Cancer Medicine)
Source: Cancer Medicine - April 2, 2024 Category: Cancer & Oncology Authors: Shuo Yu,
Hui Ren,
Tingting Liu,
Xiaoyan Han,
Hui Guo,
Qian Ning,
Yang Li,
Hong Zhou,
Mingwei Chen,
Tinghua Hu Tags: RESEARCH ARTICLE Source Type: research
