Patient's experiences of coughing after lung cancer surgery: A multicenter qualitative study
ConclusionWe generated a concept framework of cough after lung cancer surgery, providing a basis for further development of measurement tools from the patients' perspective. The lack of knowledge related to coughing highlights the need for adequate and timely health education and professional medical care. (Source: Cancer Medicine)
Source: Cancer Medicine - February 5, 2024 Category: Cancer & Oncology Authors: Xiangxi Zhou,
Cheng Lei,
Xing Wei,
Wei Dai,
Wei Xu,
Yongping Ao,
Xianglin Li,
Guibin Qiao,
Qiuling Shi Tags: RESEARCH ARTICLE Source Type: research
Hearing preservation after stereotactic radiosurgery for sporadic intracanalicular vestibular schwannomas classified as Koos grade 1
ConclusionsPetit VSs that can be treated with 4-mm single or double shots with a marginal dose of 12 Gy may achieve hearing preservation after SRS. (Source: Cancer Medicine)
Source: Cancer Medicine - February 5, 2024 Category: Cancer & Oncology Authors: Ho Kang,
So Young Ji,
Chae ‐Yong Kim,
Ja‐Won Koo,
Jae‐Jin Song,
Byung Yoon Choi,
Kihwan Hwang,
Jung Ho Han Tags: RESEARCH ARTICLE Source Type: research
Prognostic implications of HER2NEU ‐low in metastatic breast cancer
ConclusionsIn the largest such analysis performed to date, our study demonstrates a small but statistically significant association with improved survival for HER2-low tumors compared to HER2-negative tumors in MBC. (Source: Cancer Medicine)
Source: Cancer Medicine - February 5, 2024 Category: Cancer & Oncology Authors: Zachary Neubauer,
Shaakir Hasan,
Robert H. Press,
Arpit M. Chhabra,
Jana Fox,
Richard Bakst,
Charles B. Simone,
J. Isabelle Choi Tags: RESEARCH ARTICLE Source Type: research
Associations of brain ‐derived neurotrophic factor rs6265 polymorphism and cognitive function in breast cancer survivors from a cross‐sectional study
ConclusionOur findings suggest that carrying the BDNF rs6265 Met/Met genotype increases the risk for CRCI in BCS. These results are foundational in nature and provide important information to identify mechanisms underpinning CRCI. (Source: Cancer Medicine)
Source: Cancer Medicine - February 5, 2024 Category: Cancer & Oncology Authors: Taichi Goto,
Leorey N. Saligan,
Xiaobai Li,
Lichen Xiang,
Catherine Kwiat,
Christopher Nguyen,
Adele Crouch,
Diane Von Ah Tags: RESEARCH ARTICLE Source Type: research
Implementing systematic melanoma risk assessment and risk ‐tailored surveillance in a skin cancer focussed dermatology clinic: A qualitative study of feasibility and acceptability to patients and clinic staff
ConclusionsIt is feasible and acceptable to patients and clinic staff to calculate and deliver personalised melanoma risk information and tailored surveillance as part of routine clinical care within dermatology clinics. (Source: Cancer Medicine)
Source: Cancer Medicine - February 5, 2024 Category: Cancer & Oncology Authors: A. L. Smith,
A. K. Smit,
B. I. Laginha,
N. Singh,
B. Gallo,
L. Martin,
A. E. Cust Tags: RESEARCH ARTICLE Source Type: research
Regulation of regulatory T cells and tumor ‐associated macrophages in gastric cancer tumor microenvironment
ConclusionDiscussing the distinct tumor immune microenvironment (TIME) of GC can deepen our understanding on the mechanism of cancer immune evasion, invasion, and metastasis, help us to reduce the incidence of GC, and guide the innovation of new therapeutic targets for GC eventually. (Source: Cancer Medicine)
Source: Cancer Medicine - February 5, 2024 Category: Cancer & Oncology Authors: Zhang Shaopeng,
Zheng Yang,
Fang Yuan,
Huang Chen,
Qiu Zhengjun Tags: REVIEW Source Type: research
Genomic heterogeneity of multiple synchronous lung cancers in Chinese population
ConclusionIn summary, unlike intrapulmonary metastases, patients with MSLC harbor distinct genomic profiles in different tumor lesions, and we could distinguish MSLC from intrapulmonary metastases via clonality estimation. (Source: Cancer Medicine)
Source: Cancer Medicine - February 5, 2024 Category: Cancer & Oncology Authors: Lei Zhao,
Jin Wang,
Yixiang Zhang,
Peng Wang,
Changsheng Lv,
Shilei Zhao,
Tao Guo,
Fengzhou Li,
Chundong Gu,
Yuntao Zhu Tags: RESEARCH ARTICLE Source Type: research
Genomic disparity impacts variant classification of cancer susceptibility genes in Turkish breast cancer patients
ConclusionTo our knowledge, this is the first study of population genetic effects in breast cancer subtypes in Turkish women. Our findings underscore the need for a large genomic database representing Turkish population-specific variants. It further highlights the significance of the ancestry-appropriate population database for accurate variant assessment in clinical settings. (Source: Cancer Medicine)
Source: Cancer Medicine - February 3, 2024 Category: Cancer & Oncology Authors: Nihat B. Agaoglu,
Busra Unal,
Connor P. Hayes,
McKenzie Walker,
Ozden Hatirnaz Ng,
Levent Doganay,
Nisan D. Can,
Huma Q. Rana,
Arezou A. Ghazani Tags: RESEARCH ARTICLE Source Type: research
BRCA1, BRCA2, and TP53 germline and somatic variants and clinicopathological characteristics of Brazilian patients with epithelial ovarian cancer
ConclusionFrequency of pathogenic or likely pathogenic germline variants inBRCA1 andBRCA2 (12.5%) was lower in comparison with other studies.TP53 was the most altered gene in tumors, with 62.5% presenting likely non-functional or non-functional somatic variants, while eight 14.2% presented likely non-functional or non-functional somatic variants inBRCA1 orBRCA2. (Source: Cancer Medicine)
Source: Cancer Medicine - February 3, 2024 Category: Cancer & Oncology Authors: Caroline Stahnke Richau,
Nicole de Miranda Scherer,
Bruna Palma Matta,
Elvismary Molina de Armas,
F ábio Carvalho de Barros Moreira,
Anke Bergmann,
Claudia Bessa Pereira Chaves,
Mariana Boroni,
Anna Claudia Evangelista dos Santos,
Miguel Angel Tags: RESEARCH ARTICLE Source Type: research
RGD peptide in cancer targeting: Benefits, challenges, solutions, and possible integrin –RGD interactions
AbstractRGD peptide can be found in cell adhesion and signaling proteins, such as fibronectin, vitronectin, and fibrinogen. RGD peptides' principal function is to facilitate cell adhesion by interacting with integrin receptors on the cell surface. They have been intensively researched for use in biotechnology and medicine, including incorporation into biomaterials, conjugation to medicinal molecules or nanoparticles, and labeling with imaging agents. RGD peptides can be utilized to specifically target cancer cells and the tumor vasculature by engaging with these integrins, improving drug delivery efficiency and minimizing ...
Source: Cancer Medicine - February 2, 2024 Category: Cancer & Oncology Authors: Hossein Javid,
Mahsa Akbari Oryani,
Nastaran Rezagholinejad,
Ali Esparham,
Mahboubeh Tajaldini,
Mehdi Karimi ‐Shahri Tags: REVIEW Source Type: research
Application of computer ‐aided detection for NCCN‐based follow‐up recommendation in subsolid nodules: Effect on inter‐observer agreement
ConclusionThe application of CAD significantly improves inter-observer agreement in the follow-up management strategy for subsolid nodules. It also demonstrates the potential to reduce substantial management discrepancies and increase detection sensitivity in lung cancer cases presenting as part-solid nodules. (Source: Cancer Medicine)
Source: Cancer Medicine - February 1, 2024 Category: Cancer & Oncology Authors: Wu Quanyang,
Zhou Lina,
Huang Yao,
Wang Jiawei,
Tang Wei,
Qi Linlin,
Zhang Zewei,
Hou Donghui,
Li Hongjia,
Chen Shuluan,
Zhang Jiaxing,
Zhao Shijun Tags: RESEARCH ARTICLE Source Type: research
Somatic mutations in a multigene panel and impact on prognosis based on TP53 status in Chinese HER2 ‐positive patients undergoing neoadjuvant therapy: A single‐institution retrospective cohort
ConclusionsThe genetic mutation profiles of Chinese HER2+ patients who received NAT were discrepant with respect to HR status or DFS events. TP53 mutations have significant prognostic value in patients with NAT for HER2-positive BC and patients benefit differently depending on HR status, the neoadjuvant regimen and response, which highlights the significance of genetic factors in treatment customization based on individual genetic and clinical characteristics. (Source: Cancer Medicine)
Source: Cancer Medicine - February 1, 2024 Category: Cancer & Oncology Authors: Min Xiong,
Xuliren Wang,
Douwaner Liu,
Bingqiu Xiu,
Qi Zhang,
Weiru Chi,
Chih Wan Goh,
Liyi Zhang,
Ming Chen,
Hengyu Ren,
Zhi ‐Ming Shao,
Benlong Yang,
Jiong Wu Tags: RESEARCH ARTICLE Source Type: research
Real ‐world analysis of adverse event rates after initiation of ibrutinib among Medicare beneficiaries with chronic lymphocytic leukemia
ConclusionIn this first real-world study of a national sample of elderly US patients treated with ibrutinib, we found a clear unmet need for improved management of ibrutinib-related AEs and/or new treatments to improve real-world outcomes in patients with CLL. (Source: Cancer Medicine)
Source: Cancer Medicine - February 1, 2024 Category: Cancer & Oncology Authors: Scott F. Huntington,
Enrico de Nigris,
Justin T. Puckett,
Sachin Kamal ‐Bahl,
Mohammed Farooqui,
Katherine Ryland,
Eric M. Sarpong,
Siyang Leng,
Xiaoqin Yang,
Jalpa A. Doshi Tags: BRIEF COMMUNICATION Source Type: research
Efficacy of first ‐line treatment options beyond RET‐TKIs in advanced RET‐rearranged non‐small cell lung cancer: A multi‐center real‐world study
ConclusionsI + B + C might be a preferred option beyond RET-TKIs in the first-line therapy of RET-arranged NSCLC. Combination with Bevacizumab rather than with ICIs offered favorable survival compared with chemotherapy alone. (Source: Cancer Medicine)
Source: Cancer Medicine - February 1, 2024 Category: Cancer & Oncology Authors: Yihui Ge,
Juan Li,
Wenjing Gong,
Jian Wang,
Xiaojuan Wei,
Jing Liu,
Shuyun Wang,
Leirong Wang,
Haifeng Sun,
Qinglei Cheng,
Yanxin Sun,
Qi Dang,
Yuping Sun,
Aiqin Gao Tags: RESEARCH ARTICLE Source Type: research
Carbon ion irradiation exerts antitumor activity by inducing cGAS –STING activation and immune response in prostate cancer‐bearing mice
ConclusionThe excellent antitumor activity of CIR in immunocompetent prostate cancer-bearing C57BL/6 mice may be attributed to stronger induction of antitumor immune response and higher activation of cGAS –STING pathway. (Source: Cancer Medicine)
Source: Cancer Medicine - February 1, 2024 Category: Cancer & Oncology Authors: Wei Hu,
Zhenshan Zhang,
Yushan Xue,
Renli Ning,
Xiaomao Guo,
Yun Sun,
Qing Zhang Tags: RESEARCH ARTICLE Source Type: research
