Gut microbiota, microbiota ‐derived metabolites, and graft‐versus‐host disease
AbstractAllogeneic hematopoietic stem cell transplantation is one of the most effective treatment strategies for leukemia, lymphoma, and other hematologic malignancies. However, graft-versus-host disease (GVHD) can significantly reduce the survival rate and quality of life of patients after transplantation, and is therefore the greatest obstacle to transplantation. The recent development of new technologies, including high-throughput sequencing, metabolomics, and others, has facilitated great progress in understanding the complex interactions between gut microbiota, microbiota-derived metabolites, and the host. Of these in...
Source: Cancer Medicine - January 19, 2024 Category: Cancer & Oncology Authors: XiaoYan Yue, Hongyu Zhou, ShuFen Wang, Xu Chen, HaoWen Xiao Tags: REVIEW Source Type: research

Correction to “Impacts of pre‐existing diabetes mellitus on colorectal cancer in a mice model”
(Source: Cancer Medicine)
Source: Cancer Medicine - January 18, 2024 Category: Cancer & Oncology Tags: CORRECTION Source Type: research

Clinicopathological comparison between PTCL ‐TBX21 and PTCL‐GATA3 in Japanese patients
ConclusionThe classification of PTCL-NOS into PTCL-TBX21 and PTCL-GATA3 is useful for predicting the prognosis of Japanese patients and stratifying the administration of tumor immune checkpoint inhibitors in clinical practice. (Source: Cancer Medicine)
Source: Cancer Medicine - January 18, 2024 Category: Cancer & Oncology Authors: Yasumasa Shimasaki, Hiroaki Miyoshi, Keisuke Kawamoto, Noriaki Yoshida, Tatsuzo Mishina, Kazutaka Nakashima, Teppei Imamoto, Takeshi Sugio, Eriko Yanagida, Takeharu Kato, Kyohei Yamada, Mai Takeuchi, Takaharu Suzuki, Mayuko Moritsubo, Takuya Tags: RESEARCH ARTICLE Source Type: research

Disparities in care of older adults of color with cancer: A narrative review
Older adults of color with cancer face healthcare disparities related to both their race/ethnicity and age. Many interconnected factors contribute to these disparities including clinical, age-related physiologic, and treatment-related factors, as well as the social determinants of health related to healthcare access, socioeconomic concerns, systemic racism, mistrust, and the neighborhood or built environment where a person lives. To allow for early identification of these factors and personalized management for older patients of color with cancer, we advocate for widespread implementation of an enhanced geriatric assessmen...
Source: Cancer Medicine - January 18, 2024 Category: Cancer & Oncology Authors: Efrat Dotan, Shannon M. Lynch, Joanne C. Ryan, Edith P. Mitchell Tags: REVIEW Source Type: research

Racial differences in treatment and survival among older patients with multiple myeloma
ConclusionsThe increasing racial disparity in treatment utilization over time is concerning. Efforts are needed to eliminate the barriers of receiving treatment. (Source: Cancer Medicine)
Source: Cancer Medicine - January 18, 2024 Category: Cancer & Oncology Authors: Rong Wang, Natalia Neparidze, Xiaomei Ma, Graham A. Colditz, Su ‐Hsin Chang, Shi‐Yi Wang Tags: RESEARCH ARTICLE Source Type: research

Opportunistic lung cancer screening with low ‐dose computed tomography in National Cancer Center of China: The first 14 years' experience
ConclusionsIn our study, using LDCT for lung cancer screening proved significant for high-risk individuals. For non-high-risk populations, LDCT screening could be considered for nonsmoking women with exposure to SHS. (Source: Cancer Medicine)
Source: Cancer Medicine - January 18, 2024 Category: Cancer & Oncology Authors: Wei Tang, Li Liu, Yao Huang, Shijun Zhao, Jianwei Wang, Min Liang, Yujing Jin, Lina Zhou, Ying Liu, Yanyan Tang, Zhijian Xu, Kai Zhang, Fengwei Tan, Nan Bi, Zhijie Wang, Fei Wang, Ni Li, Ning Wu Tags: RESEARCH ARTICLE Source Type: research

The augmentation of cytotoxic immune cell functionality through physical exertion bolsters the potency of chemotherapy in models of mammary carcinoma
ConclusionsPhysical training improves the effectiveness of doxorubicin in treating breast cancer by activating cytotoxic immune cells, releasing tumor suppressor factors, and initiating mt-apoptosis, all while mitigating the adverse effects of chemotherapy. (Source: Cancer Medicine)
Source: Cancer Medicine - January 18, 2024 Category: Cancer & Oncology Authors: Bingqing Qin, Zhongshi He, Lixia Xie, Shenglan Feng, Junjie Ye, Jianjun Gui, Xiaodong Sun, Ming Sang Tags: RESEARCH ARTICLE Source Type: research

Machine learning ‐based model constructed from ultrasound radiomics and clinical features for predicting HER2 status in breast cancer patients with indeterminate (2+) immunohistochemical results
ConclusionsMachine learning models grounded on radiomics efficiently predicted IHC HER2 2+ status in breast cancer patients, suggesting potential enhancements in clinical decision-making for treatment and management. (Source: Cancer Medicine)
Source: Cancer Medicine - January 18, 2024 Category: Cancer & Oncology Authors: Meiying Yan, Jincao Yao, Xiao Zhang, Dong Xu, Chen Yang Tags: RESEARCH ARTICLE Source Type: research

Interactions of obesity, body shape, diabetes and sex steroids with respect to prostate cancer risk in the UK Biobank cohort
ConclusionsObesity and diabetes showed synergistic inverse associations with prostate cancer risk, likely involving testosterone reduction for diabetes and oestrogen generation for obesity, which were attenuated for high-ABSI. HI and SHBG showed synergistic inverse associations with prostate cancer risk. (Source: Cancer Medicine)
Source: Cancer Medicine - January 18, 2024 Category: Cancer & Oncology Authors: Sofia Christakoudi, Konstantinos K. Tsilidis, Evangelos Evangelou, Elio Riboli Tags: RESEARCH ARTICLE Source Type: research

Incidence, clinical features, and survival outcomes of primary malignant lacrimal gland tumors: A population ‐based analysis
ConclusionsAlthough primary MLGT is rare, its incidence has steadily increased in the past 46  years, and surgery was related to a better prognosis. (Source: Cancer Medicine)
Source: Cancer Medicine - January 17, 2024 Category: Cancer & Oncology Authors: Lin ‐feng He, Jin‐di Zhang, Teng‐fei Zhu, Peng‐cheng Zhao, Pei Mou, Shi‐yi Tang Tags: RESEARCH ARTICLE Source Type: research

Unveiling the potential anti ‐cancer activity of calycosin against multivarious cancers with molecular insights: A promising frontier in cancer research
ConclusionCalycosin exhibits excellent potential as a therapeutic drug against several cancer types and should be consumed until standard chemotherapeutics are available in pharma markets. (Source: Cancer Medicine)
Source: Cancer Medicine - January 17, 2024 Category: Cancer & Oncology Authors: Md Sohel, Fatema Tuj Zahra  Shova, Shahporan shuvo, Taiyara Mahjabin, Md. Mojnu Mia, Dibyendu Halder, Hafizul Islam, Md Roman Mogal, Partha Biswas, Hasi Rani Saha, Bidhan Chandra Sarkar, Abdullah Al Mamun Tags: REVIEW Source Type: research

The adverse characteristics of hepatocellular carcinoma in the non ‐cirrhotic liver disproportionately disadvantage Black patients
ConclusionsNon-cirrhotic patients had more advanced HCC than cirrhotic patients. Black patients (with or without cirrhosis) had more advanced HCC than comparable non-Black patients and higher mortality rates. Improved access to healthcare (commercial insurance) may increase early diagnosis (within Milan criteria) and reduce disparities. (Source: Cancer Medicine)
Source: Cancer Medicine - January 17, 2024 Category: Cancer & Oncology Authors: Tali Shaltiel, Umut Sarpel, Andrea D. Branch Tags: RESEARCH ARTICLE Source Type: research

Phenotype analysis of families with TP53 germline variants at the Center for Familial Breast and Ovarian Cancer, Cologne
ConclusionThe tumor spectrum and age of onset found in this study showed that tumors other than BC had low disease penetrance inTP53 PV carriers identified using the GC-HBOC criteria for genetic testing. (Source: Cancer Medicine)
Source: Cancer Medicine - January 17, 2024 Category: Cancer & Oncology Authors: K. Kast, K. Rhiem, M. Larsen, B. Wappenschmidt, R. Schmutzler Tags: RESEARCH ARTICLE Source Type: research

Biomarkers of peripheral blood neutrophil extracellular traps in the diagnosis and progression of malignant tumors
ConclusionsChanges in NETs in the peripheral blood differ between healthy controls and patients with malignant tumors. NETs may be involved in tumor-induced systemic inflammatory responses through interaction with circulating inflammatory cells, thus promoting tumor progression. NETs may be used as markers to assist in the diagnosis and progression of tumor malignancy. (Source: Cancer Medicine)
Source: Cancer Medicine - January 17, 2024 Category: Cancer & Oncology Authors: Min Wang, Xiaoyan Lv, Ying Wang, Yao Li, Honghong Li, Zhongjun Shen, Liyan Zhao Tags: RESEARCH ARTICLE Source Type: research

Prior Clinico ‐Radiological Features Informed Multi‐Modal MR Images Convolution Neural Network: A novel deep learning framework for prediction of lymphovascular invasion in breast cancer
ConclusionsThis study introduces PCMM-Net, an innovative deep learning framework that integrates prior clinico-radiological features for accurate LVI prediction in breast cancer. PCMM-Net demonstrates excellent diagnostic performance and facilitates the application of precision medicine. (Source: Cancer Medicine)
Source: Cancer Medicine - January 17, 2024 Category: Cancer & Oncology Authors: Hong Zheng, Lian Jian, Li Li, Wen Liu, Wei Chen Tags: RESEARCH ARTICLE Source Type: research