The generation of glioma organoids and the comparison of two culture methods
ConclusionThe success rates of the Matrigel and microtumor methods were 45.5% and 60.5%, respectively. The microtumor method had a higher success rate, shorter establishment time, more convenient passage and cryopreservation methods, better simulation of the cellular and histological characteristics of the parent tumor, and a high genetic guarantee. (Source: Cancer Medicine)
Source: Cancer Medicine - March 8, 2024 Category: Cancer & Oncology Authors: Yang Zhang,
Yunxiang Shao,
Yanyan Li,
Xuetao Li,
Xuewen Zhang,
Qinzhi E,
Weichao Wang,
Zuoyu Jiang,
Wenjuan Gan,
Yulun Huang Tags: RESEARCH ARTICLE Source Type: research
Psoas muscle area is an independent survival prognosticator in patients undergoing surgery for long ‐bone metastases
ConclusionsDecreased PMA on CT is associated with worse survival in surgically treated patients with extremity metastases, even after controlling for three contemporary SPAs. Physicians should consider the additional prognostic value of PMA on survival in patients undergoing consideration for operative management due to extremity metastases. (Source: Cancer Medicine)
Source: Cancer Medicine - March 8, 2024 Category: Cancer & Oncology Authors: Chia ‐Che Lee,
Ting‐En Tseng,
Ruey‐Feng Chang,
Hung‐Kuan Yen,
Yu‐An Chen,
Yu‐Yung Chen,
Chih‐Horng Wu,
Ming‐Hsiao Hu,
Mao‐Hsu Yen,
Michiel Bongers,
Olivier Q. Groot,
Cheng‐Yo Lai,
Wei‐Hsin Lin Tags: RESEARCH ARTICLE Source Type: research
Clinical utility of the Oncomine Dx Target Test multi ‐CDx system and the possibility of utilizing those original sequence data
ConclusionEven if sufficient tumor samples are obtained, rareEGFR mutations (which are excluded from the ODxTT's genetic mutation list) might not be detected using the current ODxTT system due to the program used for sequence analysis. However, such rareEGFR mutations can still be accurately detected on ODxTT's sequence data using next-generation sequencing. (Source: Cancer Medicine)
Source: Cancer Medicine - March 8, 2024 Category: Cancer & Oncology Authors: Ayaka Saito,
Hideki Terai,
Tae ‐Jung Kim,
Katsura Emoto,
Ryutaro Kawano,
Kohei Nakamura,
Hideyuki Hayashi,
Hatsuyo Takaoka,
Akihiko Ogata,
Katsuhito Kinoshita,
Fumimaro Ito,
Lisa Shigematsu,
Masahiko Okada,
Takahiro Fukushima,
Akifumi Mits Tags: RESEARCH ARTICLE Source Type: research
Impact of measurable residual disease in combination with CD19 on postremission therapy choices for adult t(8;21) acute myeloid leukemia in first complete remission
ConclusionsMRD combined with CD19 might optimize PRT choices for adult t(8;21) AML patients in CR1. (Source: Cancer Medicine)
Source: Cancer Medicine - March 8, 2024 Category: Cancer & Oncology Authors: Xi Jia,
Naying Liao,
Sijian Yu,
Huan Li,
Hui Liu,
Haiyan Zhang,
Jun Xu,
Yunqian Yao,
Han He,
Guopan Yu,
Qifa Liu,
Yu Zhang,
Pengcheng Shi Tags: RESEARCH ARTICLE Source Type: research
Laparoscopic liver resection versus radiofrequency ablation for caudate lobe solitary hepatocellular carcinoma: A propensity score matching study
ConclusionLLR should probably be recommended as the preferred method for solitary caudate lobe HCC. (Source: Cancer Medicine)
Source: Cancer Medicine - March 8, 2024 Category: Cancer & Oncology Authors: Zhengzheng Wang,
Jingzhong Ouyang,
Binyang Jia,
Yanzhao Zhou,
Yi Yang,
Xiaoting Li,
Qingjun Li,
Jinxue Zhou Tags: RESEARCH ARTICLE Source Type: research
Enhanced clinical outcomes with radiotherapy in diagnostically challenging intracranial plasmacytomas: Analysis of 190 cases
ConclusionsThis retrospective clinical analysis highlights the potential role of radiotherapy, rather than surgical resection, in improving the outcomes of intracranial plasmacytoma. Additionally, the Ki-67 index is identified as a valuable marker for predicting disease progression. This would provide some evidence for the paradigm of diagnosis and treatment modalities for intracranial plasmacytomas from the large cohort. (Source: Cancer Medicine)
Source: Cancer Medicine - March 8, 2024 Category: Cancer & Oncology Authors: Yuan Feng,
Zongpu Zhang,
Fufang Qiu,
Zixiao Yang,
Ji Xiong,
Wei Zhu,
Fangzhu Wan,
Bobin Chen,
Jiguang Wang,
Yi Zhang,
Wei Hua Tags: RESEARCH ARTICLE Source Type: research
Do Hispanic Puerto Rican men have worse outcomes after radical prostatectomy? Results from SEARCH
ConclusionsIn an equal access setting, PRH RP patients generally had better pathological features, but despite this, they had significantly worse post-treatment outcomes than men from the Continental US, regardless of race. The reasons for the poorer prognosis among PRH men require further research. (Source: Cancer Medicine)
Source: Cancer Medicine - March 8, 2024 Category: Cancer & Oncology Authors: Lourdes Guerrios ‐Rivera,
Jessica L. Janes,
Amanda M. De Hoedt,
Zachary Klaassen,
Martha K. Terris,
Matthew R. Cooperberg,
Christopher L. Amling,
Christopher J. Kane,
William J. Aronson,
Jay H. Fowke,
Stephen J. Freedland Tags: RESEARCH ARTICLE Source Type: research
Perceiving a need for dietary change in adults living with and beyond cancer: A cross ‐sectional study
ConclusionsMost of this sample of people LWBC did not perceive a need to improve their diet. More research is needed to understand the reasons for this and to target these reasons in dietary interventions. (Source: Cancer Medicine)
Source: Cancer Medicine - March 8, 2024 Category: Cancer & Oncology Authors: Susan Smith,
Abi Fisher,
Phillippa J. Lally,
Helen A. Croker,
Anna Roberts,
Rana E. Conway,
Rebecca J. Beeken Tags: RESEARCH ARTICLE Source Type: research
Cell fusion between tumor cells and macrophages promotes the metastasis of OSCC patient through the activation of the chemokine signaling pathway
ConclusionAfter fusion with macrophages, the chemokine signaling pathway in OSCC tumor cells was activated, leading to metastasis. (Source: Cancer Medicine)
Source: Cancer Medicine - March 8, 2024 Category: Cancer & Oncology Authors: Chengwan Xia,
Qian Zhang,
Yumei Pu,
Qingang Hu,
Yuxin Wang Tags: RESEARCH ARTICLE Source Type: research
POLQ identifies a better response subset to immunotherapy in muscle ‐invasive bladder cancer with high PD‐L1
ConclusionsThe study demonstrated that high POLQ expression was correlated with chromosome instability and antitumor immune microenvironment in MIBC, and the combination of POLQ and PD-L1 could be used as a superior companion biomarker for predicting the efficacy of immunotherapy. (Source: Cancer Medicine)
Source: Cancer Medicine - March 8, 2024 Category: Cancer & Oncology Authors: Ge Liu,
Kaifeng Jin,
Zhaopei Liu,
Xiaohe Su,
Ziyue Xu,
Bingyu Li,
Jingtong Xu,
Yuan Chang,
Yiwei Wang,
Yu Zhu,
Le Xu,
Jiejie Xu,
Zewei Wang,
Hailong Liu,
Weijuan Zhang Tags: RESEARCH ARTICLE Source Type: research
Deletion of concurrent chemotherapy on the basis of sequential chemoradiotherapy for non ‐metastatic stage T4 nasopharyngeal carcinoma in IMRT era
ConclusionThe survival outcomes of treating T4 NPC IMRT combined by induction chemotherapy deleting concurrent chemotherapy with or without adjuvant chemotherapy are encouraging. Moreover, mucosal reaction, nausea, and vomiting reaction were reduced during IMRT. (Source: Cancer Medicine)
Source: Cancer Medicine - March 8, 2024 Category: Cancer & Oncology Authors: Yuming Zheng,
Fen Xue,
Dan Ou,
Xiaoshuang Niu,
Chaosu Hu,
Xiayun He Tags: RESEARCH ARTICLE Source Type: research
A single ‐centre, real‐world study of BTK inhibitors for the initial treatment of MYD88mut/CD79Bmut diffuse large B‐cell lymphoma
ConclusionThis study suggests that newly diagnosed DLBCL patients with MYD88mut and/or CD79Bmut may benefit from BTKis according to real-world clinical data. (Source: Cancer Medicine)
Source: Cancer Medicine - March 8, 2024 Category: Cancer & Oncology Authors: Ting Deng,
Shiyuan Zhang,
Min Xiao,
Jia Gu,
Liang Huang,
Xiaoxi Zhou Tags: RESEARCH ARTICLE Source Type: research
Early recurrence, time ‐to‐recurrence, and recurrence patterns: Assessing their impact on survival outcomes in head and neck squamous cell carcinoma (R/M‐HNSCC) patients treated with first line platinum‐based chemotherapy
ConclusionTTRI significantly influenced the survival, while recurrence patterns did not. In our study, the retrospective design limited our ability to definitively establish whether early recurrent R/M-HNSCC patients would benefit more from platinum-doublet. Despite poor prognosis, early recurrent patients benefited from 1L systemic treatments. Given the variation in prognoses, TTRI should be considered a stratification factor in future clinical trials. (Source: Cancer Medicine)
Source: Cancer Medicine - March 8, 2024 Category: Cancer & Oncology Authors: Pasvich Pitakpaiboonkul,
Chuleeporn Jiarpinitnun,
Poompis Pattaranutaporn,
Nuttapong Ngamphaiboon Tags: RESEARCH ARTICLE Source Type: research
Clinicopathological characteristics of gastric neuroendocrine neoplasms: A comprehensive analysis
ConclusionIn short, the prognosis of g-NEC/MiNEN was worse than that of g-NET, GAC and poorly differentiated GAC, but this group benefit from postoperative adjuvant therapy. (Source: Cancer Medicine)
Source: Cancer Medicine - March 8, 2024 Category: Cancer & Oncology Authors: Mengli Zi,
Yubo Ma,
Jinxia Chen,
Chuhong Pang,
Xiao Li,
Li Yuan,
Zhuo Liu,
Pengfei Yu Tags: RESEARCH ARTICLE Source Type: research
Comparison of genomic alterations in Epstein –Barr virus‐positive and Epstein–Barr virus‐negative diffuse large B‐cell lymphoma
ConclusionsOur results confirm that genomic alteration differs significantly between EBV-posDLBCL and EBV-negDLBCL, and reveal new genetic alterations in EBV-posDLBCL. The positive correlation of c-MET and PD-L1/c-Myc expression may be involved in the pathogenesis of EBV-posDLBCL, which is should be explored prospectively in trials involving MET-directed therapies. (Source: Cancer Medicine)
Source: Cancer Medicine - March 8, 2024 Category: Cancer & Oncology Authors: Fang Liu,
Sufang Tian,
Qing Liu,
Yuanfei Deng,
Qingyan He,
Qianyun Shi,
Gang Chen,
Xiuli Xu,
Jiayin Yuan,
Shigeo Nakamura,
Kennosuke Karube,
Zhe Wang Tags: RESEARCH ARTICLE Source Type: research
