Genomic heterogeneity of multiple synchronous lung cancers in Chinese population
ConclusionIn summary, unlike intrapulmonary metastases, patients with MSLC harbor distinct genomic profiles in different tumor lesions, and we could distinguish MSLC from intrapulmonary metastases via clonality estimation. (Source: Cancer Medicine)
Source: Cancer Medicine - February 5, 2024 Category: Cancer & Oncology Authors: Lei Zhao, Jin Wang, Yixiang Zhang, Peng Wang, Changsheng Lv, Shilei Zhao, Tao Guo, Fengzhou Li, Chundong Gu, Yuntao Zhu Tags: RESEARCH ARTICLE Source Type: research

Genomic disparity impacts variant classification of cancer susceptibility genes in Turkish breast cancer patients
ConclusionTo our knowledge, this is the first study of population genetic effects in breast cancer subtypes in Turkish women. Our findings underscore the need for a large genomic database representing Turkish population-specific variants. It further highlights the significance of the ancestry-appropriate population database for accurate variant assessment in clinical settings. (Source: Cancer Medicine)
Source: Cancer Medicine - February 3, 2024 Category: Cancer & Oncology Authors: Nihat B. Agaoglu, Busra Unal, Connor P. Hayes, McKenzie Walker, Ozden Hatirnaz Ng, Levent Doganay, Nisan D. Can, Huma Q. Rana, Arezou A. Ghazani Tags: RESEARCH ARTICLE Source Type: research

BRCA1, BRCA2, and TP53 germline and somatic variants and clinicopathological characteristics of Brazilian patients with epithelial ovarian cancer
ConclusionFrequency of pathogenic or likely pathogenic germline variants inBRCA1 andBRCA2 (12.5%) was lower in comparison with other studies.TP53 was the most altered gene in tumors, with 62.5% presenting likely non-functional or non-functional somatic variants, while eight 14.2% presented likely non-functional or non-functional somatic variants inBRCA1 orBRCA2. (Source: Cancer Medicine)
Source: Cancer Medicine - February 3, 2024 Category: Cancer & Oncology Authors: Caroline Stahnke Richau, Nicole de Miranda Scherer, Bruna Palma Matta, Elvismary Molina de Armas, F ábio Carvalho de Barros Moreira, Anke Bergmann, Claudia Bessa Pereira Chaves, Mariana Boroni, Anna Claudia Evangelista dos Santos, Miguel Angel Tags: RESEARCH ARTICLE Source Type: research

RGD peptide in cancer targeting: Benefits, challenges, solutions, and possible integrin –RGD interactions
AbstractRGD peptide can be found in cell adhesion and signaling proteins, such as fibronectin, vitronectin, and fibrinogen. RGD peptides' principal function is to facilitate cell adhesion by interacting with integrin receptors on the cell surface. They have been intensively researched for use in biotechnology and medicine, including incorporation into biomaterials, conjugation to medicinal molecules or nanoparticles, and labeling with imaging agents. RGD peptides can be utilized to specifically target cancer cells and the tumor vasculature by engaging with these integrins, improving drug delivery efficiency and minimizing ...
Source: Cancer Medicine - February 2, 2024 Category: Cancer & Oncology Authors: Hossein Javid, Mahsa Akbari Oryani, Nastaran Rezagholinejad, Ali Esparham, Mahboubeh Tajaldini, Mehdi Karimi ‐Shahri Tags: REVIEW Source Type: research

Application of computer ‐aided detection for NCCN‐based follow‐up recommendation in subsolid nodules: Effect on inter‐observer agreement
ConclusionThe application of CAD significantly improves inter-observer agreement in the follow-up management strategy for subsolid nodules. It also demonstrates the potential to reduce substantial management discrepancies and increase detection sensitivity in lung cancer cases presenting as part-solid nodules. (Source: Cancer Medicine)
Source: Cancer Medicine - February 1, 2024 Category: Cancer & Oncology Authors: Wu Quanyang, Zhou Lina, Huang Yao, Wang Jiawei, Tang Wei, Qi Linlin, Zhang Zewei, Hou Donghui, Li Hongjia, Chen Shuluan, Zhang Jiaxing, Zhao Shijun Tags: RESEARCH ARTICLE Source Type: research

Somatic mutations in a multigene panel and impact on prognosis based on TP53 status in Chinese HER2 ‐positive patients undergoing neoadjuvant therapy: A single‐institution retrospective cohort
ConclusionsThe genetic mutation profiles of Chinese HER2+ patients who received NAT were discrepant with respect to HR status or DFS events. TP53 mutations have significant prognostic value in patients with NAT for HER2-positive BC and patients benefit differently depending on HR status, the neoadjuvant regimen and response, which highlights the significance of genetic factors in treatment customization based on individual genetic and clinical characteristics. (Source: Cancer Medicine)
Source: Cancer Medicine - February 1, 2024 Category: Cancer & Oncology Authors: Min Xiong, Xuliren Wang, Douwaner Liu, Bingqiu Xiu, Qi Zhang, Weiru Chi, Chih Wan Goh, Liyi Zhang, Ming Chen, Hengyu Ren, Zhi ‐Ming Shao, Benlong Yang, Jiong Wu Tags: RESEARCH ARTICLE Source Type: research

Real ‐world analysis of adverse event rates after initiation of ibrutinib among Medicare beneficiaries with chronic lymphocytic leukemia
ConclusionIn this first real-world study of a national sample of elderly US patients treated with ibrutinib, we found a clear unmet need for improved management of ibrutinib-related AEs and/or new treatments to improve real-world outcomes in patients with CLL. (Source: Cancer Medicine)
Source: Cancer Medicine - February 1, 2024 Category: Cancer & Oncology Authors: Scott F. Huntington, Enrico de Nigris, Justin T. Puckett, Sachin Kamal ‐Bahl, Mohammed Farooqui, Katherine Ryland, Eric M. Sarpong, Siyang Leng, Xiaoqin Yang, Jalpa A. Doshi Tags: BRIEF COMMUNICATION Source Type: research

Efficacy of first ‐line treatment options beyond RET‐TKIs in advanced RET‐rearranged non‐small cell lung cancer: A multi‐center real‐world study
ConclusionsI  + B + C might be a preferred option beyond RET-TKIs in the first-line therapy of RET-arranged NSCLC. Combination with Bevacizumab rather than with ICIs offered favorable survival compared with chemotherapy alone. (Source: Cancer Medicine)
Source: Cancer Medicine - February 1, 2024 Category: Cancer & Oncology Authors: Yihui Ge, Juan Li, Wenjing Gong, Jian Wang, Xiaojuan Wei, Jing Liu, Shuyun Wang, Leirong Wang, Haifeng Sun, Qinglei Cheng, Yanxin Sun, Qi Dang, Yuping Sun, Aiqin Gao Tags: RESEARCH ARTICLE Source Type: research

Carbon ion irradiation exerts antitumor activity by inducing cGAS –STING activation and immune response in prostate cancer‐bearing mice
ConclusionThe excellent antitumor activity of CIR in immunocompetent prostate cancer-bearing C57BL/6 mice may be attributed to stronger induction of antitumor immune response and higher activation of cGAS –STING pathway. (Source: Cancer Medicine)
Source: Cancer Medicine - February 1, 2024 Category: Cancer & Oncology Authors: Wei Hu, Zhenshan Zhang, Yushan Xue, Renli Ning, Xiaomao Guo, Yun Sun, Qing Zhang Tags: RESEARCH ARTICLE Source Type: research

Plateletcrit is predictive of clinical outcome and prognosis for early ‐stage breast cancer: A retrospective cohort study based on propensity score matching
ConclusionsSome blood parameters have value to predict DFS in early-stage BC patients, especially platelet-associated parameters. (Source: Cancer Medicine)
Source: Cancer Medicine - February 1, 2024 Category: Cancer & Oncology Authors: Xu Zhao, Yilan Yang, Zhe Pan, Weiluo Lv, Xinxin Rao, Xuanyi Wang, Xiaoli Yu Tags: RESEARCH ARTICLE Source Type: research

Docetaxel, cisplatin, and fluorouracil with pegfilgrastim on day 3 as neoadjuvant chemotherapy for esophageal cancer
ConclusionAdministration of pegfilgrastim on day 3 was not sufficient to prevent FN due to DCF treatment, and prophylactic administration of both pegfilgrastim and antibiotics could be a solution. (Source: Cancer Medicine)
Source: Cancer Medicine - February 1, 2024 Category: Cancer & Oncology Authors: Osamu Maeda, Satoshi Furune, Mitsuro Kanda, Kazushi Miyata, Dai Shimizu, Shizuki Sugita, Kazuki Nishida, Masahiko Ando, Yasuhiro Kodera, Yuichi Ando Tags: RESEARCH ARTICLE Source Type: research

Assessment of salivary cadmium levels and breast density in the Marin Women's Study
ConclusionSalivary Cd is a viable quantification source in large epidemiologic studies. Association analyses between Cd levels and breast density may provide additional information for breast cancer risk assessment, risk reduction plans, and future research directions. Further work is needed to demonstrate a more robust testing protocol before the extent of its usefulness can be established. (Source: Cancer Medicine)
Source: Cancer Medicine - February 1, 2024 Category: Cancer & Oncology Authors: Michaela F. George, Shayne Paff, Jenyse Rojo, Mark Powell, Christopher Benz, Karl Pope, Karla Kerlikowske, John Shepard, Matthew Willis, Rochelle Ereman, LeeAnn Prebil Tags: RESEARCH ARTICLE Source Type: research

Anti ‐tumorigenic effects of naive and TLR4‐primed adipose‐derived mesenchymal stem cells on pancreatic ductal adenocarcinoma cells
ConclusionsThese findings underscore the significance of both the naive state and different inflammatory phenotypes of MSCs in the microenvironment and represent a pivotal step toward the development of novel therapeutic approaches for pancreatic cancer. Understanding the intricate interactions between MSCs and cancer cells may open new avenues for targeted interventions in cancer therapy. (Source: Cancer Medicine)
Source: Cancer Medicine - February 1, 2024 Category: Cancer & Oncology Authors: Demet Ka çaroğlu, Seher Yaylacı, Nilgun Gurbuz Tags: RESEARCH ARTICLE Source Type: research

Comparison of percutaneous ablation and hepatectomy for liver metastasis: A single center retrospective study
ConclusionsPercutaneous thermal ablation was performed for many cancer types than hepatectomy. It is performed in elderly patients. We suggested that ablation for colorectal liver metastasis sized ≤2 cm is a suitable indication. (Source: Cancer Medicine)
Source: Cancer Medicine - February 1, 2024 Category: Cancer & Oncology Authors: Seiichi Tawara, Tetsuro Miyazaki, Ryosuke Kiyota, Yuki Maegawa, Takeshi Shimizu, Takuo Yamai, Shoichiro Kawai, Takuya Inoue, Hisateru Komatsu, Akira Tomokuni, Masaaki Motoori, Takayuki Yakushijin Tags: RESEARCH ARTICLE Source Type: research

Cancer and the family: Variations by sex and race/ethnicity
ConclusionThere are considerable differences by sex and race/ethnicity in the characteristics of cancer survivors with minor children. Clinicians should make consideration of family circumstances a routine part of their history. Doing so will help to identify potential sources of support and responsibility that may affect adherence. (Source: Cancer Medicine)
Source: Cancer Medicine - February 1, 2024 Category: Cancer & Oncology Authors: Charlotte Asiedu, Nicole S. McKinney, Alliric I. Willis, Frances M. Lewis, Shannon Virtue, Adam Davey Tags: RESEARCH ARTICLE Source Type: research