Dickkopf 1 is expressed in normal fibroblasts during early stages of colorectal tumorigenesis
ConclusionThese findings contribute valuable insights into the early stages of colorectal tumorigenesis and suggestDKK1 as a tumor suppressor. Additionally, serum DKK1 levels could serve as a biomarker to identify both cancer and adenoma, offering diagnostic possibilities for early-stage colon tumors.The present study has a few limitations. We considered using DKK1 as a candidate gene for gene transfer to organoids and NFs; however, it was difficult due to technical problems and the slow growth rate of NFs. Therefore, we used cancer cell lines instead. In addition, immunostaining and ELISA were based on the short-term coll...
Source: Cancer Medicine - February 9, 2024 Category: Cancer & Oncology Authors: Yushi Inomata, Masatake Kuroha, Yusuke Shimoyama, Takeo Naito, Rintaro Moroi, Hisashi Shiga, Yoichi Kakuta, Hideaki Karasawa, Shinobu Onuma, Yoshitaka Kinouchi, Atsushi Masamune Tags: RESEARCH ARTICLE Source Type: research

Mitochondrial dynamics as a novel treatment strategy for triple ‐negative breast cancer
ConclusionOur findings indicated that the interplay between mitophagy, linked to a worse clinical prognosis, and OXPHOS metabolism promoted chemotherapy resistance in TNBC. Mitochondrial fission is prevalent in TNBC. These findings suggest that targeting the unique mitochondrial metabolism and dynamics in TNBC may offer a novel therapeutic strategy for patients with TNBC. (Source: Cancer Medicine)
Source: Cancer Medicine - February 9, 2024 Category: Cancer & Oncology Authors: Yuechen Wang, Narumi Harada ‐Shoji, Narufumi Kitamura, Yuto Yamazaki, Akiko Ebata, Masakazu Amari, Mika Watanabe, Minoru Miyashita, Hiroshi Tada, Takaaki Abe, Takashi Suzuki, Kohsuke Gonda, Takanori Ishida Tags: RESEARCH ARTICLE Source Type: research

Retraction
(Source: Cancer Medicine)
Source: Cancer Medicine - February 9, 2024 Category: Cancer & Oncology Tags: RETRACTION Source Type: research

Neoadjuvant chemotherapy for breast cancer: Pathologic response rates but not tumor size, has an independent prognostic impact on survival
ConclusionAchievement of pCR, but not tumor size (pretreatment cT category), has an independent prognostic impact on survival. These results suggest potential NAC benefits in patients with small tumors (<2  cm), even in absence of clinically suspicious lymph nodes. Residual lymph node disease after NAC is the most powerful adverse prognostic factor. (Source: Cancer Medicine)
Source: Cancer Medicine - February 8, 2024 Category: Cancer & Oncology Authors: Gilles Houvenaeghel, Alexandre de Nonneville, Monique Cohen, Laura Sabiani, Max Buttarelli, Emmanuelle Charaffe, Aur élie Jalaguier, Marie Bannier, Agnès Tallet, Frédéric Viret, Anthony Gonçalves Tags: RESEARCH ARTICLE Source Type: research

Experiences of caregivers of children with cancer in Malawi: A qualitative study
ConclusionCaregivers of Malawian children with cancer experience physical and psychosocial challenges as they are caring for their children with cancer. Developing appropriate interventions would enable nurses to offer optimal support to these caregivers in dealing with these challenges and meeting their needs effectively. (Source: Cancer Medicine)
Source: Cancer Medicine - February 7, 2024 Category: Cancer & Oncology Authors: Lophina Phiri, William Ho Cheung Li, Patrick G. M. C. Phiri, Ankie Tan Cheung, Watipaso Wanda ‐Kalizang'oma, Anizia Kamwendo, Sellina Lemon Tags: RESEARCH ARTICLE Source Type: research

Comparative survival analysis of bladder preservation therapy versus radical cystectomy in muscle ‐invasive bladder cancer
ConclusionIn Asian populations, bladder preservation therapy yielded similar survival outcomes as radical cystectomy in MIBC patients. Based on the results, it is evident that a multidisciplinary approach and shared decision-making are recommended for bladder cancer treatment. (Source: Cancer Medicine)
Source: Cancer Medicine - February 6, 2024 Category: Cancer & Oncology Authors: Nai ‐Wen Kang, Yin‐Hsun Feng, Kuei‐Li Lin, Yi‐Chen Chen, Chung‐Han Ho, Ching‐Chieh Yang Tags: RESEARCH ARTICLE Source Type: research

Comparison of IL ‐2‐antibody to IL‐2‐Fc with or without stereotactic radiation therapy in CEA immunocompetent mice with CEA positive tumors
ConclusionsIL-2-Fc had comparable antitumor efficacy to CEA-targeted M5A-IL-2 ICK, while both fusion proteins induced immune memory when combined with SRT. Differences in the therapeutic mechanisms of both agents were observed. (Source: Cancer Medicine)
Source: Cancer Medicine - February 6, 2024 Category: Cancer & Oncology Authors: Lindsay Williams, Lin Li, Paul J. Yazaki, Patty Wong, Teresa Hong, Erasmus K. Poku, Susanta Hui, Hemendra Ghimire, John E. Shively, Maciej Kujawski Tags: RESEARCH ARTICLE Source Type: research

Referred molecular testing as a barrier to optimal treatment decision making in metastatic non ‐small cell lung cancer: Experience at a tertiary academic institution in Canada
ConclusionOur results demonstrate the advantages of in-house biomarker testing for mNSCLC at a tertiary oncology center. Incorporation of in-house testing may reduce barriers to offering personalized medicine by improving the time to optimal systemic therapy decision. (Source: Cancer Medicine)
Source: Cancer Medicine - February 6, 2024 Category: Cancer & Oncology Authors: Grace K. Grafham, Kenneth J. Craddock, Weei ‐Yuarn Huang, Alexander V. Louie, Liying Zhang, David M. Hwang, Ambica Parmar Tags: RESEARCH ARTICLE Source Type: research

Patient's experiences of coughing after lung cancer surgery: A multicenter qualitative study
ConclusionWe generated a concept framework of cough after lung cancer surgery, providing a basis for further development of measurement tools from the patients' perspective. The lack of knowledge related to coughing highlights the need for adequate and timely health education and professional medical care. (Source: Cancer Medicine)
Source: Cancer Medicine - February 5, 2024 Category: Cancer & Oncology Authors: Xiangxi Zhou, Cheng Lei, Xing Wei, Wei Dai, Wei Xu, Yongping Ao, Xianglin Li, Guibin Qiao, Qiuling Shi Tags: RESEARCH ARTICLE Source Type: research

Hearing preservation after stereotactic radiosurgery for sporadic intracanalicular vestibular schwannomas classified as Koos grade 1
ConclusionsPetit VSs that can be treated with 4-mm single or double shots with a marginal dose of 12  Gy may achieve hearing preservation after SRS. (Source: Cancer Medicine)
Source: Cancer Medicine - February 5, 2024 Category: Cancer & Oncology Authors: Ho Kang, So Young Ji, Chae ‐Yong Kim, Ja‐Won Koo, Jae‐Jin Song, Byung Yoon Choi, Kihwan Hwang, Jung Ho Han Tags: RESEARCH ARTICLE Source Type: research

Prognostic implications of HER2NEU ‐low in metastatic breast cancer
ConclusionsIn the largest such analysis performed to date, our study demonstrates a small but statistically significant association with improved survival for HER2-low tumors compared to HER2-negative tumors in MBC. (Source: Cancer Medicine)
Source: Cancer Medicine - February 5, 2024 Category: Cancer & Oncology Authors: Zachary Neubauer, Shaakir Hasan, Robert H. Press, Arpit M. Chhabra, Jana Fox, Richard Bakst, Charles B. Simone, J. Isabelle Choi Tags: RESEARCH ARTICLE Source Type: research

Associations of brain ‐derived neurotrophic factor rs6265 polymorphism and cognitive function in breast cancer survivors from a cross‐sectional study
ConclusionOur findings suggest that carrying the BDNF rs6265 Met/Met genotype increases the risk for CRCI in BCS. These results are foundational in nature and provide important information to identify mechanisms underpinning CRCI. (Source: Cancer Medicine)
Source: Cancer Medicine - February 5, 2024 Category: Cancer & Oncology Authors: Taichi Goto, Leorey N. Saligan, Xiaobai Li, Lichen Xiang, Catherine Kwiat, Christopher Nguyen, Adele Crouch, Diane Von  Ah Tags: RESEARCH ARTICLE Source Type: research

Implementing systematic melanoma risk assessment and risk ‐tailored surveillance in a skin cancer focussed dermatology clinic: A qualitative study of feasibility and acceptability to patients and clinic staff
ConclusionsIt is feasible and acceptable to patients and clinic staff to calculate and deliver personalised melanoma risk information and tailored surveillance as part of routine clinical care within dermatology clinics. (Source: Cancer Medicine)
Source: Cancer Medicine - February 5, 2024 Category: Cancer & Oncology Authors: A. L. Smith, A. K. Smit, B. I. Laginha, N. Singh, B. Gallo, L. Martin, A. E. Cust Tags: RESEARCH ARTICLE Source Type: research

Regulation of regulatory T cells and tumor ‐associated macrophages in gastric cancer tumor microenvironment
ConclusionDiscussing the distinct tumor immune microenvironment (TIME) of GC can deepen our understanding on the mechanism of cancer immune evasion, invasion, and metastasis, help us to reduce the incidence of GC, and guide the innovation of new therapeutic targets for GC eventually. (Source: Cancer Medicine)
Source: Cancer Medicine - February 5, 2024 Category: Cancer & Oncology Authors: Zhang Shaopeng, Zheng Yang, Fang Yuan, Huang Chen, Qiu Zhengjun Tags: REVIEW Source Type: research

Genomic heterogeneity of multiple synchronous lung cancers in Chinese population
ConclusionIn summary, unlike intrapulmonary metastases, patients with MSLC harbor distinct genomic profiles in different tumor lesions, and we could distinguish MSLC from intrapulmonary metastases via clonality estimation. (Source: Cancer Medicine)
Source: Cancer Medicine - February 5, 2024 Category: Cancer & Oncology Authors: Lei Zhao, Jin Wang, Yixiang Zhang, Peng Wang, Changsheng Lv, Shilei Zhao, Tao Guo, Fengzhou Li, Chundong Gu, Yuntao Zhu Tags: RESEARCH ARTICLE Source Type: research