American Journal of Translational Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Non-alcoholic fatty liver disease: pathogenesis and models
Am J Transl Res. 2024 Feb 15;16(2):387-399. doi: 10.62347/KMSA5983. eCollection 2024.ABSTRACTNon-alcoholic fatty liver disease (NAFLD) is a complex disease characterized by a massive accumulation of lipids in the liver, with a continuous progression of simple steatosis, non-alcoholic steatohepatitis (NASH), cirrhosis, and hepatocellular carcinoma. Non-alcoholic fatty liver disease is associated with obesity, insulin resistance, and metabolic syndrome; it is a severe public health risk and is currently the most common liver disease of the world. In addition to the fatty infiltration of the liver in non-alcoholic fatty liver...
Source: American Journal of Translational Research - March 11, 2024 Category: Research Authors: Hanxiang Zhong Jiayong Dong Liye Zhu Jiaxi Mao Junfeng Dong Yuanyu Zhao You Zou Meng Guo Guoshan Ding Source Type: research

Comparing suspension laryngoscopic mucosal dissection and plasma resection for laryngeal leukoplakia: prognostic outcomes
CONCLUSION: Both suspension laryngoscopic mucosal dissection and plasma resection can provide significant efficacy in the treatment of laryngeal leukoplakia, and cryo-plasma resection can contribute to a lower incidence of relapse, enhanced postoperative recovery, and superior short- and long-term outcomes than plasma resection.PMID:38463580 | PMC:PMC10918126 | DOI:10.62347/NXGS1826 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - March 11, 2024 Category: Research Authors: Ye Liu Guihua Xia Shaosheng Liu Ke Ji Source Type: research

Transcriptomics data integration and analysis to uncover hallmark genes in hypertrophic cardiomyopathy
CONCLUSION: In summary, the identification of key hub genes and their enrichment analysis in the current study may shed light on the mechanisms behind the occurrence and development of HCM.PMID:38463581 | PMC:PMC10918138 | DOI:10.62347/AXOY3338 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - March 11, 2024 Category: Research Authors: Peng Chen Warda Yawar Ayesha Rida Farooqui Saqib Ali Nida Lathiya Zeeshan Ghous Rizwana Sultan Majid Alhomrani Saleh A Alghamdi Abdulraheem Ali Almalki Ahmad A Alghamdi Naif ALSuhaymi Muhammad Razi Ul Islam Hashmi Yasir Hameed Source Type: research

New-onset tachycardia-bradycardia syndrome following acute non-medullary brainstem infarction
We present the case of a 46-year-old female who developed severe dizziness with vomiting, diplopia, and slurred speech, which gradually worsened to quadriplegia, severe hypophonia, and dysphagia. Brain magnetic resonance imaging (MRI) demonstrated acute midbrain and pontine infarction. Except for neurological symptoms, the patient experienced unexpected TBS with the symptoms of excessive sweating, palpitations, and irritability without any other predisposing factors. The frequency of the episodes gradually declined until it spontaneously disappeared the 5th day after admission. Given the unpredictable nature of the tachyca...
Source: American Journal of Translational Research - March 11, 2024 Category: Research Authors: Jingmin Zhao Yu Gao Zhengxian Jin Yujing Huang Kwee-Yum Lee Guangxun Shen Source Type: research

Effects of neoadjuvant chemotherapy combined with radical laparoscopic surgery with quality nursing care on clinical efficacy and sex hormones in patients with cervical cancer
CONCLUSION: Neoadjuvant chemotherapy combined with laparoscopic radical surgery is more effective in reducing the levels of tumor markers and significantly affects the levels of sex hormones. E2, LH, and SCC-Ag are the independent prognostic factors for 2-year survival in patients with cervical cancer. This study provides evidence to support the comprehensive treatment of cervical cancer.PMID:38463583 | PMC:PMC10918130 | DOI:10.62347/NKJK1347 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - March 11, 2024 Category: Research Authors: Haifeng Hu Zhishang Wang Lanhui Xue Tongmei Zhang Yanru Jing Yawen Li Source Type: research

Thyroid autoimmunity in relation to HLA-DRB1 and HLA-DQB1 polymorphism in nonsegmental vitiligo: a cross-sectional-study
CONCLUSION: Our findings suggest that HLA-DQ polymorphisms influence TAI risk in subjects with NSV, although HLA does not completely explain the co-occurrence of these two diseases.PMID:38463584 | PMC:PMC10918139 | DOI:10.62347/LDYE8203 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - March 11, 2024 Category: Research Authors: Abdellatif Bouayad Laila Benzekri Source Type: research

Synergistic impact of Gui Zhi Shao Yao Zhi Mu Decoction and leflunomide on gut microbiota in rheumatoid arthritis: insights from 16S rDNA sequencing
CONCLUSION: GSZD combined with leflunomide significantly modulates the gut microbiota in RA patients. This study provides insights into the mechanisms underlying the therapeutic effects of GSZD and highlights the potential of integrating traditional Chinese medicine with conventional treatments in managing RA.PMID:38463585 | PMC:PMC10918140 | DOI:10.62347/TDTJ1944 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - March 11, 2024 Category: Research Authors: Ying Sun Xiaoheng Chen Ye Zhang Xiaojun Chen Chen Zhang Jing Zhao Songge Sun Yanzhen Zhang Xinping Qiu Source Type: research

Expression of circular RNA has-circ-0009158 and identification of associated miRNA-mRNA network in hepatocellular carcinoma
This study explored the expression and associated miRNA-mRNA network of has-circ-0009158 in HCC. Quantitative real-time polymerase chain reaction was used to measure the expression of hsa-circ-0009158 in the HCC tissues of 143 patients and four human HCC cell lines. Then, the potential relationship of hsa-circ-0009158 expression with clinical characteristics and prognosis of patients was analyzed using the GO and KEGG databases. Correlated miRNA-mRNA networks were forecasted using the TCGA database and Cytoscape software. The hsa-circ-0009158 expression was significantly upregulated in HCC tissues and cell lines (P<0.00...
Source: American Journal of Translational Research - March 11, 2024 Category: Research Authors: Lili Sun Buerlan Yeerkenbieke Anwaier Yuemaierabola Fuzhong Liu Dilinaer Yeerxiati Xiaogang Dong Wenjia Guo Source Type: research

Effects of Shixiao Huoxue Decoction on pain, tumor necrosis factor- α, and interleukin-8 in patients with adenomyosis
CONCLUSION: Xiaoxiao Huoxue Decoction demonstrated a better treatment efficacy in patients with adenomyosis through improving dysmenorrhea and Traditional Chinese Medicine symptoms, as well as reducing the levels of body inflammatory factors, non-menstrual pelvic pain, and dyspareunia, thus contributing to early recovery of patients. Therefore, Xiaoxiao Huoxue Decoction is worthy of promotion in clinical treatment of adenomyosis.PMID:38463587 | PMC:PMC10918143 | DOI:10.62347/VQVR4400 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - March 11, 2024 Category: Research Authors: Weihua Li Chao Shao Jing Liang Source Type: research

Dysregulation of kidney proteases in the pathogenesis of hypertension following unilateral nephrectomy in juvenile mice
CONCLUSION: UNX results in the development of persistent and progressive hypertension. Down-regulation of KLK1 and up-regulation of various cathepsins may contribute to the development of hypertension via multiple mechanisms including a decrease in nitric oxide (NO) production.PMID:38463588 | PMC:PMC10918144 | DOI:10.62347/HONT9617 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - March 11, 2024 Category: Research Authors: Rasha Aly Yunus E Dogan Niharika Bala Carlos Lugo Seena Darwish Lawrence Shoemaker Abdel A Alli Source Type: research

Screening sensibility and antifungal activity after topical application of a synthetic lactoferrin-derived antimicrobial peptide
CONCLUSIONS: This study showed a positive therapeutic effect of a commercial product containing hLF1-11 in the case of 88.9% of the patients with onychomycosis. The present formulation of hLF1-11 into PBS is stable enough to permit storage at room temperature for at least two years.PMID:38463589 | PMC:PMC10918136 | DOI:10.62347/TCOY1289 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - March 11, 2024 Category: Research Authors: Carlo Brouwer Teun Boekhout Saleh Alwasel Mahfuzur Rahman Ruth Janga Mick M Welling Source Type: research

Complex phenotypic heterogeneity of combined hepatocellular-cholangiocarcinoma with a homogenous < em > TERT < /em > promoter mutation
Am J Transl Res. 2024 Feb 25;16(2):690-699. doi: 10.62347/CQJW7490. eCollection 2024.ABSTRACTTo clarify the mechanism underlying the development and poor prognosis of combined hepatocellular-cholangiocarcinoma (cHCC-CCA), we characterized liver cancer driver mutations and poor prognostic markers in both the HCC and intrahepatic CCA (iCCA) components of a cHCC-CCA tumor. The telomerase reverse transcriptase (TERT) promoter mutation C228T was quantified by digital polymerase chain reaction using DNA from multiple microdissected cancer components of a single cHCC-CCA nodule. The protein expression of cancer-related markers, i...
Source: American Journal of Translational Research - March 11, 2024 Category: Research Authors: Sumie Ohni Hiromi Yamaguchi Yukari Hirotani Yoko Nakanishi Yutaka Midorikawa Masahiko Sugitani Tomohiro Nakayama Makoto Makishima Mariko Esumi Source Type: research

IL-1RA autoantibodies: insights into mechanisms and associated diseases
Am J Transl Res. 2024 Feb 15;16(2):374-386. doi: 10.62347/NTVU5728. eCollection 2024.ABSTRACTThe association of neutralizing autoantibodies targeting interleukin-1 receptor antagonist (IL-1RA) with multisystem inflammatory syndrome, IgG4-related disease, and vaccine-related myocarditis is increasingly recognized. The detection of IL-1RA autoantibodies can be notably affected by the techniques and methods employed. Two categories of assays are available: solid-phase immunoassays, which detect binding of IL-1RA autoantibodies, and functional IL-1 signaling reporter cell assays, which offer greater specificity by determining ...
Source: American Journal of Translational Research - March 11, 2024 Category: Research Authors: Abdellatif Bouayad Source Type: research

Clinical significance of measuring MP-DNA, C-reactive protein, and inflammatory cytokines in children with mycoplasma pneumoniae pneumonia
CONCLUSION: Indicators such as MP-DAN, IL-6, IL-8 are crucial in the development and progression of MPP, playing an important role in diagnosing and treating patients with MPP.PMID:38463592 | PMC:PMC10918132 | DOI:10.62347/VCVW7593 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - March 11, 2024 Category: Research Authors: Wangqiang Li Fang Deng Source Type: research

Primary perihilar bile duct neuroendocrine tumor: a case report and review of the literature
This article chronicles a case study detailing a neuroendocrine tumor's diagnostic and treatment course within the perihilar bile duct. Integrating pertinent literature, it encapsulates the clinical attributes and diagnostic and therapeutic advancements in biliary neuroendocrine tumors. The aspiration is to augment awareness of this category of ailments, mitigating the occurrence of both missed and erroneous diagnoses, and furnishing a reference for forthcoming clinical endeavors.PMID:38463593 | PMC:PMC10918117 | DOI:10.62347/HFBY5551 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - March 11, 2024 Category: Research Authors: Haidong Ai Ting Gong Yongbiao Ma Guixu Ma Jingjing Zhao Xuelin Zhao Source Type: research