Gene expression profiling of sequential metastatic biopsies for biomarker discovery in breast cancer

The feasibility of longitudinal metastatic biopsies for gene expression profiling in breast cancer is unexplored. Dynamic changes in gene expression can potentially predict efficacy of targeted cancer drugs.Patients enrolled in a phase III trial of metastatic breast cancer with docetaxel monotherapy versus combination of docetaxel + sunitinib were offered to participate in a translational substudy comprising longitudinal fine needle aspiration biopsies and Positron Emission Tomography imaging before (T1) and two weeks after start of treatment (T2).

Source: Molecular Oncology - April 2, 2015 Category: Cancer & Oncology Authors: Theodoros Foukakis, John Lövrot, Patricia Sandqvist, Hanjing Xie, Linda S. Lindström, Carla Giorgetti, Hans Jacobsson, Elham Hedayati, Jonas Bergh Source Type: research