Architectural and Biochemical Adaptations in Skeletal Muscle and Bone Following Rotator Cuff Injury in a Rat Model

Conclusions:
These data suggest that tenotomy alone interferes with normal age-related muscle growth. The addition of chemical paralysis yielded profound structural changes to the muscle and bone, potentially leading to impaired muscle function, increased muscle stiffness, and decreased bone strength.

Clinical Relevance:
Structural musculoskeletal changes occur after tendon injury, and these changes are severely exacerbated with the addition of neuromuscular compromise.

Source: The Journal of Bone and Joint Surgery - April 1, 2015 Category: Orthopaedics Authors: Sato, E. J., Killian, M. L., Choi, A. J., Lin, E., Choo, A. D., Rodriguez-Soto, A. E., Lim, C. T., Thomopoulos, S., Galatz, L. M., Ward, S. R. Tags: Basic Science Scientific Articles Source Type: research