False interpretation of diagnostic serology tests for patients treated with pooled human immunoglobulin G infusions: a trap for the unwary.

We present two example cases of clinical situations where this could cause concern. We tested multiple IgG products with a range of serological tests performed in infective or autoimmune conditions, including hepatitis B, syphilis, human immunodeficiency virus, human T-lymphotropic virus, anti-neutrophil cytoplasmic antibody (ANCA), anti-nuclear antibody (ANA), anti-cardiolipin antibodies and anti-double stranded DNA (dsDNA) antibody. We found positivity within these products for hepatitis B surface and core antibody, syphilis, ANCA, ANA, anti-cardiolipin IgG and dsDNA antibody, which may result from specific or non-specific reactivity. The serological testing of patients who have received IgG treatment detects the administered IgG in addition to IgG produced by the patient. PMID: 25824062 [PubMed - in process]

http://www.ncbi.nlm.nih.gov/pubmed/25824062?dopt=Abstract

Source: Clinical Medicine - April 1, 2015 Category: Journals (General) Authors: Bright PD, Smith L, Usher J, Donati M, Johnston SL, Gompels MM, Unsworth DJ Tags: Clin Med Source Type: research