Preclinical Validation of Anti-Nuclear Factor-kappa B Therapy to Inhibit Human Vestibular Schwannoma Growth

Vestibular schwannomas (VSs), the most common tumors of the cerebellopontine angle, arise from Schwann cells lining the vestibular nerve. Pharmacotherapies against VS are almost non-existent. Although the therapeutic inhibition of inflammatory modulators has been established for other neoplasms, it has not been explored in VS. A bioinformatic network analysis of all genes reported to be differentially expressed in human VS revealed a pro-inflammatory transcription factor nuclear factor-kappa B (NF-κB) as a central molecule in VS pathobiology.

Source: Molecular Oncology - March 31, 2015 Category: Cancer & Oncology Authors: Sonam Dilwali, Martijn C. Briët, Shyan-Yuan Kao, Takeshi Fujita, Lukas D. Landegger, Michael P. Platt, Konstantina M. Stankovic Source Type: research